Tshering Lama-Sherpa
Postdoctoral Fellow at UT Southwestern Medical Center with over 10 years of experience in cancer research.
Research Interests
About
Publications
Adipocyte-Lineage Cells Support Growth and Dissemination of Multiple Myeloma in Bone
The American Journal of Pathology / Nov 01, 2016
Trotter, T. N., Gibson, J. T., Sherpa, T. L., Gowda, P. S., Peker, D., & Yang, Y. (2016). Adipocyte-Lineage Cells Support Growth and Dissemination of Multiple Myeloma in Bone. The American Journal of Pathology, 186(11), 3054–3063. https://doi.org/10.1016/j.ajpath.2016.07.012
Hedgehog Signaling Regulates Metabolism and Polarization of Mammary Tumor-Associated Macrophages
Cancer Research / Jul 21, 2021
Hinshaw, D. C., Hanna, A., Lama-Sherpa, T., Metge, B., Kammerud, S. C., Benavides, G. A., Kumar, A., Alsheikh, H. A., Mota, M., Chen, D., Ballinger, S. W., Rathmell, J. C., Ponnazhagan, S., Darley-Usmar, V., Samant, R. S., & Shevde, L. A. (2021). Hedgehog Signaling Regulates Metabolism and Polarization of Mammary Tumor-Associated Macrophages. Cancer Research, 81(21), 5425–5437. https://doi.org/10.1158/0008-5472.can-20-1723
An Emerging Regulatory Role for the Tumor Microenvironment in the DNA Damage Response to Double-Strand Breaks
Molecular Cancer Research / Feb 01, 2020
Lama-Sherpa, T. D., & Shevde, L. A. (2020). An Emerging Regulatory Role for the Tumor Microenvironment in the DNA Damage Response to Double-Strand Breaks. Molecular Cancer Research, 18(2), 185–193. https://doi.org/10.1158/1541-7786.mcr-19-0665
AKAP13 couples GPCR signaling to mTORC1 inhibition
PLOS Genetics / Oct 21, 2021
Zhang, S., Wang, H., Melick, C. H., Jeong, M.-H., Curukovic, A., Tiwary, S., Lama-Sherpa, T. D., Meng, D., Servage, K. A., James, N. G., & Jewell, J. L. (2021). AKAP13 couples GPCR signaling to mTORC1 inhibition. PLOS Genetics, 17(10), e1009832. https://doi.org/10.1371/journal.pgen.1009832
Normalizing glucose levels reconfigures the mammary tumor immune and metabolic microenvironment and decreases metastatic seeding
Cancer Letters / Oct 01, 2021
Alsheikh, H. A. M., Metge, B. J., Ha, C., Hinshaw, D. C., Mota, M. S. V., Kammerud, S. C., Lama-Sherpa, T., Sharafeldin, N., Wende, A. R., Samant, R. S., & Shevde, L. A. (2021). Normalizing glucose levels reconfigures the mammary tumor immune and metabolic microenvironment and decreases metastatic seeding. Cancer Letters, 517, 24–34. https://doi.org/10.1016/j.canlet.2021.05.022
Regulation of mTORC1 by the Rag GTPases
Biochemical Society Transactions / Mar 16, 2023
Lama-Sherpa, T. D., Jeong, M.-H., & Jewell, J. L. (2023). Regulation of mTORC1 by the Rag GTPases. Biochemical Society Transactions, 51(2), 655–664. https://doi.org/10.1042/bst20210038
SNAT7 regulates mTORC1 via macropinocytosis
Proceedings of the National Academy of Sciences / May 13, 2022
Meng, D., Yang, Q., Jeong, M.-H., Curukovic, A., Tiwary, S., Melick, C. H., Lama-Sherpa, T. D., Wang, H., Huerta-Rosario, M., Urquhart, G., Zacharias, L. G., Lewis, C., DeBerardinis, R. J., & Jewell, J. L. (2022). SNAT7 regulates mTORC1 via macropinocytosis. Proceedings of the National Academy of Sciences, 119(20). https://doi.org/10.1073/pnas.2123261119
Hedgehog signaling enables repair of ribosomal DNA double-strand breaks
Nucleic Acids Research / Sep 07, 2020
Lama-Sherpa, T. D., Lin, V. T. G., Metge, B. J., Weeks, S. E., Chen, D., Samant, R. S., & Shevde, L. A. (2020). Hedgehog signaling enables repair of ribosomal DNA double-strand breaks. Nucleic Acids Research, 48(18), 10342–10352. https://doi.org/10.1093/nar/gkaa733
Quantitative Longitudinal Imaging Reveals that Inhibiting Hedgehog Activity Alleviates the Hypoxic Tumor Landscape
Molecular Cancer Research / Sep 30, 2021
Lama-Sherpa, T. D., Das, S., Hinshaw, D. C., Kammerud, S. C., Song, P. N., Alsheikh, H. A., Sorace, A. G., Samant, R. S., & Shevde, L. A. (2021). Quantitative Longitudinal Imaging Reveals that Inhibiting Hedgehog Activity Alleviates the Hypoxic Tumor Landscape. Molecular Cancer Research, 20(1), 150–160. https://doi.org/10.1158/1541-7786.mcr-21-0257
Curcumin/cellulose micro crystals/chitosan films: Water absorption behavior and in vitro cytotoxicity
International Journal of Biological Macromolecules / Apr 01, 2015
Bajpai, S. K., Chand, N., Ahuja, S., & Roy, M. K. (2015). Curcumin/cellulose micro crystals/chitosan films: Water absorption behavior and in vitro cytotoxicity. International Journal of Biological Macromolecules, 75, 239–247. https://doi.org/10.1016/j.ijbiomac.2015.01.038
Abstract 115: Hedgehog signaling pathway promotes breast cancer adaptation to hypoxia
Cancer Research / Aug 15, 2020
Lama-Sherpa, T. D., Kammerud, S. C., & Shevde, L. A. (2020). Abstract 115: Hedgehog signaling pathway promotes breast cancer adaptation to hypoxia. Cancer Research, 80(16_Supplement), 115–115. https://doi.org/10.1158/1538-7445.am2020-115
Hedgehog Signaling in Carcinogenesis
Predictive Biomarkers in Oncology / Dec 07, 2018
Lin, V. T. G., Lama-Sherpa, T. D., & Shevde, L. A. (2018). Hedgehog Signaling in Carcinogenesis. In Predictive Biomarkers in Oncology (pp. 297–304). Springer International Publishing. https://doi.org/10.1007/978-3-319-95228-4_24
The Role of Adipocyte Lineage Cells in Myeloma Growth and Dissemination in Bone
Blood / Dec 03, 2015
Trotter, T. N., Lama-Sherpa, T. D., Peker, D., Javed, A., Suva, L. J., & Yang, Y. (2015). The Role of Adipocyte Lineage Cells in Myeloma Growth and Dissemination in Bone. Blood, 126(23), 1797–1797. https://doi.org/10.1182/blood.v126.23.1797.1797
Abstract 2103: Hedgehog signaling regulates metabolism and polarization of mammary tumor-associated macrophages
Cancer Research / Jun 15, 2022
Hinshaw, D. C., Hanna, A., Lama-Sherpa, T., Metge, B., Kammerud, S. C., Benavides, G. A., Kumar, A., Alsheikh, H. A., Mota, M., Chen, D., Ballinger, S., Rathmell, J. C., Ponnazhagan, S., Darley-Usmar, V., Samant, R. S., & Shevde, L. A. (2022). Abstract 2103: Hedgehog signaling regulates metabolism and polarization of mammary tumor-associated macrophages. Cancer Research, 82(12_Supplement), 2103–2103. https://doi.org/10.1158/1538-7445.am2022-2103
Hedgehog signaling induced metabolic reprogramming is essential for M2 polarization of macrophages in breast cancer
The Journal of Immunology / May 01, 2020
Hinshaw, D. C., Hanna, A., Sherpa, T., Samant, R., & Shevde, L. (2020). Hedgehog signaling induced metabolic reprogramming is essential for M2 polarization of macrophages in breast cancer. The Journal of Immunology, 204(1_Supplement), 164.16-164.16. https://doi.org/10.4049/jimmunol.204.supp.164.16
Abstract P3-01-25: Hedgehog signaling-mediated adaptation to hypoxic microenvironment promotes osteoclastogenesis in advanced breast cancer
Cancer Research / Feb 15, 2020
Lama-Sherpa, T. D., Das, S., Hanna, A., Kammerud, S., & Shevde, L. A. (2020). Abstract P3-01-25: Hedgehog signaling-mediated adaptation to hypoxic microenvironment promotes osteoclastogenesis in advanced breast cancer. Cancer Research, 80(4_Supplement), P3-01-25-P3-01–25. https://doi.org/10.1158/1538-7445.sabcs19-p3-01-25
Abstract P3-01-25: Hedgehog signaling-mediated adaptation to hypoxic microenvironment promotes osteoclastogenesis in advanced breast cancer
Cancer Research / Feb 15, 2020
Lama-Sherpa, T. D., Das, S., Hanna, A., Kammerud, S., & Shevde, L. A. (2020). Abstract P3-01-25: Hedgehog signaling-mediated adaptation to hypoxic microenvironment promotes osteoclastogenesis in advanced breast cancer. Cancer Research, 80(4_Supplement), P3-01-25-P3-01–25. https://doi.org/10.1158/1538-7445.sabcs19-p3-01-25
Abstract 3740: Ionizing radiation-induced transcriptomic changes in triple-negative breast cancer cells reveal putative mechanisms of treatment resistance
Cancer Research / Jul 01, 2019
Lin, V. T., Lama-Sherpa, T. D., Samant, R. S., & Shevde, L. A. (2019). Abstract 3740: Ionizing radiation-induced transcriptomic changes in triple-negative breast cancer cells reveal putative mechanisms of treatment resistance. Cancer Research, 79(13_Supplement), 3740–3740. https://doi.org/10.1158/1538-7445.am2019-3740
1H NMR spectral analysis as a new aspect to evaluate the stability of some edible oils
Annals of Agricultural Sciences / Dec 01, 2014
Almoselhy, R. I. M., Allam, M. H., El-Kalyoubi, M. H., & El-Sharkawy, A. A. (2014). 1H NMR spectral analysis as a new aspect to evaluate the stability of some edible oils. Annals of Agricultural Sciences, 59(2), 201–206. https://doi.org/10.1016/j.aoas.2014.11.006
Reversible Modulation of Myofibroblast Differentiation in Adipose-Derived Mesenchymal Stem Cells
PLoS ONE / Jan 23, 2014
Desai, V. D., Hsia, H. C., & Schwarzbauer, J. E. (2014). Reversible Modulation of Myofibroblast Differentiation in Adipose-Derived Mesenchymal Stem Cells. PLoS ONE, 9(1), e86865. https://doi.org/10.1371/journal.pone.0086865
Ubiquitin-Dependent Protein Degradation
Reference Module in Chemistry, Molecular Sciences and Chemical Engineering / Jan 01, 2013
Hegde, A. N. (2013). Ubiquitin-Dependent Protein Degradation. In Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Elsevier. https://doi.org/10.1016/b978-0-12-409547-2.02826-2
Amyloid Formation and Polymerization-dependent Inactivation of the Yeast Prion Protein, Ure2p
GBM Annual Spring meeting Mosbach 2005 / Apr 01, 2005
Steven, A. (2005). Amyloid Formation and Polymerization-dependent Inactivation of the Yeast Prion Protein, Ure2p. GBM Annual Spring Meeting Mosbach 2005, 2005(Spring). https://doi.org/10.1240/sav_gbm_2005_m_001086
Education
Mississippi University for Women
Bachelor of Science in Biology, Science and Mathematics / May, 2014
University of Alabama at Birmingham
Ph.D., Molecular biology, Genetics, Biochemistry, Cancer Biology / December, 2020
Mississippi University for Women
Bachelor of Science in Biology, Science and Mathematics / May, 2014
Experience
University of Texas Southwestern Medical Center
Postdoctoral Researcher / February, 2021 — Present
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