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Garrett A. Perchetti, Research Scientist - Virology

Research Scientist and MD Candidate in virology with publications on infectious diseases, laboratory medicine, viral genetics, and clinical medicine

New York

Research Interests

Virology
Microbiology
Infectious Diseases
SARS-CoV-2
COVID-19
Microbiology (medical)
Biochemistry (medical)
Clinical Biochemistry
Molecular Medicine
Immunology and Allergy
Pulmonary and Respiratory Medicine
Transplantation
Hematology
Pediatrics, Perinatology and Child Health
Oncology

About

Garrett A. Perchetti is a highly accomplished research scientist in the field of virology. He received a Bachelor of Science in Microbiology and a Bachelor of Arts in Art History from the University of Washington. His interest in both science and the arts led him to pursue a career in virology, where he could combine his passion for understanding the natural world with his creative thinking skills. After completing his undergraduate studies, Garrett continued his education by earning a Medical Degree from Ross University School of Medicine in 2025. During his time in medical school, he developed a keen interest in virology and infectious diseases, which ultimately led him to specialize in this field. Garrett's educational background is complemented by his extensive experience as a research scientist. He has worked at the University of Washington School of Medicine, where he has conducted groundbreaking research on various types of viruses. His work has been published in numerous scientific journals, and he has presented his findings at international conferences. Garrett's contributions to the field of virology have been widely recognized, and he has received several awards and accolades for his work. He is known for his meticulous attention to detail, innovative thinking, and ability to collaborate effectively with other researchers. In his free time, Garrett enjoys painting, hiking, and traveling. He is also passionate about raising awareness about the importance of vaccinations and promoting public health initiatives. With his exceptional education and extensive experience, Garrett A. Perchetti is a valuable asset to the field of virology and will continue to make significant contributions in the future.

Publications

Comparative Performance of SARS-CoV-2 Detection Assays using Seven Different Primer/Probe Sets and One Assay Kit

Mar 17, 2020

Casto, A. M., Huang, M.-L., Nalla, A., Perchetti, G., Sampoleo, R., Shrestha, L., Wei, Y., Zhu, H., Greninger, A. L., & Jerome, K. R. (2020). Comparative Performance of SARS-CoV-2 Detection Assays using Seven Different Primer/Probe Sets and One Assay Kit. https://doi.org/10.1101/2020.03.13.20035618

Direct RT-qPCR detection of SARS-CoV-2 RNA from patient nasopharyngeal swabs without an RNA extraction step

PLOS Biology / Oct 02, 2020

Bruce, E. A., Huang, M.-L., Perchetti, G. A., Tighe, S., Laaguiby, P., Hoffman, J. J., Gerrard, D. L., Nalla, A. K., Wei, Y., Greninger, A. L., Diehl, S. A., Shirley, D. J., Leonard, D. G. B., Huston, C. D., Kirkpatrick, B. D., Dragon, J. A., Crothers, J. W., Jerome, K. R., & Botten, J. W. (2020). Direct RT-qPCR detection of SARS-CoV-2 RNA from patient nasopharyngeal swabs without an RNA extraction step. PLOS Biology, 18(10), e3000896. https://doi.org/10.1371/journal.pbio.3000896

Analytical Sensitivity of the Abbott BinaxNOW COVID-19 Ag Card

Journal of Clinical Microbiology / Feb 18, 2021

Perchetti, G. A., Huang, M.-L., Mills, M. G., Jerome, K. R., & Greninger, A. L. (2021). Analytical Sensitivity of the Abbott BinaxNOW COVID-19 Ag Card. Journal of Clinical Microbiology, 59(3). https://doi.org/10.1128/jcm.02880-20

Validation of SARS-CoV-2 detection across multiple specimen types

Journal of Clinical Virology / Jul 01, 2020

Perchetti, G. A., Nalla, A. K., Huang, M.-L., Zhu, H., Wei, Y., Stensland, L., Loprieno, M. A., Jerome, K. R., & Greninger, A. L. (2020). Validation of SARS-CoV-2 detection across multiple specimen types. Journal of Clinical Virology, 128, 104438. https://doi.org/10.1016/j.jcv.2020.104438

Predicting infectivity: comparing four PCR‐based assays to detect culturable SARS‐CoV‐2 in clinical samples

EMBO Molecular Medicine / Dec 13, 2021

Bruce, E. A., Mills, M. G., Sampoleo, R., Perchetti, G. A., Huang, M., Despres, H. W., Schmidt, M. M., Roychoudhury, P., Shirley, D. J., Jerome, K. R., Greninger, A. L., & Botten, J. W. (2021). Predicting infectivity: comparing four PCR‐based assays to detect culturable SARS‐CoV‐2 in clinical samples. EMBO Molecular Medicine, 14(2). Portico. https://doi.org/10.15252/emmm.202115290

20. Risk Factors for Breakthrough Cytomegalovirus (CMV) Infection and De Novo Resistance in Hematopoietic Cell Transplantation (HCT) Recipients Receiving Letermovir Prophylaxis

Open Forum Infectious Diseases / Nov 01, 2021

Zamora, D., Perchetti, G., Biernacki, M., Xie, H., Castor, J. L., Joncas-schronce, L., Blazevic, R., Leisenring, W., Huang, M.-L., Jerome, K., Martin, P. J., Boeckh, M., & Greninger, A. L. (2021). 20. Risk Factors for Breakthrough Cytomegalovirus (CMV) Infection and De Novo Resistance in Hematopoietic Cell Transplantation (HCT) Recipients Receiving Letermovir Prophylaxis. Open Forum Infectious Diseases, 8(Supplement_1), S13–S14. https://doi.org/10.1093/ofid/ofab466.020

Positive selection underlies repeated knockout of ORF8 in SARS-CoV-2 evolution

Nature Communications / Apr 13, 2024

Wagner, C., Kistler, K. E., Perchetti, G. A., Baker, N., Frisbie, L. A., Torres, L. M., Aragona, F., Yun, C., Figgins, M., Greninger, A. L., Cox, A., Oltean, H. N., Roychoudhury, P., & Bedford, T. (2024). Positive selection underlies repeated knockout of ORF8 in SARS-CoV-2 evolution. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-47599-5

Positive selection underlies repeated knockout of ORF8 in SARS-CoV-2 evolution

Sep 23, 2023

Wagner, C., Kistler, K. E., Perchetti, G. A., Baker, N., Frisbie, L. A., Torres, L. M., Aragona, F., Yun, C., Figgins, M., Greninger, A. L., Cox, A., Oltean, H. N., Roychoudhury, P., & Bedford, T. (2023). Positive selection underlies repeated knockout of ORF8 in SARS-CoV-2 evolution. https://doi.org/10.1101/2023.09.21.23295927

Cytomegalovirus breakthrough and resistance during letermovir prophylaxis

Bone Marrow Transplantation / Jan 24, 2023

Perchetti, G. A., Biernacki, M. A., Xie, H., Castor, J., Joncas-Schronce, L., Ueda Oshima, M., Kim, Y., Jerome, K. R., Sandmaier, B. M., Martin, P. J., Boeckh, M., Greninger, A. L., & Zamora, D. (2023). Cytomegalovirus breakthrough and resistance during letermovir prophylaxis. Bone Marrow Transplantation, 58(4), 430–436. https://doi.org/10.1038/s41409-023-01920-w

Rapid and accurate identification of SARS-CoV-2 Omicron variants using droplet digital PCR (RT-ddPCR)

Journal of Clinical Virology / Sep 01, 2022

Mills, M. G., Hajian, P., Bakhash, S. M., Xie, H., Mantzke, D., Zhu, H., Perchetti, G. A., Huang, M.-L., Pepper, G., Jerome, K. R., Roychoudhury, P., & Greninger, A. L. (2022). Rapid and accurate identification of SARS-CoV-2 Omicron variants using droplet digital PCR (RT-ddPCR). Journal of Clinical Virology, 154, 105218. https://doi.org/10.1016/j.jcv.2022.105218

Specific allelic discrimination of N501Y and other SARS‐CoV‐2 mutations by ddPCR detects B.1.1.7 lineage in Washington State

Journal of Medical Virology / Jul 03, 2021

Perchetti, G. A., Zhu, H., Mills, M. G., Shrestha, L., Wagner, C., Bakhash, S. M., Lin, M. J., Xie, H., Huang, M., Mathias, P., Bedford, T., Jerome, K. R., Greninger, A. L., & Roychoudhury, P. (2021). Specific allelic discrimination of N501Y and other SARS‐CoV‐2 mutations by ddPCR detects B.1.1.7 lineage in Washington State. Journal of Medical Virology, 93(10), 5931–5941. Portico. https://doi.org/10.1002/jmv.27155

A SARS-CoV-2 Nucleocapsid Variant that Affects Antigen Test Performance

Journal of Clinical Virology / Aug 01, 2021

Bourassa, L., Perchetti, G. A., Phung, Q., Lin, M. J., Mills, M. G., Roychoudhury, P., Harmon, K. G., Reed, J. C., & Greninger, A. L. (2021). A SARS-CoV-2 Nucleocapsid Variant that Affects Antigen Test Performance. Journal of Clinical Virology, 141, 104900. https://doi.org/10.1016/j.jcv.2021.104900

Predicting Infectivity: Comparing Four PCR-based Assays to Detect Culturable SARS-CoV-2 in Clinical Samples

Jul 18, 2021

Bruce, E. A., Mills, M. G., Sampoleo, R., Perchetti, G. A., Huang, M.-L., Despres, H. W., Shirley, D. J., Jerome, K. R., Greninger, A. L., & Botten, J. W. (2021). Predicting Infectivity: Comparing Four PCR-based Assays to Detect Culturable SARS-CoV-2 in Clinical Samples. https://doi.org/10.1101/2021.07.14.21260544

Performance characteristics of the Abbott Alinity m SARS-CoV-2 assay

Journal of Clinical Virology / Jul 01, 2021

Perchetti, G. A., Pepper, G., Shrestha, L., LaTurner, K., Yae Kim, D., Huang, M.-L., Jerome, K. R., & Greninger, A. L. (2021). Performance characteristics of the Abbott Alinity m SARS-CoV-2 assay. Journal of Clinical Virology, 140, 104869. https://doi.org/10.1016/j.jcv.2021.104869

A SARS-CoV-2 Nucleocapsid Variant that Affects Antigen Test Performance

May 05, 2021

Bourassa, L., Perchetti, G. A., Phung, Q., Lin, M. J., Mills, M. G., Roychoudhury, P., Harmon, K. G., Reed, J. C., & Greninger, A. L. (2021). A SARS-CoV-2 Nucleocapsid Variant that Affects Antigen Test Performance. https://doi.org/10.1101/2021.05.05.21256527

Human Metapneumovirus Infection and Genotyping of Infants in Rural Nepal

Journal of the Pediatric Infectious Diseases Society / Nov 02, 2020

Perchetti, G. A., Wilcox, N., Chu, H. Y., Katz, J., Khatry, S. K., LeClerq, S. C., Tielsch, J. M., Jerome, K. R., Englund, J. A., & Kuypers, J. (2020). Human Metapneumovirus Infection and Genotyping of Infants in Rural Nepal. Journal of the Pediatric Infectious Diseases Society, 10(4), 408–416. https://doi.org/10.1093/jpids/piaa118

Pooling of SARS-CoV-2 samples to increase molecular testing throughput

Journal of Clinical Virology / Oct 01, 2020

Perchetti, G. A., Sullivan, K.-W., Pepper, G., Huang, M.-L., Breit, N., Mathias, P., Jerome, K. R., & Greninger, A. L. (2020). Pooling of SARS-CoV-2 samples to increase molecular testing throughput. Journal of Clinical Virology, 131, 104570. https://doi.org/10.1016/j.jcv.2020.104570

Multiplexing primer/probe sets for detection of SARS-CoV-2 by qRT-PCR

Journal of Clinical Virology / Aug 01, 2020

Perchetti, G. A., Nalla, A. K., Huang, M.-L., Jerome, K. R., & Greninger, A. L. (2020). Multiplexing primer/probe sets for detection of SARS-CoV-2 by qRT-PCR. Journal of Clinical Virology, 129, 104499. https://doi.org/10.1016/j.jcv.2020.104499

Detection of SARS-CoV-2 by bronchoscopy after negative nasopharyngeal testing: Stay vigilant for COVID-19

Respiratory Medicine Case Reports / Jan 01, 2020

Ramos, K. J., Kapnadak, S. G., Collins, B. F., Pottinger, P. S., Wall, R., Mays, J. A., Perchetti, G. A., Jerome, K. R., Khot, S., Limaye, A. P., Mathias, P. C., & Greninger, A. (2020). Detection of SARS-CoV-2 by bronchoscopy after negative nasopharyngeal testing: Stay vigilant for COVID-19. Respiratory Medicine Case Reports, 30, 101120. https://doi.org/10.1016/j.rmcr.2020.101120

Stability of SARS-CoV-2 in Phosphate-Buffered Saline for Molecular Detection

Journal of Clinical Microbiology / Jul 23, 2020

Perchetti, G. A., Huang, M.-L., Peddu, V., Jerome, K. R., & Greninger, A. L. (2020). Stability of SARS-CoV-2 in Phosphate-Buffered Saline for Molecular Detection. Journal of Clinical Microbiology, 58(8). https://doi.org/10.1128/jcm.01094-20

Metagenomic Analysis Reveals Clinical SARS-CoV-2 Infection and Bacterial or Viral Superinfection and Colonization

Clinical Chemistry / Jun 12, 2020

Peddu, V., Shean, R. C., Xie, H., Shrestha, L., Perchetti, G. A., Minot, S. S., Roychoudhury, P., Huang, M.-L., Nalla, A., Reddy, S. B., Phung, Q., Reinhardt, A., Jerome, K. R., & Greninger, A. L. (2020). Metagenomic Analysis Reveals Clinical SARS-CoV-2 Infection and Bacterial or Viral Superinfection and Colonization. Clinical Chemistry, 66(7), 966–972. https://doi.org/10.1093/clinchem/hvaa106

Comparative Performance of SARS-CoV-2 Detection Assays Using Seven Different Primer-Probe Sets and One Assay Kit

Journal of Clinical Microbiology / May 26, 2020

Nalla, A. K., Casto, A. M., Huang, M.-L. W., Perchetti, G. A., Sampoleo, R., Shrestha, L., Wei, Y., Zhu, H., Jerome, K. R., & Greninger, A. L. (2020). Comparative Performance of SARS-CoV-2 Detection Assays Using Seven Different Primer-Probe Sets and One Assay Kit. Journal of Clinical Microbiology, 58(6). https://doi.org/10.1128/jcm.00557-20

DIRECT RT-qPCR DETECTION OF SARS-CoV-2 RNA FROM PATIENT NASOPHARYNGEAL SWABS WITHOUT AN RNA EXTRACTION STEP

Mar 21, 2020

Bruce, E. A., Huang, M.-L., Perchetti, G. A., Tighe, S., Laaguiby, P., Hoffman, J. J., Gerrard, D. L., Nalla, A. K., Wei, Y., Greninger, A. L., Diehl, S. A., Shirley, D. J., Leonard, D. G. B., Huston, C. D., Kirkpatrick, B. D., Dragon, J. A., Crothers, J. W., Jerome, K. R., & Botten, J. W. (2020). DIRECT RT-qPCR DETECTION OF SARS-CoV-2 RNA FROM PATIENT NASOPHARYNGEAL SWABS WITHOUT AN RNA EXTRACTION STEP. https://doi.org/10.1101/2020.03.20.001008

Phylogenetic characterization of rhinoviruses from infants in Sarlahi, Nepal

Journal of Medical Virology / Aug 21, 2019

Kuypers, J., Perchetti, G. A., Chu, H. Y., Newman, K. L., Katz, J., Khatry, S. K., LeClerq, S. C., Jerome, K. R., Tielsch, J. M., & Englund, J. A. (2019). Phylogenetic characterization of rhinoviruses from infants in Sarlahi, Nepal. Journal of Medical Virology, 91(12), 2108–2116. Portico. https://doi.org/10.1002/jmv.25563

2626. Rhinovirus in Children Presenting to the Emergency Department: Role of Viral Load in Disease Severity and Co-Infections

Open Forum Infectious Diseases / Oct 01, 2019

Waghmare, A., Strelitz, B., Lacombe, K., Perchetti, G., Nalla, A., Rha, B., Midgley, C., Lively, J. Y., Klein, E. J., Kuypers, J., & Englund, J. A. (2019). 2626. Rhinovirus in Children Presenting to the Emergency Department: Role of Viral Load in Disease Severity and Co-Infections. Open Forum Infectious Diseases, 6(Supplement_2), S915–S916. https://doi.org/10.1093/ofid/ofz360.2304

Large, Stable, Contemporary Interspecies Recombination Events in Circulating Human Herpes Simplex Viruses

The Journal of Infectious Diseases / Apr 23, 2019

Casto, A. M., Roychoudhury, P., Xie, H., Selke, S., Perchetti, G. A., Wofford, H., Huang, M.-L., Verjans, G. M. G. M., Gottlieb, G. S., Wald, A., Jerome, K. R., Koelle, D. M., Johnston, C., & Greninger, A. L. (2019). Large, Stable, Contemporary Interspecies Recombination Events in Circulating Human Herpes Simplex Viruses. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiz199

Specific allelic discrimination of N501Y and other SARS-CoV-2 mutations by ddPCR detects B.1.1.7 lineage in Washington State

Mar 12, 2021

Perchetti, G. A., Zhu, H., Mills, M. G., Shrestha, L., Wagner, C., Bakhash, S. M., Lin, M., Xie, H., Huang, M.-L., Mathias, P., Bedford, T., Jerome, K. R., Greninger, A. L., & Roychoudhury, P. (2021). Specific allelic discrimination of N501Y and other SARS-CoV-2 mutations by ddPCR detects B.1.1.7 lineage in Washington State. https://doi.org/10.1101/2021.03.10.21253321

The impact of interspecies recombination on human herpes simplex virus evolution and host immune recognition

Nov 19, 2018

Casto, A. M., Roychoudhury, P., Xie, H., Selke, S., Perchetti, G. A., Wofford, H., Huang, M.-L., Verjans, G. M. G. M., Gottlieb, G. S., Wald, A., Jerome, K. R., Koelle, D. M., Johnston, C., & Greninger, A. L. (2018). The impact of interspecies recombination on human herpes simplex virus evolution and host immune recognition. https://doi.org/10.1101/472639

Education

University of Washington

BS, BA, Microbiology; Art History

Seattle, Washington, United States of America

Ross University School of Medicine

MD, Infectious Diseases / April, 2025 (anticipated)

Bridgetown

Harvard University

SSP, Psychology

Cambridge, Massachusetts, United States of America

Experience

University of Washington

Research Scientist / 2015 — Present

Links & Social Media

LinkedIn

ORCID
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