Experts and Thought Leaders in Biomedicine

Ping Luo

Toronto, Ontario, Canada
Bioinformatics Specialist at Princess Margaret Cancer Centre with experience in deep learning
Most Relevant Research Interests
Biochemistry
Structural Biology
Other Research Interests (20)
single-cell genomics
deep learning
complex network analysis
Genetics (clinical)
Genetics
And 15 more
About
8 years of science and engineering experience integrating multi-omics data to identify biomarkers for cancer studies. Seeking to apply data analytics expertise to develop new diagnosis and treatment strategies.
Most Relevant Publications (6+)

23 total publications

Enhancing the prediction of disease–gene associations with multimodal deep learning

Bioinformatics / Mar 02, 2019

Luo, P., Li, Y., Tian, L.-P., & Wu, F.-X. (2019). Enhancing the prediction of disease–gene associations with multimodal deep learning. Bioinformatics, 35(19), 3735–3742. https://doi.org/10.1093/bioinformatics/btz155

Identifying cell types from single-cell data based on similarities and dissimilarities between cells

BMC Bioinformatics / May 01, 2021

Li, Y., Luo, P., Lu, Y., & Wu, F.-X. (2021). Identifying cell types from single-cell data based on similarities and dissimilarities between cells. BMC Bioinformatics, 22(S3). https://doi.org/10.1186/s12859-020-03873-z

Ensemble disease gene prediction by clinical sample-based networks

BMC Bioinformatics / Mar 01, 2020

Luo, P., Tian, L.-P., Chen, B., Xiao, Q., & Wu, F.-X. (2020). Ensemble disease gene prediction by clinical sample-based networks. BMC Bioinformatics, 21(S2). https://doi.org/10.1186/s12859-020-3346-8

A Novel Core-Attachment-Based Method to Identify Dynamic Protein Complexes Based on Gene Expression Profiles and PPI Networks

PROTEOMICS / Feb 20, 2019

Xiao, Q., Luo, P., Li, M., Wang, J., & Wu, F.-X. (2019). A Novel Core-Attachment-Based Method to Identify Dynamic Protein Complexes Based on Gene Expression Profiles and PPI Networks. PROTEOMICS, 19(5), 1800129. Portico. https://doi.org/10.1002/pmic.201800129

Normalization of the Immune Microenvironment during Lenalidomide Maintenance Is Associated with Sustained MRD Negativity in Patients with Multiple Myeloma

Blood / Nov 05, 2021

Coffey, D. G., Maura, F., Gonzalez-Kozlova, E., Diaz-Mejia3, J., Luo, P., Zhang, Y., Xu, Y., Warren, E. H., Smith, E. L., Cho, H. J., Lesokhin, A., Diamond, B., Kazandjian, D., Pugh, T. J., Green, D. J., Gnjatic, S., & Landgren, O. (2021). Normalization of the Immune Microenvironment during Lenalidomide Maintenance Is Associated with Sustained MRD Negativity in Patients with Multiple Myeloma. Blood, 138(Supplement 1), 329–329. https://doi.org/10.1182/blood-2021-154506

Evaluation of single-cell RNA-seq clustering algorithms on cancer tumor datasets

Computational and Structural Biotechnology Journal / Jan 01, 2022

Mahalanabis, A., Turinsky, A. L., Husić, M., Christensen, E., Luo, P., Naidas, A., Brudno, M., Pugh, T., Ramani, A. K., & Shooshtari, P. (2022). Evaluation of single-cell RNA-seq clustering algorithms on cancer tumor datasets. Computational and Structural Biotechnology Journal, 20, 6375–6387. https://doi.org/10.1016/j.csbj.2022.10.029

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Mohammad Imran Khan

College Park, Maryland, United States of America
Postdoctoral Associate at University of Maryland College Park in the Department of Nutrition and Food Science
Most Relevant Research Interests
Biomedical Engineering
Bioengineering
Biomaterials
Histology
Structural Biology
Biochemistry
Other Research Interests (17)
Nanotechology
Wound healing
Infection and Immunity
Biotechnology
Environmental Engineering
And 12 more
About
Research work is focused on the formulation of nanoparticles encapsulated materials which could be useful for tissue engineering, stem cells, drug delivery and biomechanics to create biologically inspired tissue and organ constructs. Furthermore, 3D material may play significant role in the healing of complex tissues and organs in vitro and in vivo.
Most Relevant Publications (4+)

11 total publications

Facile bio-synthesis of gold nanoparticles by using extract of Hibiscus sabdariffa and evaluation of its cytotoxicity against U87 glioblastoma cells under hyperglycemic condition

Biochemical Engineering Journal / Jan 01, 2016

Mishra, P., Ray, S., Sinha, S., Das, B., Khan, Md. I., Behera, S. K., Yun, S.-I., Tripathy, S. K., & Mishra, A. (2016). Facile bio-synthesis of gold nanoparticles by using extract of Hibiscus sabdariffa and evaluation of its cytotoxicity against U87 glioblastoma cells under hyperglycemic condition. Biochemical Engineering Journal, 105, 264–272. https://doi.org/10.1016/j.bej.2015.09.021

Biosynthesis of magnesium oxide (MgO) nanoflakes by using leaf extract of Bauhinia purpurea and evaluation of its antibacterial property against Staphylococcus aureus

Materials Science and Engineering: C / Oct 01, 2018

Das, B., Moumita, S., Ghosh, S., Khan, M. I., Indira, D., Jayabalan, R., Tripathy, S. K., Mishra, A., & Balasubramanian, P. (2018). Biosynthesis of magnesium oxide (MgO) nanoflakes by using leaf extract of Bauhinia purpurea and evaluation of its antibacterial property against Staphylococcus aureus. Materials Science and Engineering: C, 91, 436–444. https://doi.org/10.1016/j.msec.2018.05.059

Cytotoxic Potential of Biogenic Zinc Oxide Nanoparticles Synthesized From Swertia chirayita Leaf Extract on Colorectal Cancer Cells

Frontiers in Bioengineering and Biotechnology / Dec 15, 2021

Berehu, H. M., S, A., Khan, M. I., Chakraborty, R., Lavudi, K., Penchalaneni, J., Mohapatra, B., Mishra, A., & Patnaik, S. (2021). Cytotoxic Potential of Biogenic Zinc Oxide Nanoparticles Synthesized From Swertia chirayita Leaf Extract on Colorectal Cancer Cells. Frontiers in Bioengineering and Biotechnology, 9. https://doi.org/10.3389/fbioe.2021.788527

Cytotoxic and pharmacokinetic studies of Indian seaweed polysaccharides for formulating raindrop synbiotic candy

International Journal of Biological Macromolecules / Jul 01, 2020

Praveen, M. A., Parvathy, K. R. K., Patra, S., Khan, I., Natarajan, P., & Balasubramanian, P. (2020). Cytotoxic and pharmacokinetic studies of Indian seaweed polysaccharides for formulating raindrop synbiotic candy. International Journal of Biological Macromolecules, 154, 557–566. https://doi.org/10.1016/j.ijbiomac.2020.03.086

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Luciano Dibona, Ph.D

Santiago

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Dr. Fantai Kong, Ph.D.

Dallas, Texas, United States of America
Hunt Energy
Most Relevant Research Interests
Biochemistry
Biomaterials
Other Research Interests (18)
Energy Storage
Renewable Energy, Sustainability and the Environment
Electronic, Optical and Magnetic Materials
Surfaces, Coatings and Films
Materials Chemistry
And 13 more
About
With over 10 years of research and development experience in the field of energy storage and conversion technologies, I have gained extensive expertise in diverse areas such as Li-ion batteries, Zn-ion batteries, Na-ion batteries, Li extraction, fuel cells, and topological insulators. Throughout my career, I have actively collaborated with partners from industrial, national labs, and universities to overcome technology challenges and develop innovative solutions that have resulted in a prolific publication record, including more than 30 peer-reviewed articles, and 10 awarded/pending patents.
Most Relevant Publications (2+)

31 total publications

Stable and Active Oxidation Catalysis by Cooperative Lattice Oxygen Redox on SmMn2O5 Mullite Surface

Journal of the American Chemical Society / Jun 18, 2019

Zheng, Y., Thampy, S., Ashburn, N., Dillon, S., Wang, L., Jangjou, Y., Tan, K., Kong, F., Nie, Y., Kim, M. J., Epling, W. S., Chabal, Y. J., Hsu, J. W. P., & Cho, K. (2019). Stable and Active Oxidation Catalysis by Cooperative Lattice Oxygen Redox on SmMn2O5 Mullite Surface. Journal of the American Chemical Society, 141(27), 10722–10728. https://doi.org/10.1021/jacs.9b03334

Atomic Insights into Phase Evolution in Ternary Transition‐Metal Dichalcogenides Nanostructures

Small / May 01, 2018

Zou, Y., Chen, Z., Liu, S., Aso, K., Zhang, C., Kong, F., Hong, M., Matsumura, S., Cho, K., & Zou, J. (2018). Atomic Insights into Phase Evolution in Ternary Transition‐Metal Dichalcogenides Nanostructures. Small, 14(22). Portico. https://doi.org/10.1002/smll.201800780

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Ajay Badhan

Lethbridge, Alberta, Canada
Research Biologist, Lethbridge Research Center, Canada
Most Relevant Research Interests
Bioengineering
Applied Microbiology and Biotechnology
Biochemistry
Drug Discovery
Structural Biology
Other Research Interests (22)
Animal nutrition
cell wall biosynthesis and its deconstruction
biofuels
Waste Management and Disposal
Renewable Energy, Sustainability and the Environment
And 17 more
About
I am a proficient researcher with valuable research and teaching experience acquired at distinguished institutes like Complex Carbohydrate Research Center, US, University of Alberta, Canada, and Lethbridge Research Center (AAFC), Canada. I have been working for past 15 years on multiple projects focused on the economical, environmental and social sustainability of agricultural production. Improvement in livestock performance, productivity, and health by unlocking the microbiome, development of clean technologies, improving agriculture environmental performance, and Increase agro-ecosystem resilience are prime objectives for my research.
Most Relevant Publications (15+)

29 total publications

Production of multiple xylanolytic and cellulolytic enzymes by thermophilic fungus Myceliophthora sp. IMI 387099

Bioresource Technology / Feb 01, 2007

Badhan, A. K., Chadha, B. S., Kaur, J., Saini, H. S., & Bhat, M. K. (2007). Production of multiple xylanolytic and cellulolytic enzymes by thermophilic fungus Myceliophthora sp. IMI 387099. Bioresource Technology, 98(3), 504–510. https://doi.org/10.1016/j.biortech.2006.02.009

Purification and characterization of ß-glucosidase from Melanocarpus sp. MTCC 3922

Electronic Journal of Biotechnology / Apr 15, 2007

Kaur, J., Chadha, B. S., Kumar, B. A., Ghatora, S. K., & Saini, H. S. (2007). Purification and characterization of ß-glucosidase from Melanocarpus sp. MTCC 3922. Electronic Journal of Biotechnology, 10(2), 0–0. https://doi.org/10.2225/vol10-issue2-fulltext-4

Purification and characterization of two endoglucanases from Melanocarpus sp. MTCC 3922

Bioresource Technology / Jan 01, 2007

KAUR, J., CHADHA, B., KUMAR, B., & SAINI, H. (2007). Purification and characterization of two endoglucanases from Melanocarpus sp. MTCC 3922. Bioresource Technology, 98(1), 74–81. https://doi.org/10.1016/j.biortech.2005.11.019

Identification and characterization of diverse xylanases from thermophilic and thermotolerant fungi

BioResources / Jul 01, 2006

Ghatora, S. K., Chadha, B. S., Badhan, A. K., Saini, H. S., & Bhat, M. K. (2006). Identification and characterization of diverse xylanases from thermophilic and thermotolerant fungi. BioResources, 1(1), 18–33. https://doi.org/10.15376/biores.1.1.18-33

Functionally diverse multiple xylanases of thermophilic fungus Myceliophthora sp. IMI 387099

Enzyme and Microbial Technology / Oct 01, 2004

Badhan, A. K., Chadha, B. S., Sonia, K. G., Saini, H. S., & Bhat, M. K. (2004). Functionally diverse multiple xylanases of thermophilic fungus Myceliophthora sp. IMI 387099. Enzyme and Microbial Technology, 35(5), 460–466. https://doi.org/10.1016/j.enzmictec.2004.07.002

Expression of a fungal ferulic acid esterase in alfalfa modifies cell wall digestibility

Biotechnology for Biofuels / Mar 20, 2014

Badhan, A., Jin, L., Wang, Y., Han, S., Kowalczys, K., Brown, D. C., Ayala, C. J., Latoszek-Green, M., Miki, B., Tsang, A., & McAllister, T. (2014). Expression of a fungal ferulic acid esterase in alfalfa modifies cell wall digestibility. Biotechnology for Biofuels, 7(1). https://doi.org/10.1186/1754-6834-7-39

Identification of glucose tolerant acid active β-glucosidases from thermophilic and thermotolerant fungi

World Journal of Microbiology and Biotechnology / Aug 23, 2007

Sonia, K. G., Chadha, B. S., Badhan, A. K., Saini, H. S., & Bhat, M. K. (2007). Identification of glucose tolerant acid active β-glucosidases from thermophilic and thermotolerant fungi. World Journal of Microbiology and Biotechnology, 24(5), 599–604. https://doi.org/10.1007/s11274-007-9512-6

Two endoxylanases active and stable at alkaline pH from the newly isolated thermophilic fungus, Myceliophthora sp. IMI 387099

Journal of Biotechnology / Apr 01, 2004

Chadha, B. S., Ajay, B. K., Mellon, F., & Bhat, M. K. (2004). Two endoxylanases active and stable at alkaline pH from the newly isolated thermophilic fungus, Myceliophthora sp. IMI 387099. Journal of Biotechnology, 109(3), 227–237. https://doi.org/10.1016/j.jbiotec.2003.12.010

Identification of novel enzymes to enhance the ruminal digestion of barley straw

Bioresource Technology / Jul 01, 2018

Badhan, A., Ribeiro, G. O., Jones, D. R., Wang, Y., Abbott, D. W., Di Falco, M., Tsang, A., & McAllister, T. A. (2018). Identification of novel enzymes to enhance the ruminal digestion of barley straw. Bioresource Technology, 260, 76–84. https://doi.org/10.1016/j.biortech.2018.03.086

Role of Transglycosylation Products in the Expression of Multiple Xylanases in Myceliophthora sp. IMI 387099

Current Microbiology / May 14, 2007

Badhan, A. K., Chadha, B. S., Kaur, J., Sonia, K. G., Saini, H. S., & Bhat, M. K. (2007). Role of Transglycosylation Products in the Expression of Multiple Xylanases in Myceliophthora sp. IMI 387099. Current Microbiology, 54(6), 405–409. https://doi.org/10.1007/s00284-006-0204-5

Designer Plants for Biofuels: A Review

Current Metabolomics / Mar 02, 2016

Badhan, A., & McAllister, T. (2016). Designer Plants for Biofuels: A Review. Current Metabolomics, 4(1), 49–55. https://doi.org/10.2174/2213235x03666141226213656

Purification of the alkaliphilic xylanases from Myceliophthora sp. IMI 387099 using cellulose-binding domain as an affinity tag

World Journal of Microbiology and Biotechnology / Sep 19, 2007

Badhan, A. K., Chadha, B. S., & Saini, H. S. (2007). Purification of the alkaliphilic xylanases from Myceliophthora sp. IMI 387099 using cellulose-binding domain as an affinity tag. World Journal of Microbiology and Biotechnology, 24(7), 973–981. https://doi.org/10.1007/s11274-007-9561-x

Mechanistic insights into the digestion of complex dietary fibre by the rumen microbiota using combinatorial high-resolution glycomics and transcriptomic analyses

Computational and Structural Biotechnology Journal / Jan 01, 2022

Badhan, A., Low, K. E., Jones, D. R., Xing, X., Milani, M. R. M., Polo, R. O., Klassen, L., Venketachalam, S., Hahn, M. G., Abbott, D. W., & McAllister, T. A. (2022). Mechanistic insights into the digestion of complex dietary fibre by the rumen microbiota using combinatorial high-resolution glycomics and transcriptomic analyses. Computational and Structural Biotechnology Journal, 20, 148–164. https://doi.org/10.1016/j.csbj.2021.12.009

Saccharification efficiencies of multi-enzyme complexes produced by aerobic fungi

New Biotechnology / Nov 01, 2018

Badhan, A., Huang, J., Wang, Y., Abbott, D. W., Di Falco, M., Tsang, A., & McAllister, T. (2018). Saccharification efficiencies of multi-enzyme complexes produced by aerobic fungi. New Biotechnology, 46, 1–6. https://doi.org/10.1016/j.nbt.2018.05.003

Comparative analysis of functional diversity of rumen microbiome in bison and beef heifers

Applied and Environmental Microbiology / Dec 21, 2023

Nguyen, T. T. M., Badhan, A. K., Reid, I. D., Ribeiro, G., Gruninger, R., Tsang, A., Guan, L. L., & McAllister, T. (2023). Comparative analysis of functional diversity of rumen microbiome in bison and beef heifers. Applied and Environmental Microbiology, 89(12). https://doi.org/10.1128/aem.01320-23

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Aayudh Das, Ph.D.

Boston, Massachusetts, United States of America
Scientist at Garuda therapeutics, specialized in Genomics and Computational Biology
Most Relevant Research Interests
Biochemistry
Other Research Interests (14)
Transcriptomics
Genomics
Proteomics
Computational Biology
Metabolomics
And 9 more
About
I am a dedicated Scientist-I at Garuda Therapeutics, where I specialize in computational biology and genomics within the R&D department. My work primarily revolves around developing and optimizing pipelines for variant calling using Strelka2 and GATK4 with Whole Genome Sequencing (WGS) to identify oncogenes in human induced pluripotent stem cells (iPSCs). This involves extensive work in the qualification and validation of these pipelines for regulatory filings, as well as leveraging databases such as ClinVar, COSMIC, and DepMap to craft targeted oncogenes panels for deep sequencing. I also apply Next-Generation Sequencing (NGS) for downstream sequencing to validate CRISPR knockouts, including the identification and validation of CRISPR off-targets using techniques like rhAMPseq and Induce-seq. Additionally, my expertise extends to single-cell sequencing analysis and understanding structural variants with Optical Genome Mapping (Bionano). Prior to joining Garuda Therapeutics, I completed a postdoctoral fellowship in computational biology at Pennsylvania State University, where I honed my skills in identifying climate-adaptive variants and conducted Genome-Wide Association Studies (GWAS) to uncover resistance genes against parasites and other stressors. My academic journey began at the University of Vermont, where I explored abiotic stress resistance genes using transcriptomics and developed a robust understanding of RNA-seq data analysis, from assembly to gene annotation. My work is driven by a passion for leveraging computational and genomics tools to address pressing challenges in biology and healthcare, combining my rigorous academic training with a practical, solution-oriented approach to research and development.
Most Relevant Publications (1+)

10 total publications

Investigation of the Cardiotonic Steroids, Marinobufagenin and Resibufogenin, in the Acute Respiratory Distress Syndrome

The FASEB Journal / Apr 01, 2016

Abbas, M. M. K., Chen, Q., Das, A., Oliver, J., Jiang, W., Moorthy, B., Patel, B., Morin, K., & Puschett, J. (2016). Investigation of the Cardiotonic Steroids, Marinobufagenin and Resibufogenin, in the Acute Respiratory Distress Syndrome. The FASEB Journal, 30(S1). Portico. https://doi.org/10.1096/fasebj.30.1_supplement.982.4

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