Xander van Wijk, PhD, DABCC, FADLM

Strategic Leader in Clinical Diagnostics | Expert in Laboratory and Precision Medicine | Award-Winning Scientist & Author | CLIA Laboratory Director

Research Interests

Clinical Chemistry
Cardiac Biomarkers
Analytical Toxicology
Pharmacogenomics
Blood Gas
Internal Medicine
Urology
Clinical Biochemistry
Cancer Research
Physiology
Molecular Biology
Biochemistry
Cell Biology
Nephrology
Immunology
Infectious Diseases
Parasitology
Microbiology
Genetics
Biotechnology
Virology
Molecular Medicine
Health (social science)
Health, Toxicology and Mutagenesis
Epidemiology
Health Information Management
Toxicology
Biochemistry (medical)
Environmental Chemistry
Chemical Health and Safety
Analytical Chemistry
Pharmacology
Pharmacology (medical)
Oncology
Neurology (clinical)
Neurology
Genetics (clinical)
Pediatrics, Perinatology and Child Health
Cardiology and Cardiovascular Medicine
Anesthesiology and Pain Medicine
Physiology (medical)

About

A leader in the field of laboratory and precision medicine, passionate about improving healthcare through innovative solutions. Well versed in working in regulated environments (CLIA, FDA). Holding multiple board and leadership positions. Strong track record of scientific contributions with 70+ peer-reviewed articles, book chapters, and (inter)national podium presentations. Received several recent major awards & recognitions.

Publications

Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type

Scientific Reports / Aug 21, 2017

Ihse, E., Yamakado, H., van Wijk, X. M., Lawrence, R., Esko, J. D., & Masliah, E. (2017). Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type. Scientific Reports, 7(1). https://doi.org/10.1038/s41598-017-08720-5

Adverse Effects From Counterfeit Alprazolam Tablets

JAMA Internal Medicine / Oct 01, 2016

Arens, A. M., van Wijk, X. M. R., Vo, K. T., Lynch, K. L., Wu, A. H. B., & Smollin, C. G. (2016). Adverse Effects From Counterfeit Alprazolam Tablets. JAMA Internal Medicine, 176(10), 1554. https://doi.org/10.1001/jamainternmed.2016.4306

The Distribution and Function of Chondroitin Sulfate and Other Sulfated Glycosaminoglycans in the Human Bladder and Their Contribution to the Protective Bladder Barrier

Journal of Urology / Jan 01, 2013

Janssen, D. A. W., van Wijk, X. M. R., Jansen, K. C. F. J., van Kuppevelt, T. H., Heesakkers, J. P. F. A., & Schalken, J. A. (2013). The Distribution and Function of Chondroitin Sulfate and Other Sulfated Glycosaminoglycans in the Human Bladder and Their Contribution to the Protective Bladder Barrier. Journal of Urology, 189(1), 336–342. https://doi.org/10.1016/j.juro.2012.09.022

Heparan sulfate in angiogenesis: a target for therapy

Angiogenesis / Oct 22, 2013

van Wijk, X. M. R., & van Kuppevelt, T. H. (2013). Heparan sulfate in angiogenesis: a target for therapy. Angiogenesis. https://doi.org/10.1007/s10456-013-9401-6

The Polybasic Insertion in Autotaxin α Confers Specific Binding to Heparin and Cell Surface Heparan Sulfate Proteoglycans

Journal of Biological Chemistry / Jan 01, 2013

Houben, A. J. S., van Wijk, X. M. R., van Meeteren, L. A., van Zeijl, L., van de Westerlo, E. M. A., Hausmann, J., Fish, A., Perrakis, A., van Kuppevelt, T. H., & Moolenaar, W. H. (2013). The Polybasic Insertion in Autotaxin α Confers Specific Binding to Heparin and Cell Surface Heparan Sulfate Proteoglycans. Journal of Biological Chemistry, 288(1), 510–519. https://doi.org/10.1074/jbc.m112.358416

Modulation of heparan sulfate in the glomerular endothelial glycocalyx decreases leukocyte influx during experimental glomerulonephritis

Kidney International / Nov 01, 2014

LWMM Rops, A., Loeven, M. A., van Gemst, J. J., Eversen, I., Van Wijk, X. M., Dijkman, H. B., van Kuppevelt, T. H., Berden, J. H. M., Rabelink, T. J., Esko, J. D., & van der Vlag, J. (2014). Modulation of heparan sulfate in the glomerular endothelial glycocalyx decreases leukocyte influx during experimental glomerulonephritis. Kidney International, 86(5), 932–942. https://doi.org/10.1038/ki.2014.115

Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity

Infection and Immunity / Sep 01, 2015

Xu, D., Olson, J., Cole, J. N., van Wijk, X. M., Brinkmann, V., Zychlinsky, A., Nizet, V., Esko, J. D., & Chang, Y.-C. (2015). Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity. Infection and Immunity, 83(9), 3648–3656. https://doi.org/10.1128/iai.00545-15

Role of von Willebrand Factor in COVID-19 Associated Coagulopathy

The Journal of Applied Laboratory Medicine / Jun 13, 2021

Mei, Z. W., van Wijk, X. M. R., Pham, H. P., & Marin, M. J. (2021). Role of von Willebrand Factor in COVID-19 Associated Coagulopathy. The Journal of Applied Laboratory Medicine, 6(5), 1305–1315. https://doi.org/10.1093/jalm/jfab042

A common sugar‐nucleotide‐mediated mechanism of inhibition of (glycosamino)glycan biosynthesis, as evidenced by 6F‐GalNAc (Ac 3 )

The FASEB Journal / Apr 13, 2015

Wijk, X. M., Lawrence, R., Thijssen, V. L., Broek, S. A., Troost, R., Scherpenzeel, M., Naidu, N., Oosterhof, A., Griffioen, A. W., Lefeber, D. J., Delft, F. L., & Kuppevelt, T. H. (2015). A common sugar‐nucleotide‐mediated mechanism of inhibition of (glycosamino)glycan biosynthesis, as evidenced by 6F‐GalNAc (Ac 3 ). The FASEB Journal, 29(7), 2993–3002. Portico. https://doi.org/10.1096/fj.14-264226

Whole-Genome Sequencing of Invasion-Resistant Cells Identifies Laminin α2 as a Host Factor for Bacterial Invasion

mBio / Mar 08, 2017

van Wijk, X. M., Döhrmann, S., Hallström, B. M., Li, S., Voldborg, B. G., Meng, B. X., McKee, K. K., van Kuppevelt, T. H., Yurchenco, P. D., Palsson, B. O., Lewis, N. E., Nizet, V., & Esko, J. D. (2017). Whole-Genome Sequencing of Invasion-Resistant Cells Identifies Laminin α2 as a Host Factor for Bacterial Invasion. MBio, 8(1). https://doi.org/10.1128/mbio.02128-16

Interfering with UDP-GlcNAc Metabolism and Heparan Sulfate Expression Using a Sugar Analogue Reduces Angiogenesis

ACS Chemical Biology / Sep 03, 2013

van Wijk, X. M., Thijssen, V. L., Lawrence, R., van den Broek, S. A., Dona, M., Naidu, N., Oosterhof, A., van de Westerlo, E. M., Kusters, L. J., Khaled, Y., Jokela, T. A., Nowak-Sliwinska, P., Kremer, H., Stringer, S. E., Griffioen, A. W., van Wijk, E., van Delft, F. L., & van Kuppevelt, T. H. (2013). Interfering with UDP-GlcNAc Metabolism and Heparan Sulfate Expression Using a Sugar Analogue Reduces Angiogenesis. ACS Chemical Biology, 8(10), 2331–2338. https://doi.org/10.1021/cb4004332

Analytical and Clinical Evaluation of the Automated Elecsys Anti–SARS-CoV-2 Antibody Assay on the Roche cobas e602 Analyzer

American Journal of Clinical Pathology / Aug 20, 2020

Chan, C. W., Parker, K., Tesic, V., Baldwin, A., Tang, N. Y., van Wijk, X. M. R., & Yeo, K.-T. J. (2020). Analytical and Clinical Evaluation of the Automated Elecsys Anti–SARS-CoV-2 Antibody Assay on the Roche cobas e602 Analyzer. American Journal of Clinical Pathology, 154(5), 620–626. https://doi.org/10.1093/ajcp/aqaa155

Counterfeit Norco Poisoning Outbreak — San Francisco Bay Area, California, March 25–April 5, 2016

MMWR. Morbidity and Mortality Weekly Report / Apr 29, 2016

Vo, K. T., van Wijk, X. M. R., Lynch, K. L., Wu, A. H. B., & Smollin, C. G. (2016). Counterfeit Norco Poisoning Outbreak — San Francisco Bay Area, California, March 25–April 5, 2016. MMWR. Morbidity and Mortality Weekly Report, 65(16), 420–423. https://doi.org/10.15585/mmwr.mm6516e1

Synthetic agents off the darknet: a case of U-47700 and phenazepam abuse

Clinical Toxicology / Oct 13, 2016

Vo, K. T., van Wijk, X. M. R., Wu, A. H. B., Lynch, K. L., & Ho, R. Y. (2016). Synthetic agents off the darknet: a case of U-47700 and phenazepam abuse. Clinical Toxicology, 55(1), 71–72. https://doi.org/10.1080/15563650.2016.1240806

A 4-deoxy analogue of N-acetyl-d-glucosamine inhibits heparan sulphate expression and growth factor binding in vitro

Experimental Cell Research / Sep 01, 2010

van Wijk, X. M. R., Oosterhof, A., van den Broek, S. A. M. W., Griffioen, A. W., ten Dam, G. B., Rutjes, F. P. J. T., van Delft, F. L., & van Kuppevelt, T. H. (2010). A 4-deoxy analogue of N-acetyl-d-glucosamine inhibits heparan sulphate expression and growth factor binding in vitro. Experimental Cell Research, 316(15), 2504–2512. https://doi.org/10.1016/j.yexcr.2010.04.025

Mass spectrometry in emergency toxicology: Current state and future applications

Critical Reviews in Clinical Laboratory Sciences / Apr 01, 2019

Van Wijk, X. M. R., Goodnough, R., & Colby, J. M. (2019). Mass spectrometry in emergency toxicology: Current state and future applications. Critical Reviews in Clinical Laboratory Sciences, 56(4), 225–238. https://doi.org/10.1080/10408363.2019.1585415

A Liquid-Chromatography High-Resolution Mass Spectrometry Method for Non-FDA Approved Benzodiazepines

Journal of Analytical Toxicology / Nov 14, 2018

van Wijk, X. M. R., Yun, C., Hooshfar, S., Arens, A. M., Lung, D., Wu, A. H. B., & Lynch, K. L. (2018). A Liquid-Chromatography High-Resolution Mass Spectrometry Method for Non-FDA Approved Benzodiazepines. Journal of Analytical Toxicology, 43(4), 316–320. https://doi.org/10.1093/jat/bky092

The ImPreSS Trial: Implementation of Point‐of‐Care Pharmacogenomic Decision Support in Perioperative Care

Clinical Pharmacology & Therapeutics / Aug 21, 2019

Truong, T. M., Apfelbaum, J., Shahul, S., Anitescu, M., Danahey, K., Knoebel, R. W., Liebovitz, D., Karrison, T., van Wijk, X. M. R., Yeo, K. J., Meltzer, D., Ratain, M. J., & O’Donnell, P. H. (2019). The ImPre<scp>SS</scp> Trial: Implementation of Point‐of‐Care Pharmacogenomic Decision Support in Perioperative Care. Clinical Pharmacology &amp; Therapeutics, 106(6), 1179–1183. Portico. https://doi.org/10.1002/cpt.1567

Impact of CYP2D6 Pharmacogenomic Status on Pain Control Among Opioid-Treated Oncology Patients

The Oncologist / Sep 19, 2021

Reizine, N., Danahey, K., Schierer, E., Liu, P., Middlestadt, M., Ludwig, J., Truong, T. M., Wijk, X. M. R., Yeo, K.-T. J., Malec, M., Ratain, M. J., & O’Donnell, P. H. (2021). Impact of CYP2D6 Pharmacogenomic Status on Pain Control Among <scp>Opioid-Treated</scp> Oncology Patients. The Oncologist, 26(11), e2042–e2052. https://doi.org/10.1002/onco.13953

Release of cardiac troponin using a high sensitivity assay after exercise: Type 2 acute myocardial infarction?

Clinica Chimica Acta / Jun 01, 2015

Aw, T. C., van Wijk, X. M. R., Wu, A. H. B., & Jaffe, A. S. (2015). Release of cardiac troponin using a high sensitivity assay after exercise: Type 2 acute myocardial infarction? Clinica Chimica Acta, 446, 6–8. https://doi.org/10.1016/j.cca.2015.04.002

Implementation of pharmacogenomic testing in oncology care (PhOCus): study protocol of a pragmatic, randomized clinical trial

Therapeutic Advances in Medical Oncology / Jan 01, 2020

Reizine, N., Vokes, E. E., Liu, P., Truong, T. M., Nanda, R., Fleming, G. F., Catenacci, D. V. T., Pearson, A. T., Parsad, S., Danahey, K., van Wijk, X. M. R., Yeo, K.-T. J., Ratain, M. J., & O’Donnell, P. H. (2020). Implementation of pharmacogenomic testing in oncology care (PhOCus): study protocol of a pragmatic, randomized clinical trial. Therapeutic Advances in Medical Oncology, 12, 175883592097411. https://doi.org/10.1177/1758835920974118

Cardiac troponin I is present in plasma of type 1 myocardial infarction patients and patients with troponin I elevations due to other etiologies as complex with little free I

Clinical Biochemistry / Nov 01, 2019

van Wijk, X. M. R., Claassen, S., Enea, N. S., Li, P., Yang, S., Brouwer, M. A., Cramer, G. E., Zuk, R., Lynch, K. L., & Wu, A. H. B. (2019). Cardiac troponin I is present in plasma of type 1 myocardial infarction patients and patients with troponin I elevations due to other etiologies as complex with little free I. Clinical Biochemistry, 73, 35–43. https://doi.org/10.1016/j.clinbiochem.2019.06.012

Pharmacogenomic‐Based Decision Support to Predict Adherence to Medications

Clinical Pharmacology & Therapeutics / May 25, 2020

Christian, C., Borden, B. A., Danahey, K., Yeo, K. J., van Wijk, X. M. R., Ratain, M. J., & O’Donnell, P. H. (2020). Pharmacogenomic‐Based Decision Support to Predict Adherence to Medications. Clinical Pharmacology &amp; Therapeutics, 108(2), 368–376. Portico. https://doi.org/10.1002/cpt.1838

Polymorphisms in CACNA1E and Camk2d are associated with seizure susceptibility of Sprague–Dawley rats

Epilepsy Research / Sep 01, 2010

Rijkers, K., Mescheriakova, J., Majoie, M., Lemmens, E., van Wijk, X., Philippens, M., Van Kranen-Mastenbroek, V., Schijns, O., Vles, J., & Hoogland, G. (2010). Polymorphisms in CACNA1E and Camk2d are associated with seizure susceptibility of Sprague–Dawley rats. Epilepsy Research, 91(1), 28–34. https://doi.org/10.1016/j.eplepsyres.2010.06.006

Evaluation of Biomarkers in Sepsis: High Dimethylarginine (ADMA and SDMA) Concentrations Are Associated with Mortality

The Journal of Applied Laboratory Medicine / Dec 31, 2020

van Wijk, X. M. R., Yun, C., & Lynch, K. L. (2020). Evaluation of Biomarkers in Sepsis: High Dimethylarginine (ADMA and SDMA) Concentrations Are Associated with Mortality. The Journal of Applied Laboratory Medicine, 6(3), 592–605. https://doi.org/10.1093/jalm/jfaa156

Two cases of severe opiate toxicity after ingestion of poppy seed tea

Toxicology Communications / Jan 01, 2018

Spyres, M. B., van Wijk, X. M. R., Lapoint, J., & Levine, M. (2018). Two cases of severe opiate toxicity after ingestion of poppy seed tea. Toxicology Communications, 2(1), 102–104. https://doi.org/10.1080/24734306.2018.1540178

A comparison of methods for evaluation of a case of suspected macro-aspartate aminotransferase

Clinica Chimica Acta / Dec 01, 2016

van Wijk, X. M. R., Magee, C. A., Wu, A. H. B., Tana, M. M., & Lynch, K. L. (2016). A comparison of methods for evaluation of a case of suspected macro-aspartate aminotransferase. Clinica Chimica Acta, 463, 1–3. https://doi.org/10.1016/j.cca.2016.10.011

Extraction and structural analysis of glycosaminoglycans from formalin-fixed, paraffin-embedded tissues

Glycobiology / Aug 02, 2012

van Wijk, X. M. R., Vallen, M. J., van de Westerlo, E. M., Oosterhof, A., Hao, W., Versteeg, E. M., Raben, J., Wismans, R. G., Smetsers, T. F. C. M., Dijkman, H. B. P. M., Schalkwijk, J., & van Kuppevelt, T. H. (2012). Extraction and structural analysis of glycosaminoglycans from formalin-fixed, paraffin-embedded tissues. Glycobiology, 22(12), 1666–1672. https://doi.org/10.1093/glycob/cws119

Clinically actionable genotypes for anticancer prescribing among >1500 patients with pharmacogenomic testing

Cancer / Jan 28, 2022

Reizine, N. M., Danahey, K., Truong, T. M., George, D., House, L. K., Karrison, T. G., van Wijk, X. M. R., Yeo, K. J., Ratain, M. J., & O’Donnell, P. H. (2022). Clinically actionable genotypes for anticancer prescribing among &gt;1500 patients with pharmacogenomic testing. Cancer, 128(8), 1649–1657. Portico. https://doi.org/10.1002/cncr.34104

Evaluation of a New Generation Automated Assay for 25-Hydroxy Vitamin D Based on Competitive Protein Binding

The Journal of Applied Laboratory Medicine / Sep 01, 2019

Asif, M., Groboske, S. E., Leung, E. K. Y., Yeo, K.-T. J., & van Wijk, X. M. R. (2019). Evaluation of a New Generation Automated Assay for 25-Hydroxy Vitamin D Based on Competitive Protein Binding. The Journal of Applied Laboratory Medicine, 4(2), 247–253. https://doi.org/10.1373/jalm.2018.028415

Oncology

Self-Assessment Q&A in Clinical Laboratory Science, III / Jan 01, 2021

Marin, M. J., & van Wijk, X. M. R. (2021). Oncology. In Self-Assessment Q&amp;A in Clinical Laboratory Science, III (pp. 37–47). Elsevier. https://doi.org/10.1016/b978-0-12-822093-1.00004-1

Validation of a Large Custom-Designed Pharmacogenomics Panel on an Array Genotyping Platform

The Journal of Applied Laboratory Medicine / Jul 15, 2021

Tang, N. Y., Pei, X., George, D., House, L., Danahey, K., Lipschultz, E., Ratain, M. J., O’Donnell, P. H., Yeo, K.-T. J., & van Wijk, X. M. R. (2021). Validation of a Large Custom-Designed Pharmacogenomics Panel on an Array Genotyping Platform. The Journal of Applied Laboratory Medicine, 6(6), 1505–1516. https://doi.org/10.1093/jalm/jfab056

Cardiac Troponin Composition Characterization after Non ST-Elevation Myocardial Infarction: Relation with Culprit Artery, Ischemic Time Window, and Severity of Injury

Clinical Chemistry / Nov 22, 2020

Damen, S. A. J., Cramer, G. E., Dieker, H.-J., Gehlmann, H., Ophuis, T. J. M. O., Aengevaeren, W. R. M., Fokkert, M., Verheugt, F. W. A., Suryapranata, H., Wu, A. H., van Wijk, X. M. R., & Brouwer, M. A. (2020). Cardiac Troponin Composition Characterization after Non ST-Elevation Myocardial Infarction: Relation with Culprit Artery, Ischemic Time Window, and Severity of Injury. Clinical Chemistry, 67(1), 227–236. https://doi.org/10.1093/clinchem/hvaa231

Cocaine use is associated with a higher prevalence of elevated ST2 concentrations

Clinical Biochemistry / Sep 01, 2017

van Wijk, X. M. R., Vittinghoff, E., Wu, A. H. B., Lynch, K. L., & Riley, E. D. (2017). Cocaine use is associated with a higher prevalence of elevated ST2 concentrations. Clinical Biochemistry, 50(13–14), 791–793. https://doi.org/10.1016/j.clinbiochem.2017.04.015

Implementation of pharmacogenomics into inpatient general medicine

Pharmacogenetics and Genomics / Dec 09, 2022

Chen, T., O’Donnell, P. H., Middlestadt, M., Ruhnke, G. W., Danahey, K., van Wijk, X. M. R., Choksi, A., Knoebel, R., Hartman, S., Yeo, K.-T. J., Friedman, P. N., Ratain, M. J., Nutescu, E. A., O’Leary, K. J., Perera, M. A., & Meltzer, D. O. (2022). Implementation of pharmacogenomics into inpatient general medicine. Pharmacogenetics and Genomics, 33(2), 19–23. https://doi.org/10.1097/fpc.0000000000000487

Stability of Whole Blood Electrolyte Specimens at Room Temperature vs. Slushed Ice Conditions

The Journal of Applied Laboratory Medicine / Aug 27, 2021

Zavorsky, G. S., van Wijk, X. M. R., Gasparyan, S., Stollenwerk, N. S., & Brooks, R. A. (2021). Stability of Whole Blood Electrolyte Specimens at Room Temperature vs. Slushed Ice Conditions. The Journal of Applied Laboratory Medicine, 7(2), 541–554. https://doi.org/10.1093/jalm/jfab089

Anticholinergic toxicity associated with ingestion of water containing lupini bean extract

Clinical Toxicology / Apr 26, 2017

Li, K., van Wijk, X. M. R., Hayashi, S., Lynch, K. L., Wu, A. H. B., & Smollin, C. G. (2017). Anticholinergic toxicity associated with ingestion of water containing lupini bean extract. Clinical Toxicology, 55(7), 687–688. https://doi.org/10.1080/15563650.2017.1315821

‘Immunosequencing’ of heparan sulfate from human cell lines and rat kidney: the (GlcNS6S-IdoA2S)3 motif, recognized by antibody NS4F5, is located towards the non-reducing end

Biochemical Journal / Jul 10, 2014

van Wijk, X. M. R., Oosterhof, A., Versteeg, E. M. M., van de Westerlo, E. M. A., & van Kuppevelt, T. H. (2014). ‘Immunosequencing’ of heparan sulfate from human cell lines and rat kidney: the (GlcNS6S-IdoA2S)3 motif, recognized by antibody NS4F5, is located towards the non-reducing end. Biochemical Journal, 461(3), 461–468. https://doi.org/10.1042/bj20140355

Machine Learning in Healthcare: Mapping a Path to Title 21

Clinical Chemistry / Mar 30, 2022

Marin, M. J., Van Wijk, X. M. R., & Durant, T. J. S. (2022). Machine Learning in Healthcare: Mapping a Path to Title 21. Clinical Chemistry, 68(4), 609–610. https://doi.org/10.1093/clinchem/hvab285

Large inter-assay difference of serum creatinine in pediatric population: a threat to accurate staging of chronic kidney disease

Pediatric Nephrology / Nov 10, 2021

Lao, K., Sykes, E., van Wijk, X. M. R., Li, J., Williams, J., Gherasim, C., & Sun, Q. (2021). Large inter-assay difference of serum creatinine in pediatric population: a threat to accurate staging of chronic kidney disease. Pediatric Nephrology, 37(3), 677–681. https://doi.org/10.1007/s00467-021-05335-x

A retrospective analysis of high sensitivity cardiac troponin-T ranges in non-myocardial infarction emergency department visits

BMC Cardiovascular Disorders / Jun 07, 2021

Kong, N., Chua, R. F. M., Besser, S. A., Heelan, L., Nathan, S., Spiegel, T. F., van Wijk, X. M. R., & Tabit, C. E. (2021). A retrospective analysis of high sensitivity cardiac troponin-T ranges in non-myocardial infarction emergency department visits. BMC Cardiovascular Disorders, 21(1). https://doi.org/10.1186/s12872-021-02089-0

Evaluation of interference effects from hemolysis, icterus and lipemia on the Roche Elecsys® Anti-SARS-CoV-2 assay

Clinica Chimica Acta / Oct 01, 2020

Tang, N.-Y., Yeo, K.-T. J., & van Wijk, X. M. R. (2020). Evaluation of interference effects from hemolysis, icterus and lipemia on the Roche Elecsys® Anti-SARS-CoV-2 assay. Clinica Chimica Acta, 509, 293–294. https://doi.org/10.1016/j.cca.2020.06.041

Pilot Findings of Pharmacogenomics in Perioperative Care: Initial Results From the First Phase of the ImPreSS Trial

Anesthesia & Analgesia / Feb 25, 2022

Truong, T. M., Apfelbaum, J. L., Danahey, K., Schierer, E., Ludwig, J., George, D., House, L., Karrison, T., Shahul, S., Anitescu, M., Choksi, A., Hartman, S., Knoebel, R. W., van Wijk, X. M. R., Yeo, K.-T. J., Meltzer, D. O., Ratain, M. J., & O’Donnell, P. H. (2022). Pilot Findings of Pharmacogenomics in Perioperative Care: Initial Results From the First Phase of the ImPreSS Trial. Anesthesia &amp; Analgesia, 135(5), 929–940. https://doi.org/10.1213/ane.0000000000005951

Applicability of Pharmacogenomically Guided Medication Treatment during Hospitalization of At-Risk Minority Patients

Journal of Personalized Medicine / Dec 10, 2021

Saulsberry, L., Danahey, K., Middlestadt, M., O’Leary, K. J., Nutescu, E. A., Chen, T., Lee, J. C., Ruhnke, G. W., George, D., House, L., van Wijk, X. M. R., Yeo, K.-T. J., Choksi, A., Hartman, S. W., Knoebel, R. W., Friedman, P. N., Rasmussen, L. V., Ratain, M. J., Perera, M. A., … O’Donnell, P. H. (2021). Applicability of Pharmacogenomically Guided Medication Treatment during Hospitalization of At-Risk Minority Patients. Journal of Personalized Medicine, 11(12), 1343. https://doi.org/10.3390/jpm11121343

False-Positive Hepatitis B Surface Antibody Results: An Example of Reagent Carryover

The Journal of Applied Laboratory Medicine / Mar 01, 2020

Tang, N.-Y., Groboske, S. E., Baldwin, A. D., Yeo, K.-T. J., & van Wijk, X. M. R. (2020). False-Positive Hepatitis B Surface Antibody Results: An Example of Reagent Carryover. The Journal of Applied Laboratory Medicine, 5(2), 429–431. https://doi.org/10.1093/jalm/jfz015

A new ultra-high sensitivity troponin I assay for chest pain patients with no evidence of troponin I using a conventional assay

Clinical Biochemistry / Mar 01, 2015

Wu, A. H. B., & van Wijk, X. M. R. (2015). A new ultra-high sensitivity troponin I assay for chest pain patients with no evidence of troponin I using a conventional assay. Clinical Biochemistry, 48(4–5), 358–359. https://doi.org/10.1016/j.clinbiochem.2014.11.018

The stability of blood gases and CO-oximetry under slushed ice and room temperature conditions

Clinical Chemistry and Laboratory Medicine (CCLM) / Apr 06, 2023

Zavorsky, G. S., & van Wijk, X. M. R. (2023). The stability of blood gases and CO-oximetry under slushed ice and room temperature conditions. Clinical Chemistry and Laboratory Medicine (CCLM), 61(10), 1750–1759. https://doi.org/10.1515/cclm-2022-1085

Reducing Specimen Rejection Rates Using Concentration-Dependent Hemolysis Rejection Thresholds

The Journal of Applied Laboratory Medicine / Jan 02, 2023

Tang, N. Y., Mitchell, K. R., Groboske, S. E., Baldwin, A. D., Lenza, M., Yeo, K.-T. J., & van Wijk, X. M. R. (2023). Reducing Specimen Rejection Rates Using Concentration-Dependent Hemolysis Rejection Thresholds. The Journal of Applied Laboratory Medicine, 8(2), 285–295. https://doi.org/10.1093/jalm/jfac095

Abstract 13919: Race and Gender Specific High Sensitivity Troponin-t Cutoff Values Improve Detection in Patients’ With Ischemic Heart Disease

Circulation / Nov 17, 2020

Kong, N., Chua, R., Besser, S., Heelan, L., Nathan, S., Spiegel, T., van Wijk, X., & Tabit, C. E. (2020). Abstract 13919: Race and Gender Specific High Sensitivity Troponin-t Cutoff Values Improve Detection in Patients’ With Ischemic Heart Disease. Circulation, 142(Suppl_3). https://doi.org/10.1161/circ.142.suppl_3.13919

A comparison of venous blood gas analysis with paired specimens collected in syringes and evacuated blood collection tubes

Clinica Chimica Acta / Nov 01, 2020

Tang, N.-Y., Leanse, J. H., Tesic, V., & van Wijk, X. M. R. (2020). A comparison of venous blood gas analysis with paired specimens collected in syringes and evacuated blood collection tubes. Clinica Chimica Acta, 510, 671–674. https://doi.org/10.1016/j.cca.2020.08.023

A root cause analysis of ‘falsely elevated’ oxygen saturation: investigation of pneumatic tube transport and differences between estimated and measured saturation in a critical patient population

Clinical Chemistry and Laboratory Medicine (CCLM) / Sep 17, 2019

van Wijk, X. M. R., Leanse, J. H., Poinier, A., Uriel, N., O’Connor, M. F., Weber, S. G., Tesic, V., & Staneva, I. (2019). A root cause analysis of ‘falsely elevated’ oxygen saturation: investigation of pneumatic tube transport and differences between estimated and measured saturation in a critical patient population. Clinical Chemistry and Laboratory Medicine (CCLM), 58(3), e72–e74. https://doi.org/10.1515/cclm-2019-0776

Development of an LC-MS/MS Method for Measurement of Irinotecan and Its Major Metabolites in Plasma: Technical Considerations

Laboratory Medicine / Aug 05, 2021

Aoullay, Z., Van Wijk, X. M. R., Yanhui, M., Meddah, B., Lynch, K. L., Cherrah, Y., & Wu, A. H. B. (2021). Development of an LC-MS/MS Method for Measurement of Irinotecan and Its Major Metabolites in Plasma: Technical Considerations. Laboratory Medicine, 53(1), 47–52. https://doi.org/10.1093/labmed/lmab059

Short-term analytical imprecision for a fifth generation cardiac troponin T assay does not exceed rule-in and rule-out thresholds of the ESC 0/1-h algorithm

Clinica Chimica Acta / Aug 01, 2021

Tang, N. Y., Datoru, A. D., & van Wijk, X. M. R. (2021). Short-term analytical imprecision for a fifth generation cardiac troponin T assay does not exceed rule-in and rule-out thresholds of the ESC 0/1-h algorithm. Clinica Chimica Acta, 519, 204–205. https://doi.org/10.1016/j.cca.2021.05.005

Intraoperative Fine Needle Aspiration Parathyroid Hormone Assay Can Be Used as an Alternative to Frozen Section Analysis for the Identification of Parathyroid Tissue

American Journal of Clinical Pathology / Oct 01, 2020

Olivas, A. D., van Wijk, X. M., & Angelos, P. (2020). Intraoperative Fine Needle Aspiration Parathyroid Hormone Assay Can Be Used as an Alternative to Frozen Section Analysis for the Identification of Parathyroid Tissue. American Journal of Clinical Pathology, 154(Supplement_1), S43–S44. https://doi.org/10.1093/ajcp/aqaa161.092

Can We Improve Current Cancer Screening Programs?

Clinical Chemistry / Apr 30, 2020

Marin, M. J., & van Wijk, X. M. R. (2020). Can We Improve Current Cancer Screening Programs? Clinical Chemistry, 66(5), 746–746. https://doi.org/10.1093/clinchem/hvaa078

Sensitive immunoassay testing platforms

Biomarkers for Traumatic Brain Injury / Jan 01, 2020

Marin, M. J., & van Wijk, X. M. R. (2020). Sensitive immunoassay testing platforms. In Biomarkers for Traumatic Brain Injury (pp. 243–264). Elsevier. https://doi.org/10.1016/b978-0-12-816346-7.00018-x

P4503A multi-site coronary vein sampling study on cardiac troponin T degradation in non-ST-elevation myocardial infarction

European Heart Journal / Oct 01, 2019

Cramer, G. E., Damen, S. A. J., Vroemen, W. H. M., Mezger, S. T. P., Suryapranata, H., Van Royen, N., Bekers, O., Meex, S. J. R., Wodzig, W. K. W. H., Verheugt, F. W. A., De Boer, D., Brouwer, M. A., & Mingels, A. M. A. (2019). P4503A multi-site coronary vein sampling study on cardiac troponin T degradation in non-ST-elevation myocardial infarction. European Heart Journal, 40(Supplement_1). https://doi.org/10.1093/eurheartj/ehz745.0896

Losing sight of the Forest for the trees: Why clinical laboratories need to perform their own interference studies

Clinica Chimica Acta / Aug 01, 2018

Marin, M. J., van Wijk, X. M. R., & Yeo, K.-T. J. (2018). Losing sight of the Forest for the trees: Why clinical laboratories need to perform their own interference studies. Clinica Chimica Acta, 483, 239–240. https://doi.org/10.1016/j.cca.2018.05.008

Inactivation of heparan sulfate 2‐O‐sulfotransferase reduce neutrophil bactericidal activity and endothelial integrity to exacerbate host survival upon Group B Streptococcus infection (607.14)

The FASEB Journal / Apr 01, 2014

Chang, Y., Xu, D., van Wijk, X., Esko, J., & Nizet, V. (2014). Inactivation of heparan sulfate 2‐O‐sulfotransferase reduce neutrophil bactericidal activity and endothelial integrity to exacerbate host survival upon Group B Streptococcus infection (607.14). The FASEB Journal, 28(S1). Portico. https://doi.org/10.1096/fasebj.28.1_supplement.607.14

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