Susan Song, MD/PhD
Research Assistant Professor in Neuroscience at University of Pittsburgh
Research Interests
About
Publications
Selective knockout of astrocytic Na+/H+ exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke
Glia / Sep 19, 2017
Begum, G., Song, S., Wang, S., Zhao, H., Bhuiyan, M. I. H., Li, E., Nepomuceno, R., Ye, Q., Sun, M., Calderon, M. J., Stolz, D. B., St. Croix, C., Watkins, S. C., Chen, Y., He, P., Shull, G. E., & Sun, D. (2017). Selective knockout of astrocytic Na+/H+ exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke. Glia, 66(1), 126–144. Portico. https://doi.org/10.1002/glia.23232
Activation of endothelial Wnt/β-catenin signaling by protective astrocytes repairs BBB damage in ischemic stroke
Progress in Neurobiology / Apr 01, 2021
Song, S., Huang, H., Guan, X., Fiesler, V., Bhuiyan, M. I. H., Liu, R., Jalali, S., Hasan, M. N., Tai, A. K., Chattopadhyay, A., Chaparala, S., Sun, M., Stolz, D. B., He, P., Agalliu, D., Sun, D., & Begum, G. (2021). Activation of endothelial Wnt/β-catenin signaling by protective astrocytes repairs BBB damage in ischemic stroke. Progress in Neurobiology, 199, 101963. https://doi.org/10.1016/j.pneurobio.2020.101963
Ion channels and transporters in microglial function in physiology and brain diseases
Neurochemistry International / Jan 01, 2021
Luo, L., Song, S., Ezenwukwa, C. C., Jalali, S., Sun, B., & Sun, D. (2021). Ion channels and transporters in microglial function in physiology and brain diseases. Neurochemistry International, 142, 104925. https://doi.org/10.1016/j.neuint.2020.104925
Roles of glial ion transporters in brain diseases
Glia / Aug 16, 2019
Song, S., Luo, L., Sun, B., & Sun, D. (2019). Roles of glial ion transporters in brain diseases. Glia, 68(3), 472–494. Portico. https://doi.org/10.1002/glia.23699
A Novel Na + -K + -Cl − Cotransporter 1 Inhibitor STS66* Reduces Brain Damage in Mice After Ischemic Stroke
Stroke / Apr 01, 2019
Huang, H., Bhuiyan, M. I. H., Jiang, T., Song, S., Shankar, S., Taheri, T., Li, E., Schreppel, P., Hintersteininger, M., Yang, S.-S., Lin, S.-H., Molyneaux, B. J., Zhang, Z., Erker, T., & Sun, D. (2019). A Novel Na + -K + -Cl − Cotransporter 1 Inhibitor STS66* Reduces Brain Damage in Mice After Ischemic Stroke. Stroke, 50(4), 1021–1025. https://doi.org/10.1161/strokeaha.118.024287
Selective role of Na+/H+ exchanger in Cx3cr1+ microglial activation, white matter demyelination, and post‐stroke function recovery
Glia / Jul 25, 2018
Song, S., Wang, S., Pigott, V. M., Jiang, T., Foley, L. M., Mishra, A., Nayak, R., Zhu, W., Begum, G., Shi, Y., Carney, K. E., Hitchens, T. K., Shull, G. E., & Sun, D. (2018). Selective role of Na+/H+ exchanger in Cx3cr1+ microglial activation, white matter demyelination, and post‐stroke function recovery. Glia, 66(11), 2279–2298. Portico. https://doi.org/10.1002/glia.23456
Attenuating vascular stenosis-induced astrogliosis preserves white matter integrity and cognitive function
Journal of Neuroinflammation / Aug 28, 2021
Liu, Q., Bhuiyan, M. I. H., Liu, R., Song, S., Begum, G., Young, C. B., Foley, L. M., Chen, F., Hitchens, T. K., Cao, G., Chattopadhyay, A., He, L., & Sun, D. (2021). Attenuating vascular stenosis-induced astrogliosis preserves white matter integrity and cognitive function. Journal of Neuroinflammation, 18(1). https://doi.org/10.1186/s12974-021-02234-8
The WNK-SPAK/OSR1 Kinases and the Cation-Chloride Cotransporters as Therapeutic Targets for Neurological Diseases
Aging and disease / Jan 01, 2019
Huang, H., Song, S., Banerjee, S., Jiang, T., Zhang, J., Kahle, K. T., Sun, D., & Zhang, Z. (2019). The WNK-SPAK/OSR1 Kinases and the Cation-Chloride Cotransporters as Therapeutic Targets for Neurological Diseases. Aging and Disease, 10(3), 626. https://doi.org/10.14336/ad.2018.0928
Elevated microglial oxidative phosphorylation and phagocytosis stimulate post-stroke brain remodeling and cognitive function recovery in mice
Communications Biology / Jan 11, 2022
Song, S., Yu, L., Hasan, M. N., Paruchuri, S. S., Mullett, S. J., Sullivan, M. L. G., Fiesler, V. M., Young, C. B., Stolz, D. B., Wendell, S. G., & Sun, D. (2022). Elevated microglial oxidative phosphorylation and phagocytosis stimulate post-stroke brain remodeling and cognitive function recovery in mice. Communications Biology, 5(1). https://doi.org/10.1038/s42003-021-02984-4
WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats
Journal of Cerebral Blood Flow & Metabolism / Jan 01, 2016
Bhuiyan, M. I. H., Song, S., Yuan, H., Begum, G., Kofler, J., Kahle, K. T., Yang, S.-S., Lin, S.-H., Alper, S. L., Subramanya, A. R., & Sun, D. (2016). WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats. Journal of Cerebral Blood Flow & Metabolism, 37(8), 2780–2794. https://doi.org/10.1177/0271678x16675368
Blocking NHE1 stimulates glioma tumor immunity by restoring OXPHOS function of myeloid cells
Theranostics / Jan 01, 2021
Hasan, M. N., Luo, L., Ding, D., Song, S., Bhuiyan, M. I. H., Liu, R., Foley, L. M., Guan, X., Kohanbash, G., Hitchens, T. K., Castro, M. G., Zhang, Z., & Sun, D. (2021). Blocking NHE1 stimulates glioma tumor immunity by restoring OXPHOS function of myeloid cells. Theranostics, 11(3), 1295–1309. https://doi.org/10.7150/thno.50150
Microglial–oligodendrocyte interactions in myelination and neurological function recovery after traumatic brain injury
Journal of Neuroinflammation / Oct 05, 2022
Song, S., Hasan, M. N., Yu, L., Paruchuri, S. S., Bielanin, J. P., Metwally, S., Oft, H. C. M., Fischer, S. G., Fiesler, V. M., Sen, T., Gupta, R. K., Foley, L. M., Hitchens, T. K., Dixon, C. E., Cambi, F., Sen, N., & Sun, D. (2022). Microglial–oligodendrocyte interactions in myelination and neurological function recovery after traumatic brain injury. Journal of Neuroinflammation, 19(1). https://doi.org/10.1186/s12974-022-02608-6
Inhibition of Na+/H+ exchanger modulates microglial activation and scar formation following microelectrode implantation
Journal of Neural Engineering / Mar 19, 2021
Dubaniewicz, M., Eles, J. R., Lam, S., Song, S., Cambi, F., Sun, D., Wellman, S. M., & Kozai, T. D. Y. (2021). Inhibition of Na+/H+ exchanger modulates microglial activation and scar formation following microelectrode implantation. Journal of Neural Engineering, 18(4), 045001. https://doi.org/10.1088/1741-2552/abe8f1
Pharmacological Inhibition of NHE1 Protein Increases White Matter Resilience and Neurofunctional Recovery after Ischemic Stroke
International Journal of Molecular Sciences / Aug 27, 2023
Metwally, S. A. H., Paruchuri, S. S., Yu, L., Capuk, O., Pennock, N., Sun, D., & Song, S. (2023). Pharmacological Inhibition of NHE1 Protein Increases White Matter Resilience and Neurofunctional Recovery after Ischemic Stroke. International Journal of Molecular Sciences, 24(17), 13289. https://doi.org/10.3390/ijms241713289
Transient axonal glycoprotein-1 induces apoptosis-related gene expression without triggering apoptosis in U251 glioma cells
Neural Regeneration Research / Jan 01, 2014
Jin, B., Jiang, X., Chang, H., Song, S., Chen, Z., Wang, Y., Yang, L., Du, M., Ke, Y., & Xu, R. (2014). Transient axonal glycoprotein-1 induces apoptosis-related gene expression without triggering apoptosis in U251 glioma cells. Neural Regeneration Research, 9(5), 519. https://doi.org/10.4103/1673-5374.130079
Deletion of Slc9a1 in Cx3cr1+ cells stimulated microglial subcluster CREB1-BDNF signaling and microglia-oligodendrocyte crosstalk
Dec 11, 2023
Song, S., Oft, H., Metwally, S., Paruchuri, S., Bielanin, J., Fiesler, V., Sneiderman, C., Kohanbash, G., & Sun, D. (2023). Deletion of Slc9a1 in Cx3cr1+ cells stimulated microglial subcluster CREB1-BDNF signaling and microglia-oligodendrocyte crosstalk. https://doi.org/10.21203/rs.3.rs-3710892/v1
Transient ischemic stroke triggers sustained damage of the choroid plexus blood-CSF barrier
Frontiers in Cellular Neuroscience / Dec 01, 2023
Chen, Y., Lin, L., Bhuiyan, M. I. H., He, K., Jha, R., Song, S., Fiesler, V. M., Begum, G., Yin, Y., & Sun, D. (2023). Transient ischemic stroke triggers sustained damage of the choroid plexus blood-CSF barrier. Frontiers in Cellular Neuroscience, 17. https://doi.org/10.3389/fncel.2023.1279385
Does Adjuvant Gamma Knife Stereotactic Radiosurgery Have a Role in Treating Optic Nerve Sheath Meningiomas?
Journal of Neuro-Ophthalmology / Jul 05, 2023
Wei, Z., Taori, S., Song, S., Deng, H., Niranjan, A., & Lunsford, L. D. (2023). Does Adjuvant Gamma Knife Stereotactic Radiosurgery Have a Role in Treating Optic Nerve Sheath Meningiomas? Journal of Neuro-Ophthalmology. https://doi.org/10.1097/wno.0000000000001914
Abstract P761: Reducing Reactive Astrocytes Improves Cognitive Function in a Mouse Model of Vascular Cognitive Impairment and Dementia
Stroke / Mar 01, 2021
Liu, Q., Bhuiyan, M. I., song, S., Begum, G., Liu, R., chen, fenghua, Cao, G., He, L., & Sun, D. (2021). Abstract P761: Reducing Reactive Astrocytes Improves Cognitive Function in a Mouse Model of Vascular Cognitive Impairment and Dementia. Stroke, 52(Suppl_1). https://doi.org/10.1161/str.52.suppl_1.p761
Microglia-oligodendrocyte interactions in post-injury brain repair
IBRO Reports / Sep 01, 2019
Sun, D. (2019). Microglia-oligodendrocyte interactions in post-injury brain repair. IBRO Reports, 6, S22. https://doi.org/10.1016/j.ibror.2019.07.056
Education
Southern Medical University
MD/PhD, Neurology, Neuroscience / June, 2015
University of Pittsburgh
Post-doc, Neuroscience / December, 2019
Experience
University of Pittsburgh
Research Assistant Professor / January, 2022 — Present
Research Instructor / January, 2020 — December, 2021
Postdoctoral Scholar / October, 2015 — December, 2019
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