Dr. Kevin Pawlak, Ph.D.
Xavier University School of Medicine
Research Interests
Publications
Mitochondria-associated Endoplasmic Reticulum Membrane (MAM) Regulates Steroidogenic Activity via Steroidogenic Acute Regulatory Protein (StAR)-Voltage-dependent Anion Channel 2 (VDAC2) Interaction
Journal of Biological Chemistry / Jan 01, 2015
Prasad, M., Kaur, J., Pawlak, K. J., Bose, M., Whittal, R. M., & Bose, H. S. (2015). Mitochondria-associated Endoplasmic Reticulum Membrane (MAM) Regulates Steroidogenic Activity via Steroidogenic Acute Regulatory Protein (StAR)-Voltage-dependent Anion Channel 2 (VDAC2) Interaction. Journal of Biological Chemistry, 290(5), 2604–2616. https://doi.org/10.1074/jbc.m114.605808
Mitochondrial metabolic regulation by GRP78
Science Advances / Feb 03, 2017
Prasad, M., Pawlak, K. J., Burak, W. E., Perry, E. E., Marshall, B., Whittal, R. M., & Bose, H. S. (2017). Mitochondrial metabolic regulation by GRP78. Science Advances, 3(2). https://doi.org/10.1126/sciadv.1602038
The role of progesterone metabolites in breast cancer: Potential for new diagnostics and therapeutics
The Journal of Steroid Biochemistry and Molecular Biology / Feb 01, 2005
Wiebe, J. P., Lewis, M. J., Cialacu, V., Pawlak, K. J., & Zhang, G. (2005). The role of progesterone metabolites in breast cancer: Potential for new diagnostics and therapeutics. The Journal of Steroid Biochemistry and Molecular Biology, 93(2–5), 201–208. https://doi.org/10.1016/j.jsbmb.2004.12.003
Inner Mitochondrial Translocase Tim50 Interacts with 3β-Hydroxysteroid Dehydrogenase Type 2 to Regulate Adrenal and Gonadal Steroidogenesis
Journal of Biological Chemistry / Nov 01, 2011
Pawlak, K. J., Prasad, M., Thomas, J. L., Whittal, R. M., & Bose, H. S. (2011). Inner Mitochondrial Translocase Tim50 Interacts with 3β-Hydroxysteroid Dehydrogenase Type 2 to Regulate Adrenal and Gonadal Steroidogenesis. Journal of Biological Chemistry, 286(45), 39130–39140. https://doi.org/10.1074/jbc.m111.290031
Regulation of estrogen receptor (ER) levels in MCF-7 cells by progesterone metabolites
The Journal of Steroid Biochemistry and Molecular Biology / Nov 01, 2007
Pawlak, K. J., & Wiebe, J. P. (2007). Regulation of estrogen receptor (ER) levels in MCF-7 cells by progesterone metabolites. The Journal of Steroid Biochemistry and Molecular Biology, 107(3–5), 172–179. https://doi.org/10.1016/j.jsbmb.2007.05.030
Membrane 5α-pregnane-3,20-dione (5αP) receptors in MCF-7 and MCF-10A breast cancer cells are up-regulated by estradiol and 5αP and down-regulated by the progesterone metabolites, 3α-dihydroprogesterone and 20α-dihydroprogesterone, with associated changes in cell proliferation and detachment
The Journal of Steroid Biochemistry and Molecular Biology / Nov 01, 2005
Pawlak, K. J., Zhang, G., & Wiebe, J. P. (2005). Membrane 5α-pregnane-3,20-dione (5αP) receptors in MCF-7 and MCF-10A breast cancer cells are up-regulated by estradiol and 5αP and down-regulated by the progesterone metabolites, 3α-dihydroprogesterone and 20α-dihydroprogesterone, with associated changes in cell proliferation and detachment. The Journal of Steroid Biochemistry and Molecular Biology, 97(3), 278–288. https://doi.org/10.1016/j.jsbmb.2005.05.014
An Outer Mitochondrial Translocase, Tom22, Is Crucial for Inner Mitochondrial Steroidogenic Regulation in Adrenal and Gonadal Tissues
Molecular and Cellular Biology / Mar 01, 2016
Rajapaksha, M., Kaur, J., Prasad, M., Pawlak, K. J., Marshall, B., Perry, E. W., Whittal, R. M., & Bose, H. S. (2016). An Outer Mitochondrial Translocase, Tom22, Is Crucial for Inner Mitochondrial Steroidogenic Regulation in Adrenal and Gonadal Tissues. Molecular and Cellular Biology, 36(6), 1032–1047. https://doi.org/10.1128/mcb.01107-15
Mechanism of action of the breast cancer-promoter hormone, 5α-dihydroprogesterone (5αP), involves plasma membrane-associated receptors and MAPK activation
The Journal of Steroid Biochemistry and Molecular Biology / Jan 01, 2016
Wiebe, J. P., Pawlak, K. J., & Kwok, A. (2016). Mechanism of action of the breast cancer-promoter hormone, 5α-dihydroprogesterone (5αP), involves plasma membrane-associated receptors and MAPK activation. The Journal of Steroid Biochemistry and Molecular Biology, 155, 166–176. https://doi.org/10.1016/j.jsbmb.2015.10.021
Decreased CytochromecOxidase IV Expression Reduces Steroidogenesis
Journal of Pharmacology and Experimental Therapeutics / May 10, 2011
Pawlak, K. J., Prasad, M., McKenzie, K. A., Wiebe, J. P., Gairola, C. G., Whittal, R. M., & Bose, H. S. (2011). Decreased CytochromecOxidase IV Expression Reduces Steroidogenesis. Journal of Pharmacology and Experimental Therapeutics, 338(2), 598–604. https://doi.org/10.1124/jpet.111.182634
Plasma Membrane Receptors for the Cancer-Regulating Progesterone Metabolites, 5α-Pregnane-3,20-dione and 3α-Hydroxy-4-pregnen-20-one in MCF-7 Breast Cancer Cells
Biochemical and Biophysical Research Communications / Jun 01, 2000
Weiler, P. J., & Wiebe, J. P. (2000). Plasma Membrane Receptors for the Cancer-Regulating Progesterone Metabolites, 5α-Pregnane-3,20-dione and 3α-Hydroxy-4-pregnen-20-one in MCF-7 Breast Cancer Cells. Biochemical and Biophysical Research Communications, 272(3), 731–737. https://doi.org/10.1006/bbrc.2000.2847
Plasma Membrane Receptors for the Cancer-Regulating Progesterone Metabolites, 5α-Pregnane-3,20-dione and 3α-Hydroxy-4-pregnen-20-one in MCF-7 Breast Cancer Cells
Biochemical and Biophysical Research Communications / Jun 01, 2000
Weiler, P. J., & Wiebe, J. P. (2000). Plasma Membrane Receptors for the Cancer-Regulating Progesterone Metabolites, 5α-Pregnane-3,20-dione and 3α-Hydroxy-4-pregnen-20-one in MCF-7 Breast Cancer Cells. Biochemical and Biophysical Research Communications, 272(3), 731–737. https://doi.org/10.1006/bbrc.2000.2847
Plasma Membrane Receptors for the Cancer-Regulating Progesterone Metabolites, 5α-Pregnane-3,20-dione and 3α-Hydroxy-4-pregnen-20-one in MCF-7 Breast Cancer Cells
Biochemical and Biophysical Research Communications / Jun 01, 2000
Weiler, P. J., & Wiebe, J. P. (2000). Plasma Membrane Receptors for the Cancer-Regulating Progesterone Metabolites, 5α-Pregnane-3,20-dione and 3α-Hydroxy-4-pregnen-20-one in MCF-7 Breast Cancer Cells. Biochemical and Biophysical Research Communications, 272(3), 731–737. https://doi.org/10.1006/bbrc.2000.2847
Education
University of Western Ontario
PhD, Biology (Physiology) / October, 2008
Experience
Xavier University School of Medicine
Associate Professor of Physiology / April, 2017 — Present
Dean of Pre-Health Sciences / July, 2019 — Present
Zirve University School of Medicine
Assistant Professor / September, 2014 — June, 2016
Mercer University School of Medicine
Post Doctoral Fellow / August, 2008 — June, 2014
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