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Work with thought leaders and academic experts in biochemistry

Companies can greatly benefit from working with experts in the field of Biochemistry. These researchers bring a deep understanding of molecular processes, biochemical reactions, and the structure and function of biomolecules. They can provide valuable insights and solutions for various industries, including pharmaceuticals, biotechnology, agriculture, food science, and environmental science. By collaborating with Biochemistry experts, companies can enhance their research and development efforts, accelerate innovation, improve product quality, optimize production processes, and address complex challenges. Their expertise can also contribute to the discovery of new drugs, the development of sustainable technologies, and the improvement of health and well-being.

Researchers on NotedSource with backgrounds in biochemistry include Edward Elliott, Ph.D., Dr. Everson A Nunes, Ph.D., Dr. Shilpa Patil, Ph.D, IQRAM HUSSAIN, Ph.D., Ping Luo, Luca Delfinis, Mohammad Imran Khan, Luciano Dibona, Ph.D, Dr. Fantai Kong, Ph.D., Ajay Badhan, Aayudh Das, Ph.D., Aimee Eggler, Sheed Itaman, and Michael W Harman.

Edward Elliott, Ph.D.

Portland, Oregon, United States of America
Ph.D. Chemist with expertise in nanoparticle synthesis and characterization, medical diagnostics, materials chemistry, additive manufacturing, and development of novel composites.
Most Relevant Research Interests
Biochemistry
Other Research Interests (15)
Nanoscale Characterization
Nanoparticle Synthesis
Surface Chemistry
Atomic and Molecular Physics, and Optics
Physical and Theoretical Chemistry
And 10 more
About
Ed has been working in the field of nanoscience and chemistry since completing his Ph.D. in 2014. He has worked on a variety of projects ranging from drug delivery to nanodevice fabrication and characterization. Elliott has published numerous papers in both peer-reviewed journals and conferences and holds several US patents. He has also presented his research at various international conferences and workshops and currently works as a consultant focused on sustainability and green chemistry.

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Dr. Everson A Nunes, Ph.D.

Hamilton, Ontario, Canada
Post-Doctoral Fellow at McMaster University | former Associate Professor - Physiological Sciences
Most Relevant Research Interests
Biochemistry
Other Research Interests (39)
skeletal muscle
nutrition
physical activity
obesity
cancer
And 34 more
About
Dr. Everson A Nunes is a highly accomplished researcher and educator in the field of physiological sciences. He received his Ph.D. in Cellular and Molecular Biology with a focus on Physiological Sciences from Universidade Federal do Paraná in 2009, after completing a BSc in Human Nutrition and an MSc in Physiological Sciences. He also holds a specialization in Exercise Physiology and a BSc in Biological Sciences from Universidade Federal do Paraná. Dr. Nunes has a strong background in research, having completed two post-doctoral fellowships at McMaster University and Universidade Federal do Paraná. He has also held positions as an associate professor and assistant professor at Universidade Federal de Santa Catarina. He has published numerous articles in peer-reviewed journals, and his research focuses on the effects of exercise and nutrition on physiological processes in the human body. In addition to his research, Dr. Nunes is also a dedicated educator. He has taught at various universities in Brazil, including Universidade Federal de Santa Catarina, Universidade Gama Filho, Faculdades Integradas Espírita, Pontificia Universidade Católica do Paraná, and Faculdade do Litoral Sul. He is known for his dynamic teaching style and his ability to engage students in complex physiological concepts. Dr. Nunes is a member of several professional organizations, including the American Society for Nutrition, the Canadian Society of Exercise Physiology, the Canadian Nutrition Society and the Brazilian Society of Physiology. He is also a regular speaker at national and international conferences, sharing his expertise and research findings with colleagues and students. Overall, Dr. Nunes is a highly qualified and experienced professional in physiological sciences, metabolism, cancer and nutrition. His dedication to research and education makes him a valuable asset to any institution.
Most Relevant Publications (8+)

97 total publications

Fish Oil Decreases C‐Reactive Protein/Albumin Ratio Improving Nutritional Prognosis and Plasma Fatty Acid Profile in Colorectal Cancer Patients

Lipids / Jul 26, 2013

Mocellin, M. C., Pastore e Silva, J. de A., Camargo, C. de Q., Fabre, M. E. de S., Gevaerd, S., Naliwaiko, K., Moreno, Y. M. F., Nunes, E. A., & Trindade, E. B. S. de M. (2013). Fish Oil Decreases C‐Reactive Protein/Albumin Ratio Improving Nutritional Prognosis and Plasma Fatty Acid Profile in Colorectal Cancer Patients. Lipids, 48(9), 879–888. Portico. https://doi.org/10.1007/s11745-013-3816-0

Fish Oil Supplementation Improves Neutrophil Function During Cancer Chemotherapy

Lipids / Dec 11, 2011

Bonatto, S. J. R., Oliveira, H. H. P., Nunes, E. A., Pequito, D., Iagher, F., Coelho, I., Naliwaiko, K., Kryczyk, M., Brito, G. A. P., Repka, J., Sabóia, L. V., Fukujima, G., Calder, P. C., & Fernandes, L. C. (2011). Fish Oil Supplementation Improves Neutrophil Function During Cancer Chemotherapy. Lipids, 47(4), 383–389. Portico. https://doi.org/10.1007/s11745-011-3643-0

Insulin rapidly increases skeletal muscle mitochondrial ADP sensitivity in the absence of a high lipid environment

Biochemical Journal / Jul 09, 2021

Brunetta, H. S., Petrick, H. L., Vachon, B., Nunes, E. A., & Holloway, G. P. (2021). Insulin rapidly increases skeletal muscle mitochondrial ADP sensitivity in the absence of a high lipid environment. Biochemical Journal, 478(13), 2539–2553. https://doi.org/10.1042/bcj20210264

Nitrate consumption preserves HFD-induced skeletal muscle mitochondrial ADP sensitivity and lysine acetylation: A potential role for SIRT1

Redox Biology / Jun 01, 2022

Brunetta, H. S., Petrick, H. L., Momken, I., Handy, R. M., Pignanelli, C., Nunes, E. A., Piquereau, J., Mericskay, M., & Holloway, G. P. (2022). Nitrate consumption preserves HFD-induced skeletal muscle mitochondrial ADP sensitivity and lysine acetylation: A potential role for SIRT1. Redox Biology, 52, 102307. https://doi.org/10.1016/j.redox.2022.102307

Impact of combined long-term fructose and prednisolone intake on glucose and lipid homeostasis in rats: benefits of intake interruption or fish oil administration

The Journal of Nutritional Biochemistry / Apr 01, 2021

Santos, C. dos, da Silva, J. S., Brunetta, H. S., Chagas, T. R., Zoccal, D. B., Nunes, E. A., & Rafacho, A. (2021). Impact of combined long-term fructose and prednisolone intake on glucose and lipid homeostasis in rats: benefits of intake interruption or fish oil administration. The Journal of Nutritional Biochemistry, 90, 108572. https://doi.org/10.1016/j.jnutbio.2020.108572

Fructose Intake Impairs Cortical Antioxidant Defenses Allied to Hyperlocomotion in Middle-Aged C57BL/6 Female Mice

Neurochemical Research / Sep 23, 2020

dos Santos, B., Schmitz, A. E., de Almeida, G. R. L., de Souza, L. F., Szczepanik, J. C., Nunes, E. A., Brunetta, H. S., Mack, J. M., Prediger, R. D., Cunha, M. P., & Dafre, A. L. (2020). Fructose Intake Impairs Cortical Antioxidant Defenses Allied to Hyperlocomotion in Middle-Aged C57BL/6 Female Mice. Neurochemical Research, 45(12), 2868–2883. https://doi.org/10.1007/s11064-020-03135-7

Does l-leucine supplementation cause any effect on glucose homeostasis in rodent models of glucose intolerance? A systematic review

Amino Acids / Sep 27, 2018

Brunetta, H. S., de Camargo, C. Q., & Nunes, E. A. (2018). Does l-leucine supplementation cause any effect on glucose homeostasis in rodent models of glucose intolerance? A systematic review. Amino Acids, 50(12), 1663–1678. https://doi.org/10.1007/s00726-018-2658-8

Lymphocytes transfer [14C]‐labeled fatty acids to skeletal muscle in culture; modulation by exercise

Cell Biochemistry and Function / May 26, 2010

Brito, G. A. P., Nunes, E. A., Nogata, C., Yamazaky, R. K., Naliwaiko, K., Curi, R., & Fernandes, L. C. (2010). Lymphocytes transfer [14C]‐labeled fatty acids to skeletal muscle in culture; modulation by exercise. Cell Biochemistry and Function, 28(4), 278–282. Portico. https://doi.org/10.1002/cbf.1652

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Dr. Shilpa Patil, Ph.D

Vancouver, British Columbia, Canada
PhD & Postdoc level expertise in Cancer Research
Most Relevant Research Interests
Biochemistry
Other Research Interests (11)
Cancer
epigenetics
development
Oncology
Cancer Research
And 6 more
About
Dr. Shilpa Patil is a highly experienced cancer researcher with a strong background in Preclinical studies. She received her Ph.D. in Molecular Medicine from the University of Göttingen in 2020, where she focused on developing novel treatments for pancreatic cancer. Prior to that, she completed her MSc in Regenerative Medicine from Manipal University in 2014 and her BSc in Biotechnology from the same institution in 2012. With over 6 years of research experience, Dr. Patil has worked at prestigious institutions such as the University of British Columbia, University of Göttingen and JNCASR. Her expertise lies in the areas of cancer biology, epigenetics, cell and molecular biology, and regenerative medicine. She has published numerous research articles in reputed journals and has presented her work at various international conferences. Dr. Patil is a dedicated and passionate scientist, committed to using her knowledge and skills to contribute to the fight against cancer. She is driven by her curiosity to unravel complex biological processes and her desire to make a positive impact in the field of cancer research. She is also driven to bridge the academia-industry gap.
Most Relevant Publications (1+)

20 total publications

Oligomers of human histone chaperone NPM1 alter p300/KAT3B folding to induce autoacetylation

Biochimica et Biophysica Acta (BBA) - General Subjects / Aug 01, 2018

Kaypee, S., Sahadevan, S. A., Sudarshan, D., Halder Sinha, S., Patil, S., Senapati, P., Kodaganur, G. S., Mohiyuddin, A., Dasgupta, D., & Kundu, T. K. (2018). Oligomers of human histone chaperone NPM1 alter p300/KAT3B folding to induce autoacetylation. Biochimica et Biophysica Acta (BBA) - General Subjects, 1862(8), 1729–1741. https://doi.org/10.1016/j.bbagen.2018.05.003

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IQRAM HUSSAIN, Ph.D.

New York City, New York, United States of America
Weill Cornell Medicine, Cornell University, NY, USA
Most Relevant Research Interests
Biochemistry
Other Research Interests (32)
Biomedical & Medical Physics
AI (Machine & Deep Learning)
Anesthesiology
Sleep Medicine
Human Gait & brain
And 27 more
About
Iqram Hussain works at the Department of Anesthesiology, Weill Cornell Medicine, Cornell University, NY, USA. Earlier, he was a postdoctoral researcher at the Medical Research Center, Department of Biomedical Engineering, Seoul National University. He pursued a Ph.D. degree in Medical Physics from the University of Science and Technology (UST), South Korea. He worked as a Research Associate with the Korea Research Institute of Standards and Science (KRISS), Daejeon, South Korea. He worked on the Knowledgebase Super Brain (KSB) project at the Electronics and Telecommunication Research Institute (ETRI), Daejeon. He received a B.Sc. degree in mechanical engineering from the Khulna University of Engineering & Technology, Bangladesh, in 2007. He has ten years of work experience in power plant operation and maintenance and power plant project management. His research interests include wearable sleep monitoring, neuroscience, medical physics, human factors, and ergonomics. He has experience in healthcare research, project management, power plant operation, and maintenance. He is a reviewer in IEEE Access, Sensors, Applied Sciences, Biomedical Signal Processing and Control, IEEE Transactions, Science of the Total Environment, Neuroscience Informatics, Brain Sciences, etc. He is a guest editor in special issues of several Journals. Website: https://sites.google.com/view/iqram/home
Most Relevant Publications (7+)

44 total publications

Quantitative Evaluation of EEG-Biomarkers for Prediction of Sleep Stages

Sensors / Apr 17, 2022

Hussain, I., Hossain, M. A., Jany, R., Bari, M. A., Uddin, M., Kamal, A. R. M., Ku, Y., & Kim, J.-S. (2022). Quantitative Evaluation of EEG-Biomarkers for Prediction of Sleep Stages. Sensors, 22(8), 3079. https://doi.org/10.3390/s22083079

Explainable Artificial Intelligence Model for Stroke Prediction Using EEG Signal

Sensors / Dec 15, 2022

Islam, M. S., Hussain, I., Rahman, M. M., Park, S. J., & Hossain, M. A. (2022). Explainable Artificial Intelligence Model for Stroke Prediction Using EEG Signal. Sensors, 22(24), 9859. https://doi.org/10.3390/s22249859

Prediction of Myoelectric Biomarkers in Post-Stroke Gait

Sensors / Aug 07, 2021

Hussain, I., & Park, S.-J. (2021). Prediction of Myoelectric Biomarkers in Post-Stroke Gait. Sensors, 21(16), 5334. https://doi.org/10.3390/s21165334

Driving-Induced Neurological Biomarkers in an Advanced Driver-Assistance System

Sensors / Oct 21, 2021

Hussain, I., Young, S., & Park, S.-J. (2021). Driving-Induced Neurological Biomarkers in an Advanced Driver-Assistance System. Sensors, 21(21), 6985. https://doi.org/10.3390/s21216985

Quantifying Physiological Biomarkers of a Microwave Brain Stimulation Device

Sensors / Mar 08, 2021

Hussain, I., Young, S., Kim, C. H., Benjamin, H. C. M., & Park, S. J. (2021). Quantifying Physiological Biomarkers of a Microwave Brain Stimulation Device. Sensors, 21(5), 1896. https://doi.org/10.3390/s21051896

Interpreting Stroke-Impaired Electromyography Patterns through Explainable Artificial Intelligence

Sensors / Feb 21, 2024

Hussain, I., & Jany, R. (2024). Interpreting Stroke-Impaired Electromyography Patterns through Explainable Artificial Intelligence. Sensors, 24(5), 1392. https://doi.org/10.3390/s24051392

An Explainable EEG-Based Human Activity Recognition Model Using Machine-Learning Approach and LIME

Sensors / Aug 27, 2023

Hussain, I., Jany, R., Boyer, R., Azad, A., Alyami, S. A., Park, S. J., Hasan, M. M., & Hossain, M. A. (2023). An Explainable EEG-Based Human Activity Recognition Model Using Machine-Learning Approach and LIME. Sensors, 23(17), 7452. https://doi.org/10.3390/s23177452

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Ping Luo

Toronto, Ontario, Canada
Bioinformatics Specialist at Princess Margaret Cancer Centre with experience in deep learning
Most Relevant Research Interests
Biochemistry
Other Research Interests (21)
single-cell genomics
deep learning
complex network analysis
Genetics (clinical)
Genetics
And 16 more
About
8 years of science and engineering experience integrating multi-omics data to identify biomarkers for cancer studies. Seeking to apply data analytics expertise to develop new diagnosis and treatment strategies.
Most Relevant Publications (6+)

23 total publications

Enhancing the prediction of disease–gene associations with multimodal deep learning

Bioinformatics / Mar 02, 2019

Luo, P., Li, Y., Tian, L.-P., & Wu, F.-X. (2019). Enhancing the prediction of disease–gene associations with multimodal deep learning. Bioinformatics, 35(19), 3735–3742. https://doi.org/10.1093/bioinformatics/btz155

Identifying cell types from single-cell data based on similarities and dissimilarities between cells

BMC Bioinformatics / May 01, 2021

Li, Y., Luo, P., Lu, Y., & Wu, F.-X. (2021). Identifying cell types from single-cell data based on similarities and dissimilarities between cells. BMC Bioinformatics, 22(S3). https://doi.org/10.1186/s12859-020-03873-z

Ensemble disease gene prediction by clinical sample-based networks

BMC Bioinformatics / Mar 01, 2020

Luo, P., Tian, L.-P., Chen, B., Xiao, Q., & Wu, F.-X. (2020). Ensemble disease gene prediction by clinical sample-based networks. BMC Bioinformatics, 21(S2). https://doi.org/10.1186/s12859-020-3346-8

A Novel Core-Attachment-Based Method to Identify Dynamic Protein Complexes Based on Gene Expression Profiles and PPI Networks

PROTEOMICS / Feb 20, 2019

Xiao, Q., Luo, P., Li, M., Wang, J., & Wu, F.-X. (2019). A Novel Core-Attachment-Based Method to Identify Dynamic Protein Complexes Based on Gene Expression Profiles and PPI Networks. PROTEOMICS, 19(5), 1800129. Portico. https://doi.org/10.1002/pmic.201800129

Normalization of the Immune Microenvironment during Lenalidomide Maintenance Is Associated with Sustained MRD Negativity in Patients with Multiple Myeloma

Blood / Nov 05, 2021

Coffey, D. G., Maura, F., Gonzalez-Kozlova, E., Diaz-Mejia3, J., Luo, P., Zhang, Y., Xu, Y., Warren, E. H., Smith, E. L., Cho, H. J., Lesokhin, A., Diamond, B., Kazandjian, D., Pugh, T. J., Green, D. J., Gnjatic, S., & Landgren, O. (2021). Normalization of the Immune Microenvironment during Lenalidomide Maintenance Is Associated with Sustained MRD Negativity in Patients with Multiple Myeloma. Blood, 138(Supplement 1), 329–329. https://doi.org/10.1182/blood-2021-154506

Evaluation of single-cell RNA-seq clustering algorithms on cancer tumor datasets

Computational and Structural Biotechnology Journal / Jan 01, 2022

Mahalanabis, A., Turinsky, A. L., Husić, M., Christensen, E., Luo, P., Naidas, A., Brudno, M., Pugh, T., Ramani, A. K., & Shooshtari, P. (2022). Evaluation of single-cell RNA-seq clustering algorithms on cancer tumor datasets. Computational and Structural Biotechnology Journal, 20, 6375–6387. https://doi.org/10.1016/j.csbj.2022.10.029

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Luca Delfinis

Toronto, Ontario, Canada
PhD candidate in physiology researching the mechanisms that drive muscle dysfunction in cancer
Research Interests (3)
Physiology
Physiology (medical)
Cell Biology
About
Luca Delfinis is a PhD candidate at York University where his research focuses on muscle dysfunction in cancer. Luca has been a part of several research collaborations both nationally and internationally throughout his PhD that has helped him gain unique perspectives in physiology, especially in the context of metabolism. He has also presented at several conferences where he has discussed data with leaders in cachexia, metabolism, exercise and more.

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Mohammad Imran Khan

College Park, Maryland, United States of America
Postdoctoral Associate at University of Maryland College Park in the Department of Nutrition and Food Science
Most Relevant Research Interests
Biochemistry
Other Research Interests (22)
Biomedical Engineering
Nanotechology
Wound healing
Infection and Immunity
Bioengineering
And 17 more
About
Research work is focused on the formulation of nanoparticles encapsulated materials which could be useful for tissue engineering, stem cells, drug delivery and biomechanics to create biologically inspired tissue and organ constructs. Furthermore, 3D material may play significant role in the healing of complex tissues and organs in vitro and in vivo.
Most Relevant Publications (1+)

11 total publications

Cytotoxic and pharmacokinetic studies of Indian seaweed polysaccharides for formulating raindrop synbiotic candy

International Journal of Biological Macromolecules / Jul 01, 2020

Praveen, M. A., Parvathy, K. R. K., Patra, S., Khan, I., Natarajan, P., & Balasubramanian, P. (2020). Cytotoxic and pharmacokinetic studies of Indian seaweed polysaccharides for formulating raindrop synbiotic candy. International Journal of Biological Macromolecules, 154, 557–566. https://doi.org/10.1016/j.ijbiomac.2020.03.086

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Luciano Dibona, Ph.D

Santiago
Highly motivated young professional with a PhD in Chemistry and specialized in Photobiological aspects of Life Sciences and Agriculture on Crop protection.
Most Relevant Research Interests
Biochemistry
Other Research Interests (5)
Antimicrobial Photodynamic Therapy
Physical and Theoretical Chemistry
Plant Science
Horticulture
Photobiology
About
With more than 5 years of background in the field, I'm committed to drive scientific advances into impactful innovation for the industry and the market through knowledge and technology transfer. Experience as a consultant in formulation of R&D projects with a focus on teamwork, collaboration, and communication skills. Works with an analytical mindset to deliver meaningful results. Experience in designing and evaluating industry-driven scientific research and intellectual property protection processes involved.
Most Relevant Publications (1+)

7 total publications

Recent Photosensitizer Developments, Delivery Strategies and Combination‐based Approaches for Photodynamic Therapy†

Photochemistry and Photobiology / Dec 20, 2022

Mariño‐Ocampo, N., Dibona‐Villanueva, L., Escobar‐Álvarez, E., Guerra‐Díaz, D., Zúñiga‐Núñez, D., Fuentealba, D., & Robinson‐Duggon, J. (2022). Recent Photosensitizer Developments, Delivery Strategies and Combination‐based Approaches for Photodynamic Therapy†. Photochemistry and Photobiology, 99(2), 469–497. Portico. https://doi.org/10.1111/php.13749

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Dr. Fantai Kong, Ph.D.

Dallas, Texas, United States of America
Hunt Energy
Most Relevant Research Interests
Biochemistry
Other Research Interests (19)
Energy Storage
Renewable Energy, Sustainability and the Environment
Electronic, Optical and Magnetic Materials
Surfaces, Coatings and Films
Materials Chemistry
And 14 more
About
With over 10 years of research and development experience in the field of energy storage and conversion technologies, I have gained extensive expertise in diverse areas such as Li-ion batteries, Zn-ion batteries, Na-ion batteries, Li extraction, fuel cells, and topological insulators. Throughout my career, I have actively collaborated with partners from industrial, national labs, and universities to overcome technology challenges and develop innovative solutions that have resulted in a prolific publication record, including more than 30 peer-reviewed articles, and 10 awarded/pending patents.
Most Relevant Publications (1+)

31 total publications

Stable and Active Oxidation Catalysis by Cooperative Lattice Oxygen Redox on SmMn2O5 Mullite Surface

Journal of the American Chemical Society / Jun 18, 2019

Zheng, Y., Thampy, S., Ashburn, N., Dillon, S., Wang, L., Jangjou, Y., Tan, K., Kong, F., Nie, Y., Kim, M. J., Epling, W. S., Chabal, Y. J., Hsu, J. W. P., & Cho, K. (2019). Stable and Active Oxidation Catalysis by Cooperative Lattice Oxygen Redox on SmMn2O5 Mullite Surface. Journal of the American Chemical Society, 141(27), 10722–10728. https://doi.org/10.1021/jacs.9b03334

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Ajay Badhan

Lethbridge, Alberta, Canada
Research Biologist, Lethbridge Research Center, Canada
Most Relevant Research Interests
Biochemistry
Other Research Interests (26)
Animal nutrition
cell wall biosynthesis and its deconstruction
biofuels
Waste Management and Disposal
Renewable Energy, Sustainability and the Environment
And 21 more
About
I am a proficient researcher with valuable research and teaching experience acquired at distinguished institutes like Complex Carbohydrate Research Center, US, University of Alberta, Canada, and Lethbridge Research Center (AAFC), Canada. I have been working for past 15 years on multiple projects focused on the economical, environmental and social sustainability of agricultural production. Improvement in livestock performance, productivity, and health by unlocking the microbiome, development of clean technologies, improving agriculture environmental performance, and Increase agro-ecosystem resilience are prime objectives for my research.
Most Relevant Publications (2+)

29 total publications

Functionally diverse multiple xylanases of thermophilic fungus Myceliophthora sp. IMI 387099

Enzyme and Microbial Technology / Oct 01, 2004

Badhan, A. K., Chadha, B. S., Sonia, K. G., Saini, H. S., & Bhat, M. K. (2004). Functionally diverse multiple xylanases of thermophilic fungus Myceliophthora sp. IMI 387099. Enzyme and Microbial Technology, 35(5), 460–466. https://doi.org/10.1016/j.enzmictec.2004.07.002

Mechanistic insights into the digestion of complex dietary fibre by the rumen microbiota using combinatorial high-resolution glycomics and transcriptomic analyses

Computational and Structural Biotechnology Journal / Jan 01, 2022

Badhan, A., Low, K. E., Jones, D. R., Xing, X., Milani, M. R. M., Polo, R. O., Klassen, L., Venketachalam, S., Hahn, M. G., Abbott, D. W., & McAllister, T. A. (2022). Mechanistic insights into the digestion of complex dietary fibre by the rumen microbiota using combinatorial high-resolution glycomics and transcriptomic analyses. Computational and Structural Biotechnology Journal, 20, 148–164. https://doi.org/10.1016/j.csbj.2021.12.009

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Aayudh Das, Ph.D.

Boston, Massachusetts, United States of America
Scientist at Garuda therapeutics, specialized in Genomics and Computational Biology
Most Relevant Research Interests
Biochemistry
Other Research Interests (14)
Transcriptomics
Genomics
Proteomics
Computational Biology
Metabolomics
And 9 more
About
I am a dedicated Scientist-I at Garuda Therapeutics, where I specialize in computational biology and genomics within the R&D department. My work primarily revolves around developing and optimizing pipelines for variant calling using Strelka2 and GATK4 with Whole Genome Sequencing (WGS) to identify oncogenes in human induced pluripotent stem cells (iPSCs). This involves extensive work in the qualification and validation of these pipelines for regulatory filings, as well as leveraging databases such as ClinVar, COSMIC, and DepMap to craft targeted oncogenes panels for deep sequencing. I also apply Next-Generation Sequencing (NGS) for downstream sequencing to validate CRISPR knockouts, including the identification and validation of CRISPR off-targets using techniques like rhAMPseq and Induce-seq. Additionally, my expertise extends to single-cell sequencing analysis and understanding structural variants with Optical Genome Mapping (Bionano). Prior to joining Garuda Therapeutics, I completed a postdoctoral fellowship in computational biology at Pennsylvania State University, where I honed my skills in identifying climate-adaptive variants and conducted Genome-Wide Association Studies (GWAS) to uncover resistance genes against parasites and other stressors. My academic journey began at the University of Vermont, where I explored abiotic stress resistance genes using transcriptomics and developed a robust understanding of RNA-seq data analysis, from assembly to gene annotation. My work is driven by a passion for leveraging computational and genomics tools to address pressing challenges in biology and healthcare, combining my rigorous academic training with a practical, solution-oriented approach to research and development.
Most Relevant Publications (1+)

10 total publications

Investigation of the Cardiotonic Steroids, Marinobufagenin and Resibufogenin, in the Acute Respiratory Distress Syndrome

The FASEB Journal / Apr 01, 2016

Abbas, M. M. K., Chen, Q., Das, A., Oliver, J., Jiang, W., Moorthy, B., Patel, B., Morin, K., & Puschett, J. (2016). Investigation of the Cardiotonic Steroids, Marinobufagenin and Resibufogenin, in the Acute Respiratory Distress Syndrome. The FASEB Journal, 30(S1). Portico. https://doi.org/10.1096/fasebj.30.1_supplement.982.4

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Aimee Eggler

Villanova, Pennsylvania, United States of America
Professor of Chemistry and Biochemistry at Villanova University
Most Relevant Research Interests
Biochemistry
Other Research Interests (18)
Physiology (medical)
Toxicology
Organic Chemistry
Clinical Biochemistry
Drug Discovery
And 13 more
About
Dr. Eggler has 20 years of experience in the field of redox biology, with a focus on the Nrf2 transcription factor, a master regulator of antioxidant, detoxification and anti-inflammatory genes. She is also an award-winning educator and the recipient of the Villanova University Junior Faculty Excellence in Teaching award. Her interests in education include innovation in teaching metabolism from a logic-based perspective.
Most Relevant Publications (10+)

25 total publications

Kinetic assessment of Michael addition reactions of alpha, beta-unsaturated carbonyl compounds to amino acid and protein thiols

Free Radical Biology and Medicine / Jun 01, 2021

Sauerland, M., Mertes, R., Morozzi, C., Eggler, A. L., Gamon, L. F., & Davies, M. J. (2021). Kinetic assessment of Michael addition reactions of alpha, beta-unsaturated carbonyl compounds to amino acid and protein thiols. Free Radical Biology and Medicine, 169, 1–11. https://doi.org/10.1016/j.freeradbiomed.2021.03.040

Dr. Jekyll and Mr. Hyde: Oxidizable phenol-generated reactive oxygen species enhance sulforaphane's antioxidant response element activation, even as they suppress Nrf2 protein accumulation

Free Radical Biology and Medicine / Aug 01, 2018

Bauman, B. M., Jeong, C., Savage, M., Briker, A. L., Janigian, N. G., Nguyen, L. L., Kemmerer, Z. A., & Eggler, A. L. (2018). Dr. Jekyll and Mr. Hyde: Oxidizable phenol-generated reactive oxygen species enhance sulforaphane’s antioxidant response element activation, even as they suppress Nrf2 protein accumulation. Free Radical Biology and Medicine, 124, 532–540. https://doi.org/10.1016/j.freeradbiomed.2018.06.039

Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding

Bioorganic & Medicinal Chemistry Letters / Nov 01, 2013

Turlington, M., Chun, A., Tomar, S., Eggler, A., Grum-Tokars, V., Jacobs, J., Daniels, J. S., Dawson, E., Saldanha, A., Chase, P., Baez-Santos, Y. M., Lindsley, C. W., Hodder, P., Mesecar, A. D., & Stauffer, S. R. (2013). Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding. Bioorganic & Medicinal Chemistry Letters, 23(22), 6172–6177. https://doi.org/10.1016/j.bmcl.2013.08.112

Screening for natural chemoprevention agents that modify human Keap1

Analytical Biochemistry / Feb 01, 2012

Hu, C., Nikolic, D., Eggler, A. L., Mesecar, A. D., & van Breemen, R. B. (2012). Screening for natural chemoprevention agents that modify human Keap1. Analytical Biochemistry, 421(1), 108–114. https://doi.org/10.1016/j.ab.2011.10.028

Development of an efficient E. coli expression and purification system for a catalytically active, human Cullin3–RINGBox1 protein complex and elucidation of its quaternary structure with Keap1

Biochemical and Biophysical Research Communications / Oct 01, 2010

Small, E., Eggler, A., & Mesecar, A. D. (2010). Development of an efficient E. coli expression and purification system for a catalytically active, human Cullin3–RINGBox1 protein complex and elucidation of its quaternary structure with Keap1. Biochemical and Biophysical Research Communications, 400(4), 471–475. https://doi.org/10.1016/j.bbrc.2010.08.062

Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1

Biochemical Journal / Jul 29, 2009

Eggler, A. L., Small, E., Hannink, M., & Mesecar, A. D. (2009). Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1. Biochemical Journal, 422(1), 171–180. https://doi.org/10.1042/bj20090471

The structures of T87I phosphono-CheY and T87I/Y106W phosphono-CheY help to explain their binding affinities to the FliM and CheZ peptides

Archives of Biochemistry and Biophysics / Nov 01, 2008

McAdams, K., Casper, E. S., Matthew Haas, R., Santarsiero, B. D., Eggler, A. L., Mesecar, A., & Halkides, C. J. (2008). The structures of T87I phosphono-CheY and T87I/Y106W phosphono-CheY help to explain their binding affinities to the FliM and CheZ peptides. Archives of Biochemistry and Biophysics, 479(2), 105–113. https://doi.org/10.1016/j.abb.2008.08.019

The C Terminus of the Escherichia coli RecA Protein Modulates the DNA Binding Competition with Single-stranded DNA-binding Protein

Journal of Biological Chemistry / May 01, 2003

Eggler, A. L., Lusetti, S. L., & Cox, M. M. (2003). The C Terminus of the Escherichia coli RecA Protein Modulates the DNA Binding Competition with Single-stranded DNA-binding Protein. Journal of Biological Chemistry, 278(18), 16389–16396. https://doi.org/10.1074/jbc.m212920200

The Rad51-dependent Pairing of Long DNA Substrates Is Stabilized by Replication Protein A

Journal of Biological Chemistry / Oct 01, 2002

Eggler, A. L., Inman, R. B., & Cox, M. M. (2002). The Rad51-dependent Pairing of Long DNA Substrates Is Stabilized by Replication Protein A. Journal of Biological Chemistry, 277(42), 39280–39288. https://doi.org/10.1074/jbc.m204328200

DNA Pairing and Strand Exchange by the Escherichia coli RecA and Yeast Rad51 Proteins without ATP Hydrolysis

Journal of Biological Chemistry / Oct 01, 2001

Rice, K. P., Eggler, A. L., Sung, P., & Cox, M. M. (2001). DNA Pairing and Strand Exchange by the Escherichia coli RecA and Yeast Rad51 Proteins without ATP Hydrolysis. Journal of Biological Chemistry, 276(42), 38570–38581. https://doi.org/10.1074/jbc.m105678200

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Sheed Itaman

New York, New York, United States of America
Neurobiologist | Biopharma Consultant | Let's Connect!
Research Interests (0)
About
1. Eight years of wet laboratory and lab management experience 2. Excellent organizational, analytical and technical skills to execute effectively on complex projects and meet tight timelines 3. Outstanding interpersonal and communication skills; multiple awards for presentations and writing # TECHNICAL SKILLS 1. **Animal Handling:** Mouse handling, tissue harvest, IV/IP/IM/SC injections 2. **Cell Biology:** Cell culture, Cell assays, Cell fractionation 3. **Microscopy/Imaging:** Confocal microscopy, Cell imaging and analysis 4. **Tissue Culture:** Primary cell isolation and culture 5. **Biochemistry:** Western Blotting, BCA protein assay, Bradford assay, IHC, IP 6. **Molecular biology:** PCR, transfection, transduction, mini prep, DNA/RNA isolation

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Michael W Harman

East Greenwich, RI, Rhode Island, United States of America
Distinguished Subject Matter Expert & Leader in Medical Technologies.
Most Relevant Research Interests
Biochemistry
Other Research Interests (13)
Bacteria & Cell Bio-Physics
Biomechanics
Infectious Diseases
Immunology
Microbiology
And 8 more
About
Highly skilled, energetic, and motivated professional empowered by over a decade of cross-disciplinary engineering and scientific applications experience. Presenting elegant solutions to prevalent biomedical challenges. Motivated by driving deliverable outcomes from complex research studies through effective leadership, active consulting work, and innovative problem-solving techniques. Seeking to make an immediate impact in a fast-paced biotechnology environment capitalizing on my advanced comprehension, continued professional growth, strategic product development expertise, and active network of personal connections across all areas of science, engineering, medicine, manufacturing and healthcare.
Most Relevant Publications (2+)

15 total publications

Measuring DNA content in live cells by fluorescence microscopy

Cell Division / Sep 04, 2018

Gomes, C. J., Harman, M. W., Centuori, S. M., Wolgemuth, C. W., & Martinez, J. D. (2018). Measuring DNA content in live cells by fluorescence microscopy. Cell Division, 13(1). https://doi.org/10.1186/s13008-018-0039-z

Vinculin in Neutrophil Adhesion, Motility and Trafficking

The FASEB Journal / Apr 01, 2018

Wilson, Z., Harman, M., Hazlett, L., Odzer, J., Witt, H., Franck, C., Reichner, J., & Lefort, C. (2018). Vinculin in Neutrophil Adhesion, Motility and Trafficking. The FASEB Journal, 32(S1). Portico. https://doi.org/10.1096/fasebj.2018.32.1_supplement.280.11

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Example biochemistry projects

How can companies collaborate more effectively with researchers, experts, and thought leaders to make progress on biochemistry?

Drug Discovery and Development

A pharmaceutical company can collaborate with a Biochemistry expert to identify and validate drug targets, design and optimize drug molecules, and evaluate their efficacy and safety. This collaboration can accelerate the drug discovery and development process, leading to the creation of new and effective treatments for various diseases.

Biotechnology Advancements

Biochemistry researchers can contribute to the development of biotechnological products and processes. They can optimize enzyme reactions, engineer proteins with desired properties, and improve the efficiency of biofuel production. By collaborating with these experts, companies can enhance their biotechnology capabilities and create innovative solutions for a wide range of applications.

Crop Improvement and Agriculture

Companies in the agriculture industry can benefit from collaborating with Biochemistry experts to improve crop yield, quality, and resistance to pests and diseases. These researchers can study the biochemical pathways involved in plant growth and development, identify key genes and proteins, and develop strategies for genetic engineering and crop improvement. This collaboration can lead to the development of more productive and sustainable agricultural practices.

Food Science and Nutrition

Biochemistry experts can contribute to the development of healthier and more nutritious food products. They can study the biochemical composition of food, analyze nutritional content, and develop methods for food fortification and preservation. By collaborating with these researchers, companies can create innovative food products that meet consumer demands for health, sustainability, and taste.

Environmental Remediation

Biochemistry researchers can play a crucial role in addressing environmental challenges. They can study the biochemical processes involved in pollutant degradation, develop bioremediation strategies, and optimize the use of microorganisms for environmental cleanup. By collaborating with these experts, companies can develop sustainable solutions for pollution control and environmental remediation.