Christine Wong, Ph.D.
Science and Innovation • Neuroscientist • Co-founder of NOON
Research Interests
Publications
Prenatal exposure to common environmental factors affects brain lipids and increases risk of developing autism spectrum disorders
European Journal of Neuroscience / Sep 19, 2015
Wong, C. T., Wais, J., & Crawford, D. A. (2015). Prenatal exposure to common environmental factors affects brain lipids and increases risk of developing autism spectrum disorders. European Journal of Neuroscience, 42(10), 2742–2760. Portico. https://doi.org/10.1111/ejn.13028
Prostaglandin E2 alters Wnt-dependent migration and proliferation in neuroectodermal stem cells: implications for autism spectrum disorders
Cell Communication and Signaling / Mar 23, 2014
Wong, C. T., Ahmad, E., Li, H., & Crawford, D. A. (2014). Prostaglandin E2 alters Wnt-dependent migration and proliferation in neuroectodermal stem cells: implications for autism spectrum disorders. Cell Communication and Signaling, 12(1). https://doi.org/10.1186/1478-811x-12-19
Prostaglandin E2promotes neural proliferation and differentiation and regulates Wnt target gene expression
Journal of Neuroscience Research / Jun 05, 2016
Wong, C. T., Ussyshkin, N., Ahmad, E., Rai-Bhogal, R., Li, H., & Crawford, D. A. (2016). Prostaglandin E2promotes neural proliferation and differentiation and regulates Wnt target gene expression. Journal of Neuroscience Research, 94(8), 759–775. Portico. https://doi.org/10.1002/jnr.23759
Autism‐related behaviors in the cyclooxygenase‐2‐deficient mouse model
Genes, Brain and Behavior / Aug 12, 2018
Wong, C. T., Bestard‐Lorigados, I., & Crawford, D. A. (2018). Autism‐related behaviors in the cyclooxygenase‐2‐deficient mouse model. Genes, Brain and Behavior, 18(1). Portico. https://doi.org/10.1111/gbb.12506
Lipid Signalling in the Pathology of Autism Spectrum Disorders
Comprehensive Guide to Autism / Jan 01, 2014
Wong, C., & Crawford, D. A. (2014). Lipid Signalling in the Pathology of Autism Spectrum Disorders. Comprehensive Guide to Autism, 1259–1283. https://doi.org/10.1007/978-1-4614-4788-7_68
Maternal exposure to prostaglandin E2 modifies expression of Wnt genes in mouse brain – An autism connection
Biochemistry and Biophysics Reports / Jul 01, 2018
Rai-Bhogal, R., Wong, C., Kissoondoyal, A., Davidson, J., Li, H., & Crawford, D. A. (2018). Maternal exposure to prostaglandin E2 modifies expression of Wnt genes in mouse brain – An autism connection. Biochemistry and Biophysics Reports, 14, 43–53. https://doi.org/10.1016/j.bbrep.2018.03.012
Prostaglandin E2 elevates calcium in differentiated neuroectodermal stem cells
Molecular and Cellular Neuroscience / Jul 01, 2016
Davidson, J. M., Wong, C. T., Rai-Bhogal, R., Li, H., & Crawford, D. A. (2016). Prostaglandin E2 elevates calcium in differentiated neuroectodermal stem cells. Molecular and Cellular Neuroscience, 74, 71–77. https://doi.org/10.1016/j.mcn.2016.03.010
Prostaglandin E2 facilitates subcellular translocation of the EP4 receptor in neuroectodermal NE-4C stem cells
Biochemistry and Biophysics Reports / Sep 01, 2016
Davidson, J. M., Wong, C. T., Li, H., & Crawford, D. A. (2016). Prostaglandin E2 facilitates subcellular translocation of the EP4 receptor in neuroectodermal NE-4C stem cells. Biochemistry and Biophysics Reports, 7, 173–179. https://doi.org/10.1016/j.bbrep.2016.06.001
Education
York University
Ph.D., Neuroscience / 2019
Experience
NOON LIFE CO.
Co-Founder & Chief Science Offier / 2022 — Present
NOON Nootropics. Now launched in the USA and select EU markets. Inspired by Eastern plant wisdom and backed by science; We are focused on harnessing the nootropic power of neuroactive botanicals to deliver innovative products that can elevate your every day. www.noonlife.co. • Leading the science and innovation at NOON through the direction and management of research operations and product development. • Forging collaborations with research teams at the forefront of nootropic sciences to deliver novel and effective products to market. • Driving manufacturing partnerships and international logistics via coordination and communication with key stakeholders. • Everything in-between, above and beyond as a passionate founder with a focused and resilient drive to deliver innovative tools and solutions for healthy living.
BenchSci
Senior Operations Manager / 2022 — 2022
BenchSci exponentially increases the speed and quality of life-saving research by empowering scientists with the world’s most advanced biomedical artificial intelligence to run more successful experiments. Backed by F-Prime and Google’s AI fund, Gradient Ventures, BenchSci uses machine learning to diagnose and improve pharmaceutical R&D health. A turnkey application of AI, BenchSci now optimizes reagent procurement and experimental success in 15 of the top 20 pharmaceutical companies and over 3,600 leading academic centers globally.
R&D Operations Manager / 2021 — 2021
R&D Scientist / 2020 — 2021
Biomedical Data Analyst / 2019 — 2020
• Analyzed, cleaned, and curated data for the generation and expansion of Bioinformatic Databases • Refined biomedical research data used for training and validation data, which fuelled the development of machine learning models • Shared scientific input with the UX Research team to influence product development • Worked across the R&D and Science Teams to improve the quality of machine learning outputs and product mapping.
York University
PhD Researcher | Developmental Neuroscience Laboratory / 2012 — 2019
"Neurobiology of Lipid Signalling in the Developing Brain : Link to Autism Spectrum Disorders" • Collaborated with cross-departmental colleagues and executed multi-disciplinary molecular, cellular and animal laboratory techniques to produce 8 peer-reviewed scientific publications and 13 conference presentations. • Pioneered new behavioural testing unit in Dr. Crawford's Developmental Laboratory yielding 3 new studies. • Optimized and authored laboratory protocols (SOPs) that continue to be used today. • Managed laboratory procedures, practices, and personnel following principles of Good Laboratory and Documentation Practices (GLP/GDP). • Provided technical training and personalized mentorship to over 30 research staff.
Teaching Assistant & Lab Demonstrator / 2010 — 2018
Courses: Molecular and Cellular Neuroscience, Neuronal Development for Activity and Health, Human Anatomy, Human Anatomy for Fine Arts, Human Development, Forensic Sciences . • Impacted 1,000+ students by providing individually tailored assistance on learning material. • Encouraged and facilitated active participation, discussion, and team building. • Created and developed testing material for undergraduate neuroscience courses. • Conducted and demonstrated lab dissections for human anatomy courses. • Successfully engaged over 100 non-science majors in STEM topics.
Research Assistant | Centre for Aging Research – Cardiovascular Health Awareness Program / 2014 — 2016
• Recruited clinical participants, collected patient physiological information, and administered interviews on their health and sensitive topics including discrimination and mental health. • Liaised with site personnel and volunteers to provide a smooth and welcoming experience for participants and promoted a supportive environment through active listening and clear communication.
Research Assistant | Developmental Neuroscience Laboratory / 2010 — 2012
"Effects of Prostaglandin E2 on Neural Stem Cells: Interaction with Wnt and Implications in Autism" • Investigated the transcriptional regulation and functions of neural stem cells (proliferation, migration, differentiation) and the impact of environmental stressors on bioactive lipid molecules that regulate development and inflammation.
Research Assistant | Sensorimotor Control Laboratory / 2008 — 2010
• Organized and analyzed data from computer-interface visuomotor experiments. • Coordinated and delivered technical training for undergraduate volunteers. • Edited research manuscripts and grants as well as summarized literature research.
HELIX : Summer Science Institute
Course Director / 2017 — 2017
• Created and taught a lab-based course: “Human Anatomy – A journey through the body”. • Independently developed science educational material (Powerpoint presentations, handouts, worksheets) plus organized field trips introducing real-world STEM working environments and job opportunities to students pursuing biomedical careers.
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