Nicholas Chehade

Ph.D. candidate in systems neuroscience researching spatiotemporal dynamics of neural activity in support of forelimb movements

Pittsburgh , Pennsylvania, United States of America

Research Interests

Neurology
Cognitive Neuroscience
Biomedical Engineering

About

I am a neurophysiologist with training in multi-modal techniques in order to elucidate the spatiotemporal dynamics of cortical activity that support coordinated movements of the forelimb. Specifically, I aim to relate the spatial organization of cortical outputs to muscles of the arm and hand to the temporal dynamics of unit activity in primary motor cortex (M1) during reach-to-grasp movements of non-human primates (NHP). My research efforts consist of collecting and analyzing four different types of data: electromyography, kinematic, intrinsic signal imaging (ISOI) and electrophysiological data. ISOI was used to delineate the spatial organization of neural activity that supports reaching and grasping. Then, a laminar multielectrode placed in a multitude of locations of M1 captured the temporal activation of \~1,500 individual neurons during reaching and grasping. Additionally, EMG and kinematic recordings of the forelimb provided proxies for behavior to relate muscle and joint activity to neural activity.

Publications

Optical imaging reveals functional domains in primate sensorimotor cortex

NeuroImage / Nov 01, 2020

Friedman, R. M., Chehade, N. G., Roe, A. W., & Gharbawie, O. A. (2020). Optical imaging reveals functional domains in primate sensorimotor cortex. NeuroImage, 221, 117188. https://doi.org/10.1016/j.neuroimage.2020.117188

Integrated biocircuits: engineering functional multicellular circuits and devices

Journal of Neural Engineering / Feb 14, 2018

Prox, J., Smith, T., Holl, C., Chehade, N., & Guo, L. (2018). Integrated biocircuits: engineering functional multicellular circuits and devices. Journal of Neural Engineering, 15(2), 023001. https://doi.org/10.1088/1741-2552/aaa906

Education

University of Pittsburgh

Neuroscience

Pittsburgh, Pennsylvania, United States of America

The Ohio State University

B.S. in Neuroscience and Computer Information Science, Neuroscience / May, 2017

Columbus

Links & Social Media

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