Throughout my career, I've used various in vivo and in vitro models to investigate the molecular and cellular mechanisms of fibrosis and inflammation in the heart, and how these mechanisms are affected in mice with different genetic backgrounds. My experience includes project management and mentoring. I completed three projects involving international collaborations, supervised two junior researchers, and taught cellular and molecular techniques to at least six professionals. As one of the launching editors and senior editor at Nature Cardiovascular Research, I oversaw the quality of the content published in the journal and the editorial process. I collaborated with authors, reviewers, and editors to ensure the highest standards of scientific rigor, relevance, and innovation. I also contributed to the journal's vision, strategy, and outreach, promoting the latest advances and discoveries in the cardiovascular and hematology fields. This experience has sharpened my analytical and communication skills and broadened my understanding of the field, covering a wide range of studies, from basic research to clinical, epidemiological, and public health research. My mission is to advance the knowledge and practice of cardiovascular medicine and to bridge the gap between research and clinical applications. Keywords: cardiovascular, #fibrosis, inflammation, cardioimmunology, RNA, single-cell biology, #transcriptomics, imaging, animal models, small animal surgery, and scientific writing.
Elvira Forte
Scientific strategist • Senior Scientist • Senior Scientific Editor
Research Interests
About
Publications
Fibroblasts: Origins, definitions, and functions in health and disease
Cell / Jul 01, 2021
Plikus, M. V., Wang, X., Sinha, S., Forte, E., Thompson, S. M., Herzog, E. L., Driskell, R. R., Rosenthal, N., Biernaskie, J., & Horsley, V. (2021). Fibroblasts: Origins, definitions, and functions in health and disease. Cell, 184(15), 3852–3872. https://doi.org/10.1016/j.cell.2021.06.024
Differentiation of human adult cardiac stem cells exposed to extremely low-frequency electromagnetic fields
Cardiovascular Research / Feb 19, 2009
Gaetani, R., Ledda, M., Barile, L., Chimenti, I., De Carlo, F., Forte, E., Ionta, V., Giuliani, L., D’Emilia, E., Frati, G., Miraldi, F., Pozzi, D., Messina, E., Grimaldi, S., Giacomello, A., & Lisi, A. (2009). Differentiation of human adult cardiac stem cells exposed to extremely low-frequency electromagnetic fields. Cardiovascular Research, 82(3), 411–420. https://doi.org/10.1093/cvr/cvp067
Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction
Nature Communications / Jan 29, 2021
Tombor, L. S., John, D., Glaser, S. F., Luxán, G., Forte, E., Furtado, M., Rosenthal, N., Baumgarten, N., Schulz, M. H., Wittig, J., Rogg, E.-M., Manavski, Y., Fischer, A., Muhly-Reinholz, M., Klee, K., Looso, M., Selignow, C., Acker, T., Bibli, S.-I., … Dimmeler, S. (2021). Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-20905-1
Cardiac stem cells: isolation, expansion and experimental use for myocardial regeneration
Nature Clinical Practice Cardiovascular Medicine / Feb 01, 2007
Barile, L., Chimenti, I., Gaetani, R., Forte, E., Miraldi, F., Frati, G., Messina, E., & Giacomello, A. (2007). Cardiac stem cells: isolation, expansion and experimental use for myocardial regeneration. Nature Clinical Practice Cardiovascular Medicine, 4(S1), S9–S14. https://doi.org/10.1038/ncpcardio0738
Dynamic Interstitial Cell Response during Myocardial Infarction Predicts Resilience to Rupture in Genetically Diverse Mice
Cell Reports / Mar 01, 2020
Forte, E., Skelly, D. A., Chen, M., Daigle, S., Morelli, K. A., Hon, O., Philip, V. M., Costa, M. W., Rosenthal, N. A., & Furtado, M. B. (2020). Dynamic Interstitial Cell Response during Myocardial Infarction Predicts Resilience to Rupture in Genetically Diverse Mice. Cell Reports, 30(9), 3149-3163.e6. https://doi.org/10.1016/j.celrep.2020.02.008
The interstitium in cardiac repair: role of the immune–stromal cell interplay
Nature Reviews Cardiology / Sep 04, 2018
Forte, E., Furtado, M. B., & Rosenthal, N. (2018). The interstitium in cardiac repair: role of the immune–stromal cell interplay. Nature Reviews Cardiology, 15(10), 601–616. https://doi.org/10.1038/s41569-018-0077-x
Developmental origin and lineage plasticity of endogenous cardiac stem cells
Development / Apr 15, 2016
Santini, M. P., Forte, E., Harvey, R. P., & Kovacic, J. C. (2016). Developmental origin and lineage plasticity of endogenous cardiac stem cells. Development, 143(8), 1242–1258. https://doi.org/10.1242/dev.111591
Human cardiosphere-seeded gelatin and collagen scaffolds as cardiogenic engineered bioconstructs
Biomaterials / Dec 01, 2011
Chimenti, I., Rizzitelli, G., Gaetani, R., Angelini, F., Ionta, V., Forte, E., Frati, G., Schussler, O., Barbetta, A., Messina, E., Dentini, M., & Giacomello, A. (2011). Human cardiosphere-seeded gelatin and collagen scaffolds as cardiogenic engineered bioconstructs. Biomaterials, 32(35), 9271–9281. https://doi.org/10.1016/j.biomaterials.2011.08.049
EMT/MET at the Crossroad of Stemness, Regeneration and Oncogenesis: The Ying-Yang Equilibrium Recapitulated in Cell Spheroids
Cancers / Jul 29, 2017
Forte, E., Chimenti, I., Rosa, P., Angelini, F., Pagano, F., Calogero, A., Giacomello, A., & Messina, E. (2017). EMT/MET at the Crossroad of Stemness, Regeneration and Oncogenesis: The Ying-Yang Equilibrium Recapitulated in Cell Spheroids. Cancers, 9(12), 98. https://doi.org/10.3390/cancers9080098
Isolation and Expansion of Adult Cardiac Stem/Progenitor Cells in the Form of Cardiospheres from Human Cardiac Biopsies and Murine Hearts
Somatic Stem Cells / Jan 01, 2012
Chimenti, I., Gaetani, R., Barile, L., Forte, E., Ionta, V., Angelini, F., Frati, G., Messina, E., & Giacomello, A. (2012). Isolation and Expansion of Adult Cardiac Stem/Progenitor Cells in the Form of Cardiospheres from Human Cardiac Biopsies and Murine Hearts. In Methods in Molecular Biology (pp. 327–338). Humana Press. https://doi.org/10.1007/978-1-61779-815-3_19
Developmental origins and lineage descendants of endogenous adult cardiac progenitor cells
Stem Cell Research / Nov 01, 2014
Chong, J. J. H., Forte, E., & Harvey, R. P. (2014). Developmental origins and lineage descendants of endogenous adult cardiac progenitor cells. Stem Cell Research, 13(3), 592–614. https://doi.org/10.1016/j.scr.2014.09.008
Serum and supplement optimization for
EU GMP ‐compliance in
cardiospheres cell culture
Journal of Cellular and Molecular Medicine / Jan 20, 2014
Chimenti, I., Gaetani, R., Forte, E., Angelini, F., De Falco, E., Zoccai, G. B., Messina, E., Frati, G., & Giacomello, A. (2014). Serum and supplement optimization for <scp>EU GMP</scp>‐compliance in cardiospheres cell culture. Journal of Cellular and Molecular Medicine, 18(4), 624–634. Portico. https://doi.org/10.1111/jcmm.12210
Cross-Priming Dendritic Cells Exacerbate Immunopathology After Ischemic Tissue Damage in the Heart
Circulation / Feb 23, 2021
Forte, E., Perkins, B., Sintou, A., Kalkat, H. S., Papanikolaou, A., Jenkins, C., Alsubaie, M., Chowdhury, R. A., Duffy, T. M., Skelly, D. A., Branca, J., Bellahcene, M., Schneider, M. D., Harding, S. E., Furtado, M. B., Ng, F. S., Hasham, M. G., Rosenthal, N., & Sattler, S. (2021). Cross-Priming Dendritic Cells Exacerbate Immunopathology After Ischemic Tissue Damage in the Heart. Circulation, 143(8), 821–836. https://doi.org/10.1161/circulationaha.120.044581
Cardiospheres and tissue engineering for myocardial regeneration: potential for clinical application
Journal of Cellular and Molecular Medicine / May 01, 2010
Gaetani, R., Rizzitelli, G., Chimenti, I., Barile, L., Forte, E., Ionta, V., Angelini, F., Sluijter, J. P. G., Barbetta, A., Messina, E., & Frati, G. (2010). Cardiospheres and tissue engineering for myocardial regeneration: potential for clinical application. Journal of Cellular and Molecular Medicine, no-no. https://doi.org/10.1111/j.1582-4934.2010.01078.x
TGFβ-Dependent Epithelial-to-Mesenchymal Transition Is Required to Generate Cardiospheres from Human Adult Heart Biopsies
Stem Cells and Development / Nov 20, 2012
Forte, E., Miraldi, F., Chimenti, I., Angelini, F., Zeuner, A., Giacomello, A., Mercola, M., & Messina, E. (2012). TGFβ-Dependent Epithelial-to-Mesenchymal Transition Is Required to Generate Cardiospheres from Human Adult Heart Biopsies. Stem Cells and Development, 21(17), 3081–3090. https://doi.org/10.1089/scd.2012.0277
Different types of cultured human adult Cardiac Progenitor Cells have a high degree of transcriptome similarity
Journal of Cellular and Molecular Medicine / Oct 14, 2014
Gaetani, R., Feyen, D. A. M., Doevendans, P. A., Gremmels, H., Forte, E., Fledderus, J. O., Ramjankhan, F. Z., Messina, E., Sussman, M. A., Giacomello, A., & Sluijter, J. P. G. (2014). Different types of cultured human adult Cardiac Progenitor Cells have a high degree of transcriptome similarity. Journal of Cellular and Molecular Medicine, 18(11), 2147–2151. Portico. https://doi.org/10.1111/jcmm.12458
Cardiac Cell Therapy: The Next (Re)Generation
Stem Cell Reviews and Reports / Mar 25, 2011
Forte, E., Chimenti, I., Barile, L., Gaetani, R., Angelini, F., Ionta, V., Messina, E., & Giacomello, A. (2011). Cardiac Cell Therapy: The Next (Re)Generation. Stem Cell Reviews and Reports, 7(4), 1018–1030. https://doi.org/10.1007/s12015-011-9252-8
Bone marrow‐derived cells can acquire cardiac stem cells properties in damaged heart
Journal of Cellular and Molecular Medicine / Jan 01, 2011
Barile, L., Cerisoli, F., Frati, G., Gaetani, R., Chimenti, I., Forte, E., Cassinelli, L., Spinardi, L., Altomare, C., Kizana, E., Giacomello, A., Messina, E., Ottolenghi, S., & Magli, M. C. (2011). Bone marrow‐derived cells can acquire cardiac stem cells properties in damaged heart. Journal of Cellular and Molecular Medicine, 15(1), 63–71. Portico. https://doi.org/10.1111/j.1582-4934.2009.00968.x
New Perspectives to Repair a Broken Heart
Cardiovascular & Hematological Agents in Medicinal Chemistry / Apr 01, 2009
Gaetani, R., Barile, L., Forte, E., Chimenti, I., Ionta, V., Di Consiglio, A., Miraldi, F., Frati, G., Messina, E., & Giacomello, A. (2009). New Perspectives to Repair a Broken Heart. Cardiovascular & Hematological Agents in Medicinal Chemistry, 7(2), 91–107. https://doi.org/10.2174/187152509787847128
A Chemical Biology Approach to Myocardial Regeneration
Journal of Cardiovascular Translational Research / Mar 22, 2011
Willems, E., Lanier, M., Forte, E., Lo, F., Cashman, J., & Mercola, M. (2011). A Chemical Biology Approach to Myocardial Regeneration. Journal of Cardiovascular Translational Research, 4(3), 340–350. https://doi.org/10.1007/s12265-011-9270-6
Type 2 MI induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart
Journal of Cellular and Molecular Medicine / Nov 29, 2020
Forte, E., Panahi, M., Baxan, N., Ng, F. S., Boyle, J. J., Branca, J., Bedard, O., Hasham, M. G., Benson, L., Harding, S. E., Rosenthal, N., & Sattler, S. (2020). Type 2 MI induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart. Journal of Cellular and Molecular Medicine, 25(1), 229–243. Portico. https://doi.org/10.1111/jcmm.15937
From Ontogenesis to Regeneration
Progress in Molecular Biology and Translational Science / Jan 01, 2012
Chimenti, I., Forte, E., Angelini, F., Giacomello, A., & Messina, E. (2012). From Ontogenesis to Regeneration. In Genetics of Stem Cells, Part A (pp. 109–137). Elsevier. https://doi.org/10.1016/b978-0-12-398459-3.00005-8
PDGFRα signaling in cardiac fibroblasts modulates quiescence, metabolism and self-renewal, and promotes anatomical and functional repair
Nov 28, 2017
Asli, N. S., Xaymardan, M., Patrick, R., Farbehi, N., Cornwell, J., Forte, E., Waardenberg, A. J., Janbandhu, V., Kesteven, S., Chandrakanthan, V., Malinowska, H., Reinhard, H., Schofield, P., Christ, D., Ahmed, I., Bouveret, R., Srivastava, S., Mishra, R. K., Dhawan, J., … Harvey, R. P. (2017). PDGFRα signaling in cardiac fibroblasts modulates quiescence, metabolism and self-renewal, and promotes anatomical and functional repair. https://doi.org/10.1101/225979
Adult mouse fibroblasts retain organ-specific transcriptomic identity
eLife / Mar 16, 2022
Forte, E., Ramialison, M., Nim, H. T., Mara, M., Li, J. Y., Cohn, R., Daigle, S. L., Boyd, S., Stanley, E. G., Elefanty, A. G., Hinson, J. T., Costa, M. W., Rosenthal, N. A., & Furtado, M. B. (2022). Adult mouse fibroblasts retain organ-specific transcriptomic identity. ELife, 11. CLOCKSS. https://doi.org/10.7554/elife.71008
Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease
Molecular Metabolism / Feb 01, 2019
Wilmanns, J. C., Pandey, R., Hon, O., Chandran, A., Schilling, J. M., Forte, E., Wu, Q., Cagnone, G., Bais, P., Philip, V., Coleman, D., Kocalis, H., Archer, S. K., Pearson, J. T., Ramialison, M., Heineke, J., Patel, H. H., Rosenthal, N. A., Furtado, M. B., & Costa, M. W. (2019). Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease. Molecular Metabolism, 20, 102–114. https://doi.org/10.1016/j.molmet.2018.11.002
Continuous Subcutaneous Insulin Infusion in Italy: Third National Survey
Diabetes Technology & Therapeutics / Feb 01, 2015
Bruttomesso, D., Laviola, L., Lepore, G., Bonfanti, R., Bozzetto, L., Corsi, A., Di Blasi, V., Girelli, A., Grassi, G., Iafusco, D., Rabbone, I., & Schiaffini, R. (2015). Continuous Subcutaneous Insulin Infusion in Italy: Third National Survey. Diabetes Technology & Therapeutics, 17(2), 96–104. https://doi.org/10.1089/dia.2014.0242
Biochemistry and biology: Heart-to-heart to investigate cardiac progenitor cells
Biochimica et Biophysica Acta (BBA) - General Subjects / Feb 01, 2013
Chimenti, I., Forte, E., Angelini, F., Messina, E., & Giacomello, A. (2013). Biochemistry and biology: Heart-to-heart to investigate cardiac progenitor cells. Biochimica et Biophysica Acta (BBA) - General Subjects, 1830(2), 2459–2469. https://doi.org/10.1016/j.bbagen.2012.08.004
Editorial: Fibrosis and Inflammation in Tissue Pathophysiology
Frontiers in Physiology / Jan 21, 2022
Chimenti, I., Sattler, S., del Monte-Nieto, G., & Forte, E. (2022). Editorial: Fibrosis and Inflammation in Tissue Pathophysiology. Frontiers in Physiology, 12. https://doi.org/10.3389/fphys.2021.830683
Evidence for the Existence of Resident Cardiac Stem Cells
Regenerating the Heart / Jan 01, 2011
Chimenti, I., Gaetani, R., Barile, L., Forte, E., Ionta, V., Angelini, F., Messina, E., & Giacomello, A. (2011). Evidence for the Existence of Resident Cardiac Stem Cells. In Regenerating the Heart (pp. 131–147). Humana Press. https://doi.org/10.1007/978-1-61779-021-8_9
Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction
European Heart Journal / Nov 01, 2020
Tombor, L., John, D., Glaser, S. F., Luxan, G., Forte, E., Furtado, M., Rosenthal, N., Manavski, Y., Fischer, A., Muhly-Reinholz, M., Looso, M., Acker, T., Harvey, R., Abplanalp, A., & Dimmeler, S. (2020). Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction. European Heart Journal, 41(Supplement_2). https://doi.org/10.1093/ehjci/ehaa946.3736
Protocol for Isolation of Cardiac Interstitial Cells from Adult Murine Hearts for Unbiased Single Cell Profiling
STAR Protocols / Sep 01, 2020
Forte, E., Daigle, S., & Rosenthal, N. A. (2020). Protocol for Isolation of Cardiac Interstitial Cells from Adult Murine Hearts for Unbiased Single Cell Profiling. STAR Protocols, 1(2), 100077. https://doi.org/10.1016/j.xpro.2020.100077
Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19
Nature Communications / Jul 25, 2023
Robertson, S. J., Bedard, O., McNally, K. L., Shaia, C., Clancy, C. S., Lewis, M., Broeckel, R. M., Chiramel, A. I., Shannon, J. G., Sturdevant, G. L., Rosenke, R., Anzick, S. L., Forte, E., Preuss, C., Baker, C. N., Harder, J. M., Brunton, C., Munger, S., Bruno, D. P., … Best, S. M. (2023). Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-40076-5
Circulating spike protein may contribute to myocarditis after COVID-19 vaccination
Nature Cardiovascular Research / Feb 08, 2023
Forte, E. (2023). Circulating spike protein may contribute to myocarditis after COVID-19 vaccination. Nature Cardiovascular Research, 2(2), 100–100. https://doi.org/10.1038/s44161-023-00222-0
Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19
Sep 18, 2021
Robertson, S. J., Bedard, O., McNally, K. L., Shaia, C., Clancy, C., Lewis, M., Broeckel, R. M., Chiramel, A. I., Shannon, J. G., Sturdevant, G. L., Rosenke, R., Anzick, S. L., Forte, E., Preuss, C., Baker, C. N., Harder, J., Brunton, C., Munger, S., Bruno, D. P., … Best, S. M. (2021). Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19. https://doi.org/10.1101/2021.09.17.460664
Adult fibroblasts retain organ-specific transcriptomic identity
Jun 04, 2021
Forte, E., Ramialison, M., Nim, H. T., Mara, M., Cohn, R., Daigle, S. L., Boyd, S., Hinson, J. T., Costa, M. W., Rosenthal, N. A., & Furtado, M. B. (2021). Adult fibroblasts retain organ-specific transcriptomic identity. https://doi.org/10.1101/2021.06.03.446915
Myocardial damage induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart
Feb 27, 2020
Forte, E., Panahi, M., Ng, F. S., Boyle, J. J., Branca, J., Bedard, O., Hasham, M. G., Benson, L., Harding, S. E., Rosenthal, N., & Sattler, S. (2020). Myocardial damage induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart. https://doi.org/10.1101/2020.02.27.962696
HLA-DQ8 Supports Development of Insulitis Mediated by Insulin-Reactive Human TCR-Transgenic T Cells in Nonobese Diabetic Mice
The Journal of Immunology / Dec 15, 2023
Racine, J. J., Misherghi, A., Dwyer, J. R., Maser, R., Forte, E., Bedard, O., Sattler, S., Pugliese, A., Landry, L., Elso, C., Nakayama, M., Mannering, S., Rosenthal, N., & Serreze, D. V. (2023). HLA-DQ8 Supports Development of Insulitis Mediated by Insulin-Reactive Human TCR-Transgenic T Cells in Nonobese Diabetic Mice. The Journal of Immunology, 211(12), 1792–1805. https://doi.org/10.4049/jimmunol.2300303
Recruited macrophages are a potential therapeutic target in atrial fibrillation
Nature Cardiovascular Research / Aug 07, 2023
Forte, E. (2023). Recruited macrophages are a potential therapeutic target in atrial fibrillation. Nature Cardiovascular Research, 2(8), 715–715. https://doi.org/10.1038/s44161-023-00321-y
A cell-intrinsic regulator of emergency hematopoiesis
Nature Cardiovascular Research / Jan 10, 2023
Forte, E. (2023). A cell-intrinsic regulator of emergency hematopoiesis. Nature Cardiovascular Research, 2(1), 8–8. https://doi.org/10.1038/s44161-022-00207-5
The multifaceted effect of efferocytosis on cardiac repair after infarction
Nature Cardiovascular Research / Apr 04, 2022
Forte, E. (2022). The multifaceted effect of efferocytosis on cardiac repair after infarction. Nature Cardiovascular Research, 1(4), 283–283. https://doi.org/10.1038/s44161-022-00054-4
Ex uno, plures–From One Tissue to Many Cells: A Review of Single-Cell Transcriptomics in Cardiovascular Biology
International Journal of Molecular Sciences / Feb 19, 2021
Forte, E., McLellan, M. A., Skelly, D. A., & Rosenthal, N. A. (2021). Ex uno, plures–From One Tissue to Many Cells: A Review of Single-Cell Transcriptomics in Cardiovascular Biology. International Journal of Molecular Sciences, 22(4), 2071. https://doi.org/10.3390/ijms22042071
Cardiac stem cells can be generated in damaged heart from bone marrow-derived cells
Journal of Molecular and Cellular Cardiology / Jun 01, 2007
Barile, L., Cerisoli, F., Gaetani, R., Forte, E., Ottolenghi, S., Magli, M. C., & Messina, E. (2007). Cardiac stem cells can be generated in damaged heart from bone marrow-derived cells. Journal of Molecular and Cellular Cardiology, 42(6), S100. https://doi.org/10.1016/j.yjmcc.2007.03.220
Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8 Develop Severe Myocarditis and Myositis in Response to Anti–PD-1 Immune Checkpoint Inhibitor Cancer Therapy
The Journal of Immunology / Mar 01, 2024
Racine, J. J., Bachman, J. F., Zhang, J.-G., Misherghi, A., Khadour, R., Kaisar, S., Bedard, O., Jenkins, C., Abbott, A., Forte, E., Rainer, P., Rosenthal, N., Sattler, S., & Serreze, D. V. (2024). Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8 Develop Severe Myocarditis and Myositis in Response to Anti–PD-1 Immune Checkpoint Inhibitor Cancer Therapy. The Journal of Immunology, 212(8), 1287–1306. https://doi.org/10.4049/jimmunol.2300841
Abnormal complement activation is a sign of long COVID
Nature Cardiovascular Research / Feb 07, 2024
Forte, E. (2024). Abnormal complement activation is a sign of long COVID. Nature Cardiovascular Research, 3(2), 95–95. https://doi.org/10.1038/s44161-024-00434-y
The leading example of the Leducq Foundation
Nature Cardiovascular Research / Jan 17, 2024
Forte, E. (2024). The leading example of the Leducq Foundation. Nature Cardiovascular Research, 3(1), 4–7. https://doi.org/10.1038/s44161-023-00406-8
Patisiran improves quality of life in patients with ATTR cardiac amyloidosis
Nature Cardiovascular Research / Nov 29, 2023
Forte, E. (2023). Patisiran improves quality of life in patients with ATTR cardiac amyloidosis. Nature Cardiovascular Research, 2(12), 1101–1101. https://doi.org/10.1038/s44161-023-00399-4
Scar fibroblasts affect cardiac excitability
Nature Cardiovascular Research / Oct 23, 2023
Forte, E. (2023). Scar fibroblasts affect cardiac excitability. Nature Cardiovascular Research, 2(11), 959–959. https://doi.org/10.1038/s44161-023-00366-z
Particulate matter pollution and cardiovascular health
Nature Cardiovascular Research / Oct 09, 2023
Forte, E. (2023). Particulate matter pollution and cardiovascular health. Nature Cardiovascular Research, 2(10), 855–857. https://doi.org/10.1038/s44161-023-00342-7
A cardiac dyad component controls cardiomyocytes maturation in regenerative hearts
Nature Cardiovascular Research / Jun 07, 2023
Forte, E. (2023). A cardiac dyad component controls cardiomyocytes maturation in regenerative hearts. Nature Cardiovascular Research, 2(6), 491–491. https://doi.org/10.1038/s44161-023-00292-0
Gene-edited cardiomyocytes to prevent engraftment arrhythmias
Nature Cardiovascular Research / May 03, 2023
Forte, E. (2023). Gene-edited cardiomyocytes to prevent engraftment arrhythmias. Nature Cardiovascular Research, 2(5), 417–417. https://doi.org/10.1038/s44161-023-00273-3
BeNeDuctus trial supports expectant management of PDA
Nature Cardiovascular Research / Apr 06, 2023
Forte, E. (2023). BeNeDuctus trial supports expectant management of PDA. Nature Cardiovascular Research, 2(4), 337–337. https://doi.org/10.1038/s44161-023-00263-5
A liver-secreted coagulation factor protects against heart dysfunction
Nature Cardiovascular Research / Oct 26, 2022
Forte, E. (2022). A liver-secreted coagulation factor protects against heart dysfunction. Nature Cardiovascular Research, 1(11), 971–971. https://doi.org/10.1038/s44161-022-00167-w
CD69 as a potential prognostic marker for heart failure
Nature Cardiovascular Research / Oct 03, 2022
Forte, E. (2022). CD69 as a potential prognostic marker for heart failure. Nature Cardiovascular Research, 1(10), 869–869. https://doi.org/10.1038/s44161-022-00149-y
Visualization and targeting of the cardiac conduction system
Nature Cardiovascular Research / Sep 13, 2022
Forte, E. (2022). Visualization and targeting of the cardiac conduction system. Nature Cardiovascular Research, 1(9), 792–792. https://doi.org/10.1038/s44161-022-00135-4
Missing the Y in cardiac fibrosis
Nature Cardiovascular Research / Aug 11, 2022
Forte, E. (2022). Missing the Y in cardiac fibrosis. Nature Cardiovascular Research, 1(8), 696–696. https://doi.org/10.1038/s44161-022-00122-9
Tracing the source of blood cells
Nature Cardiovascular Research / Jul 07, 2022
Forte, E. (2022). Tracing the source of blood cells. Nature Cardiovascular Research, 1(7), 605–605. https://doi.org/10.1038/s44161-022-00106-9
The single-cell footprints of coronary artery disease progression
Nature Cardiovascular Research / Jun 08, 2022
Forte, E. (2022). The single-cell footprints of coronary artery disease progression. Nature Cardiovascular Research, 1(6), 545–545. https://doi.org/10.1038/s44161-022-00089-7
Rilzabrutinib for immune thrombocytopenia
Nature Cardiovascular Research / May 11, 2022
Forte, E. (2022). Rilzabrutinib for immune thrombocytopenia. Nature Cardiovascular Research, 1(5), 416–416. https://doi.org/10.1038/s44161-022-00076-y
Net fishing for de novo variants in congenital heart disease
Nature Cardiovascular Research / Mar 07, 2022
Forte, E. (2022). Net fishing for de novo variants in congenital heart disease. Nature Cardiovascular Research, 1(3), 195–195. https://doi.org/10.1038/s44161-022-00040-w
How sex matters to aortic valves
Nature Cardiovascular Research / Feb 11, 2022
Forte, E. (2022). How sex matters to aortic valves. Nature Cardiovascular Research, 1(2), 107–107. https://doi.org/10.1038/s44161-022-00024-w
Response by Forte and Sattler to Letter Regarding Article, “Cross-Priming Dendritic Cells Exacerbate Immunopathology After Ischemic Tissue Damage in the Heart”
Circulation / Aug 03, 2021
Forte, E., & Sattler, S. (2021). Response by Forte and Sattler to Letter Regarding Article, “Cross-Priming Dendritic Cells Exacerbate Immunopathology After Ischemic Tissue Damage in the Heart.” Circulation, 144(5). https://doi.org/10.1161/circulationaha.121.055584
Abstract 704: Profiling Differential Response to Myocardial Infarction by Single Cell Analysis of the Cardiac Interstitium
Circulation Research / Aug 02, 2019
Forte, E. (2019). Abstract 704: Profiling Differential Response to Myocardial Infarction by Single Cell Analysis of the Cardiac Interstitium. Circulation Research, 125(Suppl_1). https://doi.org/10.1161/res.125.suppl_1.704
Abstract 12: Physiological Role of Endogenous Adult Cardiac Colony-forming Unit Fibroblasts
Circulation Research / Jul 17, 2015
Forte, E., Janbandhu, V., Asli, N. S., Cornwell, J., Abeygunawardena, D., Xaymardan, M., & Harvey, R. P. (2015). Abstract 12: Physiological Role of Endogenous Adult Cardiac Colony-forming Unit Fibroblasts. Circulation Research, 117(suppl_1). https://doi.org/10.1161/res.117.suppl_1.12
Abstract 12: Physiological Role of Endogenous Adult Cardiac Colony-forming Unit Fibroblasts
Circulation Research / Jul 17, 2015
Forte, E., Janbandhu, V., Asli, N. S., Cornwell, J., Abeygunawardena, D., Xaymardan, M., & Harvey, R. P. (2015). Abstract 12: Physiological Role of Endogenous Adult Cardiac Colony-forming Unit Fibroblasts. Circulation Research, 117(suppl_1). https://doi.org/10.1161/res.117.suppl_1.12
Abstract 12: Physiological Role of Endogenous Adult Cardiac Colony-forming Unit Fibroblasts
Circulation Research / Jul 17, 2015
Forte, E., Janbandhu, V., Asli, N. S., Cornwell, J., Abeygunawardena, D., Xaymardan, M., & Harvey, R. P. (2015). Abstract 12: Physiological Role of Endogenous Adult Cardiac Colony-forming Unit Fibroblasts. Circulation Research, 117(suppl_1). https://doi.org/10.1161/res.117.suppl_1.12
Education
Sapienza University of Rome
PhD, Pasteurian Sciences / January, 2011
Sapienza University of Rome
Master, Medical, Molecular and Cellular Biotechnology / October, 2006
Sapienza University of Rome
Bachelor, Biotechnology / October, 2004
Experience
Springer Nature
Associate/Senior Editor / June, 2021 — February, 2024
Helped shape and launch a new journal, Nature Cardiovascular Research, which publishes exceptional advances in the fields of cardiac, vascular, and blood biology, covering fundamental, translational, clinical, and public health research. • Assessed the novelty and impact of manuscripts within all the topics covered by the journal and chaperoned the whole revision process until acceptance for over 40% of all the content published by the journal since its start, with optimal processing times and excellent feedback from the authors. • Interfaced with scientists around the World, provided scientific guidance on how to improve manuscripts, or recommended more appropriate journals to publish with. Commissioned Comments, Reviews, News and Views on current topics, and summarized novel scientific findings in meaningful snippets and Research Highlights. • Contributed to the training and supervision of 2 Associate Editors; covered the Chief Editor's functions when needed.
Research Fellow/Associate Research Scientist / January, 2017 — June, 2021
• Analyzed the dynamic cellular changes during the fibrotic repair post-myocardial infarction, using cutting-edge techniques such as single-cell RNAseq with 10xChromium. Learned how to perform myocardial infarction in mice and assess the cardiac function via echography; analyze scRNAseq data using the Seurat package on R studio. • Completed a project aimed to characterize similarities and differences among fibroblasts from different organs cultured in the same conditions. Through cytometric, transcriptomic analysis, functional assays, shRNA and CRISPR-Cas9-mediated in vitro gene knockdowns we showed that fibroblasts isolated from different organs retain the expression of key transcription factors reflecting their embryological origin. • Collaborated with other laboratories in the Institute to design new mice models that could possibly recapitulate the symptoms of COVID-19; to analyze the response of mice with diverse genetic backgrounds to stressors.
Post-doctoral fellow/ Co-joint lecturer / May, 2013 — November, 2016
Developed projects aimed at understanding the embryological origin and function of a population of putative progenitor cells, cardiac colony forming unit fibroblasts cCFU-F, identified 2 years before in the lab (PMID: 22136928). • Performed cell lineage tracing and designed in vitro and in vivo cellular assays to assess the functional and immunomodulatory properties of PDGFRa+ fibroblasts in homeostasis and post-myocardial infarction with or without treatment with the PDGF-AB ligands. The data, presented in 3 international conferences and included in a preprint manuscript, have supported the use of a short-term treatment with PDGF-AB in a preclinical model of acute myocardial infarction in pigs. • Co-supervised 2 Ph.D. students at University of New South Wales
Scientific Editor / March, 2024 — Present
Consultant freelancer position within a team of former journal editors and grants specialists • Helped scientists increase the impact of their science by providing advice, in-depth editing, and feedback on manuscripts.
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