Stan Karsten

Experienced R&D Investigator

Research Interests

Medical Laboratory Technology
Computer Science Applications
Electrical and Electronic Engineering
Control and Systems Engineering
Mechanical Engineering
Instrumentation
Electronic, Optical and Magnetic Materials
Materials Chemistry
Metals and Alloys
Surfaces, Coatings and Films
Condensed Matter Physics
Biochemistry
Biomedical Engineering
Bioengineering
Analytical Chemistry
Oncology
Radiology, Nuclear Medicine and imaging
Cancer Research
Pharmacology
Drug Discovery
Environmental Chemistry
Electrochemistry
Spectroscopy
Molecular Biology
Neurology (clinical)
Cellular and Molecular Neuroscience

Publications

Automated Capillary-Based Vacuum Pulse-Assisted Instrument for Single-Cell Acquisition and Concurrent Detachment/Adhesion Assay, A-picK

SLAS Technology / Oct 01, 2021

Ma, D., Ma, Z., Kudo, L. C., & Karsten, S. L. (2021). Automated Capillary-Based Vacuum Pulse-Assisted Instrument for Single-Cell Acquisition and Concurrent Detachment/Adhesion Assay, A-picK. SLAS Technology, 26(5), 519–531. https://doi.org/10.1177/2472630320987219

Nanopin - A MEMS Based Sensor for the Analysis of Single Cell Mechanical Properties

2020 IEEE 33rd International Conference on Micro Electro Mechanical Systems (MEMS) / Jan 01, 2020

Kumemura, M., Kudo, L. C., Ma, Z., & Karsten, S. L. (2020, January). Nanopin - A MEMS Based Sensor for the Analysis of Single Cell Mechanical Properties. 2020 IEEE 33rd International Conference on Micro Electro Mechanical Systems (MEMS). https://doi.org/10.1109/mems46641.2020.9056113

Developing a MEMS Device with Built-in Microfluidics for Biophysical Single Cell Characterization

Micromachines / Jun 01, 2018

Takayama, Y., Perret, G., Kumemura, M., Ataka, M., Meignan, S., Karsten, S., Fujita, H., Collard, D., Lagadec, C., & Tarhan, M. (2018). Developing a MEMS Device with Built-in Microfluidics for Biophysical Single Cell Characterization. Micromachines, 9(6), 275. https://doi.org/10.3390/mi9060275

Microfluidic Tissue Mesodissection in Molecular Cancer Diagnostics

SLAS Technology / Aug 01, 2017

Surrette, C., Shoudy, D., Corwin, A., Gao, W., Zavodszky, M. I., Karsten, S. L., Miller, T., Gerdes, M. J., Wood, N., Nelson, J. R., & Puleo, C. M. (2017). Microfluidic Tissue Mesodissection in Molecular Cancer Diagnostics. SLAS Technology, 22(4), 425–430. https://doi.org/10.1177/2211068216680208

Microtubule density and landing rate as parameters to analyze tau protein in the MT-kinesin “gliding” assay

Sensors and Actuators B: Chemical / Jan 01, 2017

Subramaniyan Parimalam, S., Tarhan, M. C., Karsten, S. L., Fujita, H., Shintaku, H., Kotera, H., & Yokokawa, R. (2017). Microtubule density and landing rate as parameters to analyze tau protein in the MT-kinesin “gliding” assay. Sensors and Actuators B: Chemical, 238, 954–961. https://doi.org/10.1016/j.snb.2016.07.082

Direct electrical and mechanical characterization of in situ generated DNA between the tips of silicon nanotweezers (SNT)

Lab on a Chip / Jan 01, 2016

Karsten, S. L., Kumemura, M., Jalabert, L., Lafitte, N., Kudo, L. C., Collard, D., & Fujita, H. (2016). Direct electrical and mechanical characterization of in situ generated DNA between the tips of silicon nanotweezers (SNT). Lab on a Chip, 16(11), 2099–2107. https://doi.org/10.1039/c6lc00309e

Nano systems and devices for applications in biology and nanotechnology

Solid-State Electronics / Jan 01, 2016

Perret, G., Ginet, P., Tarhan, M. C., Baccouche, A., Lacornerie, T., Kumemura, M., Jalabert, L., Cleri, F., Lartigau, E. F., Kim, B. J., Karsten, S. L., Fujita, H., Rondelez, Y., Fujii, T., & Collard, D. (2016). Nano systems and devices for applications in biology and nanotechnology. Solid-State Electronics, 115, 66–73. https://doi.org/10.1016/j.sse.2015.08.019

On-chip microtubule gliding assay for parallel measurement of tau protein species

Lab on a Chip / Jan 01, 2016

Subramaniyan Parimalam, S., Tarhan, M. C., Karsten, S. L., Fujita, H., Shintaku, H., Kotera, H., & Yokokawa, R. (2016). On-chip microtubule gliding assay for parallel measurement of tau protein species. Lab on a Chip, 16(9), 1691–1697. https://doi.org/10.1039/c5lc01486g

On-chip detection of wild 3R, 4R and mutant 4R tau through kinesin-microtubule binding

2015 28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS) / Jan 01, 2015

Subramaniyan, S. P., Tarhan, M. C., Karsten, S. L., Fujita, H., Shintaku, H., Kotera, H., & Yokokawa, R. (2015, January). On-chip detection of wild 3R, 4R and mutant 4R tau through kinesin-microtubule binding. 2015 28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS). https://doi.org/10.1109/memsys.2015.7050988

Point-of-care (POC) devices by means of advanced MEMS

Talanta / Dec 01, 2015

Karsten, S. L., Tarhan, M. C., Kudo, L. C., Collard, D., & Fujita, H. (2015). Point-of-care (POC) devices by means of advanced MEMS. Talanta, 145, 55–59. https://doi.org/10.1016/j.talanta.2015.04.032

Detection of mutations in the binding domain of tau protein by kinesin-microtubule gliding assay

2014 IEEE 27th International Conference on Micro Electro Mechanical Systems (MEMS) / Jan 01, 2014

Subramaniyan, S. P., Tarhan, M. C., Karsten, S. L., Fujita, H., Shintaku, H., Kotera, H., & Yokokawa, R. (2014, January). Detection of mutations in the binding domain of tau protein by kinesin-microtubule gliding assay. 2014 IEEE 27th International Conference on Micro Electro Mechanical Systems (MEMS). https://doi.org/10.1109/memsys.2014.6765639

Intestinal tumor suppression in ApcMin/+ mice by prostaglandin D2 receptor PTGDR

Cancer Medicine / Apr 12, 2014

Tippin, B. L., Kwong, A. M., Inadomi, M. J., Lee, O. J., Park, J. M., Materi, A. M., Buslon, V. S., Lin, A. M., Kudo, L. C., Karsten, S. L., French, S. W., Narumiya, S., Urade, Y., Salido, E., & Lin, H. J. (2014). Intestinal tumor suppression in ApcMin/+ mice by prostaglandin D2 receptor <scp>PTGDR</scp>. Cancer Medicine, 3(4), 1041–1051. Portico. https://doi.org/10.1002/cam4.251

Biosensing MAPs as “roadblocks”: kinesin-based functional analysis of tau protein isoforms and mutants using suspended microtubules (sMTs)

Lab on a Chip / Jan 01, 2013

Tarhan, M. C., Orazov, Y., Yokokawa, R., Karsten, S. L., & Fujita, H. (2013). Biosensing MAPs as “roadblocks”: kinesin-based functional analysis of tau protein isoforms and mutants using suspended microtubules (sMTs). Lab on a Chip, 13(16), 3217. https://doi.org/10.1039/c3lc50151e

Motor protein based tau protein detection device

2013 Transducers & Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII) / Jun 01, 2013

Orazov, Y., Tarhan, M. C., Yokokawa, R., Karsten, S. L., & Fujita, H. (2013, June). Motor protein based tau protein detection device. 2013 Transducers &amp; Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS &amp; EUROSENSORS XXVII). https://doi.org/10.1109/transducers.2013.6627301

Nano bioresearch approach by microtechnology

Drug Discovery Today / Jun 01, 2013

Collard, D., Kim, S. H., Osaki, T., Kumemura, M., Kim, B., Fourmy, D., Fujii, T., Takeuchi, S., Karsten, S. L., & Fujita, H. (2013). Nano bioresearch approach by microtechnology. Drug Discovery Today, 18(11–12), 552–559. https://doi.org/10.1016/j.drudis.2013.02.002

Suspended microtubules demonstrate high sensitivity and low experimental variability in kinesin bead assay

The Analyst / Jan 01, 2013

Tarhan, M. C., Orazov, Y., Yokokawa, R., Karsten, S. L., & Fujita, H. (2013). Suspended microtubules demonstrate high sensitivity and low experimental variability in kinesin bead assay. The Analyst, 138(6), 1653. https://doi.org/10.1039/c3an36545j

Puromycin-sensitive aminopeptidase is involved in wild-type huntingtin clearance

Molecular Neurodegeneration / Feb 07, 2012

Ren, G., Ma, Z., Hui, M., Kudo, L. C., Hui, K.-S., & Karsten, S. L. (2012). Puromycin-sensitive aminopeptidase is involved in wild-type huntingtin clearance. Molecular Neurodegeneration, 7(S1). https://doi.org/10.1186/1750-1326-7-s1-s5

Education

Uppsala University

PhD, Genetics and Pathology

Uppsala

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