Dr. Gaurav Mehta, Ph.D.
PhD Scientist with 13+ years of research experience in cancer biology, cell and molecular biology, genomics, metabolomics, and epigenetics
Research Interests
Publications
Tumor mutational burden is a determinant of immune-mediated survival in breast cancer
OncoImmunology / Jul 30, 2018
Thomas, A., Routh, E. D., Pullikuth, A., Jin, G., Su, J., Chou, J. W., Hoadley, K. A., Print, C., Knowlton, N., Black, M. A., Demaria, S., Wang, E., Bedognetti, D., Jones, W. D., Mehta, G. A., Gatza, M. L., Perou, C. M., Page, D. B., Triozzi, P., & Miller, L. D. (2018). Tumor mutational burden is a determinant of immune-mediated survival in breast cancer. OncoImmunology, 7(10), e1490854. https://doi.org/10.1080/2162402x.2018.1490854
BRG1 interacts with SOX10 to establish the melanocyte lineage and to promote differentiation
Nucleic Acids Research / Apr 20, 2017
Marathe, H. G., Watkins-Chow, D. E., Weider, M., Hoffmann, A., Mehta, G., Trivedi, A., Aras, S., Basuroy, T., Mehrotra, A., Bennett, D. C., Wegner, M., Pavan, W. J., & de la Serna, I. L. (2017). BRG1 interacts with SOX10 to establish the melanocyte lineage and to promote differentiation. Nucleic Acids Research, 45(11), 6442–6458. https://doi.org/10.1093/nar/gkx259
Amplification of SOX4 promotes PI3K/Akt signaling in human breast cancer
Breast Cancer Research and Treatment / Feb 07, 2017
Mehta, G. A., Parker, J. S., Silva, G. O., Hoadley, K. A., Perou, C. M., & Gatza, M. L. (2017). Amplification of SOX4 promotes PI3K/Akt signaling in human breast cancer. Breast Cancer Research and Treatment, 162(3), 439–450. https://doi.org/10.1007/s10549-017-4139-2
MITF interacts with the SWI/SNF subunit, BRG1, to promote GATA4 expression in cardiac hypertrophy
Journal of Molecular and Cellular Cardiology / Nov 01, 2015
Mehta, G., Kumarasamy, S., Wu, J., Walsh, A., Liu, L., Williams, K., Joe, B., & de la Serna, I. L. (2015). MITF interacts with the SWI/SNF subunit, BRG1, to promote GATA4 expression in cardiac hypertrophy. Journal of Molecular and Cellular Cardiology, 88, 101–110. https://doi.org/10.1016/j.yjmcc.2015.09.010
SWI/SNF Enzymes Promote SOX10- Mediated Activation of Myelin Gene Expression
PLoS ONE / Jul 16, 2013
Marathe, H. G., Mehta, G., Zhang, X., Datar, I., Mehrotra, A., Yeung, K. C., & de la Serna, I. L. (2013). SWI/SNF Enzymes Promote SOX10- Mediated Activation of Myelin Gene Expression. PLoS ONE, 8(7), e69037. https://doi.org/10.1371/journal.pone.0069037
Emerging Role of SOX Proteins in Breast Cancer Development and Maintenance
Journal of Mammary Gland Biology and Neoplasia / May 09, 2019
Mehta, G. A., Khanna, P., & Gatza, M. L. (2019). Emerging Role of SOX Proteins in Breast Cancer Development and Maintenance. Journal of Mammary Gland Biology and Neoplasia, 24(3), 213–230. https://doi.org/10.1007/s10911-019-09430-6
SWI/SNF Chromatin Remodeling Enzymes in Melanocyte Differentiation and Melanoma
Critical Reviews in Eukaryotic Gene Expression / Jan 01, 2014
Mehrotra, A., Mehta, G., Aras, S., Trivedi, A., & de la Serna, I. (2014). SWI/SNF Chromatin Remodeling Enzymes in Melanocyte Differentiation and Melanoma. Critical Reviews in Eukaryotic Gene Expression, 24(2), 151–161. https://doi.org/10.1615/critreveukaryotgeneexpr.2014007882
CPT1A and fatty acid β-oxidation are essential for tumor cell growth and survival in hormone receptor-positive breast cancer
NAR Cancer / Jul 02, 2021
Jariwala, N., Mehta, G. A., Bhatt, V., Hussein, S., Parker, K. A., Yunus, N., Parker, J. S., Guo, J. Y., & Gatza, M. L. (2021). CPT1A and fatty acid β-oxidation are essential for tumor cell growth and survival in hormone receptor-positive breast cancer. NAR Cancer, 3(3). https://doi.org/10.1093/narcan/zcab035
Integrative proteogenomic analyses of human tumours identifies ADNP as a novel oncogenic mediator of cell cycle progression in high-grade serous ovarian cancer with poor prognosis
EBioMedicine / Dec 01, 2019
Karagoz, K., Mehta, G. A., Khella, C. A., Khanna, P., & Gatza, M. L. (2019). Integrative proteogenomic analyses of human tumours identifies ADNP as a novel oncogenic mediator of cell cycle progression in high-grade serous ovarian cancer with poor prognosis. EBioMedicine, 50, 191–202. https://doi.org/10.1016/j.ebiom.2019.11.009
Recent Advances in Integrative Multi-Omics Research in Breast and Ovarian Cancer
Journal of Personalized Medicine / Feb 19, 2021
Khella, C. A., Mehta, G. A., Mehta, R. N., & Gatza, M. L. (2021). Recent Advances in Integrative Multi-Omics Research in Breast and Ovarian Cancer. Journal of Personalized Medicine, 11(2), 149. https://doi.org/10.3390/jpm11020149
FOXA1 and adaptive response determinants to HER2 targeted therapy in TBCRC 036
npj Breast Cancer / May 12, 2021
Angus, S. P., Stuhlmiller, T. J., Mehta, G., Bevill, S. M., Goulet, D. R., Olivares-Quintero, J. F., East, M. P., Tanioka, M., Zawistowski, J. S., Singh, D., Sciaky, N., Chen, X., He, X., Rashid, N. U., Chollet-Hinton, L., Fan, C., Soloway, M. G., Spears, P. A., Jefferys, S., … Johnson, G. L. (2021). FOXA1 and adaptive response determinants to HER2 targeted therapy in TBCRC 036. Npj Breast Cancer, 7(1). https://doi.org/10.1038/s41523-021-00258-0
SOX4 and SMARCA4 cooperatively regulate PI3k signaling through transcriptional activation of TGFBR2
npj Breast Cancer / Apr 09, 2021
Mehta, G. A., Angus, S. P., Khella, C. A., Tong, K., Khanna, P., Dixon, S. A. H., Verzi, M. P., Johnson, G. L., & Gatza, M. L. (2021). SOX4 and SMARCA4 cooperatively regulate PI3k signaling through transcriptional activation of TGFBR2. Npj Breast Cancer, 7(1). https://doi.org/10.1038/s41523-021-00248-2
Abstract P2-03-03: BRG1-SOX4 mediates a novel and essential signaling network that activates PI3K/Akt signaling in TNBC
Cancer Research / Feb 15, 2019
Gatza, M., Angus, S., Khella, C., Tong, K., Verzi, M., & Mehta, G. (2019). Abstract P2-03-03: BRG1-SOX4 mediates a novel and essential signaling network that activates PI3K/Akt signaling in TNBC. Cancer Research, 79(4_Supplement), P2-03-03-P2-03–03. https://doi.org/10.1158/1538-7445.sabcs18-p2-03-03
Abstract PD15-09: Sox4 and smarca4 upregulate glycolysis-driven tumor proliferation through hexokinase 2 in tnbc
Cancer Research / Feb 15, 2021
Khanna, P., Mehta, G., & Gatza, M. L. (2021). Abstract PD15-09: Sox4 and smarca4 upregulate glycolysis-driven tumor proliferation through hexokinase 2 in tnbc. Cancer Research, 81(4_Supplement), PD15-09-PD15-09. https://doi.org/10.1158/1538-7445.sabcs20-pd15-09
Abstract PO-035: SOX4 and SMARCA4 upregulate glycolysis-driven tumor proliferation through Hexokinase 2 in Triple Negative Breast Cancer
Cancer Research / Dec 01, 2020
Khanna, P., Mehta, G., Bhatt, V., Guo, J. Y., & Gatza, M. L. (2020). Abstract PO-035: SOX4 and SMARCA4 upregulate glycolysis-driven tumor proliferation through Hexokinase 2 in Triple Negative Breast Cancer. Cancer Research, 80(23_Supplement), PO-035-PO-035. https://doi.org/10.1158/1538-7445.epimetab20-po-035
Wound healing, anti-microbial and antioxidant potential of Dendrophthoe falcata (L.f) Ettingsh
Journal of Ethnopharmacology / Nov 01, 2008
Pattanayak, S. P., & Sunita, P. (2008). Wound healing, anti-microbial and antioxidant potential of Dendrophthoe falcata (L.f) Ettingsh. Journal of Ethnopharmacology, 120(2), 241–247. https://doi.org/10.1016/j.jep.2008.08.019
Education
Ph.D., Biochemistry and Cancer Biology / May, 2015
University of Mumbai
M.Sc., Biotechnology / May, 2009
University of Mumbai
B.Sc., Biotechnology / May, 2007
Experience
Rutgers Cancer Institute of New Jersey
Post-Doctoral Researcher / April, 2016 — October, 2021
PMV Pharma
Research Scientist / May, 2022 — Present
WuXi Advanced Therapies
Scientist / November, 2021 — May, 2022
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