Katelyn Katelyn Masiuk
Co-Founder and CSO at Immunovec
About
Education
University of California Los Angeles
MD (MSTP program), Medicine
University of California Los Angeles
PhD, Molecular Biology
The Pennsylvania State University
B.S, Biochemistry and Molecular Biology
Experience
ImmunoVec
Co-Founder and Chief Scientific Officer / August, 2020 — Present
UCLA Graduate Medical Education
Medical Student (MSTP) / 2012 — 2021
University of California Los Angeles
Graduate Student Researcher / 2014 — 2019
The Pennsylvania State University
Undergraduate Researcher / 2008 — 2011
Publications
Editing the Sickle Cell Disease Mutation in Human Hematopoietic Stem Cells: Comparison of Endonucleases and Homologous Donor Templates
Molecular Therapy / Aug 01, 2019
Romero, Z., Lomova, A., Said, S., Miggelbrink, A., Kuo, C. Y., Campo-Fernandez, B., Hoban, M. D., Masiuk, K. E., Clark, D. N., Long, J., Sanchez, J. M., Velez, M., Miyahira, E., Zhang, R., Brown, D., Wang, X., Kurmangaliyev, Y. Z., Hollis, R. P., & Kohn, D. B. (2019). Editing the Sickle Cell Disease Mutation in Human Hematopoietic Stem Cells: Comparison of Endonucleases and Homologous Donor Templates. Molecular Therapy, 27(8), 1389–1406. https://doi.org/10.1016/j.ymthe.2019.05.014
Lentiviral Gene Therapy in HSCs Restores Lineage-Specific Foxp3 Expression and Suppresses Autoimmunity in a Mouse Model of IPEX Syndrome
Cell Stem Cell / Feb 01, 2019
Masiuk, K. E., Laborada, J., Roncarolo, M. G., Hollis, R. P., & Kohn, D. B. (2019). Lentiviral Gene Therapy in HSCs Restores Lineage-Specific Foxp3 Expression and Suppresses Autoimmunity in a Mouse Model of IPEX Syndrome. Cell Stem Cell, 24(2), 309-317.e7. https://doi.org/10.1016/j.stem.2018.12.003
PGE2 and Poloxamer Synperonic F108 Enhance Transduction of Human HSPCs with a β-Globin Lentiviral Vector
Molecular Therapy - Methods & Clinical Development / Jun 01, 2019
Masiuk, K. E., Zhang, R., Osborne, K., Hollis, R. P., Campo-Fernandez, B., & Kohn, D. B. (2019). PGE2 and Poloxamer Synperonic F108 Enhance Transduction of Human HSPCs with a β-Globin Lentiviral Vector. Molecular Therapy - Methods & Clinical Development, 13, 390–398. https://doi.org/10.1016/j.omtm.2019.03.005
Improving Gene Therapy Efficiency through the Enrichment of Human Hematopoietic Stem Cells
Molecular Therapy / Sep 01, 2017
Masiuk, K. E., Brown, D., Laborada, J., Hollis, R. P., Urbinati, F., & Kohn, D. B. (2017). Improving Gene Therapy Efficiency through the Enrichment of Human Hematopoietic Stem Cells. Molecular Therapy, 25(9), 2163–2175. https://doi.org/10.1016/j.ymthe.2017.05.023
Enrichment of Human Hematopoietic Stem/Progenitor Cells Facilitates Transduction for Stem Cell Gene Therapy
Stem Cells / Apr 23, 2015
Baldwin, K., Urbinati, F., Romero, Z., Campo-Fernandez, B., Kaufman, M. L., Cooper, A. R., Masiuk, K., Hollis, R. P., & Kohn, D. B. (2015). Enrichment of Human Hematopoietic Stem/Progenitor Cells Facilitates Transduction for Stem Cell Gene Therapy. Stem Cells, 33(5), 1532–1542. https://doi.org/10.1002/stem.1957
Detection of differential fetal and adult expression of chloride intracellular channel 4 (CLIC4) protein by analysis of a green fluorescent protein knock-in mouse line
BMC Developmental Biology / May 28, 2014
Padmakumar, V., Masiuk, K. E., Luger, D., Lee, C., Coppola, V., Tessarollo, L., Hoover, S. B., Karavanova, I., Buonanno, A., Simpson, R. M., & Yuspa, S. H. (2014). Detection of differential fetal and adult expression of chloride intracellular channel 4 (CLIC4) protein by analysis of a green fluorescent protein knock-in mouse line. BMC Developmental Biology, 14(1). https://doi.org/10.1186/1471-213x-14-24
Pharmacologic Inhibition of ALK5 Causes Selective Induction of Terminal Differentiation in Mouse Keratinocytes Expressing Oncogenic HRAS
Molecular Cancer Research / Jun 01, 2011
Markell, L. M., Masiuk, K. E., Blazanin, N., & Glick, A. B. (2011). Pharmacologic Inhibition of ALK5 Causes Selective Induction of Terminal Differentiation in Mouse Keratinocytes Expressing Oncogenic HRAS. Molecular Cancer Research, 9(6), 746–756. https://doi.org/10.1158/1541-7786.mcr-11-0112
Lentiviral gene therapy for X-linked chronic granulomatous disease recapitulates endogenousCYBBregulation and expression
Blood / Mar 02, 2023
Wong, R. L., Sackey, S., Brown, D., Senadheera, S., Masiuk, K., Quintos, J. P., Colindres, N., Riggan, L., Morgan, R. A., Malech, H. L., Hollis, R. P., & Kohn, D. B. (2023). Lentiviral gene therapy for X-linked chronic granulomatous disease recapitulates endogenousCYBBregulation and expression. Blood, 141(9), 1007–1022. https://doi.org/10.1182/blood.2022016074
University of California, Los Angeles
Encyclopedia of Stem Cell Research / Jan 01, 2008
University of California, Los Angeles. (2008). Encyclopedia of Stem Cell Research. https://doi.org/10.4135/9781412963954.n281
Enrichment of Hematopoietic Stem Cells Using Immunomagnetic Beads to Facilitate Gene Therapy
Blood / Dec 02, 2016
Masiuk, K. E., Brown, D., Urbinati, F., Hollis, R. P., & Kohn, D. B. (2016). Enrichment of Hematopoietic Stem Cells Using Immunomagnetic Beads to Facilitate Gene Therapy. Blood, 128(22), 2313–2313. https://doi.org/10.1182/blood.v128.22.2313.2313
Gene Therapy for Sickle Cell Disease:A Lentiviral Vector Comparison Study
Human Gene Therapy / Oct 01, 2018
Urbinati, F., Campo Fernandez, B., Masiuk, K. E., Poletti, V., Hollis, R. P., Koziol, C., Kaufman, M. L., Brown, D., Mavilio, F., & Kohn, D. B. (2018). Gene Therapy for Sickle Cell Disease:A Lentiviral Vector Comparison Study. Human Gene Therapy, 29(10), 1153–1166. https://doi.org/10.1089/hum.2018.061
Spontaneous Skin Erosions and Reduced Skin and Corneal Wound Healing Characterize CLIC4NULL Mice
The American Journal of Pathology / Jul 01, 2012
Padmakumar, V. C., Speer, K., Pal-Ghosh, S., Masiuk, K. E., Ryscavage, A., Dengler, S. L., Hwang, S., Edwards, J. C., Coppola, V., Tessarollo, L., Stepp, M. A., & Yuspa, S. H. (2012). Spontaneous Skin Erosions and Reduced Skin and Corneal Wound Healing Characterize CLIC4NULL Mice. The American Journal of Pathology, 181(1), 74–84. https://doi.org/10.1016/j.ajpath.2012.03.025
Use of a TGFβ type I receptor inhibitor in mouse skin carcinogenesis reveals a dual role for TGFβ signaling in tumor promotion and progression
Carcinogenesis / Sep 17, 2010
Mordasky Markell, L., Pérez-Lorenzo, R., Masiuk, K. E., Kennett, M. J., & Glick, A. B. (2010). Use of a TGFβ type I receptor inhibitor in mouse skin carcinogenesis reveals a dual role for TGFβ signaling in tumor promotion and progression. Carcinogenesis, 31(12), 2127–2135. https://doi.org/10.1093/carcin/bgq191
Research Interests
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