Journal of Biological Chemistry / Oct 01, 2010

Varkey, J., Isas, J. M., Mizuno, N., Jensen, M. B., Bhatia, V. K., Jao, C. C., Petrlova, J., Voss, J. C., Stamou, D. G., Steven, A. C., & Langen, R. (2010). Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins. Journal of Biological Chemistry, 285(42), 32486–32493. https://doi.org/10.1074/jbc.m110.139576

Nature Medicine / Feb 05, 2018

Montagne, A., Nikolakopoulou, A. M., Zhao, Z., Sagare, A. P., Si, G., Lazic, D., Barnes, S. R., Daianu, M., Ramanathan, A., Go, A., Lawson, E. J., Wang, Y., Mack, W. J., Thompson, P. M., Schneider, J. A., Varkey, J., Langen, R., Mullins, E., Jacobs, R. E., & Zlokovic, B. V. (2018). Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nature Medicine, 24(3), 326–337. https://doi.org/10.1038/nm.4482

Journal of Biological Chemistry / Aug 01, 2012

Mizuno, N., Varkey, J., Kegulian, N. C., Hegde, B. G., Cheng, N., Langen, R., & Steven, A. C. (2012). Remodeling of Lipid Vesicles into Cylindrical Micelles by α-Synuclein in an Extended α-Helical Conformation. Journal of Biological Chemistry, 287(35), 29301–29311. https://doi.org/10.1074/jbc.m112.365817

Journal of the American Chemical Society / Mar 14, 2012

Meier, F., Abeywardana, T., Dhall, A., Marotta, N. P., Varkey, J., Langen, R., Chatterjee, C., & Pratt, M. R. (2012). Semisynthetic, Site-Specific Ubiquitin Modification of α-Synuclein Reveals Differential Effects on Aggregation. Journal of the American Chemical Society, 134(12), 5468–5471. https://doi.org/10.1021/ja300094r

Antimicrobial Agents and Chemotherapy / Nov 01, 2005

Varkey, J., & Nagaraj, R. (2005). Antibacterial Activity of Human Neutrophil Defensin HNP-1 Analogs without Cysteines. Antimicrobial Agents and Chemotherapy, 49(11), 4561–4566. https://doi.org/10.1128/aac.49.11.4561-4566.2005

Proceedings of the National Academy of Sciences / Nov 15, 2012

Ladiwala, A. R. A., Bhattacharya, M., Perchiacca, J. M., Cao, P., Raleigh, D. P., Abedini, A., Schmidt, A. M., Varkey, J., Langen, R., & Tessier, P. M. (2012). Rational design of potent domain antibody inhibitors of amyloid fibril assembly. Proceedings of the National Academy of Sciences, 109(49), 19965–19970. https://doi.org/10.1073/pnas.1208797109

Biochemistry / Jun 13, 2014

Lai, Y., Kim, S., Varkey, J., Lou, X., Song, J.-K., Diao, J., Langen, R., & Shin, Y.-K. (2014). Nonaggregated α-Synuclein Influences SNARE-Dependent Vesicle Docking via Membrane Binding. Biochemistry, 53(24), 3889–3896. https://doi.org/10.1021/bi5002536

Proceedings of the National Academy of Sciences / Sep 30, 2013

Cheng, C.-Y., Varkey, J., Ambroso, M. R., Langen, R., & Han, S. (2013). Hydration dynamics as an intrinsic ruler for refining protein structure at lipid membrane interfaces. Proceedings of the National Academy of Sciences, 110(42), 16838–16843. https://doi.org/10.1073/pnas.1307678110

Journal of Biological Chemistry / Jun 01, 2013

Varkey, J., Mizuno, N., Hegde, B. G., Cheng, N., Steven, A. C., & Langen, R. (2013). α-Synuclein Oligomers with Broken Helical Conformation Form Lipoprotein Nanoparticles. Journal of Biological Chemistry, 288(24), 17620–17630. https://doi.org/10.1074/jbc.m113.476697

Journal of Biological Chemistry / Jan 01, 2016

Dearborn, A. D., Wall, J. S., Cheng, N., Heymann, J. B., Kajava, A. V., Varkey, J., Langen, R., & Steven, A. C. (2016). α-Synuclein Amyloid Fibrils with Two Entwined, Asymmetrically Associated Protofibrils. Journal of Biological Chemistry, 291(5), 2310–2318. https://doi.org/10.1074/jbc.m115.698787

Genomics / Jul 01, 2019

George, G., Singh, S., Lokappa, S. B., & Varkey, J. (2019). Gene co-expression network analysis for identifying genetic markers in Parkinson’s disease - a three-way comparative approach. Genomics, 111(4), 819–830. https://doi.org/10.1016/j.ygeno.2018.05.005

Biochimica et Biophysica Acta (BBA) - Biomembranes / Sep 01, 2018

Rawat, A., Langen, R., & Varkey, J. (2018). Membranes as modulators of amyloid protein misfolding and target of toxicity. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1860(9), 1863–1875. https://doi.org/10.1016/j.bbamem.2018.04.011

Journal of Biological Chemistry / Jun 01, 2019

Rovere, M., Powers, A. E., Jiang, H., Pitino, J. C., Fonseca-Ornelas, L., Patel, D. S., Achille, A., Langen, R., Varkey, J., & Bartels, T. (2019). E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity. Journal of Biological Chemistry, 294(25), 9799–9812. https://doi.org/10.1074/jbc.ra118.006551

Peptides / Nov 01, 2006

Varkey, J., Singh, S., & Nagaraj, R. (2006). Antibacterial activity of linear peptides spanning the carboxy-terminal β-sheet domain of arthropod defensins. Peptides, 27(11), 2614–2623. https://doi.org/10.1016/j.peptides.2006.06.010

ACS Chemical Neuroscience / Nov 17, 2014

Basak, S., Prasad, G. V. R. K., Varkey, J., & Chattopadhyay, K. (2014). Early Sodium Dodecyl Sulfate Induced Collapse of α-Synuclein Correlates with Its Amyloid Formation. ACS Chemical Neuroscience, 6(2), 239–246. https://doi.org/10.1021/cn500168x

Gene / May 01, 2019

George, G., Valiya Parambath, S., Lokappa, S. B., & Varkey, J. (2019). Construction of Parkinson’s disease marker-based weighted protein-protein interaction network for prioritization of co-expressed genes. Gene, 697, 67–77. https://doi.org/10.1016/j.gene.2019.02.026

Journal of Magnetic Resonance / Jul 01, 2017

Varkey, J., & Langen, R. (2017). Membrane remodeling by amyloidogenic and non-amyloidogenic proteins studied by EPR. Journal of Magnetic Resonance, 280, 127–139. https://doi.org/10.1016/j.jmr.2017.02.014

Viruses / Dec 18, 2020

Varkey, J., Zhang, J., Kim, J., George, G., He, G., Belov, G., Langen, R., & Wang, X. (2020). An Amphipathic Alpha-Helix Domain from Poliovirus 2C Protein Tubulate Lipid Vesicles. Viruses, 12(12), 1466. https://doi.org/10.3390/v12121466

Biophysical Journal / Nov 01, 2020

Falk, A. S., Bravo-Arredondo, J. M., Varkey, J., Pacheco, S., Langen, R., & Siemer, A. B. (2020). Structural Model of the Proline-Rich Domain of Huntingtin Exon-1 Fibrils. Biophysical Journal, 119(10), 2019–2028. https://doi.org/10.1016/j.bpj.2020.10.010

Journal of Biological Chemistry / Apr 01, 2023

Bravo-Arredondo, J. M., Venkataraman, R., Varkey, J., Isas, J. M., Situ, A. J., Xu, H., Chen, J., Ulmer, T. S., & Langen, R. (2023). Molecular basis of Q-length selectivity for the MW1 antibody–huntingtin interaction. Journal of Biological Chemistry, 299(4), 104616. https://doi.org/10.1016/j.jbc.2023.104616

Microscopy and Microanalysis / Aug 01, 2015

Dearborn, A. D., Cheng, N., Bernard Heymann, J., Wall, J. S., Varkey, J., Langen, R., & Steven, A. C. (2015). α-Synuclein Amyloid Fibrils Formed of Two Protofibrils. Microscopy and Microanalysis, 21(S3), 1285–1286. https://doi.org/10.1017/s1431927615007217

Microscopy and Microanalysis / Aug 01, 2013

Dearborn, A. D., Cheng, N., Heymann, J. B., Varkey, J., Langen, R., & Steven, A. C. (2013). α Synuclein Amyloid Fibrils With Two Entwined Protofibrils Each With One Subunit Per 4.7 Å Axial Rise. Microscopy and Microanalysis, 19(S2), 82–83. https://doi.org/10.1017/s1431927613002407

Biophysical Journal / Jan 01, 2013

Cheng, C.-Y., Varkey, J., Langen, R., & Han, S. (2013). Hydration Dynamics as a Molecular Ruler for Refining Protein Structure at Lipid Membrane Interfaces. Biophysical Journal, 104(2), 221a. https://doi.org/10.1016/j.bpj.2012.11.1246

Nature Reviews Immunology / Sep 01, 2003

Ganz, T. (2003). Defensins: antimicrobial peptides of innate immunity. Nature Reviews Immunology, 3(9), 710–720. https://doi.org/10.1038/nri1180