Luca Delfinis
PhD candidate in physiology researching the mechanisms that drive muscle dysfunction in cancer
Research Interests
About
Publications
Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress
JCI Insight / Dec 22, 2022
Delfinis, L. J., Bellissimo, C. A., Gandhi, S., DiBenedetto, S. N., Garibotti, M. C., Thuhan, A. K., Tsitkanou, S., Rosa-Caldwell, M. E., Rahman, F. A., Cheng, A. J., Wiggs, M. P., Schlattner, U., Quadrilatero, J., Greene, N. P., & Perry, C. G. R. (2022). Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress. JCI Insight, 7(24). https://doi.org/10.1172/jci.insight.155147
Mitochondrial bioenergetic dysfunction in the D2.mdx model of Duchenne muscular dystrophy is associated with microtubule disorganization in skeletal muscle
PLOS ONE / Oct 01, 2020
Ramos, S. V., Hughes, M. C., Delfinis, L. J., Bellissimo, C. A., & Perry, C. G. R. (2020). Mitochondrial bioenergetic dysfunction in the D2.mdx model of Duchenne muscular dystrophy is associated with microtubule disorganization in skeletal muscle. PLOS ONE, 15(10), e0237138. https://doi.org/10.1371/journal.pone.0237138
Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H 2 O 2 emission during impaired oxidative phosphorylation
Journal of Cachexia, Sarcopenia and Muscle / Apr 02, 2019
Hughes, M. C., Ramos, S. V., Turnbull, P. C., Rebalka, I. A., Cao, A., Monaco, C. M. F., Varah, N. E., Edgett, B. A., Huber, J. S., Tadi, P., Delfinis, L. J., Schlattner, U., Simpson, J. A., Hawke, T. J., & Perry, C. G. R. (2019). Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H 2 O 2 emission during impaired oxidative phosphorylation. Journal of Cachexia, Sarcopenia and Muscle, 10(3), 643–661. Portico. https://doi.org/10.1002/jcsm.12405
Mitochondrial creatine sensitivity is lost in the D2.mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime
American Journal of Physiology-Cell Physiology / May 01, 2023
Bellissimo, C. A., Delfinis, L. J., Hughes, M. C., Turnbull, P. C., Gandhi, S., DiBenedetto, S. N., Rahman, F. A., Tadi, P., Amaral, C. A., Dehghani, A., Cobley, J. N., Quadrilatero, J., Schlattner, U., & Perry, C. G. R. (2023). Mitochondrial creatine sensitivity is lost in the D2.mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime. American Journal of Physiology-Cell Physiology, 324(5), C1141–C1157. https://doi.org/10.1152/ajpcell.00377.2022
Education
Wilfrid Laurier University
BSc, Kinesiology & Physical Education / April, 2018
York University
MSc, Molecular, Cellular and Integrative Physiology / August, 2020
York University
PhD, Molecular, Cellular and Integrative Physiology / August, 2024 (anticipated)
Experience
York University
Teaching Assistant / September, 2018 — Present
KINE 2049 (Research Methods in Kinesiology) and KINE 3012 (Human Physiology II)
Wilfrid Laurier University
Supplemental Instruction Senior Mentor / April, 2017 — April, 2018
Oversee teaching assistants with their teaching programs
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