Ace Santiago, Ph.D.
Scientist at 10x Genomics with chemistry and biology training at Cornell and Harvard
Research Interests
About
Publications
Concentration- and chromosome-organization-dependent regulator unbinding from DNA for transcription regulation in living cells
Nature Communications / Jul 06, 2015
Chen, T.-Y., Santiago, A. G., Jung, W., Krzemiński, Ł., Yang, F., Martell, D. J., Helmann, J. D., & Chen, P. (2015). Concentration- and chromosome-organization-dependent regulator unbinding from DNA for transcription regulation in living cells. Nature Communications, 6(1). https://doi.org/10.1038/ncomms8445
Staphylococcus aureus cell growth and division are regulated by an amidase that trims peptides from uncrosslinked peptidoglycan
Nature Microbiology / Jan 13, 2020
Do, T., Schaefer, K., Santiago, A. G., Coe, K. A., Fernandes, P. B., Kahne, D., Pinho, M. G., & Walker, S. (2020). Staphylococcus aureus cell growth and division are regulated by an amidase that trims peptides from uncrosslinked peptidoglycan. Nature Microbiology, 5(2), 291–303. https://doi.org/10.1038/s41564-019-0632-1
The Length of Lipoteichoic Acid Polymers Controls Staphylococcus aureus Cell Size and Envelope Integrity
Journal of Bacteriology / Jul 27, 2020
Hesser, A. R., Matano, L. M., Vickery, C. R., Wood, B. M., Santiago, A. G., Morris, H. G., Do, T., Losick, R., & Walker, S. (2020). The Length of Lipoteichoic Acid Polymers Controls Staphylococcus aureus Cell Size and Envelope Integrity. Journal of Bacteriology, 202(16). https://doi.org/10.1128/jb.00149-20
Metalloregulator CueR biases RNA polymerase’s kinetic sampling of dead-end or open complex to repress or activate transcription
Proceedings of the National Academy of Sciences / Oct 19, 2015
Martell, D. J., Joshi, C. P., Gaballa, A., Santiago, A. G., Chen, T.-Y., Jung, W., Helmann, J. D., & Chen, P. (2015). Metalloregulator CueR biases RNA polymerase’s kinetic sampling of dead-end or open complex to repress or activate transcription. Proceedings of the National Academy of Sciences, 112(44), 13467–13472. https://doi.org/10.1073/pnas.1515231112
Adaptor protein mediates dynamic pump assembly for bacterial metal efflux
Proceedings of the National Academy of Sciences / Jun 12, 2017
Santiago, A. G., Chen, T.-Y., Genova, L. A., Jung, W., George Thompson, A. M., McEvoy, M. M., & Chen, P. (2017). Adaptor protein mediates dynamic pump assembly for bacterial metal efflux. Proceedings of the National Academy of Sciences, 114(26), 6694–6699. https://doi.org/10.1073/pnas.1704729114
Mechanical stress compromises multicomponent efflux complexes in bacteria
Proceedings of the National Academy of Sciences / Nov 26, 2019
Genova, L. A., Roberts, M. F., Wong, Y.-C., Harper, C. E., Santiago, A. G., Fu, B., Srivastava, A., Jung, W., Wang, L. M., Krzemiński, Ł., Mao, X., Sun, X., Hui, C.-Y., Chen, P., & Hernandez, C. J. (2019). Mechanical stress compromises multicomponent efflux complexes in bacteria. Proceedings of the National Academy of Sciences, 116(51), 25462–25467. https://doi.org/10.1073/pnas.1909562116
Quantifying Multistate Cytoplasmic Molecular Diffusion in Bacterial Cells via Inverse Transform of Confined Displacement Distribution
The Journal of Physical Chemistry B / Nov 02, 2015
Chen, T.-Y., Jung, W., Santiago, A. G., Yang, F., Krzemiński, Ł., & Chen, P. (2015). Quantifying Multistate Cytoplasmic Molecular Diffusion in Bacterial Cells via Inverse Transform of Confined Displacement Distribution. The Journal of Physical Chemistry B, 119(45), 14451–14459. https://doi.org/10.1021/acs.jpcb.5b08654
Metal-induced sensor mobilization turns on affinity to activate regulator for metal detoxification in live bacteria
Proceedings of the National Academy of Sciences / May 28, 2020
Fu, B., Sengupta, K., Genova, L. A., Santiago, A. G., Jung, W., Krzemiński, Ł., Chakraborty, U. K., Zhang, W., & Chen, P. (2020). Metal-induced sensor mobilization turns on affinity to activate regulator for metal detoxification in live bacteria. Proceedings of the National Academy of Sciences, 117(24), 13248–13255. https://doi.org/10.1073/pnas.1919816117
Single-Molecule Dynamics and Mechanisms of Metalloregulators and Metallochaperones
Biochemistry / Oct 01, 2013
Chen, P., Keller, A. M., Joshi, C. P., Martell, D. J., Andoy, N. M., Benítez, J. J., Chen, T.-Y., Santiago, A. G., & Yang, F. (2013). Single-Molecule Dynamics and Mechanisms of Metalloregulators and Metallochaperones. Biochemistry, 52(41), 7170–7183. https://doi.org/10.1021/bi400597v
Single‐molecule dynamics of the molecular chaperone trigger factor in living cells
Molecular Microbiology / Sep 30, 2016
Yang, F., Chen, T., Krzemiński, Ł., Santiago, A. G., Jung, W., & Chen, P. (2016). Single‐molecule dynamics of the molecular chaperone trigger factor in living cells. Molecular Microbiology, 102(6), 992–1003. Portico. https://doi.org/10.1111/mmi.13529
The cell cycle in Staphylococcus aureus is regulated by an amidase that controls peptidoglycan synthesis
May 10, 2019
Do, T., Schaefer, K., Santiago, A. G., Coe, K. A., Fernandes, P. B., Kahne, D., Pinho, M. G., & Walker, S. (2019). The cell cycle in Staphylococcus aureus is regulated by an amidase that controls peptidoglycan synthesis. https://doi.org/10.1101/634089
Single‐molecule dynamics of the molecular chaperone trigger factor in living cells
Molecular Microbiology / Sep 30, 2016
Yang, F., Chen, T., Krzemiński, Ł., Santiago, A. G., Jung, W., & Chen, P. (2016). Single‐molecule dynamics of the molecular chaperone trigger factor in living cells. Molecular Microbiology, 102(6), 992–1003. Portico. https://doi.org/10.1111/mmi.13529
The cell cycle in Staphylococcus aureus is regulated by an amidase that controls peptidoglycan synthesis
May 10, 2019
Do, T., Schaefer, K., Santiago, A. G., Coe, K. A., Fernandes, P. B., Kahne, D., Pinho, M. G., & Walker, S. (2019). The cell cycle in Staphylococcus aureus is regulated by an amidase that controls peptidoglycan synthesis. https://doi.org/10.1101/634089
Single-Molecule Specific Mislocalization of Red Fluorescent Proteins in Live Escherichia coli
Biophysical Journal / Jul 01, 2016
Ghodke, H., Caldas, V. E. A., Punter, C. M., van Oijen, A. M., & Robinson, A. (2016). Single-Molecule Specific Mislocalization of Red Fluorescent Proteins in Live Escherichia coli. Biophysical Journal, 111(1), 25–27. https://doi.org/10.1016/j.bpj.2016.05.047
Education
University of the Philippines Diliman
Bachelor of Science, Chemistry
Cornell University
Doctor of Philosophy, Chemistry and Chemical Biology
Experience
Harvard Medical School
Postdoctoral Fellow / June, 2017 — Present
Cornell University
Postdoctoral Associate / August, 2016 — April, 2017
10x Genomics
Scientist II / August, 2021 — Present
Development of single cell and spatial multi-omics technologies
Siemens Healthineers
Senior Biochemist / March, 2020 — August, 2021
Analytical development of clinical diagnostics assays
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