John Joe

Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK

Publications

Sequence and characteristics or IS900, an insertion element identified in a human Crohn's disease isolate orMycobacterium paratuberculosis

Nucleic Acids Research / Jan 01, 1989

Green, E. P., Tizard, M. L. V., Moss, M. T., Thompson, J., Winterbourne, D. J., McFadden, J. J., & Hermon-Taylor, J. (1989). Sequence and characteristics or IS900, an insertion element identified in a human Crohn’s disease isolate orMycobacterium paratuberculosis. Nucleic Acids Research, 17(22), 9063–9073. https://doi.org/10.1093/nar/17.22.9063

Use of highly specific DNA probes and the polymerase chain reaction to detect Mycobacterium paratuberculosis in Johne's disease

Journal of Clinical Microbiology / May 01, 1990

Vary, P. H., Andersen, P. R., Green, E., Hermon-Taylor, J., & McFadden, J. J. (1990). Use of highly specific DNA probes and the polymerase chain reaction to detect Mycobacterium paratuberculosis in Johne’s disease. Journal of Clinical Microbiology, 28(5), 933–937. https://doi.org/10.1128/jcm.28.5.933-937.1990

Life on the edge: the coming of age of quantum biology

Choice Reviews Online / Feb 18, 2016

Life on the edge: the coming of age of quantum biology. (2016). Choice Reviews Online, 53(07), 53-3065-53–3065. https://doi.org/10.5860/choice.194602

Detection of mycobacterial DNA in sarcoidosis and tuberculosis with polymerase chain reaction

The Lancet / Apr 01, 1992

Saboor, S. A., Saboor, S. A., McFadden, J., & Johnson, N. M. (1992). Detection of mycobacterial DNA in sarcoidosis and tuberculosis with polymerase chain reaction. The Lancet, 339(8800), 1012–1015. https://doi.org/10.1016/0140-6736(92)90535-b

Crohn's disease-isolated mycobacteria are identical to Mycobacterium paratuberculosis, as determined by DNA probes that distinguish between mycobacterial species

Journal of Clinical Microbiology / May 01, 1987

McFadden, J. J., Butcher, P. D., Chiodini, R., & Hermon-Taylor, J. (1987). Crohn’s disease-isolated mycobacteria are identical to Mycobacterium paratuberculosis, as determined by DNA probes that distinguish between mycobacterial species. Journal of Clinical Microbiology, 25(5), 796–801. https://doi.org/10.1128/jcm.25.5.796-801.1987

Triple functionalisation of single-walled carbon nanotubes with doxorubicin, a monoclonal antibody, and a fluorescent marker for targeted cancer therapy

Carbon / Aug 01, 2009

Heister, E., Neves, V., Tîlmaciu, C., Lipert, K., Beltrán, V. S., Coley, H. M., Silva, S. R. P., & McFadden, J. (2009). Triple functionalisation of single-walled carbon nanotubes with doxorubicin, a monoclonal antibody, and a fluorescent marker for targeted cancer therapy. Carbon, 47(9), 2152–2160. https://doi.org/10.1016/j.carbon.2009.03.057

Quantum Evolution: How Physics’ Weirdest Theory Explains Life’s Biggest Mystery. By Johnjoe  McFadden. New York: W. W. Norton. $16.95 (paper). xiii + 338 p; ill.; index. ISBN: 0–393–32301–2. 2000.

The Quarterly Review of Biology / Dec 01, 2002

Green, E. J. (2002). <i>Quantum Evolution: How Physics’ Weirdest Theory Explains Life’s Biggest Mystery</i>. By Johnjoe  McFadden. New York: W. W. Norton. $16.95 (paper). xiii + 338 p; ill.; index. ISBN: 0–393–32301–2. 2000. The Quarterly Review of Biology, 77(4), 442–442. https://doi.org/10.1086/374429

Synchronous firing dynamics in a heterogeneous neurosecretory-cell population in an insect

Brain Research / Mar 01, 2002

Ichikawa, T. (2002). Synchronous firing dynamics in a heterogeneous neurosecretory-cell population in an insect. Brain Research, 929(2), 156–165. https://doi.org/10.1016/s0006-8993(01)03349-2

GSMN-TB: a web-based genome-scale network model of Mycobacterium tuberculosis metabolism

Genome Biology / Jan 01, 2007

Beste, D. J., Hooper, T., Stewart, G., Bonde, B., Avignone-Rossa, C., Bushell, M. E., Wheeler, P., Klamt, S., Kierzek, A. M., & McFadden, J. (2007). GSMN-TB: a web-based genome-scale network model of Mycobacterium tuberculosis metabolism. Genome Biology, 8(5), R89. https://doi.org/10.1186/gb-2007-8-5-r89

Biologically distinct subtypes of Mycobacterium avium differ in possession of insertion sequence IS901

Journal of Clinical Microbiology / Sep 01, 1992

Kunze, Z. M., Portaels, F., & McFadden, J. J. (1992). Biologically distinct subtypes of Mycobacterium avium differ in possession of insertion sequence IS901. Journal of Clinical Microbiology, 30(9), 2366–2372. https://doi.org/10.1128/jcm.30.9.2366-2372.1992

Higher Dispersion Efficacy of Functionalized Carbon Nanotubes in Chemical and Biological Environments

ACS Nano / Apr 09, 2010

Heister, E., Lamprecht, C., Neves, V., Tîlmaciu, C., Datas, L., Flahaut, E., Soula, B., Hinterdorfer, P., Coley, H. M., Silva, S. R. P., & McFadden, J. (2010). Higher Dispersion Efficacy of Functionalized Carbon Nanotubes in Chemical and Biological Environments. ACS Nano, 4(5), 2615–2626. https://doi.org/10.1021/nn100069k

PCR of peripheral blood for diagnosis of meningococcal disease

Journal of Clinical Microbiology / Jul 01, 1996

Newcombe, J., Cartwright, K., Palmer, W. H., & McFadden, J. (1996). PCR of peripheral blood for diagnosis of meningococcal disease. Journal of Clinical Microbiology, 34(7), 1637–1640. https://doi.org/10.1128/jcm.34.7.1637-1640.1996

IS901, a new member of a widespread class of atypical insertion sequences, is associated with pathogenicity inMycobacterium avium

Molecular Microbiology / Sep 01, 1991

Kunze, Z. M., Wall, S., Appelberg, R., Silva, M. T., Portaels, F., & McFadden, J. J. (1991). IS901, a new member of a widespread class of atypical insertion sequences, is associated with pathogenicity inMycobacterium avium. Molecular Microbiology, 5(9), 2265–2272. https://doi.org/10.1111/j.1365-2958.1991.tb02157.x

Polymerase chain reaction for diagnosis of meningococcal meningitis

The Lancet / Dec 01, 1992

NI, H. (1992). Polymerase chain reaction for diagnosis of meningococcal meningitis. The Lancet, 340(8833), 1432–1434. https://doi.org/10.1016/0140-6736(92)92622-m

Conscious Electromagnetic (CEMI) Field Theory

NeuroQuantology / Sep 12, 2007

McFadden, J. (2007). Conscious Electromagnetic (CEMI) Field Theory. NeuroQuantology, 5(3). https://doi.org/10.14704/nq.2007.5.3.135

Drug loading, dispersion stability, and therapeutic efficacy in targeted drug delivery with carbon nanotubes

Carbon / Feb 01, 2012

Heister, E., Neves, V., Lamprecht, C., Silva, S. R. P., Coley, H. M., & McFadden, J. (2012). Drug loading, dispersion stability, and therapeutic efficacy in targeted drug delivery with carbon nanotubes. Carbon, 50(2), 622–632. https://doi.org/10.1016/j.carbon.2011.08.074

The Genetic Requirements for Fast and Slow Growth in Mycobacteria

PLoS ONE / Apr 28, 2009

Beste, D. J. V., Espasa, M., Bonde, B., Kierzek, A. M., Stewart, G. R., & McFadden, J. (2009). The Genetic Requirements for Fast and Slow Growth in Mycobacteria. PLoS ONE, 4(4), e5349. https://doi.org/10.1371/journal.pone.0005349

A quantum mechanical model of adaptive mutation

Biosystems / Jun 01, 1999

McFadden, J., & Al-Khalili, J. (1999). A quantum mechanical model of adaptive mutation. Biosystems, 50(3), 203–211. https://doi.org/10.1016/s0303-2647(99)00004-0

Mycobacterium tuberculosis DNA in tissue affected by sarcoidosis.

BMJ / Feb 27, 1993

Fidler, H. M., Rook, G. A., Johnson, N. M., & McFadden, J. (1993). Mycobacterium tuberculosis DNA in tissue affected by sarcoidosis. BMJ, 306(6877), 546–549. https://doi.org/10.1136/bmj.306.6877.546

Carbon flux rerouting during Mycobacterium tuberculosis growth arrest

Molecular Microbiology / Oct 06, 2010

Shi, L., Sohaskey, C. D., Pfeiffer, C., Datta, P., Parks, M., McFadden, J., North, R. J., & Gennaro, M. L. (2010). Carbon flux rerouting during Mycobacterium tuberculosis growth arrest. Molecular Microbiology, 78(5), 1199–1215. https://doi.org/10.1111/j.1365-2958.2010.07399.x

The origins of quantum biology

Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences / Dec 01, 2018

McFadden, J., & Al-Khalili, J. (2018). The origins of quantum biology. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 474(2220), 20180674. https://doi.org/10.1098/rspa.2018.0674

13C-Flux Spectral Analysis of Host-Pathogen Metabolism Reveals a Mixed Diet for Intracellular Mycobacterium tuberculosis

Chemistry & Biology / Aug 01, 2013

Beste, D. J. V., Nöh, K., Niedenführ, S., Mendum, T. A., Hawkins, N. D., Ward, J. L., Beale, M. H., Wiechert, W., & McFadden, J. (2013). 13C-Flux Spectral Analysis of Host-Pathogen Metabolism Reveals a Mixed Diet for Intracellular Mycobacterium tuberculosis. Chemistry &amp; Biology, 20(8), 1012–1021. https://doi.org/10.1016/j.chembiol.2013.06.012

The use of DNA probes identifying restriction-fragment-length polymorphisms to examine the Mycobacterium avium complex

Molecular Microbiology / Jul 01, 1987

McFadden, J. J., Butcher, P. D., Thompson, J., Chiodini, R., & Hermon-Taylor, J. (1987). The use of DNA probes identifying restriction-fragment-length polymorphisms to examine the Mycobacterium avium complex. Molecular Microbiology, 1(1), 283–291. https://doi.org/10.1111/j.1365-2958.1987.tb01934.x

13C Metabolic Flux Analysis Identifies an Unusual Route for Pyruvate Dissimilation in Mycobacteria which Requires Isocitrate Lyase and Carbon Dioxide Fixation

PLoS Pathogens / Jul 21, 2011

Beste, D. J. V., Bonde, B., Hawkins, N., Ward, J. L., Beale, M. H., Noack, S., Nöh, K., Kruger, N. J., Ratcliffe, R. G., & McFadden, J. (2011). 13C Metabolic Flux Analysis Identifies an Unusual Route for Pyruvate Dissimilation in Mycobacteria which Requires Isocitrate Lyase and Carbon Dioxide Fixation. PLoS Pathogens, 7(7), e1002091. https://doi.org/10.1371/journal.ppat.1002091

Specific detection of Mycobacterium paratuberculosis DNA associated with granulomatous tissue in Crohn's disease.

Gut / Apr 01, 1994

Fidler, H. M., Thurrell, W., Johnson, N. M., Rook, G. A., & McFadden, J. J. (1994). Specific detection of Mycobacterium paratuberculosis DNA associated with granulomatous tissue in Crohn’s disease. Gut, 35(4), 506–510. https://doi.org/10.1136/gut.35.4.506

DNA PROBES DEMONSTRATE A SINGLE HIGHLY CONSERVED STRAIN OF MYCOBACTERIUM AVIUM INFECTING AIDS PATIENTS

The Lancet / Jan 01, 1989

Hampson, S. J., Thompson, J., Moss, M. T., Portaels, F., Green, E. P., Hermon-Taylor, J., & Mcfadden, J. J. (1989). DNA PROBES DEMONSTRATE A SINGLE HIGHLY CONSERVED STRAIN OF MYCOBACTERIUM AVIUM INFECTING AIDS PATIENTS. The Lancet, 333(8629), 65–68. https://doi.org/10.1016/s0140-6736(89)91427-x

Identification of spheroplast-like agents isolated from tissues of patients with Crohn's disease and control tissues by polymerase chain reaction

Journal of Clinical Microbiology / May 01, 1993

Wall, S., Kunze, Z. M., Saboor, S., Soufleri, I., Seechurn, P., Chiodini, R., & McFadden, J. J. (1993). Identification of spheroplast-like agents isolated from tissues of patients with Crohn’s disease and control tissues by polymerase chain reaction. Journal of Clinical Microbiology, 31(5), 1241–1245. https://doi.org/10.1128/jcm.31.5.1241-1245.1993

Integrating information in the brain’s EM field: the cemi field theory of consciousness

Neuroscience of Consciousness / Jan 01, 2020

McFadden, J. (2020). Integrating information in the brain’s EM field: the cemi field theory of consciousness. Neuroscience of Consciousness, 2020(1). https://doi.org/10.1093/nc/niaa016

Mycobacterium tuberculosis strains disrupted in mce3 and mce4 operons are attenuated in mice

Journal of Medical Microbiology / Feb 01, 2008

Senaratne, R. H., Sidders, B., Sequeira, P., Saunders, G., Dunphy, K., Marjanovic, O., Reader, J. R., Lima, P., Chan, S., Kendall, S., McFadden, J., & Riley, L. W. (2008). Mycobacterium tuberculosis strains disrupted in mce3 and mce4 operons are attenuated in mice. Journal of Medical Microbiology, 57(2), 164–170. https://doi.org/10.1099/jmm.0.47454-0

Polymerase chain reaction for detection of Mycobacterium leprae in nasal swab specimens

Journal of Clinical Microbiology / Mar 01, 1993

de Wit, M. Y., Douglas, J. T., McFadden, J., & Klatser, P. R. (1993). Polymerase chain reaction for detection of Mycobacterium leprae in nasal swab specimens. Journal of Clinical Microbiology, 31(3), 502–506. https://doi.org/10.1128/jcm.31.3.502-506.1993

Activity of mycobacterial promoters during intracellular and extracellular growth

Microbiology / Aug 01, 1995

Dellagostin, O. A., Esposito, G., Eales, L.-J., Dale, J. W., & McFadden, J. (1995). Activity of mycobacterial promoters during intracellular and extracellular growth. Microbiology, 141(8), 1785–1792. https://doi.org/10.1099/13500872-141-8-1785

Modeling and simulation of the main metabolism in Escherichia coli and its several single-gene knockout mutants with experimental verification

Microbial Cell Factories / Nov 19, 2010

Kadir, T. A. A., Mannan, A. A., Kierzek, A. M., McFadden, J., & Shimizu, K. (2010). Modeling and simulation of the main metabolism in Escherichia coli and its several single-gene knockout mutants with experimental verification. Microbial Cell Factories, 9(1). https://doi.org/10.1186/1475-2859-9-88

Recombination in mycobacteria

Molecular Microbiology / Jul 01, 1996

McFadden, J. (1996). Recombination in mycobacteria. Molecular Microbiology, 21(2), 205–211. Portico. https://doi.org/10.1046/j.1365-2958.1996.6271345.x

Determination of Genome Size and DNA Homology between an Unclassified Mycobacterium Species Isolated from Patients with Crohn's Disease and Other Mycobacteria

Microbiology / Jan 01, 1987

McFadden, J. J., Butcher, P. D., Chiodini, R. J., & Hermon-Taylor, J. (1987). Determination of Genome Size and DNA Homology between an Unclassified Mycobacterium Species Isolated from Patients with Crohn’s Disease and Other Mycobacteria. Microbiology, 133(1), 211–214. https://doi.org/10.1099/00221287-133-1-211

Characterization of the virulence of Mycobacterium avium complex (MAC) isolates in mice

Clinical and Experimental Immunology / Nov 01, 1994

PEDROSA, J., FLÓRIDO, M., KUNZE, Z. M., CASTRO, A. G., PORTAELS, F., McFADDEN, J., SILVA, M. T., & APPELBERG, R. (1994). Characterization of the virulence of Mycobacterium avium complex (MAC) isolates in mice. Clinical and Experimental Immunology, 98(2), 210–216. https://doi.org/10.1111/j.1365-2249.1994.tb06127.x

Compiling a Molecular Inventory for Mycobacterium bovis BCG at Two Growth Rates: Evidence for Growth Rate-Mediated Regulation of Ribosome Biosynthesis and Lipid Metabolism

Journal of Bacteriology / Mar 01, 2005

Beste, D. J. V., Peters, J., Hooper, T., Avignone-Rossa, C., Bushell, M. E., & McFadden, J. (2005). Compiling a Molecular Inventory for Mycobacterium bovis BCG at Two Growth Rates: Evidence for Growth Rate-Mediated Regulation of Ribosome Biosynthesis and Lipid Metabolism. Journal of Bacteriology, 187(5), 1677–1684. https://doi.org/10.1128/jb.187.5.1677-1684.2005

Simple enzymic method for isolation of DNA from diverse bacteria

Journal of Microbiological Methods / Sep 01, 1989

Visuvanathan, S., Moss, M. T., Stanford, J. L., Hermon-Taylor, J., & McFadden, J. J. (1989). Simple enzymic method for isolation of DNA from diverse bacteria. Journal of Microbiological Methods, 10(2), 59–64. https://doi.org/10.1016/0167-7012(89)90001-8

Identification of proteins from tuberculin purified protein derivative (PPD) by LC-MS/MS

Tuberculosis / Nov 01, 2009

Borsuk, S., Newcombe, J., Mendum, T. A., Dellagostin, O. A., & McFadden, J. (2009). Identification of proteins from tuberculin purified protein derivative (PPD) by LC-MS/MS. Tuberculosis, 89(6), 423–430. https://doi.org/10.1016/j.tube.2009.07.003

Gene replacement by homologous recombination in Mycobacterium bovis BCG

Molecular Microbiology / May 01, 1995

Norman, E., Dellagostin, O. A., McFadden, J., & Dale, J. W. (1995). Gene replacement by homologous recombination in Mycobacterium bovis BCG. Molecular Microbiology, 16(4), 755–760. https://doi.org/10.1111/j.1365-2958.1995.tb02436.x

Recombinant Mycobacterium bovis BCG Expressing the Sm14 Antigen of Schistosoma mansoni Protects Mice from Cercarial Challenge

Infection and Immunity / Jun 01, 2004

Varaldo, P. B., Leite, L. C. C., Dias, W. O., Miyaji, E. N., Torres, F. I. G., Gebara, V. C., Armôa, G. R. G., Campos, A. S., Matos, D. C. S., Winter, N., Gicquel, B., Vilar, M. M., McFadden, J., Almeida, M. S., Tendler, M., & McIntosh, D. (2004). Recombinant Mycobacterium bovis BCG Expressing the Sm14 Antigen of Schistosoma mansoni Protects Mice from Cercarial Challenge. Infection and Immunity, 72(6), 3336–3343. https://doi.org/10.1128/iai.72.6.3336-3343.2004

Quantum Biology: An Update and Perspective

Quantum Reports / Jan 26, 2021

Kim, Y., Bertagna, F., D’Souza, E. M., Heyes, D. J., Johannissen, L. O., Nery, E. T., Pantelias, A., Sanchez-Pedreño Jimenez, A., Slocombe, L., Spencer, M. G., Al-Khalili, J., Engel, G. S., Hay, S., Hingley-Wilson, S. M., Jeevaratnam, K., Jones, A. R., Kattnig, D. R., Lewis, R., Sacchi, M., … McFadden, J. (2021). Quantum Biology: An Update and Perspective. Quantum Reports, 3(1), 80–126. https://doi.org/10.3390/quantum3010006

Generation and characterization of a PhoP homologue mutant of Neisseria meningitidis

Molecular Microbiology / Feb 24, 2004

Johnson, C. R., Newcombe, J., Thorne, S., Borde, H. A., Eales-Reynolds, L.-J., Gorringe, A. R., Funnell, S. G. P., & McFadden, J. J. (2004). Generation and characterization of a PhoP homologue mutant of Neisseria meningitidis. Molecular Microbiology, 39(5), 1345–1355. https://doi.org/10.1111/j.1365-2958.2001.02324.x

Mycobacteria in Crohn's disease: DNA probes identify the wood pigeon strain of Mycobacterium avium and Mycobacterium paratuberculosis from human tissue

Journal of Clinical Microbiology / Dec 01, 1992

McFadden, J., Collins, J., Beaman, B., Arthur, M., & Gitnick, G. (1992). Mycobacteria in Crohn’s disease: DNA probes identify the wood pigeon strain of Mycobacterium avium and Mycobacterium paratuberculosis from human tissue. Journal of Clinical Microbiology, 30(12), 3070–3073. https://doi.org/10.1128/jcm.30.12.3070-3073.1992

The Acute-Phase Reactant C-Reactive Protein Binds to Phosphorylcholine-Expressing Neisseria meningitidis and Increases Uptake by Human Phagocytes

Infection and Immunity / Mar 01, 2008

Casey, R., Newcombe, J., McFadden, J., & Bodman-Smith, K. B. (2008). The Acute-Phase Reactant C-Reactive Protein Binds to Phosphorylcholine-Expressing Neisseria meningitidis and Increases Uptake by Human Phagocytes. Infection and Immunity, 76(3), 1298–1304. https://doi.org/10.1128/iai.00741-07

Generation of Chemically Unmodified Pure Single-Walled Carbon Nanotubes by Solubilizing with RNA and Treatment with Ribonuclease A

Advanced Materials / Jun 19, 2006

Jeynes, J. C. G., Mendoza, E., Chow, D. C. S., Watts, P. C. P., McFadden, J., & Silva, S. R. P. (2006). Generation of Chemically Unmodified Pure Single-Walled Carbon Nanotubes by Solubilizing with RNA and Treatment with Ribonuclease A. Advanced Materials, 18(12), 1598–1602. https://doi.org/10.1002/adma.200600362

The magnetic immuno-polymerase chain reaction assay for the detection of Campylobacter in milk and poultry

Letters in Applied Microbiology / Apr 01, 1996

Docherty, L., Adams, M. R., Patel, P., & McFadden, J. (1996). The magnetic immuno-polymerase chain reaction assay for the detection of Campylobacter in milk and poultry. Letters in Applied Microbiology, 22(4), 288–292. https://doi.org/10.1111/j.1472-765x.1996.tb01163.x

Transcriptomic Analysis Identifies Growth Rate Modulation as a Component of the Adaptation of Mycobacteria to Survival inside the Macrophage

Journal of Bacteriology / Jun 01, 2007

Beste, D. J. V., Laing, E., Bonde, B., Avignone-Rossa, C., Bushell, M. E., & McFadden, J. J. (2007). Transcriptomic Analysis Identifies Growth Rate Modulation as a Component of the Adaptation of Mycobacteria to Survival inside the Macrophage. Journal of Bacteriology, 189(11), 3969–3976. https://doi.org/10.1128/jb.01787-06

Uptake and Release of Double-Walled Carbon Nanotubes by Mammalian Cells

Advanced Functional Materials / Aug 18, 2010

Neves, V., Heister, E., Costa, S., Tîlmaciu, C., Borowiak-Palen, E., Giusca, C. E., Flahaut, E., Soula, B., Coley, H. M., McFadden, J., & Silva, S. R. P. (2010). Uptake and Release of Double-Walled Carbon Nanotubes by Mammalian Cells. Advanced Functional Materials, 20(19), 3272–3279. https://doi.org/10.1002/adfm.201000994

Construction and use of integrative vectors to express foreign genes in mycobacteria

Molecular Microbiology / Dec 01, 1993

Dellagostin, O. A., Wall, S., Norman, E., O’Shaughnessy, T., Dale, J. W., & McFadden, J. (1993). Construction and use of integrative vectors to express foreign genes in mycobacteria. Molecular Microbiology, 10(5), 983–993. https://doi.org/10.1111/j.1365-2958.1993.tb00970.x

Quadruple antimycobacterial chemotherapy in Crohn's disease: results at 9 months of a pilot study in 20 patients

Alimentary Pharmacology & Therapeutics / Mar 31, 2007

HAMPSON, S. J., PARKER, M. C., SAVERYMUTTU, S. H., JOSEPH, A. E., MCFADDEN, J.-J. P., & HERMON-TAYLOR, J. (2007). Quadruple antimycobacterial chemotherapy in Crohn’s disease: results at 9 months of a pilot study in 20 patients. Alimentary Pharmacology &amp; Therapeutics, 3(4), 343–352. https://doi.org/10.1111/j.1365-2036.1989.tb00221.x

AFM imaging of functionalized carbon nanotubes on biological membranes

Nanotechnology / Oct 02, 2009

Lamprecht, C., Liashkovich, I., Neves, V., Danzberger, J., Heister, E., Rangl, M., Coley, H. M., McFadden, J., Flahaut, E., Gruber, H. J., Hinterdorfer, P., Kienberger, F., & Ebner, A. (2009). AFM imaging of functionalized carbon nanotubes on biological membranes. Nanotechnology, 20(43), 434001. https://doi.org/10.1088/0957-4484/20/43/434001

Optimising DNA binding to carbon nanotubes by non-covalent methods

Carbon / Apr 01, 2011

Sanz, V., Borowiak, E., Lukanov, P., Galibert, A. M., Flahaut, E., Coley, H. M., Silva, S. R. P., & McFadden, J. (2011). Optimising DNA binding to carbon nanotubes by non-covalent methods. Carbon, 49(5), 1775–1781. https://doi.org/10.1016/j.carbon.2010.12.064

Systems-Based Approaches to Probing Metabolic Variation within the Mycobacterium tuberculosis Complex

PLoS ONE / Sep 17, 2013

Lofthouse, E. K., Wheeler, P. R., Beste, D. J. V., Khatri, B. L., Wu, H., Mendum, T. A., Kierzek, A. M., & McFadden, J. (2013). Systems-Based Approaches to Probing Metabolic Variation within the Mycobacterium tuberculosis Complex. PLoS ONE, 8(9), e75913. https://doi.org/10.1371/journal.pone.0075913

IS900-promoted stable integration of a foreign gene into mycobacteria

Molecular Microbiology / Aug 01, 1991

England, P. M., Wall, S., & McFadden, J. (1991). IS900-promoted stable integration of a foreign gene into mycobacteria. Molecular Microbiology, 5(8), 2047–2052. https://doi.org/10.1111/j.1365-2958.1991.tb00827.x

Investigation of mycobacteria in Crohn's disease tissue by Southern blotting and DNA hybridisation with cloned mycobacterial genomic DNA probes from a Crohn's disease isolated mycobacteria.

Gut / Sep 01, 1988

Butcher, P. D., McFadden, J. J., & Hermon-Taylor, J. (1988). Investigation of mycobacteria in Crohn’s disease tissue by Southern blotting and DNA hybridisation with cloned mycobacterial genomic DNA probes from a Crohn’s disease isolated mycobacteria. Gut, 29(9), 1222–1228. https://doi.org/10.1136/gut.29.9.1222

Design of double-walled carbon nanotubes for biomedical applications

Nanotechnology / Aug 22, 2012

Neves, V., Heister, E., Costa, S., Tîlmaciu, C., Flahaut, E., Soula, B., Coley, H. M., McFadden, J., & Silva, S. R. P. (2012). Design of double-walled carbon nanotubes for biomedical applications. Nanotechnology, 23(36), 365102. https://doi.org/10.1088/0957-4484/23/36/365102

Towards the Immunoproteome of Neisseria meningitidis

PLoS ONE / Jun 16, 2009

Mendum, T. A., Newcombe, J., McNeilly, C. L., & McFadden, J. (2009). Towards the Immunoproteome of Neisseria meningitidis. PLoS ONE, 4(6), e5940. https://doi.org/10.1371/journal.pone.0005940

Infection with an Avirulent phoP Mutant of Neisseria meningitidis Confers Broad Cross-Reactive Immunity

Infection and Immunity / Jan 01, 2004

Newcombe, J., Eales-Reynolds, L.-J., Wootton, L., Gorringe, A. R., Funnell, S. G. P., Taylor, S. C., & McFadden, J. J. (2004). Infection with an Avirulent phoP Mutant of Neisseria meningitidis Confers Broad Cross-Reactive Immunity. Infection and Immunity, 72(1), 338–344. https://doi.org/10.1128/iai.72.1.338-344.2004

Infrequent Transmission of Double-stranded RNA Virus Particles but Absence of DNA Proviruses in Single Ascospore Cultures of Gaeumannomyces graminis

Journal of General Virology / Apr 01, 1983

McFadden, J. J. P., Buck, K. W., & Rawlinson, C. J. (1983). Infrequent Transmission of Double-stranded RNA Virus Particles but Absence of DNA Proviruses in Single Ascospore Cultures of Gaeumannomyces graminis. Journal of General Virology, 64(4), 927–937. https://doi.org/10.1099/0022-1317-64-4-927

Intracellular Mycobacterium tuberculosis Exploits Multiple Host Nitrogen Sources during Growth in Human Macrophages

Cell Reports / Dec 01, 2019

Borah, K., Beyß, M., Theorell, A., Wu, H., Basu, P., Mendum, T. A., Nӧh, K., Beste, D. J. V., & McFadden, J. (2019). Intracellular Mycobacterium tuberculosis Exploits Multiple Host Nitrogen Sources during Growth in Human Macrophages. Cell Reports, 29(11), 3580-3591.e4. https://doi.org/10.1016/j.celrep.2019.11.037

Auxotrophic complementation as a selectable marker for stable expression of foreign antigens in Mycobacterium bovis BCG

Tuberculosis / Nov 01, 2007

Borsuk, S., Mendum, T. A., Fagundes, M. Q., Michelon, M., Cunha, C. W., McFadden, J., & Dellagostin, O. A. (2007). Auxotrophic complementation as a selectable marker for stable expression of foreign antigens in Mycobacterium bovis BCG. Tuberculosis, 87(6), 474–480. https://doi.org/10.1016/j.tube.2007.07.006

Identification and characterization of a novel insertion sequence, IS1106, downstream of the porA gene in B15 Neisseria meningitidis

Molecular Microbiology / Jun 01, 1992

Knight, A. I., Ni, H., Cartwright, K. A. V., & McFadden, J. J. (1992). Identification and characterization of a novel insertion sequence, IS1106, downstream of the porA gene in B15 Neisseria meningitidis. Molecular Microbiology, 6(11), 1565–1573. https://doi.org/10.1111/j.1365-2958.1992.tb00878.x

Context-sensitive transposition of IS6110 in mycobacteria

Microbiology / Nov 01, 1999

Wall, S., Ghanekar, K., McFadden, J., & Dale, J. W. (1999). Context-sensitive transposition of IS6110 in mycobacteria. Microbiology, 145(11), 3169–3176. https://doi.org/10.1099/00221287-145-11-3169

Stimulation of transposition of the Mycobacterium tuberculosis insertion sequence IS6110 by exposure to a microaerobic environment

Molecular Microbiology / Sep 01, 1999

Ghanekar, K., McBride, A., Dellagostin, O., Thorne, S., Mooney, R., & McFadden, J. (1999). Stimulation of transposition of the Mycobacterium tuberculosis insertion sequence IS6110 by exposure to a microaerobic environment. Molecular Microbiology, 33(5), 982–993. https://doi.org/10.1046/j.1365-2958.1999.01539.x

Genus- and species-specific DNA probes to identify mycobacteria using the polymerase chain reaction

Molecular and Cellular Probes / Apr 01, 1990

Fries, J. W. U., Patel, R. J., Piessens, W. F., & Wirth, D. F. (1990). Genus- and species-specific DNA probes to identify mycobacteria using the polymerase chain reaction. Molecular and Cellular Probes, 4(2), 87–105. https://doi.org/10.1016/0890-8508(90)90011-n

A microfluidic system for long-term time-lapse microscopy studies of mycobacteria

Tuberculosis / Nov 01, 2012

Golchin, S. A., Stratford, J., Curry, R. J., & McFadden, J. (2012). A microfluidic system for long-term time-lapse microscopy studies of mycobacteria. Tuberculosis, 92(6), 489–496. https://doi.org/10.1016/j.tube.2012.06.006

Mycobacteria and Crohn's disease.

Gut / Aug 01, 1988

Hampson, S. J., McFadden, J. J., & Hermon-Taylor, J. (1988). Mycobacteria and Crohn’s disease. Gut, 29(8), 1017–1019. https://doi.org/10.1136/gut.29.8.1017

Naturally occurring insertional inactivation of theporAgene ofNeisseria meningitidisby integration of IS1301

Molecular Microbiology / Oct 01, 1998

Newcombe, J., Cartwright, K., Dyer, S., & McFadden, J. (1998). Naturally occurring insertional inactivation of theporAgene ofNeisseria meningitidisby integration of IS1301. Molecular Microbiology, 30(2), 453–454. https://doi.org/10.1046/j.1365-2958.1998.01056.x

DNA fingerprinting as an indicator of active transmission of multidrug-resistant tuberculosis in Poland

International Journal of Infectious Diseases / Jul 01, 1998

Sajduda, A., Dziadek, J., Dela, A., Zalewska-Schdnthaler, N., Zwolska, Z., & McFadden, J. (1998). DNA fingerprinting as an indicator of active transmission of multidrug-resistant tuberculosis in Poland. International Journal of Infectious Diseases, 3(1), 12–17. https://doi.org/10.1016/s1201-9712(98)90089-3

Interrogation of global mutagenesis data with a genome scale model of Neisseria meningitidis to assess gene fitness in vitro and in sera

Genome Biology / Jan 01, 2011

Mendum, T. A., Newcombe, J., Mannan, A. A., Kierzek, A. M., & McFadden, J. (2011). Interrogation of global mutagenesis data with a genome scale model of Neisseria meningitidis to assess gene fitness in vitro and in sera. Genome Biology, 12(12), R127. https://doi.org/10.1186/gb-2011-12-12-r127

Phenotypic and Transcriptional Characterization of the Meningococcal PhoPQ System, a Magnesium-Sensing Two-Component Regulatory System That Controls Genes Involved in Remodeling the Meningococcal Cell Surface

Journal of Bacteriology / Jul 01, 2005

Newcombe, J., Jeynes, J. C., Mendoza, E., Hinds, J., Marsden, G. L., Stabler, R. A., Marti, M., & McFadden, J. J. (2005). Phenotypic and Transcriptional Characterization of the Meningococcal PhoPQ System, a Magnesium-Sensing Two-Component Regulatory System That Controls Genes Involved in Remodeling the Meningococcal Cell Surface. Journal of Bacteriology, 187(14), 4967–4975. https://doi.org/10.1128/jb.187.14.4967-4975.2005

Escape From Evolutionary Stasis by Transposon-mediated Deleterious Mutations

Journal of Theoretical Biology / Jun 01, 1997

McFadden, J., & Knowles, G. (1997). Escape From Evolutionary Stasis by Transposon-mediated Deleterious Mutations. Journal of Theoretical Biology, 186(4), 441–447. https://doi.org/10.1006/jtbi.1997.0403

Properties of Thirteen Viruses and Virus Variants Obtained from Eight Isolates of the Wheat Take-All Fungus, Gaeumannomyces graminis var. tritici.

Journal of General Virology / Apr 01, 1981

Buck, K. W., Almond, M. R., McFadden, J. J. P., Romanos, M. A., & Rawlinson, C. J. (1981). Properties of Thirteen Viruses and Virus Variants Obtained from Eight Isolates of the Wheat Take-All Fungus, Gaeumannomyces graminis var. tritici. Journal of General Virology, 53(2), 235–245. https://doi.org/10.1099/0022-1317-53-2-235

Chloroquine-enhanced gene delivery mediated by carbon nanotubes

Carbon / Dec 01, 2011

Sanz, V., Tilmacîu, C., Soula, B., Flahaut, E., Coley, H. M., Silva, S. R. P., & McFadden, J. (2011). Chloroquine-enhanced gene delivery mediated by carbon nanotubes. Carbon, 49(15), 5348–5358. https://doi.org/10.1016/j.carbon.2011.08.001

Comparative evaluation of Mycobacterium vaccae as a surrogate cloning host for use in the study of mycobacterial genetics

Microbiology / Jul 01, 2002

Medeiros, M. A., Dellagostin, O. A., Armôa, G. R. G., Degrave, W. M., de Mendonça-Lima, L., Lopes, M. Q., Costa, J. F., Mcfadden, J., & McIntosh, D. (2002). Comparative evaluation of Mycobacterium vaccae as a surrogate cloning host for use in the study of mycobacterial genetics. Microbiology, 148(7), 1999–2009. https://doi.org/10.1099/00221287-148-7-1999

The anaplerotic node is essential for the intracellular survival of Mycobacterium tuberculosis

Journal of Biological Chemistry / Apr 01, 2018

Basu, P., Sandhu, N., Bhatt, A., Singh, A., Balhana, R., Gobe, I., Crowhurst, N. A., Mendum, T. A., Gao, L., Ward, J. L., Beale, M. H., McFadden, J., & Beste, D. J. V. (2018). The anaplerotic node is essential for the intracellular survival of Mycobacterium tuberculosis. Journal of Biological Chemistry, 293(15), 5695–5704. https://doi.org/10.1074/jbc.ra118.001839

Epidemiological and genetic markers, virulence factors and intracellular growth of Mycobacterium avium in AIDS

Research in Microbiology / Jan 01, 1992

McFadden, J. J., Kunze, Z. M., Portaels, F., Labrousse, V., & Rastogi, N. (1992). Epidemiological and genetic markers, virulence factors and intracellular growth of Mycobacterium avium in AIDS. Research in Microbiology, 143(4), 423–430. https://doi.org/10.1016/0923-2508(92)90057-u

Mycobacterial DNA not detected in liver sections from patients with primary biliary cirrhosis

Journal of Hepatology / Mar 01, 1998

O’Donohue, J., Fidler, H., Garcia-Barcelo, M., Nouri-Aria, K., Williams, R., & McFadden, J. (1998). Mycobacterial DNA not detected in liver sections from patients with primary biliary cirrhosis. Journal of Hepatology, 28(3), 433–438. https://doi.org/10.1016/s0168-8278(98)80317-6

Slow Protein Fluctuations Explain the Emergence of Growth Phenotypes and Persistence in Clonal Bacterial Populations

PLoS ONE / Jan 29, 2013

Rocco, A., Kierzek, A. M., & McFadden, J. (2013). Slow Protein Fluctuations Explain the Emergence of Growth Phenotypes and Persistence in Clonal Bacterial Populations. PLoS ONE, 8(1), e54272. https://doi.org/10.1371/journal.pone.0054272

Expression of the B-cell and T-cell epitopes of the rabies virus nucleoprotein in Mycobacterium bovis BCG and induction of an humoral response in mice

Vaccine / Dec 01, 2001

da Cruz, F. W., McBride, A. J. A., Conceição, F. R., Dale, J. W., McFadden, J., & Dellagostin, O. A. (2001). Expression of the B-cell and T-cell epitopes of the rabies virus nucleoprotein in Mycobacterium bovis BCG and induction of an humoral response in mice. Vaccine, 20(5–6), 731–736. https://doi.org/10.1016/s0264-410x(01)00414-5

Integrating Kinetic Model of E. coli with Genome Scale Metabolic Fluxes Overcomes Its Open System Problem and Reveals Bistability in Central Metabolism

PLOS ONE / Oct 15, 2015

Mannan, A. A., Toya, Y., Shimizu, K., McFadden, J., Kierzek, A. M., & Rocco, A. (2015). Integrating Kinetic Model of E. coli with Genome Scale Metabolic Fluxes Overcomes Its Open System Problem and Reveals Bistability in Central Metabolism. PLOS ONE, 10(10), e0139507. https://doi.org/10.1371/journal.pone.0139507

Differential Producibility Analysis (DPA) of Transcriptomic Data with Metabolic Networks: Deconstructing the Metabolic Response of M. tuberculosis

PLoS Computational Biology / Jun 30, 2011

Bonde, B. K., Beste, D. J. V., Laing, E., Kierzek, A. M., & McFadden, J. (2011). Differential Producibility Analysis (DPA) of Transcriptomic Data with Metabolic Networks: Deconstructing the Metabolic Response of M. tuberculosis. PLoS Computational Biology, 7(6), e1002060. https://doi.org/10.1371/journal.pcbi.1002060

PCR-single-stranded confirmational polymorphism analysis for non-culture-based subtyping of meningococcal strains in clinical specimens

Journal of Clinical Microbiology / Jul 01, 1997

Newcombe, J., Dyer, S., Blackman, L., Cartwright, K., Palmer, W. H., McFadden, J., & Blackwell, L. (1997). PCR-single-stranded confirmational polymorphism analysis for non-culture-based subtyping of meningococcal strains in clinical specimens. Journal of Clinical Microbiology, 35(7), 1809–1812. https://doi.org/10.1128/jcm.35.7.1809-1812.1997

No evidence for antibodies to mycobacterial A60 antigen in Crohn's disease sera by enzyme-linked immunoabsorbent assay (ELISA)

Journal of Medical Microbiology / Apr 01, 1988

Mcfadden, J. J., & Houdayer, C. (1988). No evidence for antibodies to mycobacterial A60 antigen in Crohn’s disease sera by enzyme-linked immunoabsorbent assay (ELISA). Journal of Medical Microbiology, 25(4), 295–298. https://doi.org/10.1099/00222615-25-4-295

Academic Press Geology Series

Quantitative Methods / Jan 01, 1990

Academic Press Geology Series. (1990). Quantitative Methods, ii. https://doi.org/10.1016/b978-0-12-444172-9.50001-0

Protamine and Chloroquine Enhance Gene Delivery and Expression Mediated by RNA-Wrapped Single Walled Carbon Nanotubes

Journal of Nanoscience and Nanotechnology / Mar 01, 2012

Sanz, V., Coley, H. M., Silva, S. R. P., & McFadden, J. (2012). Protamine and Chloroquine Enhance Gene Delivery and Expression Mediated by RNA-Wrapped Single Walled Carbon Nanotubes. Journal of Nanoscience and Nanotechnology, 12(3), 1739–1747. https://doi.org/10.1166/jnn.2012.5172

Mycobacteria as possible causes of sarcoidosis and Crohn's disease

Journal of Applied Bacteriology / Dec 01, 1996

McFadden, J. J., & Fidler, H. M. (1996). Mycobacteria as possible causes of sarcoidosis and Crohn’s disease. Journal of Applied Bacteriology, 81, 47S-52S. https://doi.org/10.1111/j.1365-2672.1996.tb04598.x

MUFINS: multi-formalism interaction network simulator

npj Systems Biology and Applications / Nov 17, 2016

Wu, H., von Kamp, A., Leoncikas, V., Mori, W., Sahin, N., Gevorgyan, A., Linley, C., Grabowski, M., Mannan, A. A., Stoy, N., Stewart, G. R., Ward, L. T., Lewis, D. J. M., Sroka, J., Matsuno, H., Klamt, S., Westerhoff, H. V., McFadden, J., Plant, N. J., & Kierzek, A. M. (2016). MUFINS: multi-formalism interaction network simulator. Npj Systems Biology and Applications, 2(1). https://doi.org/10.1038/npjsba.2016.32

New Recombinant Mycobacterium bovis BCG Expression Vectors: Improving Genetic Control over Mycobacterial Promoters

Applied and Environmental Microbiology / Apr 15, 2016

Kanno, A. I., Goulart, C., Rofatto, H. K., Oliveira, S. C., Leite, L. C. C., & McFadden, J. (2016). New Recombinant Mycobacterium bovis BCG Expression Vectors: Improving Genetic Control over Mycobacterial Promoters. Applied and Environmental Microbiology, 82(8), 2240–2246. https://doi.org/10.1128/aem.03677-15

Updating and curating metabolic pathways of TB

Tuberculosis / Jan 01, 2013

Slayden, R. A., Jackson, M., Zucker, J., Ramirez, M. V., Dawson, C. C., Crew, R., Sampson, N. S., Thomas, S. T., Jamshidi, N., Sisk, P., Caspi, R., Crick, D. C., McNeil, M. R., Pavelka, M. S., Niederweis, M., Siroy, A., Dona, V., McFadden, J., Boshoff, H., & Lew, J. M. (2013). Updating and curating metabolic pathways of TB. Tuberculosis, 93(1), 47–59. https://doi.org/10.1016/j.tube.2012.11.001

Cellular localization, accumulation and trafficking of double-walled carbon nanotubes in human prostate cancer cells

Nano Research / Feb 22, 2012

Neves, V., Gerondopoulos, A., Heister, E., Tîlmaciu, C., Flahaut, E., Soula, B., Silva, S. R. P., McFadden, J., & Coley, H. M. (2012). Cellular localization, accumulation and trafficking of double-walled carbon nanotubes in human prostate cancer cells. Nano Research, 5(4), 223–234. https://doi.org/10.1007/s12274-012-0202-9

Modeling the binding of peptides on carbon nanotubes and their use as protein and DNA carriers

Journal of Nanoparticle Research / Jan 22, 2012

Sanz, V., Coley, H. M., Silva, S. R. P., & McFadden, J. (2012). Modeling the binding of peptides on carbon nanotubes and their use as protein and DNA carriers. Journal of Nanoparticle Research, 14(2). https://doi.org/10.1007/s11051-011-0695-2

Transposon libraries identify novel Mycobacterium bovis BCG genes involved in the dynamic interactions required for BCG to persist during in vivo passage in cattle

BMC Genomics / May 28, 2019

Mendum, T. A., Chandran, A., Williams, K., Vordermeier, H. M., Villarreal-Ramos, B., Wu, H., Singh, A., Smith, A. A., Butler, R. E., Prasad, A., Bharti, N., Banerjee, R., Kasibhatla, S. M., Bhatt, A., Stewart, G. R., & McFadden, J. (2019). Transposon libraries identify novel Mycobacterium bovis BCG genes involved in the dynamic interactions required for BCG to persist during in vivo passage in cattle. BMC Genomics, 20(1). https://doi.org/10.1186/s12864-019-5791-1

System-level strategies for studying the metabolism of Mycobacterium tuberculosis

Molecular BioSystems / Jan 01, 2010

Beste, D. J. V., & McFadden, J. (2010). System-level strategies for studying the metabolism of Mycobacterium tuberculosis. Molecular BioSystems, 6(12), 2363. https://doi.org/10.1039/c003757p

Acorn: A grid computing system for constraint based modeling and visualization of the genome scale metabolic reaction networks via a web interface

BMC Bioinformatics / May 24, 2011

Sroka, J., Bieniasz-Krzywiec, Ł., Gwóźdź, S., Leniowski, D., Łącki, J., Markowski, M., Avignone-Rossa, C., Bushell, M. E., McFadden, J., & Kierzek, A. M. (2011). Acorn: A grid computing system for constraint based modeling and visualization of the genome scale metabolic reaction networks via a web interface. BMC Bioinformatics, 12(1). https://doi.org/10.1186/1471-2105-12-196

Research Interests

microbiology
systems biology
genetics
quantum biology
Management of Technology and Innovation
General Medicine
Microbiology (medical)
General Chemistry
General Materials Science
General Agricultural and Biological Sciences
Developmental Biology
Neurology (clinical)
Molecular Biology
General Neuroscience
General Engineering
General Physics and Astronomy
Cognitive Neuroscience
Developmental Neuroscience
Atomic and Molecular Physics, and Optics
Multidisciplinary
Applied Mathematics
General Biochemistry, Genetics and Molecular Biology
Modeling and Simulation
Statistics and Probability
General Earth and Planetary Sciences
General Environmental Science
General Mathematics
Clinical Biochemistry
Drug Discovery
Pharmacology
Molecular Medicine
Biochemistry
Virology
Immunology
Parasitology
Gastroenterology
Psychiatry and Mental health
Neurology
Clinical Psychology
Experimental and Cognitive Psychology
Applied Microbiology and Biotechnology
Bioengineering
Biotechnology
Immunology and Allergy
Infectious Diseases
Physics and Astronomy (miscellaneous)
Astronomy and Astrophysics
Statistical and Nonlinear Physics
Mechanical Engineering
Mechanics of Materials
Electrochemistry
Condensed Matter Physics
Biomaterials
Electronic, Optical and Magnetic Materials
Pharmacology (medical)
Hepatology
Electrical and Electronic Engineering
Cell Biology
General Immunology and Microbiology
Public Health, Environmental and Occupational Health
General Veterinary
Computational Theory and Mathematics
Cellular and Molecular Neuroscience
Ecology
Ecology, Evolution, Behavior and Systematics
Biomedical Engineering
Computer Science Applications
Food Science
Structural Biology
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