Ashley Sproles
Senior scientist at a biotechnology company with publications on marine biology and genetic engineering
Research Expertise
Publications
Recent advancements in the genetic engineering of microalgae
Algal Research / Mar 01, 2021
Sproles, A. E., Fields, F. J., Smalley, T. N., Le, C. H., Badary, A., & Mayfield, S. P. (2021). Recent advancements in the genetic engineering of microalgae. Algal Research, 53, 102158. https://doi.org/10.1016/j.algal.2020.102158
Menthol-induced bleaching rapidly and effectively provides experimental aposymbiotic sea anemones (Aiptasiasp.) for symbiosis investigations
Journal of Experimental Biology / Jan 01, 2015
Matthews, J. L., Sproles, A. E., Oakley, C. A., Grossman, A. R., Weis, V. M., & Davy, S. K. (2015). Menthol-induced bleaching rapidly and effectively provides experimental aposymbiotic sea anemones (Aiptasiasp.) for symbiosis investigations. Journal of Experimental Biology. https://doi.org/10.1242/jeb.128934
Proteomics quantifies protein expression changes in a model cnidarian colonised by a thermally tolerant but suboptimal symbiont
The ISME Journal / May 22, 2019
Sproles, A. E., Oakley, C. A., Matthews, J. L., Peng, L., Owen, J. G., Grossman, A. R., Weis, V. M., & Davy, S. K. (2019). Proteomics quantifies protein expression changes in a model cnidarian colonised by a thermally tolerant but suboptimal symbiont. The ISME Journal, 13(9), 2334–2345. https://doi.org/10.1038/s41396-019-0437-5
Phylogenetic characterization of transporter proteins in the cnidarian-dinoflagellate symbiosis
Molecular Phylogenetics and Evolution / Mar 01, 2018
Sproles, A. E., Kirk, N. L., Kitchen, S. A., Oakley, C. A., Grossman, A. R., Weis, V. M., & Davy, S. K. (2018). Phylogenetic characterization of transporter proteins in the cnidarian-dinoflagellate symbiosis. Molecular Phylogenetics and Evolution, 120, 307–320. https://doi.org/10.1016/j.ympev.2017.12.007
Recombinant production of a functional SARS-CoV-2 spike receptor binding domain in the green algae Chlamydomonas reinhardtii
PLOS ONE / Nov 18, 2021
Berndt, A. J., Smalley, T. N., Ren, B., Simkovsky, R., Badary, A., Sproles, A. E., Fields, F. J., Torres-Tiji, Y., Heredia, V., & Mayfield, S. P. (2021). Recombinant production of a functional SARS-CoV-2 spike receptor binding domain in the green algae Chlamydomonas reinhardtii. PLOS ONE, 16(11), e0257089. https://doi.org/10.1371/journal.pone.0257089
Seasonal stability of coral-Symbiodinium associations in the subtropical coral habitat of St. Lucie Reef, Florida
Marine Ecology Progress Series / Jul 21, 2015
Klepac, C., Beal, J., Kenkel, C., Sproles, A., Polinski, J., Williams, M., Matz, M., & Voss, J. (2015). Seasonal stability of coral-Symbiodinium associations in the subtropical coral habitat of St. Lucie Reef, Florida. Marine Ecology Progress Series, 532, 137–151. https://doi.org/10.3354/meps11369
Sub‐cellular imaging shows reduced photosynthetic carbon and increased nitrogen assimilation by the non‐native endosymbiont Durusdinium trenchii in the model cnidarian Aiptasia
Environmental Microbiology / Jul 21, 2020
Sproles, A. E., Oakley, C. A., Krueger, T., Grossman, A. R., Weis, V. M., Meibom, A., & Davy, S. K. (2020). Sub‐cellular imaging shows reduced photosynthetic carbon and increased nitrogen assimilation by the non‐native endosymbiont Durusdinium trenchii in the model cnidarian Aiptasia. Environmental Microbiology, 22(9), 3741–3753. Portico. https://doi.org/10.1111/1462-2920.15142
Improved high-throughput screening technique to rapidly isolate Chlamydomonas transformants expressing recombinant proteins
Applied Microbiology and Biotechnology / Feb 01, 2022
Sproles, A. E., Berndt, A., Fields, F. J., & Mayfield, S. P. (2022). Improved high-throughput screening technique to rapidly isolate Chlamydomonas transformants expressing recombinant proteins. Applied Microbiology and Biotechnology, 106(4), 1677–1689. https://doi.org/10.1007/s00253-022-11790-9
Novel cis-regulatory elements as synthetic promoters to drive recombinant protein expression from the Chlamydomonas reinhardtii nuclear genome
New Biotechnology / May 01, 2022
McQuillan, J. L., Berndt, A. J., Sproles, A. E., Mayfield, S. P., & Pandhal, J. (2022). Novel cis-regulatory elements as synthetic promoters to drive recombinant protein expression from the Chlamydomonas reinhardtii nuclear genome. New Biotechnology, 68, 9–18. https://doi.org/10.1016/j.nbt.2022.01.001
Nutritional Interactions in the Cnidarian-Dinoflagellate Symbiosis and their Role in Symbiosis Establishment
Sproles, A. (n.d.). Nutritional Interactions in the Cnidarian-Dinoflagellate Symbiosis and their Role in Symbiosis Establishment [Victoria University of Wellington Library]. https://doi.org/10.26686/wgtn.20409396
Education
Victoria University of Wellington
PhD, Marine Biology, Biological Sciences / December, 2017
Florida Institute of Technology
BSc, Marine Biology/Conservation Biology & Ecology, Biological Sciences / December, 2012
Experience
University of California San Diego
Postdoctoral Scholar / July, 2018 — Present
Development of genetic tools for engineering of microalgae for sustainable bioproducts
Molecular Assemblies, Inc.
Senior Scientist / May, 2021 — Present
Molecular Biology; Protein Engineering; DNA synthesis; Enzymology
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