Dr. Shilpa Patil, Ph.D
PhD & Postdoc level expertise in Cancer Research
Research Interests
About
Publications
EZH2 Regulates Pancreatic Cancer Subtype Identity and Tumor Progression via Transcriptional Repression of GATA6
Cancer Research / Nov 01, 2020
Patil, S., Steuber, B., Kopp, W., Kari, V., Urbach, L., Wang, X., Küffer, S., Bohnenberger, H., Spyropoulou, D., Zhang, Z., Versemann, L., Bösherz, M. S., Brunner, M., Gaedcke, J., Ströbel, P., Zhang, J.-S., Neesse, A., Ellenrieder, V., Singh, S. K., … Hessmann, E. (2020). EZH2 Regulates Pancreatic Cancer Subtype Identity and Tumor Progression via Transcriptional Repression of GATA6. Cancer Research, 80(21), 4620–4632. https://doi.org/10.1158/0008-5472.can-20-0672
Cytosolic 5′-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites
EBioMedicine / Feb 01, 2019
Patzak, M. S., Kari, V., Patil, S., Hamdan, F. H., Goetze, R. G., Brunner, M., Gaedcke, J., Kitz, J., Jodrell, D. I., Richards, F. M., Pilarsky, C., Gruetzmann, R., Rümmele, P., Knösel, T., Hessmann, E., Ellenrieder, V., Johnsen, S. A., & Neesse, A. (2019). Cytosolic 5′-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites. EBioMedicine, 40, 394–405. https://doi.org/10.1016/j.ebiom.2019.01.037
Utilizing High Resolution Ultrasound to Monitor Tumor Onset and Growth in Genetically Engineered Pancreatic Cancer Models
Journal of Visualized Experiments / Apr 07, 2018
Goetze, R.-G., Buchholz, S. M., Patil, S., Petzold, G., Ellenrieder, V., Hessmann, E., & Neesse, A. (2018). Utilizing High Resolution Ultrasound to Monitor Tumor Onset and Growth in Genetically Engineered Pancreatic Cancer Models. Journal of Visualized Experiments, 134. https://doi.org/10.3791/56979-v
Mutant and Wild-Type Tumor Suppressor p53 Induces p300 Autoacetylation
iScience / Jun 01, 2018
Kaypee, S., Sahadevan, S. A., Patil, S., Ghosh, P., Roy, N. S., Roy, S., & Kundu, T. K. (2018). Mutant and Wild-Type Tumor Suppressor p53 Induces p300 Autoacetylation. IScience, 4, 260–272. https://doi.org/10.1016/j.isci.2018.06.002
TP53-Status-Dependent Oncogenic EZH2 Activity in Pancreatic Cancer
Cancers / Jul 15, 2022
Versemann, L., Patil, S., Steuber, B., Zhang, Z., Kopp, W., Krawczyk, H. E., Kaulfuß, S., Wollnik, B., Ströbel, P., Neesse, A., Singh, S. K., Ellenrieder, V., & Hessmann, E. (2022). TP53-Status-Dependent Oncogenic EZH2 Activity in Pancreatic Cancer. Cancers, 14(14), 3451. https://doi.org/10.3390/cancers14143451
HSP90 Inhibition Synergizes with Cisplatin to Eliminate Basal-like Pancreatic Ductal Adenocarcinoma Cells
Cancers / Dec 07, 2021
Ewers, K. M., Patil, S., Kopp, W., Thomale, J., Quilitz, T., Magerhans, A., Wang, X., Hessmann, E., & Dobbelstein, M. (2021). HSP90 Inhibition Synergizes with Cisplatin to Eliminate Basal-like Pancreatic Ductal Adenocarcinoma Cells. Cancers, 13(24), 6163. https://doi.org/10.3390/cancers13246163
Oligomers of human histone chaperone NPM1 alter p300/KAT3B folding to induce autoacetylation
Biochimica et Biophysica Acta (BBA) - General Subjects / Aug 01, 2018
Kaypee, S., Sahadevan, S. A., Sudarshan, D., Halder Sinha, S., Patil, S., Senapati, P., Kodaganur, G. S., Mohiyuddin, A., Dasgupta, D., & Kundu, T. K. (2018). Oligomers of human histone chaperone NPM1 alter p300/KAT3B folding to induce autoacetylation. Biochimica et Biophysica Acta (BBA) - General Subjects, 1862(8), 1729–1741. https://doi.org/10.1016/j.bbagen.2018.05.003
Preclinical Evaluation of 1,2-Diamino-4,5-Dibromobenzene in Genetically Engineered Mouse Models of Pancreatic Cancer
Cells / Jun 09, 2019
Goetze, R. G., Buchholz, S. M., Ou, N., Zhang, Q., Patil, S., Schirmer, M., Singh, S. K., Ellenrieder, V., Hessmann, E., Lu, Q.-B., & Neesse, A. (2019). Preclinical Evaluation of 1,2-Diamino-4,5-Dibromobenzene in Genetically Engineered Mouse Models of Pancreatic Cancer. Cells, 8(6), 563. https://doi.org/10.3390/cells8060563
Cell Type of Pancreatic Ductal Adenocarcinoma Origin: Implications for Prognosis and Clinical Outcomes
Visceral Medicine / Dec 27, 2021
Patil, S., Dou, Y., & Kopp, J. L. (2021). Cell Type of Pancreatic Ductal Adenocarcinoma Origin: Implications for Prognosis and Clinical Outcomes. Visceral Medicine, 38(1), 4–10. Portico. https://doi.org/10.1159/000520946
Chromatin-Independent Interplay of NFATc1 and EZH2 in Pancreatic Cancer
Cells / Dec 08, 2021
Patil, S., Forster, T., Reutlinger, K., Kopp, W., Versemann, L., Spitalieri, J., Gaedcke, J., Ströbel, P., Singh, S. K., Ellenrieder, V., Neesse, A., & Hessmann, E. (2021). Chromatin-Independent Interplay of NFATc1 and EZH2 in Pancreatic Cancer. Cells, 10(12), 3463. https://doi.org/10.3390/cells10123463
NFATc1 Is a Central Mediator of EGFR-Induced ARID1A Chromatin Dissociation During Acinar Cell Reprogramming
Cellular and Molecular Gastroenterology and Hepatology / Jan 01, 2023
Zhang, Z., Wang, X., Hamdan, F. H., Likhobabina, A., Patil, S., Aperdannier, L., Sen, M., Traub, J., Neesse, A., Fischer, A., Papantonis, A., Singh, S. K., Ellenrieder, V., Johnsen, S. A., & Hessmann, E. (2023). NFATc1 Is a Central Mediator of EGFR-Induced ARID1A Chromatin Dissociation During Acinar Cell Reprogramming. Cellular and Molecular Gastroenterology and Hepatology, 15(5), 1219–1246. https://doi.org/10.1016/j.jcmgh.2023.01.015
Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation
May 06, 2022
Zhang, A. M. Y., Xia, Y. H., Lin, J. S. H., Chu, K. H., Wang, W. C. K., Ruiter, T. J. J., Yang, J. C. C., Chen, N., Chhuor, J., Patil, S., Cen, H. H., Rideout, E. J., Richard, V. R., Schaeffer, D. F., Zahedi, R. P., Borchers, C. H., Johnson, J. D., & Kopp, J. L. (2022). Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation. https://doi.org/10.1101/2022.05.06.490845
Acvr1bloss promotes formation of precancerous lesions from acinar and ductal cells of origin
Jun 08, 2023
Saeki, K., Patil, S., Sun, Y., Su, G. H., & Kopp, J. L. (2023). Acvr1bloss promotes formation of precancerous lesions from acinar and ductal cells of origin. https://doi.org/10.1101/2023.06.08.544226
EZH2-GATA6 axis in Pancreatic ductal adenocarcinoma
Patil, S. (n.d.). EZH2-GATA6 axis in Pancreatic ductal adenocarcinoma [University Goettingen Repository]. https://doi.org/10.53846/goediss-8223
Kombinierte Radiochemotherapeutika zur Behandlung von endogenen Pankreaskarzinomen im KPC-Modell – eine feasibility Studie
Zeitschrift für Gastroenterologie / Aug 13, 2019
Goetze, R., Buchholz, S., Patil, S., Schirmer, M., Hessmann, E., & Neeße, A. (2019, August 13). Kombinierte Radiochemotherapeutika zur Behandlung von endogenen Pankreaskarzinomen im KPC-Modell – eine feasibility Studie. 74. Jahrestagung Der Deutschen Gesellschaft Für Gastroenterologie, Verdauungs- Und Stoffwechselkrankheiten Mit Sektion Endoskopie – 13. Herbsttagung Der Deutschen Gesellschaft Für Allgemein- Und Viszeralchirurgie Gemeinsam Mit Den Arbeitsgemeinschaften Der DGAV. https://doi.org/10.1055/s-0039-1695456
EZH2 controls PDAC plasticity by regulating differentiation genes
Pancreatology / Jun 01, 2019
Patil, S., Najafova, Z., Kari, V., Wang, X., Bohnenberger, H., Kopp, W., Spitalieri, J., Neesse, A., Ellenrieder, V., Johnsen, S., & Hessmann, E. (2019). EZH2 controls PDAC plasticity by regulating differentiation genes. Pancreatology, 19, S11. https://doi.org/10.1016/j.pan.2019.05.021
Impact of cytosolic 5'-nucleotidase 1A on chemotherapeutic resistance in pancreatic cancer
Pancreatology / Jun 01, 2018
Patzak, M. S., Hessmann, E., Kari, V., Kitz, J., Patil, S., Richards, F. M., Jodrell, D. I., Johnsen, S. A., Ellenrieder, V., & Neesse, A. (2018). Impact of cytosolic 5’-nucleotidase 1A on chemotherapeutic resistance in pancreatic cancer. Pancreatology, 18(4), S91. https://doi.org/10.1016/j.pan.2018.05.247
The Wild-type and Gain-of-function Mutant p53 Enhance p300 Autoacetylation through Conformational Switching
Sep 27, 2017
Kaypee, S., Ghosh, R., Sahadevan, S. A., Patil, S., Shasmal, M., Ghosh, P., Roy, N., Sengupta, J., Roy, S., & Kundu, T. K. (2017). The Wild-type and Gain-of-function Mutant p53 Enhance p300 Autoacetylation through Conformational Switching. https://doi.org/10.1101/194704
Role of oncogenic EZH2 histone methyltransferase activity in PDAC cellular plasticity
Pancreatology / Jul 01, 2017
Patil, S., Witte, H., Neesse, A., Johnsen, S., Ellenrieder, V., & Hessmann, E. (2017). Role of oncogenic EZH2 histone methyltransferase activity in PDAC cellular plasticity. Pancreatology, 17(3), S41. https://doi.org/10.1016/j.pan.2017.05.128
Utilizing High Resolution Ultrasound to Monitor Tumor Onset and Growth in Genetically Engineered Pancreatic Cancer Models
Journal of Visualized Experiments / Apr 07, 2018
Goetze, R.-G., Buchholz, S. M., Patil, S., Petzold, G., Ellenrieder, V., Hessmann, E., & Neesse, A. (2018). Utilizing High Resolution Ultrasound to Monitor Tumor Onset and Growth in Genetically Engineered Pancreatic Cancer Models. Journal of Visualized Experiments, 134. https://doi.org/10.3791/56979
Education
University of Göttingen
Ph.D, Cancer Research / June, 2020
Manipal Academy of Higher Education
MSc, Regenerative Medicine / August, 2014
Manipal Academy of Higher Education
BSc, Biotechnology / August, 2012
Experience
University of British Columbia
Postdoctoral Research Fellow / January, 2021 — July, 2023
University of Gottingen
Postdoctoral Researcher / July, 2020 — December, 2020
JNCASR
Research Assistant / September, 2014 — February, 2016
Links & Social Media
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