Aimee Eggler

Professor of Chemistry and Biochemistry at Villanova University

Villanova, Pennsylvania, United States of America

About

Dr. Eggler has 20 years of experience in the field of redox biology, with a focus on the Nrf2 transcription factor, a master regulator of antioxidant, detoxification and anti-inflammatory genes. She is also an award-winning educator and the recipient of the Villanova University Junior Faculty Excellence in Teaching award. Her interests in education include innovation in teaching metabolism from a logic-based perspective.

Education

University of California, Santa Cruz

BS, Chemistry / May, 1996

Santa Cruz, California, United States of America

University of Wisconsin–Madison

Ph.D., Biochemistry / May, 2002

Madison, Wisconsin, United States of America

Experience

Villanova University

Associate Professor of Chemistry / 2019Present

Villanova University

Assistant Professor / 20122019

Purdue University

Research Assistant Professor / 20102012

University of Illinois at Chicago

Research Assistant Professor / 20062010

Publications

Kinetic assessment of Michael addition reactions of alpha, beta-unsaturated carbonyl compounds to amino acid and protein thiols

Free Radical Biology and Medicine / Jun 01, 2021

Sauerland, M., Mertes, R., Morozzi, C., Eggler, A. L., Gamon, L. F., & Davies, M. J. (2021). Kinetic assessment of Michael addition reactions of alpha, beta-unsaturated carbonyl compounds to amino acid and protein thiols. Free Radical Biology and Medicine, 169, 1–11. https://doi.org/10.1016/j.freeradbiomed.2021.03.040

Dr. Jekyll and Mr. Hyde: Oxidizable phenol-generated reactive oxygen species enhance sulforaphane's antioxidant response element activation, even as they suppress Nrf2 protein accumulation

Free Radical Biology and Medicine / Aug 01, 2018

Bauman, B. M., Jeong, C., Savage, M., Briker, A. L., Janigian, N. G., Nguyen, L. L., Kemmerer, Z. A., & Eggler, A. L. (2018). Dr. Jekyll and Mr. Hyde: Oxidizable phenol-generated reactive oxygen species enhance sulforaphane’s antioxidant response element activation, even as they suppress Nrf2 protein accumulation. Free Radical Biology and Medicine, 124, 532–540. https://doi.org/10.1016/j.freeradbiomed.2018.06.039

Comparison of human Nrf2 antibodies: A tale of two proteins

Toxicology Letters / Oct 01, 2015

Kemmerer, Z. A., Ader, N. R., Mulroy, S. S., & Eggler, A. L. (2015). Comparison of human Nrf2 antibodies: A tale of two proteins. Toxicology Letters, 238(2), 83–89. https://doi.org/10.1016/j.toxlet.2015.07.004

Chemical and Biological Mechanisms of Phytochemical Activation of NRF2 and Importance in Disease Prevention

50 Years of Phytochemistry Research / Jan 01, 2013

Eggler, A. L., & Savinov, S. N. (2013). Chemical and Biological Mechanisms of Phytochemical Activation of NRF2 and Importance in Disease Prevention. 50 Years of Phytochemistry Research, 121–155. https://doi.org/10.1007/978-3-319-00581-2_7

Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding

Bioorganic & Medicinal Chemistry Letters / Nov 01, 2013

Turlington, M., Chun, A., Tomar, S., Eggler, A., Grum-Tokars, V., Jacobs, J., Daniels, J. S., Dawson, E., Saldanha, A., Chase, P., Baez-Santos, Y. M., Lindsley, C. W., Hodder, P., Mesecar, A. D., & Stauffer, S. R. (2013). Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding. Bioorganic & Medicinal Chemistry Letters, 23(22), 6172–6177. https://doi.org/10.1016/j.bmcl.2013.08.112

Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease

Journal of Medicinal Chemistry / Jan 03, 2013

Jacobs, J., Grum-Tokars, V., Zhou, Y., Turlington, M., Saldanha, S. A., Chase, P., Eggler, A., Dawson, E. S., Baez-Santos, Y. M., Tomar, S., Mielech, A. M., Baker, S. C., Lindsley, C. W., Hodder, P., Mesecar, A., & Stauffer, S. R. (2013). Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease. Journal of Medicinal Chemistry, 56(2), 534–546. https://doi.org/10.1021/jm301580n

Screening for natural chemoprevention agents that modify human Keap1

Analytical Biochemistry / Feb 01, 2012

Hu, C., Nikolic, D., Eggler, A. L., Mesecar, A. D., & van Breemen, R. B. (2012). Screening for natural chemoprevention agents that modify human Keap1. Analytical Biochemistry, 421(1), 108–114. https://doi.org/10.1016/j.ab.2011.10.028

Modification of Keap1 Cysteine Residues by Sulforaphane

Chemical Research in Toxicology / Mar 10, 2011

Hu, C., Eggler, A. L., Mesecar, A. D., & van Breemen, R. B. (2011). Modification of Keap1 Cysteine Residues by Sulforaphane. Chemical Research in Toxicology, 24(4), 515–521. https://doi.org/10.1021/tx100389r

Development of an efficient E. coli expression and purification system for a catalytically active, human Cullin3–RINGBox1 protein complex and elucidation of its quaternary structure with Keap1

Biochemical and Biophysical Research Communications / Oct 01, 2010

Small, E., Eggler, A., & Mesecar, A. D. (2010). Development of an efficient E. coli expression and purification system for a catalytically active, human Cullin3–RINGBox1 protein complex and elucidation of its quaternary structure with Keap1. Biochemical and Biophysical Research Communications, 400(4), 471–475. https://doi.org/10.1016/j.bbrc.2010.08.062

Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1

Biochemical Journal / Jul 29, 2009

Eggler, A. L., Small, E., Hannink, M., & Mesecar, A. D. (2009). Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1. Biochemical Journal, 422(1), 171–180. https://doi.org/10.1042/bj20090471

The structures of T87I phosphono-CheY and T87I/Y106W phosphono-CheY help to explain their binding affinities to the FliM and CheZ peptides

Archives of Biochemistry and Biophysics / Nov 01, 2008

McAdams, K., Casper, E. S., Matthew Haas, R., Santarsiero, B. D., Eggler, A. L., Mesecar, A., & Halkides, C. J. (2008). The structures of T87I phosphono-CheY and T87I/Y106W phosphono-CheY help to explain their binding affinities to the FliM and CheZ peptides. Archives of Biochemistry and Biophysics, 479(2), 105–113. https://doi.org/10.1016/j.abb.2008.08.019

Prospective Type 1 and Type 2 Disulfides of Keap1 Protein

Chemical Research in Toxicology / Aug 26, 2008

Holland, R., Hawkins, A. E., Eggler, A. L., Mesecar, A. D., Fabris, D., & Fishbein, J. C. (2008). Prospective Type 1 and Type 2 Disulfides of Keap1 Protein. Chemical Research in Toxicology, 21(10), 2051–2060. https://doi.org/10.1021/tx800226m

Molecular mechanisms of natural products in chemoprevention: Induction of cytoprotective enzymes by Nrf2

Molecular Nutrition & Food Research / Apr 24, 2008

Eggler, A. L., Gay, K. A., & Mesecar, A. D. (2008). Molecular mechanisms of natural products in chemoprevention: Induction of cytoprotective enzymes by Nrf2. Molecular Nutrition & Food Research. https://doi.org/10.1002/mnfr.200700249

Identification of the Highly Reactive Cysteine 151 in the Chemopreventive Agent-Sensor Keap1 Protein is Method-Dependent

Chemical Research in Toxicology / Feb 01, 2008

Eggler, A. L., Luo, Y., van Breemen, R. B., & Mesecar, A. D. (2008). Identification of the Highly Reactive Cysteine 151 in the Chemopreventive Agent-Sensor Keap1 Protein is Method-Dependent. Chemical Research in Toxicology, 21(2), 556–556. https://doi.org/10.1021/tx800015c

Identification of the Highly Reactive Cysteine 151 in the Chemopreventive Agent-Sensor Keap1 Protein is Method-Dependent

Chemical Research in Toxicology / Oct 13, 2007

Eggler, A. L., Luo, Y., van Breemen, R. B., & Mesecar, A. D. (2007). Identification of the Highly Reactive Cysteine 151 in the Chemopreventive Agent-Sensor Keap1 Protein is Method-Dependent. Chemical Research in Toxicology, 20(12), 1878–1884. https://doi.org/10.1021/tx700217c

Sites of alkylation of human Keap1 by natural chemoprevention agents

Journal of the American Society for Mass Spectrometry / Dec 01, 2007

Luo, Y., Eggler, A. L., Liu, D., Liu, G., Mesecar, A. D., & van Breemen, R. B. (2007). Sites of alkylation of human Keap1 by natural chemoprevention agents. Journal of the American Society for Mass Spectrometry, 18(12), 2226–2232. https://doi.org/10.1016/j.jasms.2007.09.015

Screening Method for the Discovery of Potential Cancer Chemoprevention Agents Based on Mass Spectrometric Detection of Alkylated Keap1

Analytical Chemistry / Sep 03, 2005

Liu, G., Eggler, A. L., Dietz, B. M., Mesecar, A. D., Bolton, J. L., Pezzuto, J. M., & van Breemen, R. B. (2005). Screening Method for the Discovery of Potential Cancer Chemoprevention Agents Based on Mass Spectrometric Detection of Alkylated Keap1. Analytical Chemistry, 77(19), 6407–6414. https://doi.org/10.1021/ac050892r

Xanthohumol Isolated from Humulus lupulus Inhibits Menadione-Induced DNA Damage through Induction of Quinone Reductase

Chemical Research in Toxicology / Jul 12, 2005

Dietz, B. M., Kang, Y.-H., Liu, G., Eggler, A. L., Yao, P., Chadwick, L. R., Pauli, G. F., Farnsworth, N. R., Mesecar, A. D., van Breemen, R. B., & Bolton, J. L. (2005). Xanthohumol Isolated from Humulus lupulus Inhibits Menadione-Induced DNA Damage through Induction of Quinone Reductase. Chemical Research in Toxicology, 18(8), 1296–1305. https://doi.org/10.1021/tx050058x

Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

Proceedings of the National Academy of Sciences / Jul 08, 2005

Eggler, A. L., Liu, G., Pezzuto, J. M., van Breemen, R. B., & Mesecar, A. D. (2005). Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. Proceedings of the National Academy of Sciences, 102(29), 10070–10075. https://doi.org/10.1073/pnas.0502402102

The C Terminus of the Escherichia coli RecA Protein Modulates the DNA Binding Competition with Single-stranded DNA-binding Protein

Journal of Biological Chemistry / May 01, 2003

Eggler, A. L., Lusetti, S. L., & Cox, M. M. (2003). The C Terminus of the Escherichia coli RecA Protein Modulates the DNA Binding Competition with Single-stranded DNA-binding Protein. Journal of Biological Chemistry, 278(18), 16389–16396. https://doi.org/10.1074/jbc.m212920200

The Rad51-dependent Pairing of Long DNA Substrates Is Stabilized by Replication Protein A

Journal of Biological Chemistry / Oct 01, 2002

Eggler, A. L., Inman, R. B., & Cox, M. M. (2002). The Rad51-dependent Pairing of Long DNA Substrates Is Stabilized by Replication Protein A. Journal of Biological Chemistry, 277(42), 39280–39288. https://doi.org/10.1074/jbc.m204328200

DNA Pairing and Strand Exchange by the Escherichia coli RecA and Yeast Rad51 Proteins without ATP Hydrolysis

Journal of Biological Chemistry / Oct 01, 2001

Rice, K. P., Eggler, A. L., Sung, P., & Cox, M. M. (2001). DNA Pairing and Strand Exchange by the Escherichia coli RecA and Yeast Rad51 Proteins without ATP Hydrolysis. Journal of Biological Chemistry, 276(42), 38570–38581. https://doi.org/10.1074/jbc.m105678200

Single-Stranded DNA-Binding Proteins (SSBs)

Encyclopedia of Genetics / Jan 01, 2001

Eggler, A. L. (2001). Single-Stranded DNA-Binding Proteins (SSBs). Encyclopedia of Genetics, 1839–1842. https://doi.org/10.1006/rwgn.2001.1233

Insecticidal Activity of Cyanohydrin and Monoterpenoid Compounds

Molecules / Apr 03, 2000

Peterson, C., Tsao, R., Eggler, A., & Coats, J. (2000). Insecticidal Activity of Cyanohydrin and Monoterpenoid Compounds. Molecules, 5(12), 648–654. https://doi.org/10.3390/50400648

Solving the Problem of Assessing Synergy and Antagonism for Non-Traditional Dosing Curve Compounds Using the DE/ZI Method: Application to Nrf2 Activators

Frontiers in Pharmacology / Jun 07, 2021

Repash, E. M., Pensabene, K. M., Palenchar, P. M., & Eggler, A. L. (2021). Solving the Problem of Assessing Synergy and Antagonism for Non-Traditional Dosing Curve Compounds Using the DE/ZI Method: Application to Nrf2 Activators. Frontiers in Pharmacology, 12. https://doi.org/10.3389/fphar.2021.686201

Links & Social Media

Research Interests

Biochemistry
Physiology (medical)
Toxicology
General Medicine
Organic Chemistry
Clinical Biochemistry
Drug Discovery
Pharmaceutical Science
Molecular Biology
Molecular Medicine
Cell Biology
Biophysics
Food Science
Biotechnology
Spectroscopy
Structural Biology
Analytical Chemistry
Multidisciplinary
Chemistry (miscellaneous)
Physical and Theoretical Chemistry
Pharmacology (medical)
Pharmacology
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