Elena Shersher, Ph.D.

Cancer researcher at University of Miami

Miami

Research Interests

Cancer Research

Molecular Biology

Biochemistry

Cell Biology

Drug discovery

Cancer cell signaling

About

Elena Shersher, Ph.D. is a highly skilled and experienced biochemist with a strong background in cancer research. She received her Ph.D. in Biochemistry from Florida International University in 2016, where she was a recipient of a prestigious Presidential fellowship. After completing her Ph.D., Elena continued her career as a clinical program development lead and coordinator at a CRO. In 2017, Elena joined a cancer research team at the University of Miami as a researcher. In this role, she utilized her expertise in advanced laboratory techniques and data analysis to study the role of specific proteins in cancer cell signaling in order to identify promising molecular targets for therapeutic intervention. Elena's research has been published in several prestigious scientific journals, and she has presented her findings at numerous conferences. In addition to her research, Elena is also passionate about mentoring and teaching the next generation of scientists. She has served as a mentor and advisor to undergraduate and graduate students, helping them develop their research skills and guiding them in their academic and career paths. Elena's dedication and contributions to the field of cancer research have made her a valuable asset to the scientific community. With her expertise and experience, she continues to make significant advancements in understanding and treating cancer, bringing hope to those affected by this devastating disease.

Publications

NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis

Cell Communication and Signaling / Sep 22, 2021

Shersher, E., Lahiry, M., Alvarez-Trotta, A., Diluvio, G., Robbins, D. J., Shiekhattar, R., & Capobianco, A. J. (2021). NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis. Cell Communication and Signaling, 19(1). https://doi.org/10.1186/s12964-021-00776-1

The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling

Oncotarget / Aug 18, 2020

Alvarez-Trotta, A., Wang, Z., Shersher, E., Li, B., Long, J., Lohse, I., Wahlestedt, C., El-Rifai, W., Robbins, D. J., & Capobianco, A. J. (2020). The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling. Oncotarget, 11(33), 3174–3187. https://doi.org/10.18632/oncotarget.27699

Pharmacological Disruption of the Notch1 Transcriptional Complex Inhibits Tumor Growth by Selectively Targeting Cancer Stem Cells

Cancer Research / Apr 05, 2021

Alvarez-Trotta, A., Guerrant, W., Astudillo, L., Lahiry, M., Diluvio, G., Shersher, E., Kaneku, H., Robbins, D. J., Orton, D., & Capobianco, A. J. (2021). Pharmacological Disruption of the Notch1 Transcriptional Complex Inhibits Tumor Growth by Selectively Targeting Cancer Stem Cells. Cancer Research, 81(12), 3347–3357. https://doi.org/10.1158/0008-5472.can-20-3611

A novel chemical attack on Notch-mediated transcription by targeting the NACK ATPase

Molecular Therapy - Oncolytics / Mar 01, 2023

Diluvio, G., Kelley, T. T., Lahiry, M., Alvarez-Trotta, A., Kolb, E. M., Shersher, E., Astudillo, L., Kovall, R. A., Schürer, S. C., & Capobianco, A. J. (2023). A novel chemical attack on Notch-mediated transcription by targeting the NACK ATPase. Molecular Therapy - Oncolytics, 28, 307–320. https://doi.org/10.1016/j.omto.2023.02.008

Education

Florida International University

Ph.D., Biochemistry / May, 2016

Miami, Florida, United States of America

Experience

University of Miami

Cancer researcher / March, 2017 — Present

I study cell signaling mechanisms to identify the most promising molecular targets for therapeutic intervention in cancer.

Links & Social Media

LinkedIn profile

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