Mohsen Omrani

CEO at OPTT Inc.

Research Interests

Electrophysiology
Motor control
sensory motor transformation
Neuromodulation
Mental Health
Physiology
Psychiatry and Mental health
Cellular and Molecular Neuroscience
Cognitive Neuroscience
Developmental Neuroscience
Public Health, Environmental and Occupational Health
Health Informatics
Clinical Psychology
Sensory Systems

About

I am passionate about technology and its use to make life better for all others. My goal is to utilize my expertise in medicine, neurology, and technology to design tools for improving mental health. <br> The growing demand for quality mental health care isn’t going anywhere. At OPTT, I lead a team of exceptional people to build digital mental health solutions for the population. Our team is working hard to change the way mental health care is delivered. With the use of AI technology, OPTT provides health care professionals with insights for effective care pathways.

Publications

Primary motor cortex underlies multi-joint integration for fast feedback control

Nature / Sep 28, 2011

Pruszynski, J. A., Kurtzer, I., Nashed, J. Y., Omrani, M., Brouwer, B., & Scott, S. H. (2011). Primary motor cortex underlies multi-joint integration for fast feedback control. Nature, 478(7369), 387–390. https://doi.org/10.1038/nature10436

Distributed task-specific processing of somatosensory feedback for voluntary motor control

eLife / Apr 14, 2016

Omrani, M., Murnaghan, C. D., Pruszynski, J. A., & Scott, S. H. (2016). Distributed task-specific processing of somatosensory feedback for voluntary motor control. ELife, 5. CLOCKSS. https://doi.org/10.7554/elife.13141

Perspectives on classical controversies about the motor cortex

Journal of Neurophysiology / Sep 01, 2017

Omrani, M., Kaufman, M. T., Hatsopoulos, N. G., & Cheney, P. D. (2017). Perspectives on classical controversies about the motor cortex. Journal of Neurophysiology, 118(3), 1828–1848. https://doi.org/10.1152/jn.00795.2016

Goal-Dependent Modulation of Fast Feedback Responses in Primary Motor Cortex

The Journal of Neuroscience / Mar 26, 2014

Pruszynski, J. A., Omrani, M., & Scott, S. H. (2014). Goal-Dependent Modulation of Fast Feedback Responses in Primary Motor Cortex. The Journal of Neuroscience, 34(13), 4608–4617. https://doi.org/10.1523/jneurosci.4520-13.2014

Rapid feedback corrections during a bimanual postural task

Journal of Neurophysiology / Jan 01, 2013

Omrani, M., Diedrichsen, J., & Scott, S. H. (2013). Rapid feedback corrections during a bimanual postural task. Journal of Neurophysiology, 109(1), 147–161. https://doi.org/10.1152/jn.00669.2011

Perturbation-evoked responses in primary motor cortex are modulated by behavioral context

Journal of Neurophysiology / Dec 01, 2014

Omrani, M., Pruszynski, J. A., Murnaghan, C. D., & Scott, S. H. (2014). Perturbation-evoked responses in primary motor cortex are modulated by behavioral context. Journal of Neurophysiology, 112(11), 2985–3000. https://doi.org/10.1152/jn.00270.2014

Online Cognitive Behavioral Therapy

Jan 01, 2019

Alavi, N., & Omrani, M. (2019). Online Cognitive Behavioral Therapy. https://doi.org/10.1007/978-3-319-99151-1

Rotational dynamics in motor cortex are consistent with a feedback controller

eLife / Nov 03, 2021

Kalidindi, H. T., Cross, K. P., Lillicrap, T. P., Omrani, M., Falotico, E., Sabes, P. N., & Scott, S. H. (2021). Rotational dynamics in motor cortex are consistent with a feedback controller. ELife, 10. CLOCKSS. https://doi.org/10.7554/elife.67256

Using the Online Psychotherapy Tool to Address Mental Health Problems in the Context of the COVID-19 Pandemic: Protocol for an Electronically Delivered Cognitive Behavioral Therapy Program

JMIR Research Protocols / Dec 18, 2020

Alavi, N., Yang, M., Stephenson, C., Nikjoo, N., Malakouti, N., Layzell, G., Jagayat, J., Shirazi, A., Groll, D., Omrani, M., O’Riordan, A., Khalid-Khan, S., Freire, R., Brietzke, E., Gomes, F. A., Milev, R., & Soares, C. N. (2020). Using the Online Psychotherapy Tool to Address Mental Health Problems in the Context of the COVID-19 Pandemic: Protocol for an Electronically Delivered Cognitive Behavioral Therapy Program. JMIR Research Protocols, 9(12), e24913. https://doi.org/10.2196/24913

Primary motor cortex neurons classified in a postural task predict muscle activation patterns in a reaching task

Journal of Neurophysiology / Apr 01, 2016

Heming, E. A., Lillicrap, T. P., Omrani, M., Herter, T. M., Pruszynski, J. A., & Scott, S. H. (2016). Primary motor cortex neurons classified in a postural task predict muscle activation patterns in a reaching task. Journal of Neurophysiology, 115(4), 2021–2032. https://doi.org/10.1152/jn.00971.2015

Effect of tactile stimulus frequency on time perception: the role of working memory

Experimental Brain Research / Nov 08, 2007

Khoshnoodi, M. A., Motiei-Langroudi, R., Omrani, M., Diamond, M. E., & Abbassian, A. H. (2007). Effect of tactile stimulus frequency on time perception: the role of working memory. Experimental Brain Research, 185(4), 623–633. https://doi.org/10.1007/s00221-007-1190-y

Kinesthetic memory in distance reproduction task: importance of initial hand position information

Experimental Brain Research / Nov 30, 2005

Khoshnoodi, M. A., Motiei-langroudi, R., Omrani, M., Ghaderi-pakdell, F., & Abbassian, A. H. (2005). Kinesthetic memory in distance reproduction task: importance of initial hand position information. Experimental Brain Research, 170(3), 312–319. https://doi.org/10.1007/s00221-005-0217-5

Delivering an online cognitive behavioural therapy program to address mental health challenges faced by correctional workers and other public safety personnel: Protocol (Preprint)

May 31, 2021

Alavi, N., Stephenson, C., Omrani, M., Gerritsen, C., Martin, M. S., Knyahnytskyi, A., Zhu, Y., Kumar, A., Jagayat, J., Shirazi, A., Moghimi, E., Patel, C., Knyahnytska, Y., Simpson, A. I., Zaheer, J., Andersen, J., Munshi, A., & Groll, D. (2021). Delivering an online cognitive behavioural therapy program to address mental health challenges faced by correctional workers and other public safety personnel: Protocol (Preprint). https://doi.org/10.2196/preprints.30845

Benefits of Digital Mental Health Care Interventions for Correctional Workers and Other Public Safety Personnel: A Narrative Review

Frontiers in Psychiatry / Jul 08, 2022

Moghimi, E., Knyahnytska, Y., Omrani, M., Nikjoo, N., Stephenson, C., Layzell, G., Frederic Simpson, A. I., & Alavi, N. (2022). Benefits of Digital Mental Health Care Interventions for Correctional Workers and Other Public Safety Personnel: A Narrative Review. Frontiers in Psychiatry, 13. https://doi.org/10.3389/fpsyt.2022.921527

Feasibility and Efficacy of Delivering Cognitive Behavioral Therapy Through an Online Psychotherapy Tool for Depression: Protocol for a Randomized Controlled Trial

JMIR Research Protocols / Jun 16, 2021

Alavi, N., Stephenson, C., Yang, M., Kumar, A., Shao, Y., Miller, S., Yee, C. S., Stefatos, A., Gholamzadehmir, M., Abbaspour, Z., Jagayat, J., Shirazi, A., Omrani, M., Patel, A., Patel, C., & Groll, D. (2021). Feasibility and Efficacy of Delivering Cognitive Behavioral Therapy Through an Online Psychotherapy Tool for Depression: Protocol for a Randomized Controlled Trial. JMIR Research Protocols, 10(6), e27489. https://doi.org/10.2196/27489

What Is Depression? What Is Anxiety?

Online Cognitive Behavioral Therapy / Dec 28, 2018

Alavi, N., & Omrani, M. (2018). What Is Depression? What Is Anxiety? Online Cognitive Behavioral Therapy, 17–31. https://doi.org/10.1007/978-3-319-99151-1_3

Developing and Implementing a Web-Based Relapse Prevention Psychotherapy Program for Patients With Alcohol Use Disorder: Protocol for a Randomized Controlled Trial

JMIR Research Protocols / Jan 25, 2023

Eadie, J., Gutierrez, G., Moghimi, E., Stephenson, C., Khalafi, P., Nikjoo, N., Jagayat, J., Gizzarelli, T., Reshetukha, T., Omrani, M., Yang, M., & Alavi, N. (2023). Developing and Implementing a Web-Based Relapse Prevention Psychotherapy Program for Patients With Alcohol Use Disorder: Protocol for a Randomized Controlled Trial. JMIR Research Protocols, 12, e44694. https://doi.org/10.2196/44694

A qualitative exploration of the mental health challenges and therapeutic needs of Canadian correctional workers

Frontiers in Psychiatry / Oct 25, 2022

Moghimi, E., Knyahnytska, Y., Zhu, Y., Kumar, A., Knyahnytski, A., Patel, C., Omrani, M., Gerritsen, C., Martin, M., Simpson, A. I. F., & Alavi, N. (2022). A qualitative exploration of the mental health challenges and therapeutic needs of Canadian correctional workers. Frontiers in Psychiatry, 13. https://doi.org/10.3389/fpsyt.2022.1004143

Online Clinic, a New Method of Delivering Psychotherapy

European Psychiatry / Apr 01, 2017

Omrani, M., Alavi, N., Rivera, M., & Khalid-Khan, S. (2017). Online Clinic, a New Method of Delivering Psychotherapy. European Psychiatry, 41(S1), S148–S148. https://doi.org/10.1016/j.eurpsy.2017.01.1997

Learning not to feel: reshaping the resolution of tactile perception

Frontiers in Systems Neuroscience / Jan 01, 2013

Omrani, M., Lak, A., & Diamond, M. E. (2013). Learning not to feel: reshaping the resolution of tactile perception. Frontiers in Systems Neuroscience, 7. https://doi.org/10.3389/fnsys.2013.00029

Mental health challenges, treatment experiences, and care needs of post-secondary students: a cross-sectional mixed-methods study

BMC Public Health / Apr 06, 2023

Moghimi, E., Stephenson, C., Gutierrez, G., Jagayat, J., Layzell, G., Patel, C., McCart, A., Gibney, C., Langstaff, C., Ayonrinde, O., Khalid-Khan, S., Milev, R., Snelgrove-Clarke, E., Soares, C., Omrani, M., & Alavi, N. (2023). Mental health challenges, treatment experiences, and care needs of post-secondary students: a cross-sectional mixed-methods study. BMC Public Health, 23(1). https://doi.org/10.1186/s12889-023-15452-x

Developing and Implementing a Web-Based Psychotherapy Program to Address Mental Health Challenges Among Patients Receiving Oncologic and Palliative Care: Protocol for an Open-Label Randomized Controlled Trial

JMIR Research Protocols / Jul 14, 2021

Alavi, N., Stephenson, C., Miller, S., Khalafi, P., Sinan, I., Kain, D., McDougall, M., Davies, J., Stark, D., Tompkins, E., Jagayat, J., Omrani, M., Shirazi, A., Groll, D., & Soares, C. (2021). Developing and Implementing a Web-Based Psychotherapy Program to Address Mental Health Challenges Among Patients Receiving Oncologic and Palliative Care: Protocol for an Open-Label Randomized Controlled Trial. JMIR Research Protocols, 10(7), e30735. https://doi.org/10.2196/30735

Understanding and Rating Our Feelings, and the Thought Record

Online Cognitive Behavioral Therapy / Dec 28, 2018

Alavi, N., & Omrani, M. (2018). Understanding and Rating Our Feelings, and the Thought Record. Online Cognitive Behavioral Therapy, 69–79. https://doi.org/10.1007/978-3-319-99151-1_7

What Is the Five-Part Model and How Can It Be Helpful?

Online Cognitive Behavioral Therapy / Dec 28, 2018

Alavi, N., & Omrani, M. (2018). What Is the Five-Part Model and How Can It Be Helpful? Online Cognitive Behavioral Therapy, 33–44. https://doi.org/10.1007/978-3-319-99151-1_4

Evaluating the Efficacy of Web-Based Cognitive Behavioral Therapy for the Treatment of Patients With Bipolar II Disorder and Residual Depressive Symptoms: Protocol for a Randomized Controlled Trial

JMIR Research Protocols / May 19, 2023

Gutierrez, G., Stephenson, C., Eadie, J., Moghimi, E., Omrani, M., Groll, D., Soares, C. N., Milev, R., Vazquez, G., Yang, M., & Alavi, N. (2023). Evaluating the Efficacy of Web-Based Cognitive Behavioral Therapy for the Treatment of Patients With Bipolar II Disorder and Residual Depressive Symptoms: Protocol for a Randomized Controlled Trial. JMIR Research Protocols, 12, e46157. https://doi.org/10.2196/46157

Investigating the effectiveness of electronically delivered cognitive behavioural therapy (e-CBTi) compared to pharmaceutical interventions in treating insomnia: Protocol for a randomized controlled trial

PLOS ONE / May 16, 2023

Zhu, Y., Stephenson, C., Moghimi, E., Jagayat, J., Nikjoo, N., Kumar, A., Shirazi, A., Patel, C., Omrani, M., & Alavi, N. (2023). Investigating the effectiveness of electronically delivered cognitive behavioural therapy (e-CBTi) compared to pharmaceutical interventions in treating insomnia: Protocol for a randomized controlled trial. PLOS ONE, 18(5), e0285757. https://doi.org/10.1371/journal.pone.0285757

Comparison of online and in-person cognitive behavioral therapy in individuals diagnosed with major depressive disorder: a non-randomized controlled trial

Frontiers in Psychiatry / Apr 28, 2023

Alavi, N., Moghimi, E., Stephenson, C., Gutierrez, G., Jagayat, J., Kumar, A., Shao, Y., Miller, S., Yee, C. S., Stefatos, A., Gholamzadehmir, M., Abbaspour, Z., Shirazi, A., Gizzarelli, T., Khan, F., Patel, C., Patel, A., Yang, M., & Omrani, M. (2023). Comparison of online and in-person cognitive behavioral therapy in individuals diagnosed with major depressive disorder: a non-randomized controlled trial. Frontiers in Psychiatry, 14. https://doi.org/10.3389/fpsyt.2023.1113956

User experiences of an online therapist-guided psychotherapy platform, OPTT: A cross-sectional study

Internet Interventions / Apr 01, 2023

Stephenson, C., Moghimi, E., Gutierrez, G., Jagayat, J., Layzell, G., Patel, C., Omrani, M., & Alavi, N. (2023). User experiences of an online therapist-guided psychotherapy platform, OPTT: A cross-sectional study. Internet Interventions, 32, 100623. https://doi.org/10.1016/j.invent.2023.100623

Investigating the effectiveness of incorporating a stepped care approach into electronically delivered CBT for depression

European Psychiatry / Mar 01, 2023

Alavi, N., Omrani, M., Jagayat, J., Shirazi, A., Kumar, A., Pannu, A., & Shao, Y. (2023). Investigating the effectiveness of incorporating a stepped care approach into electronically delivered CBT for depression. European Psychiatry, 66(S1), S481–S482. https://doi.org/10.1192/j.eurpsy.2023.1030

Efficacy of an electronic cognitive behavioural therapy program delivered via the Online Psychotherapy Tool for mental health problems related to the COVID-19 Pandemic: Pilot Study (Preprint)

Jul 20, 2023

Moghimi, E., Stephenson, C., Agrawal, A., Nikjoo, N., Malakouti, N., Layzell, G., O’Riordan, A., Jagayat, J., Shirazi, A., Gutierrez, G., Khan, F., Patel, C., Yang, M., Omrani, M., & Alavi, N. (2023). Efficacy of an electronic cognitive behavioural therapy program delivered via the Online Psychotherapy Tool for mental health problems related to the COVID-19 Pandemic: Pilot Study (Preprint). https://doi.org/10.2196/preprints.51102

Efficacious Web-Based Psychotherapy to Address Depression and Anxiety Among Patients Receiving Oncological and Palliative Care: an Open-Label Randomised Controlled Trial

European Psychiatry / Mar 01, 2023

Alavi, N., Omrani, M., Shirazi, A., Layzell, G., Eadie, J., Jagayat, J., Stephenson, C., Kain, D., Soares, C., & Yang, M. (2023). Efficacious Web-Based Psychotherapy to Address Depression and Anxiety Among Patients Receiving Oncological and Palliative Care: an Open-Label Randomised Controlled Trial. European Psychiatry, 66(S1), S482–S483. https://doi.org/10.1192/j.eurpsy.2023.1032

Developing and Implementing an Online Relapse Prevention Psychotherapy Program for Patients with Alcohol Use Disorder: Protocol for a Randomized Controlled Trial (Preprint)

Nov 30, 2022

Eadie, J., Gutierrez, G., Moghimi, E., Stephenson, C., Khalafi, P., Nikjoo, N., Jagayat, J., Gizzarelli, T., Reshetukha, T., Omrani, M., Yang, M., & Alavi, N. (2022). Developing and Implementing an Online Relapse Prevention Psychotherapy Program for Patients with Alcohol Use Disorder: Protocol for a Randomized Controlled Trial (Preprint). https://doi.org/10.2196/preprints.44694

Determining the Efficacy of Electronic Cognitive Behavioral Therapy for Generalized Anxiety Disorder Compared to Pharmaceutical Interventions: Protocol for a Quasi-Experimental Study

JMIR Research Protocols / May 27, 2021

Alavi, N., Stephenson, C., Yang, M., Shirazi, A., Shao, Y., Kumar, A., Yee, C. S., Miller, S., Stefatos, A., Gholamzadehmir, M., Abbaspour, Z., Patel, A., Patel, C., Reshetukha, T., Omrani, M., & Groll, D. (2021). Determining the Efficacy of Electronic Cognitive Behavioral Therapy for Generalized Anxiety Disorder Compared to Pharmaceutical Interventions: Protocol for a Quasi-Experimental Study. JMIR Research Protocols, 10(5), e27772. https://doi.org/10.2196/27772

Chemogenetic stimulation of a retinal circuit activates brain noradrenergic neurons, prevents apoptosis and suppresses depression-like behaviors

Apr 21, 2021

Bowrey, H. E., James, M. H., Omrani, M., Mohammadkhani, A., & Aston-Jones, G. (2021). Chemogenetic stimulation of a retinal circuit activates brain noradrenergic neurons, prevents apoptosis and suppresses depression-like behaviors. https://doi.org/10.1101/2021.04.20.440684

The 12-Step Approach to Online CBT

Online Cognitive Behavioral Therapy / Dec 28, 2018

Alavi, N., & Omrani, M. (2018). The 12-Step Approach to Online CBT. Online Cognitive Behavioral Therapy, 11–16. https://doi.org/10.1007/978-3-319-99151-1_2

Action Plans

Online Cognitive Behavioral Therapy / Dec 28, 2018

Alavi, N., & Omrani, M. (2018). Action Plans. Online Cognitive Behavioral Therapy, 145–156. https://doi.org/10.1007/978-3-319-99151-1_13

What Is the Connection Between Our Thoughts, Feelings, Behaviour, Physical Reactions, and Environment?

Online Cognitive Behavioral Therapy / Dec 28, 2018

Alavi, N., & Omrani, M. (2018). What Is the Connection Between Our Thoughts, Feelings, Behaviour, Physical Reactions, and Environment? Online Cognitive Behavioral Therapy, 45–57. https://doi.org/10.1007/978-3-319-99151-1_5

What Is Alternative and Balanced Thinking?

Online Cognitive Behavioral Therapy / Dec 28, 2018

Alavi, N., & Omrani, M. (2018). What Is Alternative and Balanced Thinking? Online Cognitive Behavioral Therapy, 117–130. https://doi.org/10.1007/978-3-319-99151-1_11

What Are Automatic Thoughts?

Online Cognitive Behavioral Therapy / Dec 28, 2018

Alavi, N., & Omrani, M. (2018). What Are Automatic Thoughts? Online Cognitive Behavioral Therapy, 81–91. https://doi.org/10.1007/978-3-319-99151-1_8

What Is Evidence and How Can It Help Us Rate Our Thoughts and Feeling?

Online Cognitive Behavioral Therapy / Dec 28, 2018

Alavi, N., & Omrani, M. (2018). What Is Evidence and How Can It Help Us Rate Our Thoughts and Feeling? Online Cognitive Behavioral Therapy, 105–116. https://doi.org/10.1007/978-3-319-99151-1_10

Strategies That Can Be Used in Stressful Situations

Online Cognitive Behavioral Therapy / Dec 28, 2018

Alavi, N., & Omrani, M. (2018). Strategies That Can Be Used in Stressful Situations. Online Cognitive Behavioral Therapy, 59–67. https://doi.org/10.1007/978-3-319-99151-1_6

Activity Scheduling

Online Cognitive Behavioral Therapy / Dec 28, 2018

Alavi, N., & Omrani, M. (2018). Activity Scheduling. Online Cognitive Behavioral Therapy, 93–104. https://doi.org/10.1007/978-3-319-99151-1_9

Experiments

Online Cognitive Behavioral Therapy / Dec 28, 2018

Alavi, N., & Omrani, M. (2018). Experiments. Online Cognitive Behavioral Therapy, 131–144. https://doi.org/10.1007/978-3-319-99151-1_12

New directions for the treatment of depression: Targeting the photic regulation of arousal and mood (PRAM) pathway

Depression and Anxiety / May 10, 2017

Bowrey, H. E., James, M. H., & Aston-Jones, G. (2017). New directions for the treatment of depression: Targeting the photic regulation of arousal and mood (PRAM) pathway. Depression and Anxiety, 34(7), 588–595. Portico. https://doi.org/10.1002/da.22635

Author response: Distributed task-specific processing of somatosensory feedback for voluntary motor control

Mar 17, 2016

Omrani, M., Murnaghan, C. D., Pruszynski, J. A., & Scott, S. H. (2016). Author response: Distributed task-specific processing of somatosensory feedback for voluntary motor control. https://doi.org/10.7554/elife.13141.012

Independent coding of movement duration in a repetitive non-visually guided movement

Somatosensory & Motor Research / Jan 01, 2006

Motiei-Langroudi, R., Omrani, M., Khoshnoodi, M. A., Pakdel, F. G., Yazdanpanah, E., & Abbassian, A. H. (2006). Independent coding of movement duration in a repetitive non-visually guided movement. Somatosensory &amp; Motor Research, 23(1–2), 19–24. https://doi.org/10.1080/08990220600700834

Resistance of peripheral and sub-cortical somatosensory pathway to electrical noise

Somatosensory & Motor Research / Sep 01, 2004

Omrani, M., Khoshnoodi, M. A., Pakarian, P., Abbassian, A. H., & Shahzadi, S. (2004). Resistance of peripheral and sub-cortical somatosensory pathway to electrical noise. Somatosensory &amp; Motor Research, 21(3–4), 155–158. https://doi.org/10.1080/08990220400012380

Comparing the efficacy of an electronically delivered cognitive behavioural therapy program to a mental health check-in program for generalized anxiety disorder: Protocol for a randomized trial (Preprint)

JMIR Research Protocols / May 10, 2023

Stephenson, C., Kumar, A., Malakouti, N., Nikjoo, N., Jagayat, J., Gizzarelli, T., Patel, C., Gutierrez, G., Shirazi, A., Yang, M., Omrani, M., & Alavi, N. (2023). Comparing the efficacy of an electronically delivered cognitive behavioural therapy program to a mental health check-in program for generalized anxiety disorder: Protocol for a randomized trial (Preprint). JMIR Research Protocols. https://doi.org/10.2196/48899

User Experiences of an Online Therapist-Guided Psychotherapy Platform: A Cross-Sectional Study

Jan 01, 2023

Stephenson, C., Moghimi, E., Gutierrez, G., Jagayat, J., Layzell, G., Patel, C., Omrani, M., & Alavi, N. (2023). User Experiences of an Online Therapist-Guided Psychotherapy Platform: A Cross-Sectional Study. https://doi.org/10.2139/ssrn.4398211

Experience

OPTT Health

Co-founder & CEO / June, 2018Present

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