VIJAYASSHEKAR MANUKONDA

Biotechnologist with core competence in biochemistry/cell-biology/molecular biology

Research Interests

Alzheimer

Type I and Type II Diabetes

Cancer

Neurobiology

Structural Biology

Cell Biology

Biochemistry

Molecular Biology

Drug Discovery

Clinical Biochemistry

Molecular Medicine

Pharmaceutical Science

Organic Chemistry

Pharmacology

Immunology and Allergy

Immunology

About

At UNC, I worked on type 1 diabetes, particularly the regulatory role of AIM2, a DNA sensor inflammasome molecule associated with autoimmune disorders. NOD mice deficient in AIM2 do not develop diabetes, indicating a potential beyond host defense. My research involves mapping AIM2's functional binding partners using various methods. During my time at FIU, I worked on characterizing glycan structures in ovarian cancer and developing a peptide and glycan array for identifying potential biomarkers. At BIIR in Dallas, I researched nuclear hormonal transcription factors implicated in autoimmune disorders and cancers, utilizing various methods. Additionally, my work at UTMB in Galveston involved studying cell adhesion molecules linked to neurological disorders, using biochemical and biophysical techniques. My academic background includes extensive knowledge of molecular and biochemical techniques gained at Jawaharlal Nehru Technological University in Hyderabad, India.

Publications

Calsyntenin-3 Molecular Architecture and Interaction with Neurexin 1α

Journal of Biological Chemistry / Dec 01, 2014

Lu, Z., Wang, Y., Chen, F., Tong, H., Reddy, M. V. V. V. S., Luo, L., Seshadrinathan, S., Zhang, L., Holthauzen, L. M. F., Craig, A. M., Ren, G., & Rudenko, G. (2014). Calsyntenin-3 Molecular Architecture and Interaction with Neurexin 1α. Journal of Biological Chemistry, 289(50), 34530–34542. https://doi.org/10.1074/jbc.m114.606806

Molecular Architecture of Contactin-associated Protein-like 2 (CNTNAP2) and Its Interaction with Contactin 2 (CNTN2)

Journal of Biological Chemistry / Nov 01, 2016

Lu, Z., Reddy, M. V. V. V. S., Liu, J., Kalichava, A., Liu, J., Zhang, L., Chen, F., Wang, Y., Holthauzen, L. M. F., White, M. A., Seshadrinathan, S., Zhong, X., Ren, G., & Rudenko, G. (2016). Molecular Architecture of Contactin-associated Protein-like 2 (CNTNAP2) and Its Interaction with Contactin 2 (CNTN2). Journal of Biological Chemistry, 291(46), 24133–24147. https://doi.org/10.1074/jbc.m116.748236

Design and synthesis of 2-substituted benzoxazoles as novel PTP1B inhibitors

Bioorganic & Medicinal Chemistry Letters / May 01, 2013

Chandrasekharappa, A. P., Badiger, S. E., Dubey, P. K., Panigrahi, S. K., & Manukonda, S. R. V. V. V. (2013). Design and synthesis of 2-substituted benzoxazoles as novel PTP1B inhibitors. Bioorganic & Medicinal Chemistry Letters, 23(9), 2579–2584. https://doi.org/10.1016/j.bmcl.2013.02.109

X-Ray Structure of PTP1B in Complex with a New PTP1B Inhibitor

Protein & Peptide Letters / Dec 31, 2013

reddy, M. V. V. V., Ghadiyaram, C., Panigrahi, S., Krishnamurthy, N., Hosahalli, S., Chandrasekharappa, A., Manna, D., Badiger, S., Dubey, P., & Mangamoori, L. (2013). X-Ray Structure of PTP1B in Complex with a New PTP1B Inhibitor. Protein & Peptide Letters, 21(1), 90–93. https://doi.org/10.2174/09298665113209990089

Structural Plasticity of Neurexin 1α: Implications for its Role as Synaptic Organizer

Journal of Molecular Biology / Oct 01, 2018

Liu, J., Misra, A., Reddy, M. V. V. V. S., White, M. A., Ren, G., & Rudenko, G. (2018). Structural Plasticity of Neurexin 1α: Implications for its Role as Synaptic Organizer. Journal of Molecular Biology, 430(21), 4325–4343. https://doi.org/10.1016/j.jmb.2018.08.026

Diphenylether Derivative as Selective Inhibitor of Protein Tyrosine Phosphatase 1B (PTP1B) Over T-cell Protein Tyrosine Phosphatase (TCPTP) Identified through Virtual Screening

Mini-Reviews in Medicinal Chemistry / Jul 31, 2013

Reddy, M., Ghadiyaram, C., Panigrahi, S., Hosahalli, S., & Mangamoori, L. (2013). Diphenylether Derivative as Selective Inhibitor of Protein Tyrosine Phosphatase 1B (PTP1B) Over T-cell Protein Tyrosine Phosphatase (TCPTP) Identified through Virtual Screening. Mini-Reviews in Medicinal Chemistry, 13(11), 1602–1606. https://doi.org/10.2174/1389557511313110006

Design and Synthesis of Novel 2- Substituted Benzothiazole Compounds as PTP1B Inhibitors

Letters in Drug Design & Discovery / Mar 31, 2014

Chandrasekharappa, A., Badiger, S., Dubey, P., Panigrahi, S., & Manukonda, S. (2014). Design and Synthesis of Novel 2- Substituted Benzothiazole Compounds as PTP1B Inhibitors. Letters in Drug Design & Discovery, 11(4), 444–453. https://doi.org/10.2174/15701808113106660076

New Developments in Autism Treatment

Autism-Open Access / Jan 01, 2018

Manukonda, V. (2018). New Developments in Autism Treatment. Autism-Open Access, 08(03). https://doi.org/10.4172/2165-7890.1000e143

Radiolabeled Small Molecule Inhibitors of VEGFR - Recent Advances

Current Pharmaceutical Design / May 01, 2012

Kniess, T. (2012). Radiolabeled Small Molecule Inhibitors of VEGFR - Recent Advances. Current Pharmaceutical Design, 18(20), 2867–2874. https://doi.org/10.2174/138161212800672796

The regulation of self-tolerance and the role of inflammasome molecules

Frontiers in Immunology / Apr 04, 2023

Ke, Q., Greenawalt, A. N., Manukonda, V., Ji, X., & Tisch, R. M. (2023). The regulation of self-tolerance and the role of inflammasome molecules. Frontiers in Immunology, 14. https://doi.org/10.3389/fimmu.2023.1154552

The clinical role of glycobiology on ovarian cancer progression

Advances in Cancer Research / Jan 01, 2023

Armbrister, R., Ochoa, L., & Abbott, K. L. (2023). The clinical role of glycobiology on ovarian cancer progression. In Novel Methods and Pathways in Cancer Glycobiology Research (pp. 1–22). Elsevier. https://doi.org/10.1016/bs.acr.2022.07.004

Meeting and Course Announcements

Glycobiology / Nov 06, 2017

Meeting and Course Announcements. (2017). Glycobiology, 27(12), 1075–1075. https://doi.org/10.1093/glycob/cwx094

Co-Occurring Disorders and Treatment

Journal of Addiction Research & Therapy / Jan 01, 2018

Manukonda, V. (2018). Co-Occurring Disorders and Treatment. Journal of Addiction Research & Therapy, 09(06). https://doi.org/10.4172/2155-6105.1000e141

ChemInform Abstract: L‐Proline‐Catalyzed Synthesis of Novel 5‐(1H‐Indol‐3‐yl‐methylene)‐thiazolidine‐2,4‐dione Derivatives as Potential Antihyperglycemic Agents.

ChemInform / Jun 21, 2012

Riyaz, S., Naidu, A., & Dubey, P. K. (2012). ChemInform Abstract: L‐Proline‐Catalyzed Synthesis of Novel 5‐(1H‐Indol‐3‐yl‐methylene)‐thiazolidine‐2,4‐dione Derivatives as Potential Antihyperglycemic Agents. ChemInform, 43(29). Portico. https://doi.org/10.1002/chin.201229139

Biophysical Rationale for the Selective Inhibition of PTP1B over TCPTP by Nonpolar Terpenoids

Biophysical Rationale for the Selective Inhibition of PTP1B over TCPTP by Nonpolar Terpenoids. (n.d.). American Chemical Society (ACS). https://doi.org/10.1021/acs.jpcb.3c03791.s001

Education

Jawaharlal Nehru Technological University, Hyderabad

BIOTECHNOLOGY / February, 2014

Hyderabad

Experience

UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

Links & Social Media

Research Web Site

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