Work with thought leaders and academic experts in cell biology

Companies can greatly benefit from working with experts in the field of Cell Biology. These researchers can provide valuable insights and expertise to enhance research and development efforts. They can help in developing innovative solutions and technologies, improving product quality and safety, and optimizing manufacturing processes. Additionally, collaborating with Cell Biology experts can lead to the discovery of new applications and opportunities in various industries such as pharmaceuticals, biotechnology, agriculture, and environmental sciences. By leveraging their knowledge and skills, companies can gain a competitive edge, accelerate scientific advancements, and drive business growth.

Researchers on NotedSource with backgrounds in cell biology include Boris Leibovitch, Ping Luo, Dr. Everson A Nunes, Ph.D., Brent Banasik, Ph.D., John M Baust, Ph.D, Claudia Litterst, Aimee Eggler, Sheed Itaman, Luca Delfinis, Regan Hamel, Burcu Vitrinel, Ph.D., and Michael W Harman.

Boris Leibovitch

New York, New York, United States of America
Experienced wet lab and in teaching Molecular Cell biologist, geneticist, cancer biologist in Academia
Most Relevant Research Interests
Cell Biology
Other Research Interests (8)
Cancer Research
Developmental Biology
Molecular Biology
Hematology
Immunology
And 3 more
About
I am experienced molecular and cell biologist with deep genetics background who worked many years in USA and Russia on the bench and as teacher. Both types of work had demanded extremely broad knowledge and understanding of developments in the fields. Participation in grant writing, editorial/reviewer work for scientific journals and consulting colleagues on these subjects added a lot to my broad experience as the scientist.
Most Relevant Publications (3+)

22 total publications

Adipocyte derived paracrine mediators of mammary ductal morphogenesis controlled by retinoic acid receptors

Developmental Biology / Jan 01, 2011

Marzan, C. V., Kupumbati, T. S., Bertran, S. P., Samuels, T., Leibovitch, B., Mira-y-Lopez, R., Ossowski, L., & Farias, E. F. (2011). Adipocyte derived paracrine mediators of mammary ductal morphogenesis controlled by retinoic acid receptors. Developmental Biology, 349(2), 125–136. https://doi.org/10.1016/j.ydbio.2010.10.018

The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor

Blood / Mar 15, 2008

Marango, J., Shimoyama, M., Nishio, H., Meyer, J. A., Min, D.-J., Sirulnik, A., Martinez-Martinez, Y., Chesi, M., Bergsagel, P. L., Zhou, M.-M., Waxman, S., Leibovitch, B. A., Walsh, M. J., & Licht, J. D. (2008). The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor. Blood, 111(6), 3145–3154. https://doi.org/10.1182/blood-2007-06-092122

GAGA Factor and the TFIID Complex Collaborate in Generating an Open Chromatin Structure at the Drosophila melanogaster hsp26 Promoter

Molecular and Cellular Biology / Sep 01, 2002

Leibovitch, B. A., Lu, Q., Benjamin, L. R., Liu, Y., Gilmour, D. S., & Elgin, S. C. R. (2002). GAGA Factor and the TFIID Complex Collaborate in Generating an Open Chromatin Structure at the Drosophila melanogaster hsp26 Promoter. Molecular and Cellular Biology, 22(17), 6148–6157. https://doi.org/10.1128/mcb.22.17.6148-6157.2002

See Full Profile

Ping Luo

Toronto, Ontario, Canada
Bioinformatics Specialist at Princess Margaret Cancer Centre with experience in deep learning
Most Relevant Research Interests
Cell Biology
Other Research Interests (21)
single-cell genomics
deep learning
complex network analysis
Genetics (clinical)
Genetics
And 16 more
About
8 years of science and engineering experience integrating multi-omics data to identify biomarkers for cancer studies. Seeking to apply data analytics expertise to develop new diagnosis and treatment strategies.
Most Relevant Publications (1+)

23 total publications

Normalization of the Immune Microenvironment during Lenalidomide Maintenance Is Associated with Sustained MRD Negativity in Patients with Multiple Myeloma

Blood / Nov 05, 2021

Coffey, D. G., Maura, F., Gonzalez-Kozlova, E., Diaz-Mejia3, J., Luo, P., Zhang, Y., Xu, Y., Warren, E. H., Smith, E. L., Cho, H. J., Lesokhin, A., Diamond, B., Kazandjian, D., Pugh, T. J., Green, D. J., Gnjatic, S., & Landgren, O. (2021). Normalization of the Immune Microenvironment during Lenalidomide Maintenance Is Associated with Sustained MRD Negativity in Patients with Multiple Myeloma. Blood, 138(Supplement 1), 329–329. https://doi.org/10.1182/blood-2021-154506

See Full Profile

Dr. Everson A Nunes, Ph.D.

Hamilton, Ontario, Canada
Post-Doctoral Fellow at McMaster University | former Associate Professor - Physiological Sciences
Most Relevant Research Interests
Cell Biology
Other Research Interests (39)
skeletal muscle
nutrition
physical activity
obesity
cancer
And 34 more
About
Dr. Everson A Nunes is a highly accomplished researcher and educator in the field of physiological sciences. He received his Ph.D. in Cellular and Molecular Biology with a focus on Physiological Sciences from Universidade Federal do Paraná in 2009, after completing a BSc in Human Nutrition and an MSc in Physiological Sciences. He also holds a specialization in Exercise Physiology and a BSc in Biological Sciences from Universidade Federal do Paraná. Dr. Nunes has a strong background in research, having completed two post-doctoral fellowships at McMaster University and Universidade Federal do Paraná. He has also held positions as an associate professor and assistant professor at Universidade Federal de Santa Catarina. He has published numerous articles in peer-reviewed journals, and his research focuses on the effects of exercise and nutrition on physiological processes in the human body. In addition to his research, Dr. Nunes is also a dedicated educator. He has taught at various universities in Brazil, including Universidade Federal de Santa Catarina, Universidade Gama Filho, Faculdades Integradas Espírita, Pontificia Universidade Católica do Paraná, and Faculdade do Litoral Sul. He is known for his dynamic teaching style and his ability to engage students in complex physiological concepts. Dr. Nunes is a member of several professional organizations, including the American Society for Nutrition, the Canadian Society of Exercise Physiology, the Canadian Nutrition Society and the Brazilian Society of Physiology. He is also a regular speaker at national and international conferences, sharing his expertise and research findings with colleagues and students. Overall, Dr. Nunes is a highly qualified and experienced professional in physiological sciences, metabolism, cancer and nutrition. His dedication to research and education makes him a valuable asset to any institution.
Most Relevant Publications (8+)

97 total publications

Fish Oil Decreases C‐Reactive Protein/Albumin Ratio Improving Nutritional Prognosis and Plasma Fatty Acid Profile in Colorectal Cancer Patients

Lipids / Jul 26, 2013

Mocellin, M. C., Pastore e Silva, J. de A., Camargo, C. de Q., Fabre, M. E. de S., Gevaerd, S., Naliwaiko, K., Moreno, Y. M. F., Nunes, E. A., & Trindade, E. B. S. de M. (2013). Fish Oil Decreases C‐Reactive Protein/Albumin Ratio Improving Nutritional Prognosis and Plasma Fatty Acid Profile in Colorectal Cancer Patients. Lipids, 48(9), 879–888. Portico. https://doi.org/10.1007/s11745-013-3816-0

Fish Oil Supplementation Improves Neutrophil Function During Cancer Chemotherapy

Lipids / Dec 11, 2011

Bonatto, S. J. R., Oliveira, H. H. P., Nunes, E. A., Pequito, D., Iagher, F., Coelho, I., Naliwaiko, K., Kryczyk, M., Brito, G. A. P., Repka, J., Sabóia, L. V., Fukujima, G., Calder, P. C., & Fernandes, L. C. (2011). Fish Oil Supplementation Improves Neutrophil Function During Cancer Chemotherapy. Lipids, 47(4), 383–389. Portico. https://doi.org/10.1007/s11745-011-3643-0

Insulin rapidly increases skeletal muscle mitochondrial ADP sensitivity in the absence of a high lipid environment

Biochemical Journal / Jul 09, 2021

Brunetta, H. S., Petrick, H. L., Vachon, B., Nunes, E. A., & Holloway, G. P. (2021). Insulin rapidly increases skeletal muscle mitochondrial ADP sensitivity in the absence of a high lipid environment. Biochemical Journal, 478(13), 2539–2553. https://doi.org/10.1042/bcj20210264

Disuse-induced skeletal muscle atrophy in disease and nondisease states in humans: mechanisms, prevention, and recovery strategies

American Journal of Physiology-Cell Physiology / Jun 01, 2022

Nunes, E. A., Stokes, T., McKendry, J., Currier, B. S., & Phillips, S. M. (2022). Disuse-induced skeletal muscle atrophy in disease and nondisease states in humans: mechanisms, prevention, and recovery strategies. American Journal of Physiology-Cell Physiology, 322(6), C1068–C1084. https://doi.org/10.1152/ajpcell.00425.2021

Glucose homeostasis in two degrees of sepsis lethality induced by caecum ligation and puncture in mice

International Journal of Experimental Pathology / Dec 01, 2017

Ferreira, F. B. D., dos Santos, C., Bruxel, M. A., Nunes, E. A., Spiller, F., & Rafacho, A. (2017). Glucose homeostasis in two degrees of sepsis lethality induced by caecum ligation and puncture in mice. International Journal of Experimental Pathology, 98(6), 329–340. Portico. https://doi.org/10.1111/iep.12255

Lymphocytes transfer [14C]‐labeled fatty acids to skeletal muscle in culture; modulation by exercise

Cell Biochemistry and Function / May 26, 2010

Brito, G. A. P., Nunes, E. A., Nogata, C., Yamazaky, R. K., Naliwaiko, K., Curi, R., & Fernandes, L. C. (2010). Lymphocytes transfer [14C]‐labeled fatty acids to skeletal muscle in culture; modulation by exercise. Cell Biochemistry and Function, 28(4), 278–282. Portico. https://doi.org/10.1002/cbf.1652

Decreased tumor growth in Walker 256 tumor-bearing rats chronically supplemented with fish oil involves COX-2 and PGE2 reduction associated with apoptosis and increased peroxidation

Prostaglandins, Leukotrienes and Essential Fatty Acids / Feb 01, 2007

Mund, R. C., Pizato, N., Bonatto, S., Nunes, E. A., Vicenzi, T., Tanhoffer, R., de Oliveira, H. H. P., Curi, R., Calder, P. C., & Fernandes, L. C. (2007). Decreased tumor growth in Walker 256 tumor-bearing rats chronically supplemented with fish oil involves COX-2 and PGE2 reduction associated with apoptosis and increased peroxidation. Prostaglandins, Leukotrienes and Essential Fatty Acids, 76(2), 113–120. https://doi.org/10.1016/j.plefa.2006.11.008

The effects of peroxovanadate and peroxovanadyl on glucose metabolism in vivo and identification of signal transduction proteins involved in the mechanism of action in isolated soleus muscle

Molecular and Cellular Biochemistry / May 01, 2005

Yamazaki, R. K., Hirabara, S. M., Tchaikovski, O., Lopes, M. C. P., Nogata, C., Aikawa, J., Nunes, E. A., Tanhoffer, R. A., Lissa, M. D., & Fernandes, L. C. (2005). The effects of peroxovanadate and peroxovanadyl on glucose metabolism in vivo and identification of signal transduction proteins involved in the mechanism of action in isolated soleus muscle. Molecular and Cellular Biochemistry, 273(1–2), 145–150. https://doi.org/10.1007/s11010-005-8265-5

See Full Profile

John M Baust, Ph.D

Ithaca, New York, United States of America
Proven success in delivering best-in-class services across scientific, commercial and education environments.
Most Relevant Research Interests
Cell Biology
Other Research Interests (16)
Biotechnology
Biomedical Engineering
Transplantation
Surgery
Management of Technology and Innovation
And 11 more
About
***Proven success in delivering best-in-class services across highly regulated scientific and commercial environments.*** * Resourceful, dynamic, and future-focused professional; equipped with strategic leadership, business, research, and academic expertise with career excellence in conducting in-depth research, leading multi-faceted R&D projects, and developing new products and treatments. * Dedicated, driven self-starter focused on developing innovative life changing technologies and procedures advancing the areas of cancer treatment, regenerative medicine and cell therapy.   * Substantial experience in providing oversight for medical device development, pre-clinical studies, cancer therapy, stem cell preservation, cell therapy, tissue engineering, and organ transplantation, etc. * Astute at establishing solid relationships with stakeholders and industry leaders to drive innovative ideas and lead collaborative efforts in pursuit of accomplishing long-term milestones. * Successful in delivering interactive academic instruction across higher education settings offering captivating lectures on Biology and Entrepreneurship courses in accordance with the organizational mission. * Accredited with authoring, managing, and executing multi-million dollar grants, corporate contracts * Accomplished author of numerous patents and high profile publications to disseminate essential research findings.
Most Relevant Publications (18+)

68 total publications

Molecular Mechanisms of Cellular Demise Associated with Cryopreservation Failure

Cell Preservation Technology / May 01, 2002

Baust, J. M. (2002). Molecular Mechanisms of Cellular Demise Associated with Cryopreservation Failure. Cell Preservation Technology, 1(1), 17–31. https://doi.org/10.1089/15383440260073266

Gene Activation of the Apoptotic Caspase Cascade Following Cryogenic Storage

Cell Preservation Technology / May 01, 2002

Baust, J. M., Van Buskirk, R., & Baust, J. G. (2002). Gene Activation of the Apoptotic Caspase Cascade Following Cryogenic Storage. Cell Preservation Technology, 1(1), 63–80. https://doi.org/10.1089/15383440260073301

Transplantation Diagnostics: A Preliminary Analysis Using Protein Microarray to Determine Kidney Status Prior To and Following Implantation

Cell Preservation Technology / Jun 01, 2004

Baust, J. M., Mathew, A. J., Snyder, K. K., Liu, E. H., van Buskirk, R. G., Hardy, M. A., & Baust, J. G. (2004). Transplantation Diagnostics: A Preliminary Analysis Using Protein Microarray to Determine Kidney Status Prior To and Following Implantation. Cell Preservation Technology, 2(2), 81–90. https://doi.org/10.1089/153834404774101936

Long-Term Function of Cryopreserved Rat Hepatocytes in a Coculture System

Cell Transplantation / Mar 01, 2004

Sugimachi, K., Sosef, M. N., Baust, J. M., Fowler, A., Tompkins, R. G., & Toner, M. (2004). Long-Term Function of Cryopreserved Rat Hepatocytes in a Coculture System. Cell Transplantation, 13(2), 187–195. https://doi.org/10.3727/000000004773301799

Cellular Components of the Coronary Vasculature Exhibit Differential Sensitivity to Low Temperature Insult

Cell Preservation Technology / Dec 01, 2002

Hollister, W. R., Baust, J. M., Van Buskirk, R. G., & Baust, J. G. (2002). Cellular Components of the Coronary Vasculature Exhibit Differential Sensitivity to Low Temperature Insult. Cell Preservation Technology, 1(4), 269–280. https://doi.org/10.1089/15383440260682099

Effect of Cell Substrate Interactions on the Desiccation Behavior of Human Fibroblasts

Cell Preservation Technology / Sep 01, 2004

Baust, J. M., Fowler, A., & Toner, M. (2004). Effect of Cell Substrate Interactions on the Desiccation Behavior of Human Fibroblasts. Cell Preservation Technology, 2(3), 188–197. https://doi.org/10.1089/cpt.2004.2.188

Enhanced Hypothermic Storage of Neonatal Cardiomyocytes

Cell Preservation Technology / Mar 01, 2005

Snyder, K. K., Baust, J. M., Van Buskirk, R. G., & Baust, J. G. (2005). Enhanced Hypothermic Storage of Neonatal Cardiomyocytes. Cell Preservation Technology, 3(1), 61–74. https://doi.org/10.1089/cpt.2005.3.61

Involvement of the Cysteine Protease Calpain Family in Cell Death After Cryopreservation

Cell Preservation Technology / Mar 01, 2006

Robilotto, A. T., Baust, J. M., Buskirk, R. V., & Baust, J. G. (2006). Involvement of the Cysteine Protease Calpain Family in Cell Death After Cryopreservation. Cell Preservation Technology, 4(1), 17–30. https://doi.org/10.1089/cpt.2006.4.17

Cardiomyocyte Responses to Thermal Excursions: Implications for Electrophysiological Cardiac Mapping

Cell Preservation Technology / Jun 01, 2007

Snyder, K. K., Baust, J. M., Van Buskirk, R. G., & Baust, J. G. (2007). Cardiomyocyte Responses to Thermal Excursions: Implications for Electrophysiological Cardiac Mapping. Cell Preservation Technology, 5(2), 116–128. https://doi.org/10.1089/cpt.2007.9995

Activation of Mitochondrial-Associated Apoptosis Contributes to Cryopreservation Failure

Cell Preservation Technology / Sep 01, 2007

Baust, J. M., Vogel, M. J., Snyder, K. K., Van Buskirk, R. G., & Baust, J. G. (2007). Activation of Mitochondrial-Associated Apoptosis Contributes to Cryopreservation Failure. Cell Preservation Technology, 5(3), 155–164. https://doi.org/10.1089/cpt.2007.9990

Preliminary Report: Evaluation of Storage Conditions and Cryococktails during Peripheral Blood Mononuclear Cell Cryopreservation

Cell Preservation Technology / Dec 01, 2007

Cosentino, L. M., Corwin, W., Baust, J. M., Diaz-Mayoral, N., Cooley, H., Shao, W., van Buskirk, R., & Baust, J. G. (2007). Preliminary Report: Evaluation of Storage Conditions and Cryococktails during Peripheral Blood Mononuclear Cell Cryopreservation. Cell Preservation Technology, 5(4), 189–204. https://doi.org/10.1089/cpt.2007.9987

Changing Paradigms in Biopreservation

Biopreservation and Biobanking / Mar 01, 2009

Baust, J. M., Snyder, K. K., VanBuskirk, R. G., & Baust, J. G. (2009). Changing Paradigms in Biopreservation. Biopreservation and Biobanking, 7(1), 3–12. https://doi.org/10.1089/bio.2009.0701.jmb

In VitroAssessment of Apoptosis and Necrosis Following Cold Storage in a Human Airway Cell Model

Biopreservation and Biobanking / Mar 01, 2009

Corwin, W. L., Baust, J. M., VanBuskirk, R. G., & Baust, J. G. (2009). In VitroAssessment of Apoptosis and Necrosis Following Cold Storage in a Human Airway Cell Model. Biopreservation and Biobanking, 7(1), 19–27. https://doi.org/10.1089/bio.2009.0002

How Much Will the Biobanking Industry Come to Rely on Private Companies?

Biopreservation and Biobanking / Dec 01, 2010

Clark, B. J., Baust, J. M., & Stacey, G. (2010). How Much Will the Biobanking Industry Come to Rely on Private Companies? Biopreservation and Biobanking, 8(4), 179–180. https://doi.org/10.1089/bio.2010.8415

Implications of Differential Stress Response Activation Following Non-Frozen Hepatocellular Storage

Biopreservation and Biobanking / Feb 01, 2013

Corwin, W. L., Baust, J. M., Baust, J. G., & Van Buskirk, R. G. (2013). Implications of Differential Stress Response Activation Following Non-Frozen Hepatocellular Storage. Biopreservation and Biobanking, 11(1), 33–44. https://doi.org/10.1089/bio.2012.0045

Integrating Molecular Control to Improve Cryopreservation Outcome

Biopreservation and Biobanking / Apr 01, 2017

Baust, J. G., Snyder, K. K., Van Buskirk, R., & Baust, J. M. (2017). Integrating Molecular Control to Improve Cryopreservation Outcome. Biopreservation and Biobanking, 15(2), 134–141. https://doi.org/10.1089/bio.2016.0119

Best practices in cell culture: an overview

In Vitro Cellular & Developmental Biology - Animal / Aug 14, 2017

Baust, J. M., Buehring, G. C., Campbell, L., Elmore, E., Harbell, J. W., Nims, R. W., Price, P., Reid, Y. A., & Simione, F. (2017). Best practices in cell culture: an overview. In Vitro Cellular & Developmental Biology - Animal, 53(8), 669–672. https://doi.org/10.1007/s11626-017-0177-7

Best practices for cryopreserving, thawing, recovering, and assessing cells

In Vitro Cellular & Developmental Biology - Animal / Nov 02, 2017

Baust, J. M., Campbell, L. H., & Harbell, J. W. (2017). Best practices for cryopreserving, thawing, recovering, and assessing cells. In Vitro Cellular & Developmental Biology - Animal, 53(10), 855–871. https://doi.org/10.1007/s11626-017-0201-y

See Full Profile

Claudia Litterst

Walnut Creek, California, United States of America
Established PhD research leader with a proven track record of developing innovative assays for the biotech industry
Most Relevant Research Interests
Cell Biology
Other Research Interests (11)
Biochemistry
Molecular Biology
Analytical Chemistry
Genetics
Cellular and Molecular Neuroscience
And 6 more
About
An established PhD research leader with 15 years of experience in the life sciences and diagnostics industries. Strong expertise in developing innovative PCR assays for oncology and infectious diseases diagnostics. Possessing post-doctoral training in cell-based assay development and high throughput screening for target identification and drug discovery. Academic background in signaling pathways that involve cancer, neurodegenerative and inflammatory diseases. Effective, productive management style to reach shared business goals and objectives. Well versed in the following areas: -Serving as a member of the extended research and development leadership team to support strategic planning initiatives. -Defining and executing experimental plans and protocols. Assuming responsibility for timely completion of activities. -Conducting in-depth analysis and interpretation of experimental data, generating comprehensive summaries, and supporting technical documents, including detailed protocols and reports and communicating progress to stakeholders. -Promoting innovation while adhering to internal and external guidelines and regulatory measures. -Working in a highly cross-functional, fast-paced environment to closely collaborate with business, scientific and medical affairs, legal, engineering, bioinformatics and other R&D teams. -Working with CROs. -Validation testing for hardware instrumentation, reagents and consumables for PCR and transfection. -Serving as subject matter expert for digital PCR.
Most Relevant Publications (8+)

26 total publications

Functional Characterization of Multiple Transactivating Elements in β-Catenin, Some of Which Interact with the TATA-binding Proteinin Vitro

Journal of Biological Chemistry / Jun 01, 1999

Hecht, A., Litterst, C. M., Huber, O., & Kemler, R. (1999). Functional Characterization of Multiple Transactivating Elements in β-Catenin, Some of Which Interact with the TATA-binding Proteinin Vitro. Journal of Biological Chemistry, 274(25), 18017–18025. https://doi.org/10.1074/jbc.274.25.18017

Akt-Mediated Phosphorylation of Argonaute 2 Downregulates Cleavage and Upregulates Translational Repression of MicroRNA Targets

Molecular Cell / May 01, 2013

Horman, S. R., Janas, M. M., Litterst, C., Wang, B., MacRae, I. J., Sever, M. J., Morrissey, D. V., Graves, P., Luo, B., Umesalma, S., Qi, H. H., Miraglia, L. J., Novina, C. D., & Orth, A. P. (2013). Akt-Mediated Phosphorylation of Argonaute 2 Downregulates Cleavage and Upregulates Translational Repression of MicroRNA Targets. Molecular Cell, 50(3), 356–367. https://doi.org/10.1016/j.molcel.2013.03.015

Ligand Binding and Calcium Influx Induce Distinct Ectodomain/γ-Secretase-processing Pathways of EphB2 Receptor

Journal of Biological Chemistry / Jun 01, 2007

Litterst, C., Georgakopoulos, A., Shioi, J., Ghersi, E., Wisniewski, T., Wang, R., Ludwig, A., & Robakis, N. K. (2007). Ligand Binding and Calcium Influx Induce Distinct Ectodomain/γ-Secretase-processing Pathways of EphB2 Receptor. Journal of Biological Chemistry, 282(22), 16155–16163. https://doi.org/10.1074/jbc.m611449200

NCoA-1/SRC-1 Is an Essential Coactivator of STAT5 That Binds to the FDL Motif in the α-Helical Region of the STAT5 Transactivation Domain

Journal of Biological Chemistry / Nov 01, 2003

Litterst, C. M., Kliem, S., Marilley, D., & Pfitzner, E. (2003). NCoA-1/SRC-1 Is an Essential Coactivator of STAT5 That Binds to the FDL Motif in the α-Helical Region of the STAT5 Transactivation Domain. Journal of Biological Chemistry, 278(46), 45340–45351. https://doi.org/10.1074/jbc.m303644200

Transcriptional Activation by STAT6 Requires the Direct Interaction with NCoA-1

Journal of Biological Chemistry / Dec 01, 2001

Litterst, C. M., & Pfitzner, E. (2001). Transcriptional Activation by STAT6 Requires the Direct Interaction with NCoA-1. Journal of Biological Chemistry, 276(49), 45713–45721. https://doi.org/10.1074/jbc.m108132200

An LXXLL Motif in the Transactivation Domain of STAT6 Mediates Recruitment of NCoA-1/SRC-1

Journal of Biological Chemistry / Sep 01, 2002

Litterst, C. M., & Pfitzner, E. (2002). An LXXLL Motif in the Transactivation Domain of STAT6 Mediates Recruitment of NCoA-1/SRC-1. Journal of Biological Chemistry, 277(39), 36052–36060. https://doi.org/10.1074/jbc.m203556200

Cadherins Mediate Both the Association between PS1 and β-Catenin and the Effects of PS1 on β-Catenin Stability

Journal of Biological Chemistry / Oct 01, 2005

Serban, G., Kouchi, Z., Baki, L., Georgakopoulos, A., Litterst, C. M., Shioi, J., & Robakis, N. K. (2005). Cadherins Mediate Both the Association between PS1 and β-Catenin and the Effects of PS1 on β-Catenin Stability. Journal of Biological Chemistry, 280(43), 36007–36012. https://doi.org/10.1074/jbc.m507503200

Peptide EphB2/CTF2 Generated by the γ-Secretase Processing of EphB2 Receptor Promotes Tyrosine Phosphorylation and Cell Surface Localization of N-Methyl-d-aspartate Receptors

Journal of Biological Chemistry / Oct 01, 2009

Xu, J., Litterst, C., Georgakopoulos, A., Zaganas, I., & Robakis, N. K. (2009). Peptide EphB2/CTF2 Generated by the γ-Secretase Processing of EphB2 Receptor Promotes Tyrosine Phosphorylation and Cell Surface Localization of N-Methyl-d-aspartate Receptors. Journal of Biological Chemistry, 284(40), 27220–27228. https://doi.org/10.1074/jbc.m109.048728

See Full Profile

Aimee Eggler

Villanova, Pennsylvania, United States of America
Professor of Chemistry and Biochemistry at Villanova University
Most Relevant Research Interests
Cell Biology
Other Research Interests (18)
Biochemistry
Physiology (medical)
Toxicology
Organic Chemistry
Clinical Biochemistry
And 13 more
About
Dr. Eggler has 20 years of experience in the field of redox biology, with a focus on the Nrf2 transcription factor, a master regulator of antioxidant, detoxification and anti-inflammatory genes. She is also an award-winning educator and the recipient of the Villanova University Junior Faculty Excellence in Teaching award. Her interests in education include innovation in teaching metabolism from a logic-based perspective.
Most Relevant Publications (6+)

25 total publications

Screening for natural chemoprevention agents that modify human Keap1

Analytical Biochemistry / Feb 01, 2012

Hu, C., Nikolic, D., Eggler, A. L., Mesecar, A. D., & van Breemen, R. B. (2012). Screening for natural chemoprevention agents that modify human Keap1. Analytical Biochemistry, 421(1), 108–114. https://doi.org/10.1016/j.ab.2011.10.028

Development of an efficient E. coli expression and purification system for a catalytically active, human Cullin3–RINGBox1 protein complex and elucidation of its quaternary structure with Keap1

Biochemical and Biophysical Research Communications / Oct 01, 2010

Small, E., Eggler, A., & Mesecar, A. D. (2010). Development of an efficient E. coli expression and purification system for a catalytically active, human Cullin3–RINGBox1 protein complex and elucidation of its quaternary structure with Keap1. Biochemical and Biophysical Research Communications, 400(4), 471–475. https://doi.org/10.1016/j.bbrc.2010.08.062

Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1

Biochemical Journal / Jul 29, 2009

Eggler, A. L., Small, E., Hannink, M., & Mesecar, A. D. (2009). Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1. Biochemical Journal, 422(1), 171–180. https://doi.org/10.1042/bj20090471

The C Terminus of the Escherichia coli RecA Protein Modulates the DNA Binding Competition with Single-stranded DNA-binding Protein

Journal of Biological Chemistry / May 01, 2003

Eggler, A. L., Lusetti, S. L., & Cox, M. M. (2003). The C Terminus of the Escherichia coli RecA Protein Modulates the DNA Binding Competition with Single-stranded DNA-binding Protein. Journal of Biological Chemistry, 278(18), 16389–16396. https://doi.org/10.1074/jbc.m212920200

The Rad51-dependent Pairing of Long DNA Substrates Is Stabilized by Replication Protein A

Journal of Biological Chemistry / Oct 01, 2002

Eggler, A. L., Inman, R. B., & Cox, M. M. (2002). The Rad51-dependent Pairing of Long DNA Substrates Is Stabilized by Replication Protein A. Journal of Biological Chemistry, 277(42), 39280–39288. https://doi.org/10.1074/jbc.m204328200

DNA Pairing and Strand Exchange by the Escherichia coli RecA and Yeast Rad51 Proteins without ATP Hydrolysis

Journal of Biological Chemistry / Oct 01, 2001

Rice, K. P., Eggler, A. L., Sung, P., & Cox, M. M. (2001). DNA Pairing and Strand Exchange by the Escherichia coli RecA and Yeast Rad51 Proteins without ATP Hydrolysis. Journal of Biological Chemistry, 276(42), 38570–38581. https://doi.org/10.1074/jbc.m105678200

See Full Profile

Burcu Vitrinel, Ph.D.

San Francisco
Cross-functional life sciences strategy professional with a Ph.D. in genetics
Most Relevant Research Interests
Cell Biology
Other Research Interests (15)
Molecular Biology
Biochemistry
Aging
Computer Science Applications
Virology
And 10 more
About
Cross-functional life sciences **strategy** professional with a doctoral degree in **genetics**; worked on 16+ projects in collaboration with 7+ big pharma clients as the lead consultant in a **client-facing** role. Exceptional understanding of current life sciences **market trends**. Scientist with 10+ years of wet-lab with hands-on **CRISPR-Cas9 gene** **editing and tandem mass-spectrometry** experience with 3 first-author papers. Experienced primary market researcher for pharmaceutical companies. Award-winning science communicator for a wide range of audiences tailored to different internal and external stakeholders.
Most Relevant Publications (2+)

10 total publications

Conserved Epigenetic Regulatory Logic Infers Genes Governing Cell Identity

Cell Systems / Dec 01, 2020

Shim, W. J., Sinniah, E., Xu, J., Vitrinel, B., Alexanian, M., Andreoletti, G., Shen, S., Sun, Y., Balderson, B., Boix, C., Peng, G., Jing, N., Wang, Y., Kellis, M., Tam, P. P. L., Smith, A., Piper, M., Christiaen, L., Nguyen, Q., … Palpant, N. J. (2020). Conserved Epigenetic Regulatory Logic Infers Genes Governing Cell Identity. Cell Systems, 11(6), 625-639.e13. https://doi.org/10.1016/j.cels.2020.11.001

The conserved histone chaperone LIN‐53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans

Aging Cell / Aug 09, 2019

Müthel, S., Uyar, B., He, M., Krause, A., Vitrinel, B., Bulut, S., Vasiljevic, D., Marchal, I., Kempa, S., Akalin, A., & Tursun, B. (2019). The conserved histone chaperone LIN‐53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Aging Cell, 18(6). Portico. https://doi.org/10.1111/acel.13012

See Full Profile

Example cell biology projects

How can companies collaborate more effectively with researchers, experts, and thought leaders to make progress on cell biology?

Drug Discovery and Development

A pharmaceutical company can collaborate with a Cell Biology expert to identify and validate potential drug targets, screen and optimize drug candidates, and evaluate their efficacy and safety. This collaboration can accelerate the drug discovery and development process, leading to the creation of new and effective treatments for various diseases.

Biotechnology and Genetic Engineering

Companies in the biotechnology industry can collaborate with Cell Biology researchers to develop genetically modified organisms (GMOs) with improved traits, such as higher crop yields, disease resistance, and enhanced nutritional value. This collaboration can also involve the production of recombinant proteins and enzymes for various applications, including pharmaceutical production and industrial processes.

Cancer Research and Treatment

Cell Biology experts can contribute to cancer research and treatment by studying the molecular mechanisms of cancer development, identifying biomarkers for early detection, and developing targeted therapies. Collaborating with these experts can lead to the development of personalized medicine approaches and more effective treatment strategies for different types of cancer.

Stem Cell Research and Regenerative Medicine

Companies interested in stem cell research and regenerative medicine can collaborate with Cell Biology experts to explore the potential of stem cells for tissue engineering, organ transplantation, and disease modeling. This collaboration can help in developing innovative therapies for conditions such as heart disease, neurodegenerative disorders, and diabetes.

Environmental Monitoring and Remediation

Cell Biology researchers can contribute to environmental monitoring and remediation efforts by studying the impact of pollutants on living organisms, developing bioindicators for pollution assessment, and designing bioremediation strategies. Companies can collaborate with these experts to ensure compliance with environmental regulations and develop sustainable solutions for pollution control and remediation.