Michael W Harman
Distinguished Subject Matter Expert & Leader in Medical Technologies.
Research Interests
About
Publications
The Hybrid Histidine Kinase Hk1 Is Part of a Two-Component System That Is Essential for Survival of Borrelia burgdorferi in Feeding Ixodes scapularis Ticks
Infection and Immunity / Aug 01, 2011
Caimano, M. J., Kenedy, M. R., Kairu, T., Desrosiers, D. C., Harman, M., Dunham-Ems, S., Akins, D. R., Pal, U., & Radolf, J. D. (2011). The Hybrid Histidine Kinase Hk1 Is Part of a Two-Component System That Is Essential for Survival of Borrelia burgdorferi in Feeding Ixodes scapularis Ticks. Infection and Immunity, 79(8), 3117–3130. https://doi.org/10.1128/iai.05136-11
The heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination through tissue
Proceedings of the National Academy of Sciences / Feb 06, 2012
Harman, M. W., Dunham-Ems, S. M., Caimano, M. J., Belperron, A. A., Bockenstedt, L. K., Fu, H. C., Radolf, J. D., & Wolgemuth, C. W. (2012). The heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination through tissue. Proceedings of the National Academy of Sciences, 109(8), 3059–3064. https://doi.org/10.1073/pnas.1114362109
Viscous Dynamics of Lyme Disease and Syphilis Spirochetes Reveal Flagellar Torque and Drag
Biophysical Journal / Nov 01, 2013
Harman, M., Vig, D. K., Radolf, J. D., & Wolgemuth, C. W. (2013). Viscous Dynamics of Lyme Disease and Syphilis Spirochetes Reveal Flagellar Torque and Drag. Biophysical Journal, 105(10), 2273–2280. https://doi.org/10.1016/j.bpj.2013.10.004
Measuring DNA content in live cells by fluorescence microscopy
Cell Division / Sep 04, 2018
Gomes, C. J., Harman, M. W., Centuori, S. M., Wolgemuth, C. W., & Martinez, J. D. (2018). Measuring DNA content in live cells by fluorescence microscopy. Cell Division, 13(1). https://doi.org/10.1186/s13008-018-0039-z
Breast tumor stiffness instructs bone metastasis via maintenance of mechanical conditioning
Cell Reports / Jun 01, 2021
Watson, A. W., Grant, A. D., Parker, S. S., Hill, S., Whalen, M. B., Chakrabarti, J., Harman, M. W., Roman, M. R., Forte, B. L., Gowan, C. C., Castro-Portuguez, R., Stolze, L. K., Franck, C., Cusanovich, D. A., Zavros, Y., Padi, M., Romanoski, C. E., & Mouneimne, G. (2021). Breast tumor stiffness instructs bone metastasis via maintenance of mechanical conditioning. Cell Reports, 35(13), 109293. https://doi.org/10.1016/j.celrep.2021.109293
Context-Dependent Role of Vinculin in Neutrophil Adhesion, Motility and Trafficking
Scientific Reports / Feb 07, 2020
Wilson, Z. S., Witt, H., Hazlett, L., Harman, M., Neumann, B. M., Whitman, A., Patel, M., Ross, R. S., Franck, C., Reichner, J. S., & Lefort, C. T. (2020). Context-Dependent Role of Vinculin in Neutrophil Adhesion, Motility and Trafficking. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-58882-y
Vancomycin Reduces Cell Wall Stiffness and Slows Swim Speed of the Lyme Disease Bacterium
Biophysical Journal / Feb 01, 2017
Harman, M. W., Hamby, A. E., Boltyanskiy, R., Belperron, A. A., Bockenstedt, L. K., Kress, H., Dufresne, E. R., & Wolgemuth, C. W. (2017). Vancomycin Reduces Cell Wall Stiffness and Slows Swim Speed of the Lyme Disease Bacterium. Biophysical Journal, 112(4), 746–754. https://doi.org/10.1016/j.bpj.2016.12.039
The induction of endoreduplication and polyploidy by elevated expression of 14-3-3γ
Genes & Cancer / Dec 24, 2017
Gomes, C. J., Centuori, S. M., Harman, M. W., Putnam, C. W., Wolgemuth, C. W., & Martinez, J. D. (2017). The induction of endoreduplication and polyploidy by elevated expression of 14-3-3γ. Genes & Cancer, 8(11–12), 771–783. https://doi.org/10.18632/genesandcancer.161
Breast tumor stiffness instructs bone metastasis via mechanical memory
Nov 20, 2019
Watson, A. W., Grant, A., Parker, S. S., Harman, M. W., Roman, M. R., Forte, B. L., Gowan, C. C., Castro-Portuguez, R., Franck, C., Cusanovich, D., Padi, M., Romanoski, C., & Mouneimne, G. (2019). Breast tumor stiffness instructs bone metastasis via mechanical memory. https://doi.org/10.1101/847699
Vinculin in Neutrophil Adhesion, Motility and Trafficking
The FASEB Journal / Apr 01, 2018
Wilson, Z., Harman, M., Hazlett, L., Odzer, J., Witt, H., Franck, C., Reichner, J., & Lefort, C. (2018). Vinculin in Neutrophil Adhesion, Motility and Trafficking. The FASEB Journal, 32(S1). Portico. https://doi.org/10.1096/fasebj.2018.32.1_supplement.280.11
Four Dimensional Traction Measurements of Chemotactic Neutrophils in Hydrogels
Biophysical Journal / Feb 01, 2018
Harman, M. W., Franck, C., & Reichner, J. (2018). Four Dimensional Traction Measurements of Chemotactic Neutrophils in Hydrogels. Biophysical Journal, 114(3), 324a. https://doi.org/10.1016/j.bpj.2017.11.1819
Context-dependent role of vinculin in neutrophil adhesion, motility and trafficking
Nov 20, 2019
Wilson, Z. S., Witt, H., Hazlett, L., Harman, M., Neumann, B. M., Whitman, A., Patel, M., Ross, R. S., Franck, C., Reichner, J. S., & Lefort, C. T. (2019). Context-dependent role of vinculin in neutrophil adhesion, motility and trafficking. https://doi.org/10.1101/847780
Abstract 3591: Expression of 14-3-3 gamma stabilizes polyploidization in NSCLC cells
Cancer Research / Jul 15, 2016
Gomes, C. J., Harman, M., Centuori, S., Wolgemuth, C., & Martinez, J. (2016). Abstract 3591: Expression of 14-3-3 gamma stabilizes polyploidization in NSCLC cells. Cancer Research, 76(14_Supplement), 3591–3591. https://doi.org/10.1158/1538-7445.am2016-3591
Abstract 2066: Aberrant upregulation of 14-3-3 gamma promotes mononucleated polyploidization in human lung cancers
Cancer Research / Aug 01, 2015
Gomes, C. J., Harman, M., Martinez, J., & Centuori, S. (2015). Abstract 2066: Aberrant upregulation of 14-3-3 gamma promotes mononucleated polyploidization in human lung cancers. Cancer Research, 75(15_Supplement), 2066–2066. https://doi.org/10.1158/1538-7445.am2015-2066
The Computational Analysis of Spirochete Motility in Viscous Fluids: Mimicking Host Reservoir Micro-Environments
Biophysical Journal / Jan 01, 2013
Harman, M. W., Vig, D. K., Radolf, J. D., & Wolgemuth, C. W. (2013). The Computational Analysis of Spirochete Motility in Viscous Fluids: Mimicking Host Reservoir Micro-Environments. Biophysical Journal, 104(2), 638a–639a. https://doi.org/10.1016/j.bpj.2012.11.3526
Education
University of Connecticut
BS, Biomedical Engineering, Biofluid Mechanics Track / May, 2008
University of Connecticut
MS, Biomedical Engineering, Biomechanics Concentration / December, 2009
University of Arizona
Ph.D, Biochemistry, Molecular and Cellular Biology / December, 2015
Experience
Brown University
Postdoctoral Research Fellow / May, 2016 — August, 2018
Critical lead asset driving preclinical collaborative cell biomechanics study managing 30 personnel between immunology, pathobiology, and experimental soft matter mechanics laboratories.
Rhode Island Hospital
Postdoctoral Research Fellow / May, 2016 — August, 2018
Critical lead asset driving preclinical collaborative cell biomechanics study managing 30 personnel between immunology, pathobiology, and experimental soft matter mechanics laboratories.
Ximedica
Research & Development Engineer / September, 2018 — October, 2019
Provided technical subject matter expertise to enhance the clinical performance of novel medical products being designed.
Research & Development Engineering Manager / October, 2019 — July, 2020
Grew a team of Research & Development Engineers out of our traditional designer, mechanical, and electrical engineering departments to form a novel team within the organization and supported each of their individual professional development needs.
Veranex Solutions (formerly Ximedica)
Director of Research & Development, Technology, and Innovation / July, 2020 — July, 2022
As a director, served in a tactical leader role on product development teams that are executing functional design efforts on cutting-edge medical products, including complex capital equipment, as well as, high-volume disposable components across all sectors of the business (medtech, diagnostics, drug delivery, and cell therapies).
BioVentrix
Director of Research & Development, and Engineering / January, 2023 — Present
Independently organize, manage, and execute the relocation of all company operations from San Ramon, CA to their new office in Mansfield, MA
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