Felipe Oyarzun-Ampuero

Professor at Universidad of Chile with wide interest in encapsulation at nano, micro and macroscale

Research Interests

Pharmaceutical Science
Food Science
Biotechnology
Pharmacology
Drug Discovery
Cell Biology
Biochemistry
Clinical Biochemistry
Molecular Biology
Physiology
Development
Bioengineering
Biomedical Engineering
Analytical Chemistry
Biomaterials
Polymers and Plastics
Materials Chemistry
Organic Chemistry
Environmental Chemistry
Molecular Medicine
Physical and Theoretical Chemistry
Medical–Surgical Nursing
Dermatology
Surgery
Surfaces, Coatings and Films
Process Chemistry and Technology
Inorganic Chemistry
Computer Science Applications
Catalysis
Spectroscopy
Pharmacology (medical)
Endocrinology, Diabetes and Metabolism
Internal Medicine
Electrochemistry
Condensed Matter Physics
Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics

About

Felipe Oyarzún Ampuero graduated as a Pharmaceutical Chemist in the Austral University of Chile (2004). He obtained a “Diploma of Advanced Studies” (year 2007) and the degree of “Doctor in Research and Development of Medicines” (year 2011) at the University of Santiago de Compostela (Spain). Later he developed postdoctoral studies (2011-2013) at the Polymer Laboratory of the Universidad Austral de Chile. To carry out these studies he has received scholarships from MINEDUC (undergraduate) and CONICYT (postgraduate). In 2013 he joined to the University of Chile as an academic with a project on “Insertion of Advanced Human Capital in the Academy”. He is currently the Director of the Department of Pharmaceutical Sciences and Technology. In the teaching field he teaches to undergraduate and graduate students (Master's and Doctorate). He has been a researcher responsible for projects related to basic science (1 Fondecyt startup, 3 Fondecyt Regular, 2 Fondecyt postdoctoral) and several technological and/or applied science projects (Fondequip, Fondef and Corfo, among others). He has also been principal investigator in projects of different kinds (Fondap, Fondef, Fondequip, Anillo, Fondecyt regular, among others). The laboratory directed by Dr. Oyarzún has the necessary equipment to characterize liquid and solid formulations of different sizes (from nanometers to millimeters), their stability and the release profile of the active molecule contained. His main lines of research are: Encapsulation of active molecules (drugs and nutrients) in nano- and microsystems mediated by non-covalent interactions. Study of chemical interactions for the formation of nano and microsystems. Development of new materials for the pharmaceutical and food industries. Dr. Oyarzún has published more than 50 ISI publications, almost all of them from the first quartile. Below are the patents in which he appears as an inventor: **Accepted patents:** Application for USA: A new and green methodology to create polymeric nanocarriers containig hydrophilic low molecular-weight drugs and providing a very high drug loading and a very high prolonged release” (US/16/888,438). Felipe Oyarzún, Gabriela Villamizar, Ignacio Moreno, Elton Molina (**GRANTED**). Application for Spain: Nanocapsules with a polimeric Shell (ES2385995B2). María José Alonso Fernández, Dolores Torres López, Gustavo Rivera Rodríguez, Felipe Andrés Oyarzún Ampuero, Giovanna Lollo Giovanna, Teresa Gonzalo Lázaro, Marcos García Fuentes (**GRANTED AND LICENSED**). Application for USA:Nanocapsules with a polimeric Shell (US 9415019, B2). María José Alonso Fernández, Dolores Torres López, Gustavo Rivera Rodríguez, Felipe Andrés Oyarzún Ampuero, Giovanna Lollo Giovanna, Teresa Gonzalo Lázaro, Marcos García Fuentes (**GRANTED**). Application for Europe: Nanocapsules with a polymeric Shell (EP2664324(B1). María José Alonso Fernández, Dolores Torres López, Gustavo Rivera Rodríguez, Felipe Andrés Oyarzún Ampuero, Giovanna Lollo Giovanna, Teresa Gonzalo Lázaro, Marcos García Fuentes (**GRANTED**). Application for Chile: Biomaterial que comprende quitosano y al menos un glicosaminoglicano” (PCT/CL2012/000023). Miguel Concha Murray, Ignacio Moreno Villoslada, Sandra Lorena Orellana Donoso, Felipe Oyarzun Ampuero, María Alejandra Vidal Villa, Annesi Gisela Giacaman Fonseca, María Francisca Pavicic Rojas, Carlos Morales Hernandez, Marcos Ruminot Bascur, Sandra Pamela Jofre Rivas (**GRANTED**). **Application patents:** M.P. Ocaranza, J.E. Jalil, J.O. Morales, F. Oyarzun-Ampuero, E. Soto-Bustamante, F. Gonzalez-Nilo. Composición farmacéutica que comprende un péptido o una combinación de péptidos agonistas de los receptores Mas, AT1 y AT2. Chilean Patent Application PCT/CL2023/050084. PCT Application: Compositions (PCT/IB2022/051550). Verónica Palma, Daniela Carrillo, Fernando Valenzuela, Felipe Oyarzún, María Gabriela Villamizar (**LICENCED**). PCT Application: Nanoparticle of chitosan and cyclodextrin containing encapsulated interferon and pharmaceutical compositions that contain it" (PCT/IB2019/052510). Rodrigo Naves, Luis González Felipe Oyarzún. PCT Application: Método para obtener nanoestructuras con carotenoides y nanoestructuras obtenidas (PCT/CL2017/0550046). Felipe Oyarzún, Javier Morales, Matías Silva, Mariela Inostroza, Andrew Quest, Marcelo Kogan, Simón Guerrero, Ignacio Moreno, Carlos Alarcón, Mario Flores, César Torres (**LICENCED**). PCT Application: Curcumin-Loaded nanoemulsions, method of manufacture, and method of preventive treatment using the same (PCT) (15/856,786). Felipe Oyarzún, Andrew Quest, Simón Guerrero, Marcelo Kogan, Pamela Contreras, Víctor Díaz, Pablo Lara, Areli Cárdenas, Lisette Leyton, Andrea Vivanco, Víctor Miranda. Application for Chile: Microdieta para especies marinas de cultivo, incluyendo peces en etapas de desarrollo, la que una vez deshidratada y reconstituida toma una forma alargada similar a un alimento vivo, y método de preparación (201603279). Felipe Andrés Oyarzún Ampuero, Ignacio Moreno-Villoslada, Mariela Inostroza Riquelme. Application for Brazil: Nanocapsules with a polymeric Shell (PI98213). María José Alonso Fernández, Dolores Torres López, Gustavo Rivera Rodríguez, Felipe Andrés Oyarzún Ampuero, Giovanna Lollo Giovanna, Teresa Gonzalo Lázaro, Marcos García Fuentes. Application for China: Nanocapsules with a polymeric Shell (CN103596558). María José Alonso Fernández, Dolores Torres López, Gustavo Rivera Rodríguez, Felipe Andrés Oyarzún Ampuero, Giovanna Lollo Giovanna, Teresa Gonzalo Lázaro, Marcos García Fuentes.

Publications

Chitosan–hyaluronic acid nanoparticles loaded with heparin for the treatment of asthma

International Journal of Pharmaceutics / Nov 01, 2009

Oyarzun-Ampuero, F. A., Brea, J., Loza, M. I., Torres, D., & Alonso, M. J. (2009). Chitosan–hyaluronic acid nanoparticles loaded with heparin for the treatment of asthma. International Journal of Pharmaceutics, 381(2), 122–129. https://doi.org/10.1016/j.ijpharm.2009.04.009

Conventional spray-drying and future trends for the microencapsulation of fish oil

Trends in Food Science & Technology / Oct 01, 2016

Encina, C., Vergara, C., Giménez, B., Oyarzún-Ampuero, F., & Robert, P. (2016). Conventional spray-drying and future trends for the microencapsulation of fish oil. Trends in Food Science & Technology, 56, 46–60. https://doi.org/10.1016/j.tifs.2016.07.014

Nanoparticles for the Treatment of Wounds

Current Pharmaceutical Design / Oct 07, 2015

Oyarzun-Ampuero, F., Vidal, A., Concha, M., Morales, J., Orellana, S., & Moreno-Villoslada, I. (2015). Nanoparticles for the Treatment of Wounds. Current Pharmaceutical Design, 21(29), 4329–4341. https://doi.org/10.2174/1381612821666150901104601

Hyaluronan nanocapsules as a new vehicle for intracellular drug delivery

European Journal of Pharmaceutical Sciences / Jul 01, 2013

Oyarzun-Ampuero, F. A., Rivera-Rodríguez, G. R., Alonso, M. J., & Torres, D. (2013). Hyaluronan nanocapsules as a new vehicle for intracellular drug delivery. European Journal of Pharmaceutical Sciences, 49(4), 483–490. https://doi.org/10.1016/j.ejps.2013.05.008

Polymeric Nanoparticles for Increasing Oral Bioavailability of Curcumin

Antioxidants / Mar 24, 2018

Umerska, A., Gaucher, C., Oyarzun-Ampuero, F., Fries-Raeth, I., Colin, F., Villamizar-Sarmiento, M., Maincent, P., & Sapin-Minet, A. (2018). Polymeric Nanoparticles for Increasing Oral Bioavailability of Curcumin. Antioxidants, 7(4), 46. https://doi.org/10.3390/antiox7040046

Curcumin-loaded nanoemulsion: a new safe and effective formulation to prevent tumor reincidence and metastasis

Nanoscale / Jan 01, 2018

Guerrero, S., Inostroza-Riquelme, M., Contreras-Orellana, P., Diaz-Garcia, V., Lara, P., Vivanco-Palma, A., Cárdenas, A., Miranda, V., Robert, P., Leyton, L., Kogan, M. J., Quest, A. F. G., & Oyarzun-Ampuero, F. (2018). Curcumin-loaded nanoemulsion: a new safe and effective formulation to prevent tumor reincidence and metastasis. Nanoscale, 10(47), 22612–22622. https://doi.org/10.1039/c8nr06173d

A new drug nanocarrier consisting of polyarginine and hyaluronic acid

European Journal of Pharmaceutics and Biopharmaceutics / Sep 01, 2011

Oyarzun-Ampuero, F. A., Goycoolea, F. M., Torres, D., & Alonso, M. J. (2011). A new drug nanocarrier consisting of polyarginine and hyaluronic acid. European Journal of Pharmaceutics and Biopharmaceutics, 79(1), 54–57. https://doi.org/10.1016/j.ejpb.2011.04.008

Lipid nanoparticles for the topical delivery of retinoids and derivatives

Nanomedicine / Jan 01, 2015

Morales, J. O., Valdés, K., Morales, J., & Oyarzun-Ampuero, F. (2015). Lipid nanoparticles for the topical delivery of retinoids and derivatives. Nanomedicine, 10(2), 253–269. https://doi.org/10.2217/nnm.14.159

Double emulsions as potential fat replacers with gallic acid and quercetin nanoemulsions in the aqueous phases

Food Chemistry / Jul 01, 2018

Silva, W., Torres-Gatica, M. F., Oyarzun-Ampuero, F., Silva-Weiss, A., Robert, P., Cofrades, S., & Giménez, B. (2018). Double emulsions as potential fat replacers with gallic acid and quercetin nanoemulsions in the aqueous phases. Food Chemistry, 253, 71–78. https://doi.org/10.1016/j.foodchem.2018.01.128

Intranasal delivery of interferon-β-loaded nanoparticles induces control of neuroinflammation in a preclinical model of multiple sclerosis: A promising simple, effective, non-invasive, and low-cost therapy

Journal of Controlled Release / Mar 01, 2021

González, L. F., Acuña, E., Arellano, G., Morales, P., Sotomayor, P., Oyarzun-Ampuero, F., & Naves, R. (2021). Intranasal delivery of interferon-β-loaded nanoparticles induces control of neuroinflammation in a preclinical model of multiple sclerosis: A promising simple, effective, non-invasive, and low-cost therapy. Journal of Controlled Release, 331, 443–459. https://doi.org/10.1016/j.jconrel.2020.11.019

Design, development and evaluation of nanoemulsion containing avocado peel extract with anticancer potential: A novel biological active ingredient to enrich food

Food Hydrocolloids / Feb 01, 2021

Cerda-Opazo, P., Gotteland, M., Oyarzun-Ampuero, F. A., & Garcia, L. (2021). Design, development and evaluation of nanoemulsion containing avocado peel extract with anticancer potential: A novel biological active ingredient to enrich food. Food Hydrocolloids, 111, 106370. https://doi.org/10.1016/j.foodhyd.2020.106370

A Simple Mathematical Model for Wound Closure Evaluation

Journal of the American College of Clinical Wound Specialists / Dec 01, 2015

Vidal, A., Mendieta Zerón, H., Giacaman, I., Camarillo Romero, M. del S., López, S. P., Meza Trillo, L. E., Pérez Pérez, D. A., Concha, M., Torres-Gallegos, C., Orellana, S. L., Oyarzun-Ampuero, F., & Moreno-Villoslada, I. (2015). A Simple Mathematical Model for Wound Closure Evaluation. Journal of the American College of Clinical Wound Specialists, 7(1–3), 40–49. https://doi.org/10.1016/j.jccw.2016.07.002

Nanocapsules as Carriers for the Transport and Targeted Delivery of Bioactive Molecules

Nanocomposite Particles for Bio-Applications / Jul 18, 2011

Hervella, P., Lollo, G., Oyarzun-Ampuero, F., Rivera, G., Torres, D., & Alonso, M. (2011). Nanocapsules as Carriers for the Transport and Targeted Delivery of Bioactive Molecules. In Nanocomposite Particles for Bio-Applications (pp. 45–67). Pan Stanford Publishing. https://doi.org/10.1201/b11035-4

Surface-Modified Nanoparticles to Improve Drug Delivery

Dekker Encyclopedia of Nanoscience and Nanotechnology, Third Edition / Oct 21, 2014

Oyarzun-Ampuero, F., Kogan, M. J., Neira-Carrillo, A., & Morales, J. O. (2014). Surface-Modified Nanoparticles to Improve Drug Delivery. In Dekker Encyclopedia of Nanoscience and Nanotechnology, Third Edition (pp. 1–7). Taylor & Francis. https://doi.org/10.1081/e-enn3-120051984

Effect of the incorporation of liposomes loaded with rutin on the transport properties of edible film produced with hydroxypropyl methylcellulose: An in vitro release study

LWT / Jan 01, 2024

Lopez-Polo, J., Soto, A., Zamorano, M., Silva-Weiss, A., Oyarzun-Ampuero, F. A., Brossard, N., Fuentes, J., & Osorio, F. A. (2024). Effect of the incorporation of liposomes loaded with rutin on the transport properties of edible film produced with hydroxypropyl methylcellulose: An in vitro release study. LWT, 191, 115583. https://doi.org/10.1016/j.lwt.2023.115583

Correction to: Microencapsulation of cellular aggregates composed of differentiated insulin and glucagon-producing cells from human mesenchymal stem cells derived from adipose tissue

Diabetology & Metabolic Syndrome / Aug 19, 2020

Jara, C., Oyarzun-Ampuero, F., Carrión, F., González-Echeverría, E., Cappelli, C., & Caviedes, P. (2020). Correction to: Microencapsulation of cellular aggregates composed of differentiated insulin and glucagon-producing cells from human mesenchymal stem cells derived from adipose tissue. Diabetology & Metabolic Syndrome, 12(1). https://doi.org/10.1186/s13098-020-00581-9

Colloidal nanomedicines with prolonged release of chloroquine based on interactions with aromatic polymers after mixing two liquids: from in silico simulation of nanoparticle formation to efficient in-bench scale up

Journal of Molecular Liquids / Feb 01, 2024

Gabriela Villamizar-Sarmiento, M., Yáñez, O., Flores, M. E., Álvarez-Acevedo, G., González-Nilo, F., Guerrero, J., Moreno-Villoslada, I., & Oyarzun-Ampuero, F. A. (2024). Colloidal nanomedicines with prolonged release of chloroquine based on interactions with aromatic polymers after mixing two liquids: from in silico simulation of nanoparticle formation to efficient in-bench scale up. Journal of Molecular Liquids, 395, 123906. https://doi.org/10.1016/j.molliq.2023.123906

Thermosensitive Chitosan Hydrogels: A Potential Strategy for Prolonged Iron Dextran Parenteral Supplementation

Polymers / Dec 31, 2023

Durán, E., Neira-Carrillo, A., Oyarzun-Ampuero, F., & Valenzuela, C. (2023). Thermosensitive Chitosan Hydrogels: A Potential Strategy for Prolonged Iron Dextran Parenteral Supplementation. Polymers, 16(1), 139. https://doi.org/10.3390/polym16010139

Thermosensitive Chitosan Hydrogels as a Vehicle for Iron Dextran as a Potential Strategy for Parenteral Nutrient Supplementation

Nov 08, 2023

Durán, E., Neira-Carrillo, A., Oyarzun-Ampuero, F., & Valenzuela, C. (2023). Thermosensitive Chitosan Hydrogels as a Vehicle for Iron Dextran as a Potential Strategy for Parenteral Nutrient Supplementation. https://doi.org/10.20944/preprints202311.0528.v1

The Critical Role of Aromatic-Aromatic Drug-Polymer Interactions to Provide Nanomedicines Containing Chloroquine: A Simple Proposal to Provide High Encapsulation, High Stability, and Prolonged Drug Release

Nov 12, 2020

Villamizar-Sarmiento, M. G., Moreno-Villoslada, I., & Oyarzun-Ampuero, F. (2020). The Critical Role of Aromatic-Aromatic Drug-Polymer Interactions to Provide Nanomedicines Containing Chloroquine: A Simple Proposal to Provide High Encapsulation, High Stability, and Prolonged Drug Release. https://doi.org/10.21203/rs.3.rs-101145/v1

Microencapsulation of cellular aggregates composed of differentiated insulin and glucagon-producing cells from human mesenchymal stem cells derived from adipose tissue.

Jul 15, 2020

Jara, C., Oyarzun-Ampuero, F., Carrión, F., González-Echeverría, E., Cappelli, C., & Caviedes, P. (2020). Microencapsulation of cellular aggregates composed of differentiated insulin and glucagon-producing cells from human mesenchymal stem cells derived from adipose tissue. https://doi.org/10.21203/rs.3.rs-22053/v2

The Anti-Oxidant Curcumin Solubilized as Oil-in-Water Nanoemulsions or Chitosan Nanocapsules Effectively Reduces Helicobacter pylori Growth, Bacterial Biofilm Formation, Gastric Cell Adhesion and Internalization

Antioxidants / Oct 16, 2023

Hidalgo, A., Bravo, D., Soto, C., Maturana, G., Cordero-Machuca, J., Zúñiga-López, M. C., Oyarzun-Ampuero, F., & Quest, A. F. G. (2023). The Anti-Oxidant Curcumin Solubilized as Oil-in-Water Nanoemulsions or Chitosan Nanocapsules Effectively Reduces Helicobacter pylori Growth, Bacterial Biofilm Formation, Gastric Cell Adhesion and Internalization. Antioxidants, 12(10), 1866. https://doi.org/10.3390/antiox12101866

Development of biodegradable and vermicompostable films based on alginate and waste eggshells

Food Hydrocolloids / Sep 01, 2023

Villanueva, V., Valdés, F., Zúñiga, R. N., Villamizar-Sarmiento, M. G., Soto-Bustamante, E., Romero-Hasler, P., Riveros, A. L., Tapia, J., Lisoni, J., Oyarzun-Ampuero, F., & Valenzuela, C. (2023). Development of biodegradable and vermicompostable films based on alginate and waste eggshells. Food Hydrocolloids, 142, 108813. https://doi.org/10.1016/j.foodhyd.2023.108813

Efficacy of stem cell secretome loaded in hyaluronate sponge for topical treatment of psoriasis

Bioengineering & Translational Medicine / Feb 21, 2023

Carrillo, D., Edwards, N., Arancibia‐Altamirano, D., Otárola, F., Villarroel, C., Prieto, C. P., Villamizar‐Sarmiento, M. G., Sauma, D., Valenzuela, F., Lattus, J., Oyarzun‐Ampuero, F., & Palma, V. (2023). Efficacy of stem cell secretome loaded in hyaluronate sponge for topical treatment of psoriasis. Bioengineering & Translational Medicine, 8(2). Portico. https://doi.org/10.1002/btm2.10443

Encapsulation of house fly larvae (Musca domestica) meal by ionic gelation as a strategy to develop a novel nutritive food ingredient with improved aroma and appearance

LWT / Jun 01, 2022

Sánchez, M., Villamizar-Sarmiento, M. G., Harmsen, I., Valdés, F., Villanueva, V., Ceballos, R., Wacyk, J., Oyarzun-Ampuero, F., & Valenzuela, C. (2022). Encapsulation of house fly larvae (Musca domestica) meal by ionic gelation as a strategy to develop a novel nutritive food ingredient with improved aroma and appearance. LWT, 163, 113597. https://doi.org/10.1016/j.lwt.2022.113597

Influence of the particle size of encapsulated chia oil on the oil release and bioaccessibility during in vitro gastrointestinal digestion

Food & Function / Jan 01, 2022

Álvarez, R., Giménez, B., Mackie, A., Torcello-Gómez, A., Quintriqueo, A., Oyarzun-Ampuero, F., & Robert, P. (2022). Influence of the particle size of encapsulated chia oil on the oil release and bioaccessibility during in vitro gastrointestinal digestion. Food & Function, 13(3), 1370–1379. https://doi.org/10.1039/d1fo03688b

MWCNT‐Organoimido Polyoxomolybdate Hybrid Material: Analytical Applications for Amperometric Sensing of Hydrogen Peroxide

Electroanalysis / May 26, 2021

Mujica, M. L., Sotomayor‐Santander, I., Hermosilla‐Ibáñez, P., Oyarzun‐Ampuero, F., Rodríguez, M. C., Rivas, G. A., Venegas‐Yazigi, D., & Bollo, S. (2021). MWCNT‐Organoimido Polyoxomolybdate Hybrid Material: Analytical Applications for Amperometric Sensing of Hydrogen Peroxide. Electroanalysis, 33(9), 2105–2114. Portico. https://doi.org/10.1002/elan.202100149

The key role of the drug self-aggregation ability to obtain optimal nanocarriers based on aromatic-aromatic drug-polymer interactions

European Journal of Pharmaceutics and Biopharmaceutics / Sep 01, 2021

Villamizar-Sarmiento, M. G., Guerrero, J., Moreno-Villoslada, I., & Oyarzun-Ampuero, F. A. (2021). The key role of the drug self-aggregation ability to obtain optimal nanocarriers based on aromatic-aromatic drug-polymer interactions. European Journal of Pharmaceutics and Biopharmaceutics, 166, 19–29. https://doi.org/10.1016/j.ejpb.2021.05.023

A New Smoothened Antagonist Bearing the Purine Scaffold Shows Antitumour Activity In Vitro and In Vivo

International Journal of Molecular Sciences / Aug 04, 2021

Zárate, A. M., Espinosa-Bustos, C., Guerrero, S., Fierro, A., Oyarzún-Ampuero, F., Quest, A. F. G., Di Marcotullio, L., Loricchio, E., Caimano, M., Calcaterra, A., González-Quiroz, M., Aguirre, A., Meléndez, J., & Salas, C. O. (2021). A New Smoothened Antagonist Bearing the Purine Scaffold Shows Antitumour Activity In Vitro and In Vivo. International Journal of Molecular Sciences, 22(16), 8372. https://doi.org/10.3390/ijms22168372

House fly (Musca domestica) larvae meal as an ingredient with high nutritional value: Microencapsulation and improvement of organoleptic characteristics

Food Research International / Jul 01, 2021

Sánchez, M., Gómez, C., Avendaño, C., Harmsen, I., Ortiz, D., Ceballos, R., Villamizar-Sarmiento, M. G., Oyarzun-Ampuero, F., Wacyk, J., & Valenzuela, C. (2021). House fly (Musca domestica) larvae meal as an ingredient with high nutritional value: Microencapsulation and improvement of organoleptic characteristics. Food Research International, 145, 110423. https://doi.org/10.1016/j.foodres.2021.110423

Microencapsulation of cellular aggregates composed of differentiated insulin and glucagon-producing cells from human mesenchymal stem cells derived from adipose tissue

Diabetology & Metabolic Syndrome / Aug 05, 2020

Jara, C., Oyarzun-Ampuero, F., Carrión, F., González-Echeverría, E., Cappelli, C., & Caviedes, P. (2020). Microencapsulation of cellular aggregates composed of differentiated insulin and glucagon-producing cells from human mesenchymal stem cells derived from adipose tissue. Diabetology & Metabolic Syndrome, 12(1). https://doi.org/10.1186/s13098-020-00573-9

Astaxanthin Counteracts Excitotoxicity and Reduces the Ensuing Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation

Marine Drugs / Jun 26, 2020

García, F., Lobos, P., Ponce, A., Cataldo, K., Meza, D., Farías, P., Estay, C., Oyarzun-Ampuero, F., Herrera-Molina, R., Paula-Lima, A., Ardiles, Á. O., Hidalgo, C., Adasme, T., & Muñoz, P. (2020). Astaxanthin Counteracts Excitotoxicity and Reduces the Ensuing Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation. Marine Drugs, 18(6), 335. https://doi.org/10.3390/md18060335

Encapsulation of Iron Oxide Nanoparticles and Oil-in-Water Nanocarriers in Microgels with Biomedical Potential

Journal of Nanoscience and Nanotechnology / Aug 01, 2019

Álvarez-Acevedo, G., Inostroza-Riquelme, M., Chornik, B., Flores, M., & Oyarzun-Ampuero, F. (2019). Encapsulation of Iron Oxide Nanoparticles and Oil-in-Water Nanocarriers in Microgels with Biomedical Potential. Journal of Nanoscience and Nanotechnology, 19(8), 4938–4945. https://doi.org/10.1166/jnn.2019.16789

A New Methodology to Create Polymeric Nanocarriers Containing Hydrophilic Low Molecular-Weight Drugs: A Green Strategy Providing a Very High Drug Loading

Molecular Pharmaceutics / Jun 03, 2019

Villamizar-Sarmiento, M. G., Molina-Soto, E. F., Guerrero, J., Shibue, T., Nishide, H., Moreno-Villoslada, I., & Oyarzun-Ampuero, F. A. (2019). A New Methodology to Create Polymeric Nanocarriers Containing Hydrophilic Low Molecular-Weight Drugs: A Green Strategy Providing a Very High Drug Loading. Molecular Pharmaceutics, 16(7), 2892–2901. https://doi.org/10.1021/acs.molpharmaceut.9b00097

Ionic Nanocomplexes of Hyaluronic Acid and Polyarginine to Form Solid Materials: A Green Methodology to Obtain Sponges with Biomedical Potential

Nanomaterials / Jun 29, 2019

Villamizar-Sarmiento, M. G., Moreno-Villoslada, I., Martínez, S., Giacaman, A., Miranda, V., Vidal, A., Orellana, S. L., Concha, M., Pavicic, F., Lisoni, J. G., Leyton, L., & Oyarzun-Ampuero, F. A. (2019). Ionic Nanocomplexes of Hyaluronic Acid and Polyarginine to Form Solid Materials: A Green Methodology to Obtain Sponges with Biomedical Potential. Nanomaterials, 9(7), 944. https://doi.org/10.3390/nano9070944

Synthesis of tuneable amphiphilic-modified polyketone polymers, their complexes with 5,10,15,20-tetrakis-(4-sulfonatophenyl)porphyrin, and their role in the photooxidation of 1,3,5-triphenylformazan confined in polymeric nanoparticles

Polymer / Mar 01, 2019

Araya-Hermosilla, E., Roscam Abbing, M., Catalán-Toledo, J., Oyarzun-Ampuero, F., Pucci, A., Raffa, P., Picchioni, F., & Moreno-Villoslada, I. (2019). Synthesis of tuneable amphiphilic-modified polyketone polymers, their complexes with 5,10,15,20-tetrakis-(4-sulfonatophenyl)porphyrin, and their role in the photooxidation of 1,3,5-triphenylformazan confined in polymeric nanoparticles. Polymer, 167, 215–223. https://doi.org/10.1016/j.polymer.2019.01.079

A simple and green methodology to assemble poly(4-vinylpyridine) and a sulfonated azo-dye for obtaining stable polymeric nanoparticles

Polymer / Dec 01, 2018

Catalán-Toledo, J., Nenen, A., Vallejos, G. A., Oyarzun-Ampuero, F., Shibue, T., Nishide, H., & Moreno-Villoslada, I. (2018). A simple and green methodology to assemble poly(4-vinylpyridine) and a sulfonated azo-dye for obtaining stable polymeric nanoparticles. Polymer, 158, 289–296. https://doi.org/10.1016/j.polymer.2018.09.062

Dermal Collagen Stabilization by Polyphenols and Spray Drying as an Encapsulation Strategy

Current Topics in Medicinal Chemistry / Oct 10, 2018

Anazco, C., Rojas, A., Gonzalez, I., Castro, M. A., Robert, P., & Oyarzun-Ampuero, F. (2018). Dermal Collagen Stabilization by Polyphenols and Spray Drying as an Encapsulation Strategy. Current Topics in Medicinal Chemistry, 18(14), 1242–1251. https://doi.org/10.2174/1568026618666180810143730

Protection of astaxanthin from photodegradation by its inclusion in hierarchically assembled nano and microstructures with potential as food

Food Hydrocolloids / Oct 01, 2018

Alarcón-Alarcón, C., Inostroza-Riquelme, M., Torres-Gallegos, C., Araya, C., Miranda, M., Sánchez-Caamaño, J. C., Moreno-Villoslada, I., & Oyarzun-Ampuero, F. A. (2018). Protection of astaxanthin from photodegradation by its inclusion in hierarchically assembled nano and microstructures with potential as food. Food Hydrocolloids, 83, 36–44. https://doi.org/10.1016/j.foodhyd.2018.04.033

Aerogels made of chitosan and chondroitin sulfate at high degree of neutralization: Biological properties toward wound healing

Journal of Biomedical Materials Research Part B: Applied Biomaterials / Feb 09, 2018

Concha, M., Vidal, A., Giacaman, A., Ojeda, J., Pavicic, F., Oyarzun‐Ampuero, F. A., Torres, C., Cabrera, M., Moreno‐Villoslada, I., & Orellana, S. L. (2018). Aerogels made of chitosan and chondroitin sulfate at high degree of neutralization: Biological properties toward wound healing. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 106(6), 2464–2471. Portico. https://doi.org/10.1002/jbm.b.34038

Encapsulation of Gold Nanostructures and Oil-in-Water Nanocarriers in Microgels with Biomedical Potential

Molecules / May 18, 2018

Inostroza-Riquelme, M., Vivanco, A., Lara, P., Guerrero, S., Salas-Huenuleo, E., Chamorro, A., Leyton, L., Bolaños, K., Araya, E., Quest, A., Kogan, M., & Oyarzun-Ampuero, F. (2018). Encapsulation of Gold Nanostructures and Oil-in-Water Nanocarriers in Microgels with Biomedical Potential. Molecules, 23(5), 1208. https://doi.org/10.3390/molecules23051208

Antibacterial activity against Staphylococcus aureus of chitosan/chondroitin sulfate nanocomplex aerogels alone and enriched with erythromycin and elephant garlic (Allium ampeloprasum L. var. ampeloprasum) extract

Pure and Applied Chemistry / Jan 17, 2018

Gómez, M. A., Bonilla, J. M., Coronel, M. A., Martínez, J., Morán-Trujillo, L., Orellana, S. L., Vidal, A., Giacaman, A., Morales, C., Torres-Gallegos, C., Concha, M., Oyarzun-Ampuero, F., Godoy, P., Lisoni, J. G., Henríquez-Báez, C., Bustos, C., & Moreno-Villoslada, I. (2018). Antibacterial activity against Staphylococcus aureus of chitosan/chondroitin sulfate nanocomplex aerogels alone and enriched with erythromycin and elephant garlic (Allium ampeloprasum L. var. ampeloprasum) extract. Pure and Applied Chemistry, 90(5), 885–900. https://doi.org/10.1515/pac-2016-1112

Chitosan/chondroitin sulfate aerogels with high polymeric electroneutralization degree: formation and mechanical properties

Pure and Applied Chemistry / Dec 21, 2017

Orellana, S. L., Giacaman, A., Vidal, A., Morales, C., Oyarzun-Ampuero, F., Lisoni, J. G., Henríquez-Báez, C., Morán-Trujillo, L., Concha, M., & Moreno-Villoslada, I. (2017). Chitosan/chondroitin sulfate aerogels with high polymeric electroneutralization degree: formation and mechanical properties. Pure and Applied Chemistry, 90(5), 901–911. https://doi.org/10.1515/pac-2016-1111

Totally Organic Redox-Active pH-Sensitive Nanoparticles Stabilized by Amphiphilic Aromatic Polyketones

The Journal of Physical Chemistry B / Jan 29, 2018

Araya-Hermosilla, E., Catalán-Toledo, J., Muñoz-Suescun, F., Oyarzun-Ampuero, F., Raffa, P., Polgar, L. M., Picchioni, F., & Moreno-Villoslada, I. (2018). Totally Organic Redox-Active pH-Sensitive Nanoparticles Stabilized by Amphiphilic Aromatic Polyketones. The Journal of Physical Chemistry B, 122(5), 1747–1755. https://doi.org/10.1021/acs.jpcb.7b11254

Aerogels containing 5,10,15,20-tetrakis-(4-sulfonatophenyl)-porphyrin with controlled state of aggregation

Dyes and Pigments / Apr 01, 2017

Pino-Pinto, J. P., Oyarzun-Ampuero, F., Orellana, S. L., Flores, M. E., Nishide, H., & Moreno-Villoslada, I. (2017). Aerogels containing 5,10,15,20-tetrakis-(4-sulfonatophenyl)-porphyrin with controlled state of aggregation. Dyes and Pigments, 139, 193–200. https://doi.org/10.1016/j.dyepig.2016.12.005

Gastric Cancer: Nanoparticles as Tools to Improve Treatment Efficacy

Current Pharmaceutical Design / Dec 14, 2016

Guerrero, A., Oyarzun-Ampuero, F., Hassan, N., Corvalán, A., Quest, A., Kogan, M., & Kogan, M. (2016). Gastric Cancer: Nanoparticles as Tools to Improve Treatment Efficacy. Current Pharmaceutical Design, 22(39), 5988–5997. https://doi.org/10.2174/1381612822666160712165409

Facile Formation of Redox‐Active Totally Organic Nanoparticles in Water by In Situ Reduction of Organic Precursors Stabilized through Aromatic–Aromatic Interactions by Aromatic Polyelectrolytes

Macromolecular Rapid Communications / Sep 12, 2016

Flores, M. E., Garcés‐Jerez, P., Fernández, D., Aros‐Perez, G., González‐Cabrera, D., Álvarez, E., Cañas, I., Oyarzun‐Ampuero, F., & Moreno‐Villoslada, I. (2016). Facile Formation of Redox‐Active Totally Organic Nanoparticles in Water by In Situ Reduction of Organic Precursors Stabilized through Aromatic–Aromatic Interactions by Aromatic Polyelectrolytes. Macromolecular Rapid Communications, 37(21), 1729–1734. Portico. https://doi.org/10.1002/marc.201600339

Photochromic Solid Materials Based on Poly(decylviologen) Complexed with Alginate and Poly(sodium 4-styrenesulfonate)

The Journal of Physical Chemistry B / Oct 06, 2015

Sanhueza, L., Castro, J., Urzúa, E., Barrientos, L., Oyarzun-Ampuero, F., Pesenti, H., Shibue, T., Sugimura, N., Tomita, W., Nishide, H., & Moreno-Villoslada, I. (2015). Photochromic Solid Materials Based on Poly(decylviologen) Complexed with Alginate and Poly(sodium 4-styrenesulfonate). The Journal of Physical Chemistry B, 119(41), 13208–13217. https://doi.org/10.1021/acs.jpcb.5b05963

Novel Nanostructured Polymeric Carriers to Enable Drug Delivery for Cardiovascular Diseases

Current Pharmaceutical Design / Oct 07, 2015

Morales, J., Sepulveda-Rivas, S., Oyarzun-Ampuero, F., Lavandero, S., & Kogan, M. (2015). Novel Nanostructured Polymeric Carriers to Enable Drug Delivery for Cardiovascular Diseases. Current Pharmaceutical Design, 21(29), 4276–4284. https://doi.org/10.2174/1381612821666150901103556

Organic and Inorganic Nanoparticles for Prevention and Diagnosis of Gastric Cancer

Current Pharmaceutical Design / Oct 07, 2015

Oyarzun-Ampuero, F., Guerrero, A., Hassan-Lopez, N., Morales, J., Bollo, S., Corvalan, A., Quest, A., & Kogan, M. (2015). Organic and Inorganic Nanoparticles for Prevention and Diagnosis of Gastric Cancer. Current Pharmaceutical Design, 21(29), 4145–4154. https://doi.org/10.2174/1381612821666150901095538

Association Efficiency of Three Ionic Forms of Oxytetracycline to Cationic and Anionic Oil-In-Water Nanoemulsions Analyzed by Diafiltration

Journal of Pharmaceutical Sciences / Mar 01, 2015

Orellana, S. L., Torres-Gallegos, C., Araya-Hermosilla, R., Oyarzun-Ampuero, F., & Moreno-Villoslada, I. (2015). Association Efficiency of Three Ionic Forms of Oxytetracycline to Cationic and Anionic Oil-In-Water Nanoemulsions Analyzed by Diafiltration. Journal of Pharmaceutical Sciences, 104(3), 1141–1152. https://doi.org/10.1002/jps.24255

Immobilization of rhodamine 6G in calcium alginate microcapsules based on aromatic–aromatic interactions with poly(sodium 4-styrenesulfonate)

Reactive and Functional Polymers / Aug 01, 2014

Araya-Hermosilla, E., Muñoz, D., Orellana, S., Yáñez, A., Olea, A. F., Oyarzun-Ampuero, F., & Moreno-Villoslada, I. (2014). Immobilization of rhodamine 6G in calcium alginate microcapsules based on aromatic–aromatic interactions with poly(sodium 4-styrenesulfonate). Reactive and Functional Polymers, 81, 14–21. https://doi.org/10.1016/j.reactfunctpolym.2014.03.017

Flow Chemistry to Control the Synthesis of Nano and Microparticles for Biomedical Applications

Current Topics in Medicinal Chemistry / Feb 01, 2014

Hassan, N., Oyarzun-Ampuero, F., Lara, P., Guerrero, S., Cabuil, V., Abou-Hassan, A., & Kogan, M. (2014). Flow Chemistry to Control the Synthesis of Nano and Microparticles for Biomedical Applications. Current Topics in Medicinal Chemistry, 14(5), 676–689. https://doi.org/10.2174/1568026614666140118213915

Therapeutic Potential of a Low-Cost Device for Wound Healing

American Journal of Therapeutics / Jul 01, 2013

Vidal, A., Giacaman, A., Oyarzun-Ampuero, F. A., Orellana, S., Aburto, I., Pavicic, M. F., Sánchez, A., López, C., Morales, C., Caro, M., Moreno-Villoslada, I., & Concha, M. (2013). Therapeutic Potential of a Low-Cost Device for Wound Healing: A Study of Three Cases of Healing After Lower-Extremity Amputation in Patients With Diabetes. American Journal of Therapeutics, 20(4), 394–398. https://doi.org/10.1097/mjt.0b013e318235f309

A Potential Nanomedicine Consisting of Heparin‐Loaded Polysaccharide Nanocarriers for the Treatment of Asthma

Macromolecular Bioscience / Nov 23, 2011

Oyarzun‐Ampuero, F. A., Brea, J., Loza, M. I., Alonso, M. J., & Torres, D. (2011). A Potential Nanomedicine Consisting of Heparin‐Loaded Polysaccharide Nanocarriers for the Treatment of Asthma. Macromolecular Bioscience, 12(2), 176–183. Portico. https://doi.org/10.1002/mabi.201100102

Chitosan-coated lipid nanocarriers for therapeutic applications

Journal of Drug Delivery Science and Technology / Jan 01, 2010

Oyarzun-Ampuero, F. A., Garcia-Fuentes, M., Torres, D., & Alonso, M. J. (2010). Chitosan-coated lipid nanocarriers for therapeutic applications. Journal of Drug Delivery Science and Technology, 20(4), 259–265. https://doi.org/10.1016/s1773-2247(10)50043-1

Binding of chlorpheniramine maleate to pharmacologically important alginic acid, carboxymethylcellulose, κ‐carageenan, and ι‐carrageenan as studied by diafiltration

Journal of Applied Polymer Science / Jul 26, 2005

Moreno‐Villoslada, I., Oyarzún, F., Miranda, V., Hess, S., & Rivas, B. L. (2005). Binding of chlorpheniramine maleate to pharmacologically important alginic acid, carboxymethylcellulose, κ‐carageenan, and ι‐carrageenan as studied by diafiltration. Journal of Applied Polymer Science, 98(2), 598–602. Portico. https://doi.org/10.1002/app.22056

Comparison between the binding of chlorpheniramine maleate to poly(sodium 4-styrenesulfonate) and the binding to other polyelectrolytes

Polymer / Aug 01, 2005

Moreno-Villoslada, I., Oyarzún, F., Miranda, V., Hess, S., & Rivas, B. L. (2005). Comparison between the binding of chlorpheniramine maleate to poly(sodium 4-styrenesulfonate) and the binding to other polyelectrolytes. Polymer, 46(18), 7240–7245. https://doi.org/10.1016/j.polymer.2005.06.033

USE OF ULTRAFILTRATION ON THE EVALUATION AND QUANTIFICATION OF THE INTERACTIONS BETWEEN POLYMERS AND LOW MOLECULAR-WEIGHT MOLECULES IN AQUEOUS SOLUTIONS

Journal of the Chilean Chemical Society / Jun 01, 2004

Moreno-Villoslada, I., Miranda, V., Oyarzún, F., Hess, S., Luna, M., & Rivas, B. L. (2004). USE OF ULTRAFILTRATION ON THE EVALUATION AND QUANTIFICATION OF THE INTERACTIONS BETWEEN POLYMERS AND LOW MOLECULAR-WEIGHT MOLECULES IN AQUEOUS SOLUTIONS. Journal of the Chilean Chemical Society, 49(2). https://doi.org/10.4067/s0717-97072004000200003

Education

Austral University of Chile

Postdoc, Faculty of Medicine / January, 2013

Valdivia

University of Santiago de Compostela

Ph.D., Department of Pharmacy / November, 2011

Santiago de Compostela

Austral University of Chile

Pharmacist, Department of Pharmacy / March, 2004

Valdivia

Experience

University of Chile

Director / January, 2021Present

Associate Professor / January, 2016Present

Assistant Professor / January, 2013January, 2016

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