Work with thought leaders and academic experts in cancer research
Companies can greatly benefit from working with experts in the field of Cancer Research. These researchers bring a deep understanding of the disease and its mechanisms, allowing them to contribute valuable insights and expertise. Here are some ways companies can collaborate with academic researchers in Cancer Research: 1. Drug Discovery and Development: Academic researchers can assist in the discovery and development of new cancer drugs, providing expertise in target identification, preclinical testing, and clinical trials. 2. Biomarker Identification: Researchers can help identify biomarkers that can be used for early cancer detection, patient stratification, and monitoring treatment response. 3. Genomic Analysis: Experts in Cancer Research can analyze genomic data to identify genetic mutations and variations associated with cancer, enabling personalized treatment approaches. 4. Translational Research: Collaboration with academic researchers can facilitate the translation of basic research findings into clinical applications, bridging the gap between bench and bedside. 5. Clinical Trials: Companies can partner with academic researchers to conduct clinical trials, leveraging their expertise in trial design, patient recruitment, and data analysis. 6. Data Analytics: Researchers can apply advanced data analytics techniques to large-scale cancer datasets, uncovering patterns and insights that can inform treatment strategies. 7. Collaborative Research Projects: Joint research projects between companies and academic researchers can lead to innovative solutions and breakthrough discoveries in cancer treatment and prevention. 8. Education and Training: Academic researchers can provide educational programs and training to company employees, keeping them updated on the latest advancements in Cancer Research. 9. Intellectual Property: Collaboration with academic researchers can result in the generation of intellectual property, including patents and publications, which can enhance a company's competitive advantage. 10. Access to Networks and Resources: Academic researchers have access to extensive networks and resources, including collaborations with other experts, funding opportunities, and state-of-the-art facilities.
Researchers on NotedSource with backgrounds in cancer research include Dr. Michael W. Craige, PhD, MBA, Elena Shersher, Ph.D., John M Baust, Ph.D, Ping Luo, Dr. Everson A Nunes, Ph.D., Dr. Shilpa Patil, Ph.D, Boris Leibovitch, Michael W Harman, Jeffrey Townsend, Dr. Justin Whalley, Ph.D, Edoardo Airoldi, Katie Barr, R. Alan Harris, Ph.D., and Lindsay Webb, PhD.
Dr. Michael W. Craige, PhD, MBA
Entrepreneurial Scientist | Research Technology, Informatics & Data Science
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3 total publications
Tissue-specific biological aging predicts progression in prostate cancer and acute myeloid leukemia
Frontiers in Oncology / Sep 06, 2023
Ramakrishnan, A., Datta, I., Panja, S., Patel, H., Liu, Y., Craige, M. W., Chu, C., Jean-Marie, G., Oladoja, A.-R., Kim, I., & Mitrofanova, A. (2023). Tissue-specific biological aging predicts progression in prostate cancer and acute myeloid leukemia. Frontiers in Oncology, 13. https://doi.org/10.3389/fonc.2023.1222168
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Elena Shersher, Ph.D.
Cancer researcher at University of Miami
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4 total publications
Pharmacological Disruption of the Notch1 Transcriptional Complex Inhibits Tumor Growth by Selectively Targeting Cancer Stem Cells
Cancer Research / Apr 05, 2021
Alvarez-Trotta, A., Guerrant, W., Astudillo, L., Lahiry, M., Diluvio, G., Shersher, E., Kaneku, H., Robbins, D. J., Orton, D., & Capobianco, A. J. (2021). Pharmacological Disruption of the Notch1 Transcriptional Complex Inhibits Tumor Growth by Selectively Targeting Cancer Stem Cells. Cancer Research, 81(12), 3347–3357. https://doi.org/10.1158/0008-5472.can-20-3611
A novel chemical attack on Notch-mediated transcription by targeting the NACK ATPase
Molecular Therapy - Oncolytics / Mar 01, 2023
Diluvio, G., Kelley, T. T., Lahiry, M., Alvarez-Trotta, A., Kolb, E. M., Shersher, E., Astudillo, L., Kovall, R. A., Schürer, S. C., & Capobianco, A. J. (2023). A novel chemical attack on Notch-mediated transcription by targeting the NACK ATPase. Molecular Therapy - Oncolytics, 28, 307–320. https://doi.org/10.1016/j.omto.2023.02.008
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John M Baust, Ph.D
Proven success in delivering best-in-class services across scientific, commercial and education environments.
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68 total publications
Issues Critical to the Successful Application of Cryosurgical Ablation of the Prostate
Technology in Cancer Research & Treatment / Apr 01, 2007
Baust, J. G., Gage, A. A., Klossner, D., Clarke, D., Miller, R., Cohen, J., Katz, A., Polascik, T., Clarke, H., & Baust, J. M. (2007). Issues Critical to the Successful Application of Cryosurgical Ablation of the Prostate. Technology in Cancer Research & Treatment, 6(2), 97–109. https://doi.org/10.1177/153303460700600206
Cryoablation of Renal Cancer: Variables Involved in Freezing-Induced Cell Death
Technology in Cancer Research & Treatment / Apr 01, 2007
Clarke, D. M., Robilotto, A. T., Rhee, E., VanBuskirk, R. G., Baust, J. G., Gage, A. A., & Baust, J. M. (2007). Cryoablation of Renal Cancer: Variables Involved in Freezing-Induced Cell Death. Technology in Cancer Research & Treatment, 6(2), 69–79. https://doi.org/10.1177/153303460700600203
Development of a Tissue Engineered Human Prostate Tumor Equivalent for Use in the Evaluation of Cryoablative Techniques
Technology in Cancer Research & Treatment / Apr 01, 2007
Robilotto, A. T., Clarke, D., Baust, J. M., Van Buskirk, R. G., Gage, A. A., & Baust, J. G. (2007). Development of a Tissue Engineered Human Prostate Tumor Equivalent for Use in the Evaluation of Cryoablative Techniques. Technology in Cancer Research & Treatment, 6(2), 81–89. https://doi.org/10.1177/153303460700600204
Integrin involvement in freeze resistance of androgen-insensitive prostate cancer
Prostate Cancer and Prostatic Diseases / Jan 12, 2010
Baust, J. G., Klossner, D. P., VanBuskirk, R. G., Gage, A. A., Mouraviev, V., Polascik, T. J., & Baust, J. M. (2010). Integrin involvement in freeze resistance of androgen-insensitive prostate cancer. Prostate Cancer and Prostatic Diseases, 13(2), 151–161. https://doi.org/10.1038/pcan.2009.59
Use of 1,25α dihydroxyvitamin D3 as a cryosensitizing agent in a murine prostate cancer model
Prostate Cancer and Prostatic Diseases / Jan 11, 2011
Santucci, K. L., Snyder, K. K., Baust, J. M., Van Buskirk, R. G., Mouraviev, V., Polascik, T. J., Gage, A. A., & Baust, J. G. (2011). Use of 1,25α dihydroxyvitamin D3 as a cryosensitizing agent in a murine prostate cancer model. Prostate Cancer and Prostatic Diseases, 14(2), 97–104. https://doi.org/10.1038/pcan.2010.52
Temperature-dependent activation of differential apoptotic pathways during cryoablation in a human prostate cancer model
Prostate Cancer and Prostatic Diseases / Dec 11, 2012
Robilotto, A. T., Baust, J. M., Van Buskirk, R. G., Gage, A. A., & Baust, J. G. (2012). Temperature-dependent activation of differential apoptotic pathways during cryoablation in a human prostate cancer model. Prostate Cancer and Prostatic Diseases, 16(1), 41–49. https://doi.org/10.1038/pcan.2012.48
Re-purposing cryoablation: a combinatorial ‘therapy’ for the destruction of tissue
Prostate Cancer and Prostatic Diseases / Jan 27, 2015
Baust, J. G., Bischof, J. C., Jiang-Hughes, S., Polascik, T. J., Rukstalis, D. B., Gage, A. A., & Baust, J. M. (2015). Re-purposing cryoablation: a combinatorial ‘therapy’ for the destruction of tissue. Prostate Cancer and Prostatic Diseases, 18(2), 87–95. https://doi.org/10.1038/pcan.2014.54
Characterization of Pancreatic Cancer Cell Thermal Response to Heat Ablation or Cryoablation
Technology in Cancer Research & Treatment / Jun 23, 2016
Baumann, K. W., Baust, J. M., Snyder, K. K., Baust, J. G., & Van Buskirk, R. G. (2016). Characterization of Pancreatic Cancer Cell Thermal Response to Heat Ablation or Cryoablation. Technology in Cancer Research & Treatment, 16(4), 393–405. https://doi.org/10.1177/1533034616655658
Investigation of the Impact of Cell Cycle Stage on Freeze Response Sensitivity of Androgen-Insensitive Prostate Cancer
Technology in Cancer Research & Treatment / Jul 08, 2016
Santucci, K. L., Baust, J. M., Snyder, K. K., Van Buskirk, R. G., & Baust, J. G. (2016). Investigation of the Impact of Cell Cycle Stage on Freeze Response Sensitivity of Androgen-Insensitive Prostate Cancer. Technology in Cancer Research & Treatment, 15(4), 609–617. https://doi.org/10.1177/1533034616648059
Assessment of Cryosurgical Device Performance Using a 3D Tissue-Engineered Cancer Model
Technology in Cancer Research & Treatment / May 17, 2017
Baust, J. M., Robilotto, A., Snyder, K. K., Santucci, K., Stewart, J., Van Buskirk, R., & Baust, J. G. (2017). Assessment of Cryosurgical Device Performance Using a 3D Tissue-Engineered Cancer Model. Technology in Cancer Research & Treatment, 16(6), 900–909. https://doi.org/10.1177/1533034617708960
Defeating Cancers’ Adaptive Defensive Strategies Using Thermal Therapies: Examining Cancer’s Therapeutic Resistance, Ablative, and Computational Modeling Strategies as a means for Improving Therapeutic Outcome
Technology in Cancer Research & Treatment / Jan 01, 2018
Baust, J. M., Rabin, Y., Polascik, T. J., Santucci, K. L., Snyder, K. K., Van Buskirk, R. G., & Baust, J. G. (2018). Defeating Cancers’ Adaptive Defensive Strategies Using Thermal Therapies: Examining Cancer’s Therapeutic Resistance, Ablative, and Computational Modeling Strategies as a means for Improving Therapeutic Outcome. Technology in Cancer Research & Treatment, 17, 153303381876220. https://doi.org/10.1177/1533033818762207
Cryoablation: physical and molecular basis with putative immunological consequences
International Journal of Hyperthermia / Nov 29, 2019
Baust, J. G., Snyder, K. K., Santucci, K. L., Robilotto, A. T., Van Buskirk, R. G., & Baust, J. M. (2019). Cryoablation: physical and molecular basis with putative immunological consequences. International Journal of Hyperthermia, 36(sup1), 10–16. https://doi.org/10.1080/02656736.2019.1647355
Breast Cancer Cryoablation: Assessment of the Impact of Fundamental Procedural Variables in an In Vitro Human Breast Cancer Model
Breast Cancer: Basic and Clinical Research / Jan 01, 2020
Snyder, K. K., Van Buskirk, R. G., Baust, J. G., & Baust, J. M. (2020). Breast Cancer Cryoablation: Assessment of the Impact of Fundamental Procedural Variables in an In Vitro Human Breast Cancer Model. Breast Cancer: Basic and Clinical Research, 14, 117822342097236. https://doi.org/10.1177/1178223420972363
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Dr. Everson A Nunes, Ph.D.
Post-Doctoral Fellow at McMaster University | former Associate Professor - Physiological Sciences
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97 total publications
Does Oil Rich in Alpha-Linolenic Fatty Acid Cause the Same Immune Modulation as Fish Oil in Walker 256 Tumor-Bearing Rats?
Nutrition and Cancer / Sep 21, 2016
Schiessel, D. L., Yamazaki, R. K., Kryczyk, M., Coelho de Castro, I., Yamaguchi, A. A., Pequito, D. C. T., Brito, G. A. P., Borghetti, G., Aikawa, J., Nunes, E. A., Naliwaiko, K., & Fernandes, L. C. (2016). Does Oil Rich in Alpha-Linolenic Fatty Acid Cause the Same Immune Modulation as Fish Oil in Walker 256 Tumor-Bearing Rats? Nutrition and Cancer, 68(8), 1369–1380. https://doi.org/10.1080/01635581.2016.1224364
Fish oil supplementation during chemotherapy increases posterior time to tumor progression in colorectal cancer
Nutrition and Cancer / Dec 23, 2015
Camargo, C. de Q., Mocellin, M. C., Pastore Silva, J. de A., Fabre, M. E. de S., Nunes, E. A., & Trindade, E. B. S. de M. (2015). Fish oil supplementation during chemotherapy increases posterior time to tumor progression in colorectal cancer. Nutrition and Cancer, 68(1), 70–76. https://doi.org/10.1080/01635581.2016.1115097
Individuals with Hematological Malignancies Before Undergoing Chemotherapy Present Oxidative Stress Parameters and Acute Phase Proteins Correlated with Nutritional Status
Nutrition and Cancer / Feb 24, 2015
Camargo, C. de Q., Borges, D. da S., Oliveira, P. F. de, Chagas, T. R., Del Moral, J. A. G., Durigon, G. S., Dias, B. V., Vieira, A. G., Gaspareto, P., Trindade, E. B. S. de M., & Nunes, E. A. (2015). Individuals with Hematological Malignancies Before Undergoing Chemotherapy Present Oxidative Stress Parameters and Acute Phase Proteins Correlated with Nutritional Status. Nutrition and Cancer, 67(3), 463–471. https://doi.org/10.1080/01635581.2015.1004732
Exercise and Shark Liver Oil Supplementation Reduce Tumor Growth and Cancer Cachexia in Walker 256 Tumor Bearing Rats
Journal of Cancer Science & Therapy / Jan 01, 2014
Bordignon, J. (2014). Exercise and Shark Liver Oil Supplementation Reduce Tumor Growth and Cancer Cachexia in Walker 256 Tumor Bearing Rats. Journal of Cancer Science & Therapy, 06(03). https://doi.org/10.4172/1948-5956.1000254
Bax/Bcl-2 Protein Expression Ratio and Leukocyte Function Are Related to Reduction of Walker-256 Tumor Growth After β-Hydroxy-β-Methylbutyrate (HMB) Administration in Wistar Rats
Nutrition and Cancer / Feb 01, 2012
Kuczera, D., Paro de Oliveira, H. H., Fonseca Guimarães, F. de S., de Lima, C., Alves, L., Machado, A. F., Coelho, I., Yamaguchi, A., Donatti, L., Naliwaiko, K., Fernandes, L. C., & Nunes, E. A. (2012). Bax/Bcl-2 Protein Expression Ratio and Leukocyte Function Are Related to Reduction of Walker-256 Tumor Growth After β-Hydroxy-β-Methylbutyrate (HMB) Administration in Wistar Rats. Nutrition and Cancer, 64(2), 286–293. https://doi.org/10.1080/01635581.2012.647229
Ratio of n6 to n-3 Fatty Acids in the Diet Affects Tumor Growth and Cachexia in Walker 256 Tumor-Bearing Rats
Nutrition and Cancer / Nov 01, 2005
Pizato, N., Bonatto, S., Yamazaki, R. K., Aikawa, J., Nogata, C., Mund, R. C., Nunes, E. A., Piconcelli, M., Naliwaiko, K., Curi, R., Calder, P. C., & Fernandes, L. C. (2005). Ratio of n6 to n-3 Fatty Acids in the Diet Affects Tumor Growth and Cachexia in Walker 256 Tumor-Bearing Rats. Nutrition and Cancer, 53(2), 194–201. https://doi.org/10.1207/s15327914nc5302_8
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Dr. Shilpa Patil, Ph.D
PhD & Postdoc level expertise in Cancer Research
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20 total publications
EZH2 Regulates Pancreatic Cancer Subtype Identity and Tumor Progression via Transcriptional Repression of GATA6
Cancer Research / Nov 01, 2020
Patil, S., Steuber, B., Kopp, W., Kari, V., Urbach, L., Wang, X., Küffer, S., Bohnenberger, H., Spyropoulou, D., Zhang, Z., Versemann, L., Bösherz, M. S., Brunner, M., Gaedcke, J., Ströbel, P., Zhang, J.-S., Neesse, A., Ellenrieder, V., Singh, S. K., … Hessmann, E. (2020). EZH2 Regulates Pancreatic Cancer Subtype Identity and Tumor Progression via Transcriptional Repression of GATA6. Cancer Research, 80(21), 4620–4632. https://doi.org/10.1158/0008-5472.can-20-0672
TP53-Status-Dependent Oncogenic EZH2 Activity in Pancreatic Cancer
Cancers / Jul 15, 2022
Versemann, L., Patil, S., Steuber, B., Zhang, Z., Kopp, W., Krawczyk, H. E., Kaulfuß, S., Wollnik, B., Ströbel, P., Neesse, A., Singh, S. K., Ellenrieder, V., & Hessmann, E. (2022). TP53-Status-Dependent Oncogenic EZH2 Activity in Pancreatic Cancer. Cancers, 14(14), 3451. https://doi.org/10.3390/cancers14143451
HSP90 Inhibition Synergizes with Cisplatin to Eliminate Basal-like Pancreatic Ductal Adenocarcinoma Cells
Cancers / Dec 07, 2021
Ewers, K. M., Patil, S., Kopp, W., Thomale, J., Quilitz, T., Magerhans, A., Wang, X., Hessmann, E., & Dobbelstein, M. (2021). HSP90 Inhibition Synergizes with Cisplatin to Eliminate Basal-like Pancreatic Ductal Adenocarcinoma Cells. Cancers, 13(24), 6163. https://doi.org/10.3390/cancers13246163
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Boris Leibovitch
Experienced wet lab and in teaching Molecular Cell biologist, geneticist, cancer biologist in Academia
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22 total publications
Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer
Molecular Cancer Therapeutics / Aug 01, 2015
Kwon, Y.-J., Petrie, K., Leibovitch, B. A., Zeng, L., Mezei, M., Howell, L., Gil, V., Christova, R., Bansal, N., Yang, S., Sharma, R., Ariztia, E. V., Frankum, J., Brough, R., Sbirkov, Y., Ashworth, A., Lord, C. J., Zelent, A., Farias, E., … Waxman, S. (2015). Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer. Molecular Cancer Therapeutics, 14(8), 1824–1836. https://doi.org/10.1158/1535-7163.mct-14-0980-t
Invasive phenotype in triple negative breast cancer is inhibited by blocking SIN3A–PF1 interaction through KLF9 mediated repression of ITGA6 and ITGB1
Translational Oncology / Feb 01, 2022
Kadamb, R., Leibovitch, B. A., Farias, E. F., Dahiya, N., Suryawanshi, H., Bansal, N., & Waxman, S. (2022). Invasive phenotype in triple negative breast cancer is inhibited by blocking SIN3A–PF1 interaction through KLF9 mediated repression of ITGA6 and ITGB1. Translational Oncology, 16, 101320. https://doi.org/10.1016/j.tranon.2021.101320
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Michael W Harman
Distinguished Subject Matter Expert & Leader in Medical Technologies.
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15 total publications
The induction of endoreduplication and polyploidy by elevated expression of 14-3-3γ
Genes & Cancer / Dec 24, 2017
Gomes, C. J., Centuori, S. M., Harman, M. W., Putnam, C. W., Wolgemuth, C. W., & Martinez, J. D. (2017). The induction of endoreduplication and polyploidy by elevated expression of 14-3-3γ. Genes & Cancer, 8(11–12), 771–783. https://doi.org/10.18632/genesandcancer.161
Abstract 3591: Expression of 14-3-3 gamma stabilizes polyploidization in NSCLC cells
Cancer Research / Jul 15, 2016
Gomes, C. J., Harman, M., Centuori, S., Wolgemuth, C., & Martinez, J. (2016). Abstract 3591: Expression of 14-3-3 gamma stabilizes polyploidization in NSCLC cells. Cancer Research, 76(14_Supplement), 3591–3591. https://doi.org/10.1158/1538-7445.am2016-3591
Abstract 2066: Aberrant upregulation of 14-3-3 gamma promotes mononucleated polyploidization in human lung cancers
Cancer Research / Aug 01, 2015
Gomes, C. J., Harman, M., Martinez, J., & Centuori, S. (2015). Abstract 2066: Aberrant upregulation of 14-3-3 gamma promotes mononucleated polyploidization in human lung cancers. Cancer Research, 75(15_Supplement), 2066–2066. https://doi.org/10.1158/1538-7445.am2015-2066
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Jeffrey Townsend
Professor of Biostatistics and Ecology & Evolutionary Biology
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207 total publications
Estimation of Neutral Mutation Rates and Quantification of Somatic Variant Selection Using cancereffectsizeR
Cancer Research / Dec 05, 2022
Mandell, J. D., Cannataro, V. L., & Townsend, J. P. (2022). Estimation of Neutral Mutation Rates and Quantification of Somatic Variant Selection Using cancereffectsizeR. Cancer Research, 83(4), 500–505. https://doi.org/10.1158/0008-5472.can-22-1508
Not only mutations but also tumorigenesis can be substantially attributed to DNA damage from reactive oxygen species in RUNX1::RUNX1T1-fusion-positive acute myeloid leukemia
Leukemia / Nov 11, 2022
Mandell, J. D., Fisk, J. N., Cyrenne, E., Xu, M. L., Cannataro, V. L., & Townsend, J. P. (2022). Not only mutations but also tumorigenesis can be substantially attributed to DNA damage from reactive oxygen species in RUNX1::RUNX1T1-fusion-positive acute myeloid leukemia. Leukemia, 36(12), 2931–2933. https://doi.org/10.1038/s41375-022-01752-5
Cancer Relevance of Human Genes
JNCI: Journal of the National Cancer Institute / Apr 13, 2022
Qing, T., Mohsen, H., Cannataro, V. L., Marczyk, M., Rozenblit, M., Foldi, J., Murray, M., Townsend, J. P., Kluger, Y., Gerstein, M., & Pusztai, L. (2022). Cancer Relevance of Human Genes. JNCI: Journal of the National Cancer Institute, 114(7), 988–995. https://doi.org/10.1093/jnci/djac068
Premetastatic shifts of endogenous and exogenous mutational processes support consolidative therapy in EGFR-driven lung adenocarcinoma
Cancer Letters / Feb 01, 2022
Fisk, J. N., Mahal, A. R., Dornburg, A., Gaffney, S. G., Aneja, S., Contessa, J. N., Rimm, D., Yu, J. B., & Townsend, J. P. (2022). Premetastatic shifts of endogenous and exogenous mutational processes support consolidative therapy in EGFR-driven lung adenocarcinoma. Cancer Letters, 526, 346–351. https://doi.org/10.1016/j.canlet.2021.11.011
Environmental and sex-specific molecular signatures of glioma causation
Neuro-Oncology / May 04, 2021
Claus, E. B., Cannataro, V. L., Gaffney, S. G., & Townsend, J. P. (2021). Environmental and sex-specific molecular signatures of glioma causation. Neuro-Oncology, 24(1), 29–36. https://doi.org/10.1093/neuonc/noab103
Heavy mutagenesis by tobacco leads to lung adenocarcinoma tumors with KRAS G12 mutations other than G12D, leading KRAS G12D tumors—on average—to exhibit a lower mutation burden
Lung Cancer / Apr 01, 2022
Tan, C., Mandell, J. D., Dasari, K., Cannataro, V. L., Alfaro-Murillo, J. A., & Townsend, J. P. (2022). Heavy mutagenesis by tobacco leads to lung adenocarcinoma tumors with KRAS G12 mutations other than G12D, leading KRAS G12D tumors—on average—to exhibit a lower mutation burden. Lung Cancer, 166, 265–269. https://doi.org/10.1016/j.lungcan.2021.10.008
Transfer RNA methyltransferase gene NSUN2 mRNA expression modifies the effect of T cell activation score on patient survival in head and neck squamous carcinoma
Oral Oncology / Feb 01, 2020
Lu, L., Gaffney, S. G., Cannataro, V. L., & Townsend, J. (2020). Transfer RNA methyltransferase gene NSUN2 mRNA expression modifies the effect of T cell activation score on patient survival in head and neck squamous carcinoma. Oral Oncology, 101, 104554. https://doi.org/10.1016/j.oraloncology.2019.104554
Combined Aurora Kinase A (AURKA) and WEE1 Inhibition Demonstrates Synergistic Antitumor Effect in Squamous Cell Carcinoma of the Head and Neck
Clinical Cancer Research / Jun 01, 2019
Lee, J. W., Parameswaran, J., Sandoval-Schaefer, T., Eoh, K. J., Yang, D., Zhu, F., Mehra, R., Sharma, R., Gaffney, S. G., Perry, E. B., Townsend, J. P., Serebriiskii, I. G., Golemis, E. A., Issaeva, N., Yarbrough, W. G., Koo, J. S., & Burtness, B. (2019). Combined Aurora Kinase A (AURKA) and WEE1 Inhibition Demonstrates Synergistic Antitumor Effect in Squamous Cell Carcinoma of the Head and Neck. Clinical Cancer Research, 25(11), 3430–3442. https://doi.org/10.1158/1078-0432.ccr-18-0440
APOBEC-induced mutations and their cancer effect size in head and neck squamous cell carcinoma
Oncogene / Jan 15, 2019
Cannataro, V. L., Gaffney, S. G., Sasaki, T., Issaeva, N., Grewal, N. K. S., Grandis, J. R., Yarbrough, W. G., Burtness, B., Anderson, K. S., & Townsend, J. P. (2019). APOBEC-induced mutations and their cancer effect size in head and neck squamous cell carcinoma. Oncogene, 38(18), 3475–3487. https://doi.org/10.1038/s41388-018-0657-6
Wagging the long tail of drivers of prostate cancer
PLOS Genetics / Jan 17, 2019
Cannataro, V. L., & Townsend, J. P. (2019). Wagging the long tail of drivers of prostate cancer. PLOS Genetics, 15(1), e1007820. https://doi.org/10.1371/journal.pgen.1007820
Somatic evolutionary timings of driver mutations
BMC Cancer / Jan 18, 2018
Gomez, K., Miura, S., Huuki, L. A., Spell, B. S., Townsend, J. P., & Kumar, S. (2018). Somatic evolutionary timings of driver mutations. BMC Cancer, 18(1). https://doi.org/10.1186/s12885-017-3977-y
Effect Sizes of Somatic Mutations in Cancer
JNCI: Journal of the National Cancer Institute / Oct 26, 2018
Cannataro, V. L., Gaffney, S. G., & Townsend, J. P. (2018). Effect Sizes of Somatic Mutations in Cancer. JNCI: Journal of the National Cancer Institute, 110(11), 1171–1177. https://doi.org/10.1093/jnci/djy168
Heterogeneity and mutation in KRAS and associated oncogenes: evaluating the potential for the evolution of resistance to targeting of KRAS G12C
Oncogene / Feb 16, 2018
Cannataro, V. L., Gaffney, S. G., Stender, C., Zhao, Z.-M., Philips, M., Greenstein, A. E., & Townsend, J. P. (2018). Heterogeneity and mutation in KRAS and associated oncogenes: evaluating the potential for the evolution of resistance to targeting of KRAS G12C. Oncogene, 37(18), 2444–2455. https://doi.org/10.1038/s41388-017-0105-z
CDKN2A Copy Number Loss Is an Independent Prognostic Factor in HPV-Negative Head and Neck Squamous Cell Carcinoma
Frontiers in Oncology / Apr 04, 2018
Chen, W. S., Bindra, R. S., Mo, A., Hayman, T., Husain, Z., Contessa, J. N., Gaffney, S. G., Townsend, J. P., & Yu, J. B. (2018). CDKN2A Copy Number Loss Is an Independent Prognostic Factor in HPV-Negative Head and Neck Squamous Cell Carcinoma. Frontiers in Oncology, 8. https://doi.org/10.3389/fonc.2018.00095
The ancestral levels of transcription and the evolution of sexual phenotypes in filamentous fungi
PLOS Genetics / Jul 13, 2017
Trail, F., Wang, Z., Stefanko, K., Cubba, C., & Townsend, J. P. (2017). The ancestral levels of transcription and the evolution of sexual phenotypes in filamentous fungi. PLOS Genetics, 13(7), e1006867. https://doi.org/10.1371/journal.pgen.1006867
PhyloOncology: Understanding cancer through phylogenetic analysis
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer / Apr 01, 2017
Somarelli, J. A., Ware, K. E., Kostadinov, R., Robinson, J. M., Amri, H., Abu-Asab, M., Fourie, N., Diogo, R., Swofford, D., & Townsend, J. P. (2017). PhyloOncology: Understanding cancer through phylogenetic analysis. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1867(2), 101–108. https://doi.org/10.1016/j.bbcan.2016.10.006
Inferring the Origin of Metastases from Cancer Phylogenies
Cancer Research / Sep 30, 2015
Hong, W. S., Shpak, M., & Townsend, J. P. (2015). Inferring the Origin of Metastases from Cancer Phylogenies. Cancer Research, 75(19), 4021–4025. https://doi.org/10.1158/0008-5472.can-15-1889
Radiation-Specific Clinical Data Should Be Included in Existing Large-Scale Genomic Datasets
International Journal of Radiation Oncology*Biology*Physics / May 01, 2017
Chen, W. S., Townsend, J. P., & Yu, J. B. (2017). Radiation-Specific Clinical Data Should Be Included in Existing Large-Scale Genomic Datasets. International Journal of Radiation Oncology*Biology*Physics, 98(1), 8–10. https://doi.org/10.1016/j.ijrobp.2017.01.023
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Dr. Justin Whalley, Ph.D
Assistant Professor of Bioinformatics, with experience in finding the quintessential features in large, multi-layered 'omic datasets.
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Most Relevant Publications (1+)
69 total publications
Abstract LB-378: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
Cancer Research / Jul 01, 2018
Cortés-Ciriano, I., Lee, J.-K., Xi, R., Jain, D., Jung, Y. L., Yang, L., Gordenin, D., Klimczak, L. J., Zhang, C.-Z., Pellman, D. S., & Park, P. J. (2018). Abstract LB-378: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing. Cancer Research, 78(13_Supplement), LB-378-LB-378. https://doi.org/10.1158/1538-7445.am2018-lb-378
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Edoardo Airoldi
Professor of Statistics & Data Science Temple University & PI, Harvard University
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Most Relevant Publications (1+)
106 total publications
Accounting for Experimental Noise Reveals That mRNA Levels, Amplified by Post-Transcriptional Processes, Largely Determine Steady-State Protein Levels in Yeast
PLOS Genetics / May 07, 2015
Csárdi, G., Franks, A., Choi, D. S., Airoldi, E. M., & Drummond, D. A. (2015). Accounting for Experimental Noise Reveals That mRNA Levels, Amplified by Post-Transcriptional Processes, Largely Determine Steady-State Protein Levels in Yeast. PLOS Genetics, 11(5), e1005206. https://doi.org/10.1371/journal.pgen.1005206
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R. Alan Harris, Ph.D.
Assistant Professor in the Human Genome Sequencing Center at Baylor College of Medicine
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Most Relevant Publications (14+)
96 total publications
Season of Conception in Rural Gambia Affects DNA Methylation at Putative Human Metastable Epialleles
PLoS Genetics / Dec 23, 2010
Waterland, R. A., Kellermayer, R., Laritsky, E., Rayco-Solon, P., Harris, R. A., Travisano, M., Zhang, W., Torskaya, M. S., Zhang, J., Shen, L., Manary, M. J., & Prentice, A. M. (2010). Season of Conception in Rural Gambia Affects DNA Methylation at Putative Human Metastable Epialleles. PLoS Genetics, 6(12), e1001252. https://doi.org/10.1371/journal.pgen.1001252
Season of Conception in Rural Gambia Affects DNA Methylation at Putative Human Metastable Epialleles
PLoS Genetics / Dec 23, 2010
Waterland, R. A., Kellermayer, R., Laritsky, E., Rayco-Solon, P., Harris, R. A., Travisano, M., Zhang, W., Torskaya, M. S., Zhang, J., Shen, L., Manary, M. J., & Prentice, A. M. (2010). Season of Conception in Rural Gambia Affects DNA Methylation at Putative Human Metastable Epialleles. PLoS Genetics, 6(12), e1001252. https://doi.org/10.1371/journal.pgen.1001252
Maternal tobacco use modestly alters correlated epigenome-wide placental DNA methylation and gene expression
Epigenetics / Nov 01, 2011
Suter, M., Ma, J., Harris, A. S., Patterson, L., Brown, K. A., Shope, C., Showalter, L., Abramovici, A., & Aagaard-Tillery, K. M. (2011). Maternal tobacco use modestly alters correlated epigenome-wide placental DNA methylation and gene expression. Epigenetics, 6(11), 1284–1294. https://doi.org/10.4161/epi.6.11.17819
GASZ Is Essential for Male Meiosis and Suppression of Retrotransposon Expression in the Male Germline
PLoS Genetics / Sep 04, 2009
Ma, L., Buchold, G. M., Greenbaum, M. P., Roy, A., Burns, K. H., Zhu, H., Han, D. Y., Harris, R. A., Coarfa, C., Gunaratne, P. H., Yan, W., & Matzuk, M. M. (2009). GASZ Is Essential for Male Meiosis and Suppression of Retrotransposon Expression in the Male Germline. PLoS Genetics, 5(9), e1000635. https://doi.org/10.1371/journal.pgen.1000635
Evolutionary Breakpoints in the Gibbon Suggest Association between Cytosine Methylation and Karyotype Evolution
PLoS Genetics / Jun 26, 2009
Carbone, L., Harris, R. A., Vessere, G. M., Mootnick, A. R., Humphray, S., Rogers, J., Kim, S. K., Wall, J. D., Martin, D., Jurka, J., Milosavljevic, A., & de Jong, P. J. (2009). Evolutionary Breakpoints in the Gibbon Suggest Association between Cytosine Methylation and Karyotype Evolution. PLoS Genetics, 5(6), e1000538. https://doi.org/10.1371/journal.pgen.1000538
Genomic Hypomethylation in the Human Germline Associates with Selective Structural Mutability in the Human Genome
PLoS Genetics / May 17, 2012
Li, J., Harris, R. A., Cheung, S. W., Coarfa, C., Jeong, M., Goodell, M. A., White, L. D., Patel, A., Kang, S.-H., Shaw, C., Chinault, A. C., Gambin, T., Gambin, A., Lupski, J. R., & Milosavljevic, A. (2012). Genomic Hypomethylation in the Human Germline Associates with Selective Structural Mutability in the Human Genome. PLoS Genetics, 8(5), e1002692. https://doi.org/10.1371/journal.pgen.1002692
DNA methylation-associated colonic mucosal immune and defense responses in treatment-naïve pediatric ulcerative colitis
Epigenetics / Jun 17, 2014
Harris, R. A., Nagy-Szakal, D., Mir, S. A., Frank, E., Szigeti, R., Kaplan, J. L., Bronsky, J., Opekun, A., Ferry, G. D., Winter, H., & Kellermayer, R. (2014). DNA methylation-associated colonic mucosal immune and defense responses in treatment-naïve pediatric ulcerative colitis. Epigenetics, 9(8), 1131–1137. https://doi.org/10.4161/epi.29446
Human metastable epiallele candidates link to common disorders
Epigenetics / Feb 01, 2013
Harris, R. A., Nagy-Szakal, D., & Kellermayer, R. (2013). Human metastable epiallele candidates link to common disorders. Epigenetics, 8(2), 157–163. https://doi.org/10.4161/epi.23438
A High-Resolution Map of Synteny Disruptions in Gibbon and Human Genomes
PLoS Genetics / Jan 01, 2005
Carbone, L., Vessere, G. M., ten Hallers, B. F. H., Zhu, B., Osoegawa, K., Mootnick, A., Kofler, A., Wienberg, J., Rogers, J., Humpray, S., Scott, C., Harris, A. R., Milosavljevic, A., & de Jong, P. J. (2005). A High-Resolution Map of Synteny Disruptions in Gibbon and Human Genomes. PLoS Genetics, preprint(2006), e223. https://doi.org/10.1371/journal.pgen.0020223.eor
Comparative Genomic Analyses of the Human NPHP1 Locus Reveal Complex Genomic Architecture and Its Regional Evolution in Primates
PLOS Genetics / Dec 07, 2015
Yuan, B., Liu, P., Gupta, A., Beck, C. R., Tejomurtula, A., Campbell, I. M., Gambin, T., Simmons, A. D., Withers, M. A., Harris, R. A., Rogers, J., Schwartz, D. C., & Lupski, J. R. (2015). Comparative Genomic Analyses of the Human NPHP1 Locus Reveal Complex Genomic Architecture and Its Regional Evolution in Primates. PLOS Genetics, 11(12), e1005686. https://doi.org/10.1371/journal.pgen.1005686
Mismatch repair gene mutations lead to lynch syndrome colorectal cancer in rhesus macaques
Genes & Cancer / Apr 28, 2018
Dray, B. K., Raveendran, M., Harris, R. A., Benavides, F., Gray, S. B., Perez, C. J., McArthur, M. J., Williams, L. E., Baze, W. B., Doddapaneni, H., Muzny, D. M., Abee, C. R., & Rogers, J. (2018). Mismatch repair gene mutations lead to lynch syndrome colorectal cancer in rhesus macaques. Genes & Cancer, 9(3–4), 142–152. https://doi.org/10.18632/genesandcancer.170
Comparative molecular genomic analyses of a spontaneous rhesus macaque model of mismatch repair-deficient colorectal cancer
PLOS Genetics / Apr 21, 2022
Ozirmak Lermi, N., Gray, S. B., Bowen, C. M., Reyes-Uribe, L., Dray, B. K., Deng, N., Harris, R. A., Raveendran, M., Benavides, F., Hodo, C. L., Taggart, M. W., Colbert Maresso, K., Sinha, K. M., Rogers, J., & Vilar, E. (2022). Comparative molecular genomic analyses of a spontaneous rhesus macaque model of mismatch repair-deficient colorectal cancer. PLOS Genetics, 18(4), e1010163. https://doi.org/10.1371/journal.pgen.1010163
Copy number variants and fixed duplications among 198 rhesus macaques (Macaca mulatta)
PLOS Genetics / May 11, 2020
Brasó-Vives, M., Povolotskaya, I. S., Hartasánchez, D. A., Farré, X., Fernandez-Callejo, M., Raveendran, M., Harris, R. A., Rosene, D. L., Lorente-Galdos, B., Navarro, A., Marques-Bonet, T., Rogers, J., & Juan, D. (2020). Copy number variants and fixed duplications among 198 rhesus macaques (Macaca mulatta). PLOS Genetics, 16(5), e1008742. https://doi.org/10.1371/journal.pgen.1008742
Confounding by Repetitive Elements and CpG Islands Does Not Explain the Association between Hypomethylation and Genomic Instability
PLoS Genetics / Feb 28, 2013
Harris, R. A., Shaw, C., Li, J., Cheung, S. W., Coarfa, C., Jeong, M., Goodell, M. A., White, L. D., Patel, A., Kang, S.-H., Chinault, A. C., Gambin, T., Gambin, A., Lupski, J. R., & Milosavljevic, A. (2013). Confounding by Repetitive Elements and CpG Islands Does Not Explain the Association between Hypomethylation and Genomic Instability. PLoS Genetics, 9(2), e1003333. https://doi.org/10.1371/journal.pgen.1003333
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Lindsay Webb, PhD
Immunologist and cancer biologist passionate about driving innovative research to improve patient health
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Most Relevant Publications (5+)
11 total publications
203 A membrane-tethered IL-15/IL-15 receptor fusion protein enhances the persistence and efficacy of CD70-targeted TRuC-T cells
Journal for ImmunoTherapy of Cancer / Nov 01, 2021
Ding, J., Webb, L., Patterson, T., Fleury, M., Zieba, A., Horton, H., Hofmeister, R., Gutierrez, D., & Tighe, R. (2021). 203 A membrane-tethered IL-15/IL-15 receptor fusion protein enhances the persistence and efficacy of CD70-targeted TRuC-T cells. Journal for ImmunoTherapy of Cancer, 9(Suppl 2), A214–A214. https://doi.org/10.1136/jitc-2021-sitc2021.203
173 Expression of a membrane-tethered IL-15/IL-15 receptor fusion protein enhances the persistence of MSLN-targeted TRuC-T cells
Journal for ImmunoTherapy of Cancer / Nov 01, 2021
Fleury, M., McCarthy, D., Horton, H., Anderson, C., Watt, A., Zieba, A., Webb, L., Ding, J., Tighe, R., Hofmeister, R., & Gutierrez, D. (2021). 173 Expression of a membrane-tethered IL-15/IL-15 receptor fusion protein enhances the persistence of MSLN-targeted TRuC-T cells. Journal for ImmunoTherapy of Cancer, 9(Suppl 2), A185–A185. https://doi.org/10.1136/jitc-2021-sitc2021.173
M9657 Is a Bispecific Tumor-Targeted Anti-CD137 Agonist That Induces MSLN-Dependent Antitumor Immunity without Liver Inflammation
Cancer Immunology Research / Dec 13, 2023
Xu, C., Zhou, X., Webb, L., Yalavarthi, S., Zheng, W., Saha, S., Schweickhardt, R., Soloviev, M., Jenkins, M. H., Brandstetter, S., Belousova, N., Alimzhanov, M., Rabinovich, B., Deshpande, A. M., Brewis, N., & Helming, L. (2023). M9657 Is a Bispecific Tumor-Targeted Anti-CD137 Agonist That Induces MSLN-Dependent Antitumor Immunity without Liver Inflammation. Cancer Immunology Research, 12(2), 195–213. https://doi.org/10.1158/2326-6066.cir-23-0243
Abstract P077: Composition of CD4 T cell subsets and impact on tumor growth control across mouse syngeneic tumor models
Cancer Immunology Research / Jan 01, 2022
Xu, C., Webb, L., Yalavarthi, S., Bourin, C., & Moisan, J. (2022). Abstract P077: Composition of CD4 T cell subsets and impact on tumor growth control across mouse syngeneic tumor models. Cancer Immunology Research, 10(1_Supplement), P077–P077. https://doi.org/10.1158/2326-6074.tumimm21-p077
757 M9657, a novel tumor-targeted conditional anti-CD137 agonist displays MSLN-dependent anti-tumor immunity
Journal for ImmunoTherapy of Cancer / Nov 01, 2021
Xu, C., Rabinovich, B., Deshpande, A., Zhou, X., Pipp, F. C., Schweickhardt, R., Webb, L., Yalavarthi, S., Bourin, C., Ghatak, P., Safi, B., Wollerton, F., Brewis, N., Munoz-Olaya, J., Belousova, N., Alimzhanov, M., Hubensack, M., Halle, J.-P., Blaukat, A., & Moisan, J. (2021). 757 M9657, a novel tumor-targeted conditional anti-CD137 agonist displays MSLN-dependent anti-tumor immunity. Journal for ImmunoTherapy of Cancer, 9(Suppl 2), A792–A792. https://doi.org/10.1136/jitc-2021-sitc2021.757
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Example cancer research projects
How can companies collaborate more effectively with researchers, experts, and thought leaders to make progress on cancer research?
Development of Targeted Therapies
An academic researcher in Cancer Research can collaborate with a pharmaceutical company to develop targeted therapies for specific types of cancer. By leveraging their expertise in molecular biology and drug discovery, the researcher can contribute to the design and optimization of novel drugs that selectively target cancer cells while minimizing side effects.
Identification of Novel Biomarkers
A company specializing in diagnostic tools can collaborate with a Cancer Research expert to identify novel biomarkers for early cancer detection. The researcher can utilize their knowledge of cancer biology and molecular techniques to identify specific biomarkers that can be incorporated into diagnostic tests, enabling early intervention and improved patient outcomes.
Genomic Analysis for Personalized Medicine
By partnering with an academic researcher in Cancer Research, a biotech company can leverage genomic analysis to develop personalized medicine approaches. The researcher can analyze genomic data from patients to identify genetic mutations and variations that can inform treatment decisions, leading to more targeted and effective therapies.
Development of Immunotherapies
Collaboration between a pharmaceutical company and a Cancer Research expert can lead to the development of innovative immunotherapies. The researcher can contribute their knowledge of the immune system and cancer immunology to design and optimize immunotherapeutic approaches, enhancing the company's portfolio of cancer treatments.
Exploration of Combination Therapies
An academic researcher in Cancer Research can collaborate with a company to explore combination therapies for cancer treatment. By combining different drugs or treatment modalities, the researcher can help identify synergistic effects and optimize treatment regimens, potentially improving patient outcomes and expanding the company's treatment options.