Anna Koster

Research Interests

Computational Theory and Mathematics
Cellular and Molecular Neuroscience
Genetics
Molecular Biology
Ecology
Modeling and Simulation
Ecology, Evolution, Behavior and Systematics
Organic Chemistry
Drug Discovery
Biochemistry

Publications

Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel

Proceedings of the National Academy of Sciences / Dec 04, 2020

Koster, A. K., Reese, A. L., Kuryshev, Y., Wen, X., McKiernan, K. A., Gray, E. E., Wu, C., Huguenard, J. R., Maduke, M., & Du Bois, J. (2020). Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel. Proceedings of the National Academy of Sciences, 117(51), 32711–32721. https://doi.org/10.1073/pnas.2009977117

Dynamical model of the CLC-2 ion channel reveals conformational changes associated with selectivity-filter gating

PLOS Computational Biology / Mar 30, 2020

McKiernan, K. A., Koster, A. K., Maduke, M., & Pande, V. S. (2020). Dynamical model of the CLC-2 ion channel reveals conformational changes associated with selectivity-filter gating. PLOS Computational Biology, 16(3), e1007530. https://doi.org/10.1371/journal.pcbi.1007530

A selective class of inhibitors for the CLC-Ka chloride ion channel

Proceedings of the National Academy of Sciences / Apr 18, 2018

Koster, A. K., Wood, C. A. P., Thomas-Tran, R., Chavan, T. S., Almqvist, J., Choi, K.-H., Du Bois, J., & Maduke, M. (2018). A selective class of inhibitors for the CLC-Ka chloride ion channel. Proceedings of the National Academy of Sciences, 115(21). https://doi.org/10.1073/pnas.1720584115

Trapping the elusive aza-oxyallylic cation: new opportunities in heterocycloaddition chemistry

Tetrahedron Letters / Aug 01, 2014

Barnes, K. L., Koster, A. K., & Jeffrey, C. S. (2014). Trapping the elusive aza-oxyallylic cation: new opportunities in heterocycloaddition chemistry. Tetrahedron Letters, 55(34), 4690–4696. https://doi.org/10.1016/j.tetlet.2014.06.050

Experience

Scripps Research Institute

Postdoctoral Researcher / September, 2019Present

Stanford University

Graduate Student / September, 2013September, 2019

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