Bruce Moran, PhD.
Cancer Genomics and Bioinformatics
Research Interests
About
Publications
Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function
Journal of Experimental Medicine / Feb 01, 2022
Dyck, L., Prendeville, H., Raverdeau, M., Wilk, M. M., Loftus, R. M., Douglas, A., McCormack, J., Moran, B., Wilkinson, M., Mills, E. L., Doughty, M., Fabre, A., Heneghan, H., LeRoux, C., Hogan, A., Chouchani, E. T., O’Shea, D., Brennan, D., & Lynch, L. (2022). Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function. Journal of Experimental Medicine, 219(3). https://doi.org/10.1084/jem.20210042
A Functional Genomic Screen Identifies the Deubiquitinase USP11 as a Novel Transcriptional Regulator of ERα in Breast Cancer
Cancer Research / Nov 13, 2020
Dwane, L., O’Connor, A. E., Das, S., Moran, B., Mulrane, L., Pinto-Fernandez, A., Ward, E., Blümel, A. M., Cavanagh, B. L., Mooney, B., Dirac, A. M., Jirström, K., Kessler, B. M., Ní Chonghaile, T., Bernards, R., Gallagher, W. M., & O’Connor, D. P. (2020). A Functional Genomic Screen Identifies the Deubiquitinase USP11 as a Novel Transcriptional Regulator of ERα in Breast Cancer. Cancer Research, 80(22), 5076–5088. https://doi.org/10.1158/0008-5472.can-20-0214
The Molecular Effects of a High Fat Diet on Endometrial Tumour Biology
Life / Sep 10, 2020
Wilkinson, M., Sinclair, P., Dellatorre-Teixeira, L., Swan, P., Brennan, E., Moran, B., Wedekind, D., Downey, P., Sheahan, K., Conroy, E., Gallagher, W. M., Docherty, N., Roux, C. le, & Brennan, D. J. (2020). The Molecular Effects of a High Fat Diet on Endometrial Tumour Biology. Life, 10(9), 188. https://doi.org/10.3390/life10090188
Evaluating liquid biopsies for methylomic profiling of prostate cancer
Epigenetics / Jan 31, 2020
Silva, R., Moran, B., Russell, N. M., Fahey, C., Vlajnic, T., Manecksha, R. P., Finn, S. P., Brennan, D. J., Gallagher, W. M., & Perry, A. S. (2020). Evaluating liquid biopsies for methylomic profiling of prostate cancer. Epigenetics, 15(6–7), 715–727. https://doi.org/10.1080/15592294.2020.1712876
Combination of variations in inflammation- and endoplasmic reticulum-associated genes as putative biomarker for bevacizumab response in KRAS wild-type colorectal cancer
Scientific Reports / Jun 17, 2020
Barat, A., Smeets, D., Moran, B., Zhang, W., Cao, S., Das, S., Klinger, R., Betge, J., Murphy, V., Bacon, O., Kay, E. W., Van Grieken, N. C. T., Verheul, H. M. W., Gaiser, T., Schulte, N., Ebert, M. P., Fender, B., Hennessy, B. T., McNamara, D. A., … Prehn, J. H. M. (2020). Combination of variations in inflammation- and endoplasmic reticulum-associated genes as putative biomarker for bevacizumab response in KRAS wild-type colorectal cancer. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-65869-2
BET Inhibition as a Rational Therapeutic Strategy for Invasive Lobular Breast Cancer
Clinical Cancer Research / Dec 01, 2019
Walsh, L., Haley, K. E., Moran, B., Mooney, B., Tarrant, F., Madden, S. F., Di Grande, A., Fan, Y., Das, S., Rueda, O. M., Dowling, C. M., Varešlija, D., Chin, S.-F., Linn, S., Young, L. S., Jirström, K., Crown, J. P., Bernards, R., Caldas, C., … Ní Chonghaile, T. (2019). BET Inhibition as a Rational Therapeutic Strategy for Invasive Lobular Breast Cancer. Clinical Cancer Research, 25(23), 7139–7150. https://doi.org/10.1158/1078-0432.ccr-19-0713
PDLIM2 Is a Marker of Adhesion and β-Catenin Activity in Triple-Negative Breast Cancer
Cancer Research / May 15, 2019
Cox, O. T., Edmunds, S. J., Simon-Keller, K., Li, B., Moran, B., Buckley, N. E., Bustamante-Garrido, M., Healy, N., O’Flanagan, C. H., Gallagher, W. M., Kennedy, R. D., Bernards, R., Caldas, C., Chin, S.-F., Marx, A., & O’Connor, R. (2019). PDLIM2 Is a Marker of Adhesion and β-Catenin Activity in Triple-Negative Breast Cancer. Cancer Research, 79(10), 2619–2633. https://doi.org/10.1158/0008-5472.can-18-2787
Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy
Nature Communications / Oct 05, 2018
Smeets, D., Miller, I. S., O’Connor, D. P., Das, S., Moran, B., Boeckx, B., Gaiser, T., Betge, J., Barat, A., Klinger, R., van Grieken, N. C. T., Cremolini, C., Prenen, H., Mazzone, M., Depreeuw, J., Bacon, O., Fender, B., Brady, J., Hennessy, B. T., … Byrne, A. T. (2018). Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy. Nature Communications, 9(1). https://doi.org/10.1038/s41467-018-06567-6
Fam60a defines a variant Sin3a‐Hdac complex in embryonic stem cells required for self‐renewal
The EMBO Journal / May 29, 2017
Streubel, G., Fitzpatrick, D. J., Oliviero, G., Scelfo, A., Moran, B., Das, S., Munawar, N., Watson, A., Wynne, K., Negri, G. L., Dillon, E. T., Jammula, S., Hokamp, K., O’Connor, D. P., Pasini, D., Cagney, G., & Bracken, A. P. (2017). Fam60a defines a variant Sin3a‐Hdac complex in embryonic stem cells required for self‐renewal. The EMBO Journal, 36(15), 2216–2232. Portico. https://doi.org/10.15252/embj.201696307
Experience
University College Dublin
Postdoc / November, 2014 — June, 2017
Cancer genomics and bioinformatics in large consortia
Oncomark Ltd.
Marie Curie Fellow / July, 2017 — December, 2018
Bioinformatics on open data to validate clinical decision-making tools
St. Vincent's University Hospital
Bioinformatics Specialist / December, 2018 — Present
Cancer diagnostic testing and clinical research
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