Jessica D. Hess, Ph.D.
T32 Postdoctoral Fellow at City of Hope Beckman Research Institute
Research Interests
About
Publications
Discovery of novel N-substituted thiazolidinediones (TZDs) as HDAC8 inhibitors: in-silico studies, synthesis, and biological evaluation
Bioorganic Chemistry / Jul 01, 2020
Upadhyay, N., Tilekar, K., Jänsch, N., Schweipert, M., Hess, J. D., Henze Macias, L., Mrowka, P., Aguilera, R. J., Choe, J., Meyer-Almes, F.-J., & Ramaa, C. S. (2020). Discovery of novel N-substituted thiazolidinediones (TZDs) as HDAC8 inhibitors: in-silico studies, synthesis, and biological evaluation. Bioorganic Chemistry, 100, 103934. https://doi.org/10.1016/j.bioorg.2020.103934
Structure guided design and synthesis of furyl thiazolidinedione derivatives as inhibitors of GLUT 1 and GLUT 4, and evaluation of their anti-leukemic potential
European Journal of Medicinal Chemistry / Sep 01, 2020
Tilekar, K., Upadhyay, N., Hess, J. D., Macias, L. H., Mrowka, P., Aguilera, R. J., Meyer-Almes, F.-J., Iancu, C. V., Choe, J., & Ramaa, C. S. (2020). Structure guided design and synthesis of furyl thiazolidinedione derivatives as inhibitors of GLUT 1 and GLUT 4, and evaluation of their anti-leukemic potential. European Journal of Medicinal Chemistry, 202, 112603. https://doi.org/10.1016/j.ejmech.2020.112603
Diversifying Representations of Female Scientists on Social Media: A Case Study From the Women Doing Science Instagram
Social Media + Society / Jul 01, 2022
Phillips, A. A., Walsh, C. R., Grayson, K. A., Penney, C. E., & Husain, F. (2022). Diversifying Representations of Female Scientists on Social Media: A Case Study From the Women Doing Science Instagram. Social Media + Society, 8(3), 205630512211130. https://doi.org/10.1177/20563051221113068
Community Exposure to Nighttime Heat in a Desert Urban Setting, El Paso, Texas
International Journal of Advanced Remote Sensing and GIS / Feb 10, 2016
Amaya, M. A., Mohammed, M., Pingitore, N. E., Aldouri, R., & Benedict, B. (2016). Community Exposure to Nighttime Heat in a Desert Urban Setting, El Paso, Texas. International Journal of Advanced Remote Sensing and GIS, 5(1), 1507–1513. https://doi.org/10.23953/cloud.ijarsg.42
Identification of a Unique Cytotoxic Thieno[2,3-c]Pyrazole Derivative with Potent and Selective Anticancer Effects In Vitro
Biology / Jun 18, 2022
Hess, J. D., Macias, L. H., Gutierrez, D. A., Moran-Santibanez, K., Contreras, L., Medina, S., Villanueva, P. J., Kirken, R. A., Varela-Ramirez, A., Penichet, M. L., & Aguilera, R. J. (2022). Identification of a Unique Cytotoxic Thieno[2,3-c]Pyrazole Derivative with Potent and Selective Anticancer Effects In Vitro. Biology, 11(6), 930. https://doi.org/10.3390/biology11060930
Identification of a Potent Cytotoxic Pyrazole with Anti-Breast Cancer Activity That Alters Multiple Pathways
Cells / Jan 12, 2022
Gutierrez, D. A., Contreras, L., Villanueva, P. J., Borrego, E. A., Morán-Santibañez, K., Hess, J. D., DeJesus, R., Larragoity, M., Betancourt, A. P., Mohl, J. E., Robles-Escajeda, E., Begum, K., Roy, S., Kirken, R. A., Varela-Ramirez, A., & Aguilera, R. J. (2022). Identification of a Potent Cytotoxic Pyrazole with Anti-Breast Cancer Activity That Alters Multiple Pathways. Cells, 11(2), 254. https://doi.org/10.3390/cells11020254
HDAC4 Inhibitors with Cyclic Linker and Non‐hydroxamate Zinc Binding Group: Design, Synthesis, HDAC Screening and in vitro Cytotoxicity evaluation.
ChemistrySelect / Jul 12, 2021
Tilekar, K., Hess, J. D., Upadhyay, N., Schweipert, M., Flath, F., Gutierrez, D. A., Loiodice, F., Lavecchia, A., Meyer‐Almes, F., Aguilera, R. J., & Ramaa, C. S. (2021). HDAC4 Inhibitors with Cyclic Linker and Non‐hydroxamate Zinc Binding Group: Design, Synthesis, HDAC Screening and in vitro Cytotoxicity evaluation. ChemistrySelect, 6(26), 6748–6763. Portico. https://doi.org/10.1002/slct.202102061
Thiazolidinedione “Magic Bullets” Simultaneously Targeting PPARγ and HDACs: Design, Synthesis, and Investigations of their In Vitro and In Vivo Antitumor Effects
Journal of Medicinal Chemistry / May 18, 2021
Tilekar, K., Hess, J. D., Upadhyay, N., Bianco, A. L., Schweipert, M., Laghezza, A., Loiodice, F., Meyer-Almes, F.-J., Aguilera, R. J., Lavecchia, A., & C S, R. (2021). Thiazolidinedione “Magic Bullets” Simultaneously Targeting PPARγ and HDACs: Design, Synthesis, and Investigations of their In Vitro and In Vivo Antitumor Effects. Journal of Medicinal Chemistry, 64(10), 6949–6971. https://doi.org/10.1021/acs.jmedchem.1c00491
Benefits and pitfalls: Epigenetic modulators in prostate cancer intervention
Current Research in Chemical Biology / Jan 01, 2021
Upadhyay, N., Tilekar, K., Hess, J. D., Pokrovsky, V. S., Aguilera, R. J., & C S, R. (2021). Benefits and pitfalls: Epigenetic modulators in prostate cancer intervention. Current Research in Chemical Biology, 1, 100006. https://doi.org/10.1016/j.crchbi.2021.100006
Permuted 2,4-thiazolidinedione (TZD) analogs as GLUT inhibitors and their in-vitro evaluation in leukemic cells
European Journal of Pharmaceutical Sciences / Nov 01, 2020
Tilekar, K., Upadhyay, N., Schweipert, M., Hess, J. D., Macias, L. H., Mrowka, P., Meyer-Almes, F.-J., Aguilera, R. J., Iancu, C. V., Choe, J., & Ramaa, C. S. (2020). Permuted 2,4-thiazolidinedione (TZD) analogs as GLUT inhibitors and their in-vitro evaluation in leukemic cells. European Journal of Pharmaceutical Sciences, 154, 105512. https://doi.org/10.1016/j.ejps.2020.105512
Synthesis and Evaluations of “1,4‐Triazolyl Combretacoumarins” and Desmethoxy Analogs
European Journal of Organic Chemistry / Aug 07, 2019
Khandaker, T. A., Hess, J. D., Aguilera, R., Andrei, G., Snoeck, R., Schols, D., Pradhan, P., & Lakshman, M. K. (2019). Synthesis and Evaluations of “1,4‐Triazolyl Combretacoumarins” and Desmethoxy Analogs. European Journal of Organic Chemistry, 2019(33), 5610–5623. Portico. https://doi.org/10.1002/ejoc.201900569
Education
The University of Texas at El Paso
Graduate Certificate (Technical and Professional Writing) / March, 2023
The University of Texas at El Paso Department of Biological Sciences
Ph.D., Biological Sciences / December, 2022
Virginia Commonwealth University
B.S., Chemistry / May, 2015
Experience
City of Hope Beckman Research Institute
T32 Postdoctoral Fellow / January, 2023 — Present
The University of Texas at El Paso
Graduate Research & Teaching Assistant / August, 2017 — December, 2022
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