Aditya Kshirsagar is a highly educated and experienced scientist focused on molecular genetics and neuroscience. He obtained his Ph.D. in Molecular Genetics and Neuroscience from the prestigious Weizmann Institute of Science in 2022. He gained extensive knowledge and expertise in genetics, molecular biology, and neuroscience during his doctoral studies. After completing his Ph.D., Adi joined St Jude Children's Research Hospital as a Postdoctoral Research Associate. Here, he has been involved in cutting-edge research projects, studying the genetic basis of various neurological disorders. He has published several research papers in top scientific journals, making significant contributions to genetics and neuroscience. Adi's passion for understanding the complex mechanisms underlying human diseases has driven him to pursue a research career. He is keen on developing integrated experimental and computational approaches for single-cell and spatial omics to uncover the mechanisms underlying complex neurological conditions and malignancies. He is highly skilled in experimental techniques and has a keen eye for detail, enabling him to design and execute innovative experiments. He is also well-versed in data analysis and interpretation, making him a valuable asset to any research team. His core competencies include embryonic stem cell biology, cortical development, 3D brain organoid models, RNA biology, next-generation sequencing, single-cell biology, multi-omics, and live imaging microscopy techniques. He is also proficient in R and Python programming and experienced in computational pipeline implementation, machine learning & AI, and comprehensive data integration. In addition to his scientific work, Adi is also dedicated to mentoring and teaching the next generation of scientists. He has supervised several master's and undergraduate students, guiding them in their research projects and helping them develop their scientific skills. Overall, Aditya Kshirsagar is a dedicated scientist with a strong background and a track record of excellence in research. His contributions to molecular genetics and neuroscience can potentially significantly impact the diagnosis and treatment of various diseases. Adi is passionate about exploring the potential of cutting-edge technologies and approaches to unravel the mysteries of the human brain and improve patients' lives.

Aditya Kshirsagar

St. Jude Children’s Research Hospital

Memphis, Tennessee, United States of America

Research Interests

Neuroscience

Developmental Biology

RNA biology

Computational biology

Tissue Engineering

Biochemistry

Cellular and Molecular Neuroscience

Neurology

Cognitive Neuroscience

About

Publications

Human brain organoids on a chip reveal the physics of folding

Nature Physics / Feb 19, 2018

Karzbrun, E., Kshirsagar, A., Cohen, S. R., Hanna, J. H., & Reiner, O. (2018). Human brain organoids on a chip reveal the physics of folding. Nature Physics, 14(5), 515–522. https://doi.org/10.1038/s41567-018-0046-7

Regulation of neuronal migration, an emerging topic in autism spectrum disorders

Journal of Neurochemistry / Nov 13, 2015

Reiner, O., Karzbrun, E., Kshirsagar, A., & Kaibuchi, K. (2015). Regulation of neuronal migration, an emerging topic in autism spectrum disorders. Journal of Neurochemistry, 136(3), 440–456. Portico. https://doi.org/10.1111/jnc.13403

Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate

Nature Communications / Feb 02, 2022

Parichha, A., Suresh, V., Chatterjee, M., Kshirsagar, A., Ben-Reuven, L., Olender, T., Taketo, M. M., Radosevic, V., Bobic-Rasonja, M., Trnski, S., Holtzman, M. J., Jovanov-Milosevic, N., Reiner, O., & Tole, S. (2022). Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate. Nature Communications, 13(1). https://doi.org/10.1038/s41467-021-27602-z

Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex

Nature Communications / Jul 21, 2022

Sapir, T., Kshirsagar, A., Gorelik, A., Olender, T., Porat, Z., Scheffer, I. E., Goldstein, D. B., Devinsky, O., & Reiner, O. (2022). Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-31752-z

Interplay of LIS1 and MeCP2: Interactions and Implications With the Neurodevelopmental Disorders Lissencephaly and Rett Syndrome

Frontiers in Cellular Neuroscience / Aug 14, 2019

Keidar, L., Gerlitz, G., Kshirsagar, A., Tsoory, M., Olender, T., Wang, X., Yang, Y., Chen, Y.-S., Yang, Y.-G., Voineagu, I., & Reiner, O. (2019). Interplay of LIS1 and MeCP2: Interactions and Implications With the Neurodevelopmental Disorders Lissencephaly and Rett Syndrome. Frontiers in Cellular Neuroscience, 13. https://doi.org/10.3389/fncel.2019.00370

LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways

Nature Communications / Jun 06, 2023

Kshirsagar, A., Doroshev, S. M., Gorelik, A., Olender, T., Sapir, T., Tsuboi, D., Rosenhek-Goldian, I., Malitsky, S., Itkin, M., Argoetti, A., Mandel-Gutfreund, Y., Cohen, S. R., Hanna, J. H., Ulitsky, I., Kaibuchi, K., & Reiner, O. (2023). LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-38797-8

The Emerging Roles ofLIS1 Biomechanics in Cellular and Cortical Homeostasis

Neocortical Neurogenesis in Development and Evolution / Aug 08, 2023

Kshirsagarand, A., & Reiner, O. (2023, August 8). The Emerging Roles of<scp>LIS</scp>1 Biomechanics in Cellular and Cortical Homeostasis. Neocortical Neurogenesis in Development and Evolution; Wiley; Portico. https://doi.org/10.1002/9781119860914.ch18

LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways

Mar 08, 2022

Kshirsagar, A., Gorelik, A., Olender, T., Sapir, T., Tsuboi, D., Rosenhek-Goldian, I., Malitsky, S., Itkin, M., Argoetti, A., Mandel-Gutfreund, Y., Cohen, S. R., Hanna, J., Ulitsky, I., Kaibuchi, K., & Reiner, O. (2022). LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways. https://doi.org/10.1101/2022.03.08.483407

Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate

Dec 09, 2020

Parichha, A., Suresh, V., Chatterjee, M., Kshirsagar, A., Ben-Reuven, L., Olender, T., Mark Taketo, M., Radosevic, V., Bobic-Rasonja, M., Trnski, S., Holtzman, M. J., Jovanov Milošević, N., Reiner, O., & Tole, S. (2020). Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate. https://doi.org/10.1101/2020.12.08.415588

Education

Weizmann Institute of Science

Ph.D., Molecular Genetics and Neuroscience / October, 2022

Rehovot

Experience

St Jude Children’s Research Hospital

Postdoctoral Research Associate / June, 2023 — Present

Links & Social Media

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