Regan Hamel
Senior bioinformatics scientist, specializing in single cell omics in the context of cellular reprogramming and neuroinflammation
Research Interests
About
Publications
Harnessing the Neural Stem Cell Secretome for Regenerative Neuroimmunology
Frontiers in Cellular Neuroscience / Nov 05, 2020
Willis, C. M., Nicaise, A. M., Hamel, R., Pappa, V., Peruzzotti-Jametti, L., & Pluchino, S. (2020). Harnessing the Neural Stem Cell Secretome for Regenerative Neuroimmunology. Frontiers in Cellular Neuroscience, 14. https://doi.org/10.3389/fncel.2020.590960
Stem Cell Therapies for Progressive Multiple Sclerosis
Frontiers in Cell and Developmental Biology / Jul 09, 2021
Smith, J. A., Nicaise, A. M., Ionescu, R.-B., Hamel, R., Peruzzotti-Jametti, L., & Pluchino, S. (2021). Stem Cell Therapies for Progressive Multiple Sclerosis. Frontiers in Cell and Developmental Biology, 9. https://doi.org/10.3389/fcell.2021.696434
Characterization of Human iPSC-derived Spinal Motor Neurons by Single-cell RNA Sequencing
Neuroscience / Dec 01, 2020
Thiry, L., Hamel, R., Pluchino, S., Durcan, T., & Stifani, S. (2020). Characterization of Human iPSC-derived Spinal Motor Neurons by Single-cell RNA Sequencing. Neuroscience, 450, 57–70. https://doi.org/10.1016/j.neuroscience.2020.04.041
Metabolic Control of Smoldering Neuroinflammation
Frontiers in Immunology / Jun 23, 2021
Peruzzotti-Jametti, L., Willis, C. M., Hamel, R., Krzak, G., & Pluchino, S. (2021). Metabolic Control of Smoldering Neuroinflammation. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.705920
Combination of In Situ Lcn2 pRNA-RNAi Nanotherapeutics and iNSC Transplantation Ameliorates Experimental SCI in Mice
Molecular Therapy / Dec 01, 2020
Braga, A., Bandiera, S., Verheyen, J., Hamel, R., Rutigliani, C., Edenhofer, F., Smith, J. A., & Pluchino, S. (2020). Combination of In Situ Lcn2 pRNA-RNAi Nanotherapeutics and iNSC Transplantation Ameliorates Experimental SCI in Mice. Molecular Therapy, 28(12), 2677–2690. https://doi.org/10.1016/j.ymthe.2020.08.001
Bioinformatics analysis identified apolipoprotein E as a hub gene regulating neuroinflammation in macrophages and microglia following spinal cord injury
Frontiers in Immunology / Aug 24, 2022
Yao, X.-Q., Chen, J.-Y., Yu, Z.-H., Huang, Z.-C., Hamel, R., Zeng, Y.-Q., Huang, Z.-P., Tu, K.-W., Liu, J.-H., Lu, Y.-M., Zhou, Z.-T., Pluchino, S., Zhu, Q.-A., & Chen, J.-T. (2022). Bioinformatics analysis identified apolipoprotein E as a hub gene regulating neuroinflammation in macrophages and microglia following spinal cord injury. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.964138
Time-resolved single-cell RNAseq profiling identifies a novel Fabp5-expressing subpopulation of inflammatory myeloid cells in chronic spinal cord injury
Oct 21, 2020
Hamel, R., Peruzzotti-Jametti, L., Ridley, K., Testa, V., Yu, B., Rowitch, D., Marioni, J. C., & Pluchino, S. (2020). Time-resolved single-cell RNAseq profiling identifies a novel Fabp5-expressing subpopulation of inflammatory myeloid cells in chronic spinal cord injury. https://doi.org/10.1101/2020.10.21.346635
Single cell biology—a Keystone Symposia report
Annals of the New York Academy of Sciences / Oct 03, 2021
Cable, J., Elowitz, M. B., Domingos, A. I., Habib, N., Itzkovitz, S., Hamidzada, H., Balzer, M. S., Yanai, I., Liberali, P., Whited, J., Streets, A., Cai, L., Stergachis, A. B., Hong, C. K. Y., Keren, L., Guilliams, M., Alon, U., Shalek, A. K., Hamel, R., … Romeike, M. (2021). Single cell biology—a Keystone Symposia report. Annals of the New York Academy of Sciences, 1506(1), 74–97. Portico. https://doi.org/10.1111/nyas.14692
The therapeutic potential of exogenous adult stem cells for the injured central nervous system
Handbook of Innovations in Central Nervous System Regenerative Medicine / Jan 01, 2020
Smith, J. A., Braga, A., Hamel, R., Rutigliani, C., Yu, B., Peruzzotti-Jametti, L., & Pluchino, S. (2020). The therapeutic potential of exogenous adult stem cells for the injured central nervous system. Handbook of Innovations in Central Nervous System Regenerative Medicine, 147–258. https://doi.org/10.1016/b978-0-12-818084-6.00006-4
Integrative multi-omics analysis reveals molecular landscape associated with chronic lipid accumulation following contusive spinal cord injury
Jan 04, 2023
Yao, X.-Q., Chen, J.-Y., Yu, Z.-H., Huang, Z.-C., Hamel, R., Liu, J.-H., Shen, X., Wang, Y.-E., Zeng, Y.-Q., Huang, Z.-P., Lu, Y.-M., Zhou, Z.-T., Liu, C.-T., Shi, J.-M., Peruzzotti-Jametti, L., Pluchino, S., Zhu, Q.-A., & Chen, J.-T. (2023). Integrative multi-omics analysis reveals molecular landscape associated with chronic lipid accumulation following contusive spinal cord injury. https://doi.org/10.21203/rs.3.rs-2437316/v1
Multiple sclerosis and neuromyelitis optica spectrum disorders
Neurobiology of Brain Disorders / Jan 01, 2023
Ionescu, R.-B., Willis, C., Nicaise, A. M., Krzak, G., Hamel, R., Peruzzotti-Jametti, L., & Pluchino, S. (2023). Multiple sclerosis and neuromyelitis optica spectrum disorders. Neurobiology of Brain Disorders, 575–608. https://doi.org/10.1016/b978-0-323-85654-6.00051-4
Time-resolved single-cell RNAseq profiling identifies a novel Fabp5+ subpopulation of inflammatory myeloid cells with delayed cytotoxic profile in chronic spinal cord injury
Heliyon / Aug 01, 2023
Hamel, R., Peruzzotti-Jametti, L., Ridley, K., Testa, V., Yu, B., Rowitch, D., Marioni, J. C., & Pluchino, S. (2023). Time-resolved single-cell RNAseq profiling identifies a novel Fabp5+ subpopulation of inflammatory myeloid cells with delayed cytotoxic profile in chronic spinal cord injury. Heliyon, 9(8), e18339. https://doi.org/10.1016/j.heliyon.2023.e18339
Education
University of Cambridge
PhD, Clinical Neurosciences / September, 2021
University of Cambridge
MPhil, Clinical Neurosciences / September, 2018
McGill University
Bachelor of Science, Neurosciences / June, 2017
Experience
Mogrify Ltd
Bioinformatics scientist / August, 2021 — June, 2023
Senior Bioinformatics Scientist / July, 2023 — Present
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