Work with academic experts in drug discovery

A scholar or researcher with expertise in drug discovery can help business and industrial clients solve their drug discovery problems and conduct drug discovery research to get ahead on R&D. Experts on NotedSource with backgrounds in drug discovery include Aimee Eggler, Giuliana Noratto, Daniel Greenfield, Katelyn Katelyn Masiuk, John Joe, and Anna Koster.

Aimee Eggler

Professor of Chemistry and Biochemistry at Villanova University
Villanova, Pennsylvania, United States of America
Most Relevant Research Interests
Drug Discovery
Other Research Interests (26)
Biochemistry
Biochemistry education
Cell culture
Oxidative stress
Natural products
And 21 more
About
Most Relevant Publications (3+)

25 total publications

Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding

Bioorganic & Medicinal Chemistry Letters / Nov 01, 2013

Turlington, M., Chun, A., Tomar, S., Eggler, A., Grum-Tokars, V., Jacobs, J., Daniels, J. S., Dawson, E., Saldanha, A., Chase, P., Baez-Santos, Y. M., Lindsley, C. W., Hodder, P., Mesecar, A. D., & Stauffer, S. R. (2013). Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding. Bioorganic & Medicinal Chemistry Letters, 23(22), 6172–6177. https://doi.org/10.1016/j.bmcl.2013.08.112

Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease

Journal of Medicinal Chemistry / Jan 03, 2013

Jacobs, J., Grum-Tokars, V., Zhou, Y., Turlington, M., Saldanha, S. A., Chase, P., Eggler, A., Dawson, E. S., Baez-Santos, Y. M., Tomar, S., Mielech, A. M., Baker, S. C., Lindsley, C. W., Hodder, P., Mesecar, A., & Stauffer, S. R. (2013). Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease. Journal of Medicinal Chemistry, 56(2), 534–546. https://doi.org/10.1021/jm301580n

Insecticidal Activity of Cyanohydrin and Monoterpenoid Compounds

Molecules / Apr 03, 2000

Peterson, C., Tsao, R., Eggler, A., & Coats, J. (2000). Insecticidal Activity of Cyanohydrin and Monoterpenoid Compounds. Molecules, 5(12), 648–654. https://doi.org/10.3390/50400648

Giuliana Noratto

Food Scientist PhD and Registered Dietician - Texas A&M University
Most Relevant Research Interests
Drug Discovery
Other Research Interests (49)
Food Science
human nutrition
disease prevention and treatment
Nutrition
Human Health
And 44 more
About
Most Relevant Publications (3+)

91 total publications

Dark Sweet Cherry (Prunus avium) Anthocyanins Suppressed ERK1/2-Akt/mTOR Cell Signaling and Oxidative Stress: Implications for TNBC Growth and Invasion

Molecules / Oct 25, 2022

Silveira Rabelo, A. C., Mertens-Talcott, S. U., Chew, B. P., & Noratto, G. (2022). Dark Sweet Cherry (Prunus avium) Anthocyanins Suppressed ERK1/2-Akt/mTOR Cell Signaling and Oxidative Stress: Implications for TNBC Growth and Invasion. Molecules, 27(21), 7245. https://doi.org/10.3390/molecules27217245

Phytocomplexes from liquorice (Glycyrrhiza glabra L.) leaves — Chemical characterization and evaluation of their antioxidant, anti-genotoxic and anti-inflammatory activity

Fitoterapia / Jun 01, 2011

Siracusa, L., Saija, A., Cristani, M., Cimino, F., D’Arrigo, M., Trombetta, D., Rao, F., & Ruberto, G. (2011). Phytocomplexes from liquorice (Glycyrrhiza glabra L.) leaves — Chemical characterization and evaluation of their antioxidant, anti-genotoxic and anti-inflammatory activity. Fitoterapia, 82(4), 546–556. https://doi.org/10.1016/j.fitote.2011.01.009

Flavonol-rich fractions of yaupon holly leaves (Ilex vomitoria, Aquifoliaceae) induce microRNA-146a and have anti-inflammatory and chemopreventive effects in intestinal myofribroblast CCD-18Co cells

Fitoterapia / Jun 01, 2011

Noratto, G. D., Kim, Y., Talcott, S. T., & Mertens-Talcott, S. U. (2011). Flavonol-rich fractions of yaupon holly leaves (Ilex vomitoria, Aquifoliaceae) induce microRNA-146a and have anti-inflammatory and chemopreventive effects in intestinal myofribroblast CCD-18Co cells. Fitoterapia, 82(4), 557–569. https://doi.org/10.1016/j.fitote.2011.01.013

Daniel Greenfield

Ph.D. candidate (anticipated Mar 2023) in Biophysics with a focus on quantitative techniques in biomedicine
Most Relevant Research Interests
Drug Discovery
Other Research Interests (13)
Machine Learning
Medical Devices
Edge Computing
Biomedical Optics
Organic Chemistry
And 8 more
Most Relevant Publications (1+)

10 total publications

Virtual Screening for Ligand Discovery at the σ1 Receptor

ACS Medicinal Chemistry Letters / Jul 27, 2020

Greenfield, D. A., Schmidt, H. R., Skiba, M. A., Mandler, M. D., Anderson, J. R., Sliz, P., & Kruse, A. C. (2020). Virtual Screening for Ligand Discovery at the σ1 Receptor. ACS Medicinal Chemistry Letters, 11(8), 1555–1561. https://doi.org/10.1021/acsmedchemlett.9b00314

Katelyn Katelyn Masiuk

Co-Founder and CSO at Immunovec
Most Relevant Research Interests
Drug Discovery
Drug Discovery
Other Research Interests (25)
Cell Biology
Genetics
Molecular Medicine
Genetics
Molecular Biology
And 20 more
About
Most Relevant Publications (2+)

13 total publications

Editing the Sickle Cell Disease Mutation in Human Hematopoietic Stem Cells: Comparison of Endonucleases and Homologous Donor Templates

Molecular Therapy / Aug 01, 2019

Romero, Z., Lomova, A., Said, S., Miggelbrink, A., Kuo, C. Y., Campo-Fernandez, B., Hoban, M. D., Masiuk, K. E., Clark, D. N., Long, J., Sanchez, J. M., Velez, M., Miyahira, E., Zhang, R., Brown, D., Wang, X., Kurmangaliyev, Y. Z., Hollis, R. P., & Kohn, D. B. (2019). Editing the Sickle Cell Disease Mutation in Human Hematopoietic Stem Cells: Comparison of Endonucleases and Homologous Donor Templates. Molecular Therapy, 27(8), 1389–1406. https://doi.org/10.1016/j.ymthe.2019.05.014

Improving Gene Therapy Efficiency through the Enrichment of Human Hematopoietic Stem Cells

Molecular Therapy / Sep 01, 2017

Masiuk, K. E., Brown, D., Laborada, J., Hollis, R. P., Urbinati, F., & Kohn, D. B. (2017). Improving Gene Therapy Efficiency through the Enrichment of Human Hematopoietic Stem Cells. Molecular Therapy, 25(9), 2163–2175. https://doi.org/10.1016/j.ymthe.2017.05.023

John Joe

Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
Most Relevant Research Interests
Drug Discovery
Other Research Interests (73)
microbiology
systems biology
genetics
quantum biology
Genetics
And 68 more
Most Relevant Publications (2+)

95 total publications

13C-Flux Spectral Analysis of Host-Pathogen Metabolism Reveals a Mixed Diet for Intracellular Mycobacterium tuberculosis

Chemistry & Biology / Aug 01, 2013

Beste, D. J. V., Nöh, K., Niedenführ, S., Mendum, T. A., Hawkins, N. D., Ward, J. L., Beale, M. H., Wiechert, W., & McFadden, J. (2013). 13C-Flux Spectral Analysis of Host-Pathogen Metabolism Reveals a Mixed Diet for Intracellular Mycobacterium tuberculosis. Chemistry & Biology, 20(8), 1012–1021. https://doi.org/10.1016/j.chembiol.2013.06.012

MUFINS: multi-formalism interaction network simulator

npj Systems Biology and Applications / Nov 17, 2016

Wu, H., von Kamp, A., Leoncikas, V., Mori, W., Sahin, N., Gevorgyan, A., Linley, C., Grabowski, M., Mannan, A. A., Stoy, N., Stewart, G. R., Ward, L. T., Lewis, D. J. M., Sroka, J., Matsuno, H., Klamt, S., Westerhoff, H. V., McFadden, J., Plant, N. J., & Kierzek, A. M. (2016). MUFINS: multi-formalism interaction network simulator. Npj Systems Biology and Applications, 2(1). https://doi.org/10.1038/npjsba.2016.32

Anna Koster

Most Relevant Research Interests
Drug Discovery
Other Research Interests (11)
Multidisciplinary
Computational Theory and Mathematics
Multidisciplinary
Cellular and Molecular Neuroscience
Genetics
And 6 more
Most Relevant Publications (1+)

4 total publications

Trapping the elusive aza-oxyallylic cation: new opportunities in heterocycloaddition chemistry

Tetrahedron Letters / Aug 01, 2014

Barnes, K. L., Koster, A. K., & Jeffrey, C. S. (2014). Trapping the elusive aza-oxyallylic cation: new opportunities in heterocycloaddition chemistry. Tetrahedron Letters, 55(34), 4690–4696. https://doi.org/10.1016/j.tetlet.2014.06.050