William Federspiel

Very knowledgeable in the area of biomedical transport phenomena in fluid mechanics, especially as applied to medical devices.


Design and development of novel artificial lung devices, including respiratory support catheters and paracorporeal assist lungs, for near term clinical use in the treatment of respiratory failure in patients with acute or acute on chronic lung insufficiencies, Design and development of membrane and particle based blood purification devices for the selective or semi-selective and patterned removal of pathogenic antibodies, inflammatory mediators, and other blood borne solutes for near term clinical use in critical care settings, Advancing the development of novel artificial lung platforms for future applications by combining microfabrication and fiber technology with cellular and biomolecular components to create biohybrid artificial alveolar capillary units and bioactive hollow fibers with improved gas exchange efficiency and capacity, Developing improved transport models and understanding of polymer degradation and drug delivery from nanoparticles and microparticles, Advanced application of fluid mechanics and mass transport principles to model and optimize artificial lungs and other membrane-based medical devices where functional performance depends on underlying transport or separation principles that dictate the device characteristics, Development of mathematical and computer simulation models related to respiratory and cardiovascular fluid mechanics and mass transport, Development of oxygen depletion devices for blood storage systems that will extend the shelf life of red cell units and deliver red cells of higher efficacy and lower toxicity for transfusion therapy


University of Rochester

Research Interests

biomedical engineering
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