Este Leidmaa, PhD
Researcher in neuroscience studing cell adhesion molecules, endocannabinoid system and the BBB
Research Expertise
Publications
Lower anxiety and a decrease in agonistic behaviour in Lsamp-deficient mice
Behavioural Brain Research / Feb 01, 2011
Innos, J., Philips, M.-A., Leidmaa, E., Heinla, I., Raud, S., Reemann, P., Plaas, M., Nurk, K., Kurrikoff, K., Matto, V., Visnapuu, T., Mardi, P., Kõks, S., & Vasar, E. (2011). Lower anxiety and a decrease in agonistic behaviour in Lsamp-deficient mice. Behavioural Brain Research, 217(1), 21–31. https://doi.org/10.1016/j.bbr.2010.09.019
Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders
Scientific Reports / Apr 01, 2019
Singh, K., Jayaram, M., Kaare, M., Leidmaa, E., Jagomäe, T., Heinla, I., Hickey, M. A., Kaasik, A., Schäfer, M. K., Innos, J., Lilleväli, K., Philips, M.-A., & Vasar, E. (2019). Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders. Scientific Reports, 9(1). https://doi.org/10.1038/s41598-019-41991-8
Enrichment and individual housing reinforce the differences in aggressiveness and amphetamine response in 129S6/SvEv and C57BL/6 strains
Behavioural Brain Research / Jul 01, 2014
Heinla, I., Leidmaa, E., Visnapuu, T., Philips, M.-A., & Vasar, E. (2014). Enrichment and individual housing reinforce the differences in aggressiveness and amphetamine response in 129S6/SvEv and C57BL/6 strains. Behavioural Brain Research, 267, 66–73. https://doi.org/10.1016/j.bbr.2014.03.024
Lsamp–/– mice display lower sensitivity to amphetamine and have elevated 5-HT turnover
Biochemical and Biophysical Research Communications / Jan 01, 2013
Innos, J., Leidmaa, E., Philips, M.-A., Sütt, S., Alttoa, A., Harro, J., Kõks, S., & Vasar, E. (2013). Lsamp–/– mice display lower sensitivity to amphetamine and have elevated 5-HT turnover. Biochemical and Biophysical Research Communications, 430(1), 413–418. https://doi.org/10.1016/j.bbrc.2012.11.077
Gene expression patterns and environmental enrichment-induced effects in the hippocampi of mice suggest importance of Lsamp in plasticity
Frontiers in Neuroscience / Jun 08, 2015
Heinla, I., Leidmaa, E., Kongi, K., Pennert, A., Innos, J., Nurk, K., Tekko, T., Singh, K., Vanaveski, T., Reimets, R., Mandel, M., Lang, A., Lilleväli, K., Kaasik, A., Vasar, E., & Philips, M.-A. (2015). Gene expression patterns and environmental enrichment-induced effects in the hippocampi of mice suggest importance of Lsamp in plasticity. Frontiers in Neuroscience, 9. https://doi.org/10.3389/fnins.2015.00205
Cannabinoid receptor 1 signalling modulates stress susceptibility and microglial responses to chronic social defeat stress
Translational Psychiatry / Mar 15, 2021
Beins, E. C., Beiert, T., Jenniches, I., Hansen, J. N., Leidmaa, E., Schrickel, J. W., & Zimmer, A. (2021). Cannabinoid receptor 1 signalling modulates stress susceptibility and microglial responses to chronic social defeat stress. Translational Psychiatry, 11(1). https://doi.org/10.1038/s41398-021-01283-0
Blunted leptin sensitivity during hedonic overeating can be reinstated by activating galanin 2 receptors (Gal2R) in the lateral hypothalamus
Acta Physiologica / Jul 31, 2019
Leidmaa, E., Gazea, M., Patchev, A. V., Pissioti, A., Christian Gassen, N., Kimura, M., Liposits, Z., Kallo, I., & Almeida, O. F. X. (2019). Blunted leptin sensitivity during hedonic overeating can be reinstated by activating galanin 2 receptors (Gal2R) in the lateral hypothalamus. Acta Physiologica, 228(2). Portico. https://doi.org/10.1111/apha.13345
Diacylglycerol lipase alpha in astrocytes is involved in maternal care and affective behaviors
Glia / Sep 02, 2020
Schüle, L., Glasmacher, S., Gertsch, J., Roggan, M. D., Transfeld, J., Bindila, L., Lutz, B., Kolbe, C., Bilkei‐Gorzo, A., Zimmer, A., & Leidmaa, E. (2020). Diacylglycerol lipase alpha in astrocytes is involved in maternal care and affective behaviors. Glia, 69(2), 377–391. Portico. https://doi.org/10.1002/glia.23903
Modulation of feeding behavior and metabolism by dynorphin
Scientific Reports / Mar 02, 2020
Ghule, A., Rácz, I., Bilkei-Gorzo, A., Leidmaa, E., Sieburg, M., & Zimmer, A. (2020). Modulation of feeding behavior and metabolism by dynorphin. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-60518-0
Regulation of adult neurogenesis by the endocannabinoid-producing enzyme diacylglycerol lipase alpha (DAGLa)
Scientific Reports / Jan 12, 2022
Schuele, L.-L., Schuermann, B., Bilkei-Gorzo, A., Gorgzadeh, S., Zimmer, A., & Leidmaa, E. (2022). Regulation of adult neurogenesis by the endocannabinoid-producing enzyme diacylglycerol lipase alpha (DAGLa). Scientific Reports, 12(1). https://doi.org/10.1038/s41598-021-04600-1
Dynamic Changes in the Endocannabinoid System during the Aging Process: Focus on the Middle-Age Crisis
International Journal of Molecular Sciences / Sep 06, 2022
Nidadavolu, P., Bilkei-Gorzo, A., Effah, F., Leidmaa, E., Schürmann, B., Berger, M., Bindila, L., Schmid, M., Lutz, B., Zimmer, A., & Bailey, A. (2022). Dynamic Changes in the Endocannabinoid System during the Aging Process: Focus on the Middle-Age Crisis. International Journal of Molecular Sciences, 23(18), 10254. https://doi.org/10.3390/ijms231810254
Expression and impact of Lsamp neural adhesion molecule in the serotonergic neurotransmission system
Pharmacology Biochemistry and Behavior / Nov 01, 2020
Bregin, A., Kaare, M., Jagomäe, T., Karis, K., Singh, K., Laugus, K., Innos, J., Leidmaa, E., Heinla, I., Visnapuu, T., Oja, E.-M., Kõiv, K., Lilleväli, K., Harro, J., Philips, M.-A., & Vasar, E. (2020). Expression and impact of Lsamp neural adhesion molecule in the serotonergic neurotransmission system. Pharmacology Biochemistry and Behavior, 198, 173017. https://doi.org/10.1016/j.pbb.2020.173017
Brain Expression, Physiological Regulation and Role in Motivation and Associative Learning of Peroxisome Proliferator-activated Receptor γ
Neuroscience / Dec 01, 2021
Moosecker, S., Pissioti, A., Leidmaa, E., Harb, M. R., Dioli, C., Gassen, N. C., Yu, S., Gazea, M., Catania, C., Anderzhanova, E., Patchev, A. V., Kühne, C., Stoffel, R., Sotiropoulos, I., & Almeida, O. F. X. (2021). Brain Expression, Physiological Regulation and Role in Motivation and Associative Learning of Peroxisome Proliferator-activated Receptor γ. Neuroscience, 479, 91–106. https://doi.org/10.1016/j.neuroscience.2021.10.029
High-Fat Diet Induces Pre-Diabetes and Distinct Sex-Specific Metabolic Alterations in Negr1-Deficient Mice
Biomedicines / Sep 03, 2021
Kaare, M., Mikheim, K., Lilleväli, K., Kilk, K., Jagomäe, T., Leidmaa, E., Piirsalu, M., Porosk, R., Singh, K., Reimets, R., Taalberg, E., Schäfer, M. K. E., Plaas, M., Vasar, E., & Philips, M.-A. (2021). High-Fat Diet Induces Pre-Diabetes and Distinct Sex-Specific Metabolic Alterations in Negr1-Deficient Mice. Biomedicines, 9(9), 1148. https://doi.org/10.3390/biomedicines9091148
Restoring Serotonergic Homeostasis in the Lateral Hypothalamus Rescues Sleep Disturbances Induced by Early-Life Obesity
The Journal of Neuroscience / Dec 01, 2017
Gazea, M., Patchev, A. V., Anderzhanova, E., Leidmaa, E., Pissioti, A., Flachskamm, C., Almeida, O. F. X., & Kimura, M. (2017). Restoring Serotonergic Homeostasis in the Lateral Hypothalamus Rescues Sleep Disturbances Induced by Early-Life Obesity. The Journal of Neuroscience, 38(2), 441–451. https://doi.org/10.1523/jneurosci.1333-17.2017
Depression-Associated Negr1 Gene-Deficiency Induces Alterations in the Monoaminergic Neurotransmission Enhancing Time-Dependent Sensitization to Amphetamine in Male Mice
Brain Sciences / Dec 10, 2022
Kaare, M., Jayaram, M., Jagomäe, T., Singh, K., Kilk, K., Mikheim, K., Leevik, M., Leidmaa, E., Varul, J., Nõmm, H., Rähn, K., Visnapuu, T., Plaas, M., Lilleväli, K., Schäfer, M. K. E., Philips, M.-A., & Vasar, E. (2022). Depression-Associated Negr1 Gene-Deficiency Induces Alterations in the Monoaminergic Neurotransmission Enhancing Time-Dependent Sensitization to Amphetamine in Male Mice. Brain Sciences, 12(12), 1696. https://doi.org/10.3390/brainsci12121696
Autocrine regulation of adult neurogenesis by the endocannabinoid 2-arachidonoylglycerol (2-AG)
Feb 12, 2021
Schuele, L.-L., Schürmann, B., Bilkei-Gorzo, A., Zimmer, A., & Leidmaa, E. (2021). Autocrine regulation of adult neurogenesis by the endocannabinoid 2-arachidonoylglycerol (2-AG). https://doi.org/10.1101/2021.02.11.430731
Early development of hedonic and motivational aspects of eating behaviour
Appetite / Jun 01, 2016
Nicklaus, S. (2016). Early development of hedonic and motivational aspects of eating behaviour. Appetite, 101, 215. https://doi.org/10.1016/j.appet.2016.02.039
Epidrugs in the Therapy of Central Nervous System Disorders: A Way to Drive on?
Cells / May 24, 2023
Gladkova, M. G., Leidmaa, E., & Anderzhanova, E. A. (2023). Epidrugs in the Therapy of Central Nervous System Disorders: A Way to Drive on? Cells, 12(11), 1464. https://doi.org/10.3390/cells12111464
Education
Graduate School of Systemic Neuroscience and Ludwig-Maximilians-Universität München
PhD (Neurosciences), Max Planck Institute of Psychiatry / June, 2016
Georg-August Universität Göttingen
MSc (Neurosciences), International Max Planck Research School / October, 2011
University of Tartu
MSc (Biomedicine), Institute of Physiology / September, 2011
University of Tartu
BA, Dept. of Psychology / June, 2008
Experience
University of Tartu
Associate Professor / December, 2022 — Present
University of Bonn
Post-doctoral fellow / 2017 — November, 2022
Max-Planck-Institut für Psychiatrie
PhD student / September, 2011 — February, 2016
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