Liam D. Hendrikse, Ph.D.

Bioinformatician at the University Health Network in Toronto, CA, specializing in computational cancer research using various sequencing modalities.

Toronto, Ontario, Canada

Research Interests

Medulloblastoma

Bioinformatics

Genomics

Oncology

Virology

Infectious Diseases

Cancer Research

Neurology (clinical)

About

Liam Hendrikse is a recent Ph.D. graduate from the Department of Medical Biophysics at the University of Toronto, now working as a Bioinformatician at the University Health Network. His research focuses on deepening our understanding of various cancer types using computational methods, in order to develop novel treatment options. Liam has a particular strength in analysis of various single-cell sequencing technologies (RNA, ATAC, CITE, TCR/BCR, etc.), as well as traditional sequencing technologies, such as bulk RNAseq. Liam has a proven track record of deriving highly impactful biological insights through his research, as evidenced by publications in high impact journals such as Nature and Cancer Discovery. Previously, Liam earned his Bachelor of Science in biochemistry and immunology from Western University in 2018.

Publications

Childhood cerebellar tumours mirror conserved fetal transcriptional programs

Nature / May 01, 2019

Vladoiu, M. C., El-Hamamy, I., Donovan, L. K., Farooq, H., Holgado, B. L., Sundaravadanam, Y., Ramaswamy, V., Hendrikse, L. D., Kumar, S., Mack, S. C., Lee, J. J. Y., Fong, V., Juraschka, K., Przelicki, D., Michealraj, A., Skowron, P., Luu, B., Suzuki, H., Morrissy, A. S., … Taylor, M. D. (2019). Childhood cerebellar tumours mirror conserved fetal transcriptional programs. Nature, 572(7767), 67–73. https://doi.org/10.1038/s41586-019-1158-7

Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma

Nature Medicine / Apr 27, 2020

Donovan, L. K., Delaidelli, A., Joseph, S. K., Bielamowicz, K., Fousek, K., Holgado, B. L., Manno, A., Srikanthan, D., Gad, A. Z., Van Ommeren, R., Przelicki, D., Richman, C., Ramaswamy, V., Daniels, C., Pallota, J. G., Douglas, T., Joynt, A. C. M., Haapasalo, J., Nor, C., … Taylor, M. D. (2020). Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma. Nature Medicine, 26(5), 720–731. https://doi.org/10.1038/s41591-020-0827-2

H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone

Cancer Discovery / Dec 01, 2020

Khazaei, S., De Jay, N., Deshmukh, S., Hendrikse, L. D., Jawhar, W., Chen, C. C. L., Mikael, L. G., Faury, D., Marchione, D. M., Lanoix, J., Bonneil, É., Ishii, T., Jain, S. U., Rossokhata, K., Sihota, T. S., Eveleigh, R., Lisi, V., Harutyunyan, A. S., Jung, S., … Jabado, N. (2020). H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone. Cancer Discovery, 10(12), 1968–1987. https://doi.org/10.1158/2159-8290.cd-20-0461

Identification of a Novel Gammaherpesvirus in Canada lynx (Lynx canadensis)

Viruses / Apr 20, 2019

Hendrikse, L. D., Kambli, A., Kayko, C., Canuti, M., Rodrigues, B., Stevens, B., Vashon, J., Lang, A. S., Needle, D. B., & Troyer, R. M. (2019). Identification of a Novel Gammaherpesvirus in Canada lynx (Lynx canadensis). Viruses, 11(4), 363. https://doi.org/10.3390/v11040363

MDB-07. MYC AND TGFΒ PROMOTE GROUP 3 MEDULLOBLASTOMA TUMOR RESISTANCE THROUGH DEREGULATION OF KDM2B TARGETS

Neuro-Oncology / Jun 01, 2023

Qadeer, Z., Westelman, S., Johnson, M., Grele, S., Hou, E., Hendrikse, L., Wang, L., Husain, S., Beytagh, M. C., Schmidt, C., Huang, M., Taylor, M., & Weiss, W. (2023). MDB-07. MYC AND TGFΒ PROMOTE GROUP 3 MEDULLOBLASTOMA TUMOR RESISTANCE THROUGH DEREGULATION OF KDM2B TARGETS. Neuro-Oncology, 25(Supplement_1), i62–i63. https://doi.org/10.1093/neuonc/noad073.240

MDB-21. THE OTX2-REGULATED ALTERNATIVE SPLICING LANDSCAPE CONTROLS DIFFERENTIATION AND RECONSTITUTES THE DEVELOPMENTAL ORIGINS OF GROUP 3 MEDULLOBLASTOMA

Neuro-Oncology / Jun 01, 2023

Saulnier, O., Zagozewski, J., Liang, L., Hendrikse, L. D., Gordon, V., Aldinger, K. A., Haldipur, P., Borlase, S., Coudiere-Morrison, L., Layug, P., Cai, T., Porter, C. J., Richard, S., Doble, B. W., Millen, K. J., Taylor, M. D., & Werbowetski-Ogilvie, T. E. (2023). MDB-21. THE OTX2-REGULATED ALTERNATIVE SPLICING LANDSCAPE CONTROLS DIFFERENTIATION AND RECONSTITUTES THE DEVELOPMENTAL ORIGINS OF GROUP 3 MEDULLOBLASTOMA. Neuro-Oncology, 25(Supplement_1), i66–i67. https://doi.org/10.1093/neuonc/noad073.254

DDDR-33. TARGETING TGFΒ PATHWAY DEPENDENCIES IN GROUP 3 MEDULLOBLASTOMA

Neuro-Oncology / Nov 01, 2022

Qadeer, Z., Westelman, S., Johnson, M., Grele, S., Hendrikse, L., Taylor, M., & Weiss, W. (2022). DDDR-33. TARGETING TGFΒ PATHWAY DEPENDENCIES IN GROUP 3 MEDULLOBLASTOMA. Neuro-Oncology, 24(Supplement_7), vii106–vii106. https://doi.org/10.1093/neuonc/noac209.398

Enhancement of mitochondrial function fosters B cell immune memory

Jun 22, 2022

Shukla, A., Tiwari, A., Saulnier, O., Hendrikse, L., Hall, B., Rickert, R., Taylor, M. D., Shukla, V., & Bagchi, A. (2022). Enhancement of mitochondrial function fosters B cell immune memory. https://doi.org/10.1101/2022.06.21.497040

Failure of human rhombic lip differentiation underlies medulloblastoma formation

Nature / Sep 21, 2022

Hendrikse, L. D., Haldipur, P., Saulnier, O., Millman, J., Sjoboen, A. H., Erickson, A. W., Ong, W., Gordon, V., Coudière-Morrison, L., Mercier, A. L., Shokouhian, M., Suárez, R. A., Ly, M., Borlase, S., Scott, D. S., Vladoiu, M. C., Farooq, H., Sirbu, O., Nakashima, T., … Taylor, M. D. (2022). Failure of human rhombic lip differentiation underlies medulloblastoma formation. Nature, 609(7929), 1021–1028. https://doi.org/10.1038/s41586-022-05215-w

The transcriptional landscape of Shh medulloblastoma

Nature Communications / Mar 19, 2021

Skowron, P., Farooq, H., Cavalli, F. M. G., Morrissy, A. S., Ly, M., Hendrikse, L. D., Wang, E. Y., Djambazian, H., Zhu, H., Mungall, K. L., Trinh, Q. M., Zheng, T., Dai, S., Stucklin, A. S. G., Vladoiu, M. C., Fong, V., Holgado, B. L., Nor, C., Wu, X., … Taylor, M. D. (2021). The transcriptional landscape of Shh medulloblastoma. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-21883-0

Education

University of Toronto

Ph.D., Bioinformatics / June, 2023 (anticipated)

Toronto, Ontario, Canada

Western University

BMSc, Biochemistry and Immunology / June, 2018

London, Ontario, Canada

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