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Work with thought leaders and academic experts in molecular medicine

Companies can greatly benefit from working with experts in the field of Molecular Medicine. These researchers possess in-depth knowledge and skills that can contribute to various aspects of a company's operations. They can provide valuable insights and expertise in areas such as drug discovery and development, personalized medicine, genomics, biomarker identification, and therapeutic interventions. By collaborating with Molecular Medicine experts, companies can accelerate their research and development processes, improve the effectiveness of their products and services, and stay at the forefront of scientific advancements. Additionally, these collaborations can lead to the identification of new business opportunities, partnerships, and potential commercialization of scientific discoveries.

Experts on NotedSource with backgrounds in molecular medicine include Dr. Sakshi Kabra Malpani, Regan Hamel, Aimee Eggler, Keisha Walters, Jeffrey Townsend, Giuliana Noratto, Nora S Vyas, Ph.D., Craig Hawker, Jennifer Aaker, Ping Luo, Marina Baretti, Samiul Amin, Katelyn Katelyn Masiuk, Kayvan Najarian, Maham Zain, Dr. Kevin Pawlak, Ph.D., Olivier Saulnier, Andrew Mikhail, Gianfranco Santovito, Ernesto Lowy, Niko Popitsch, and John Joe.

Dr. Sakshi Kabra Malpani

Redmond, Washington, United States of America
Researcher with 10+ years expertise in Organic Chemistry, Solid Waste Management, Heterogeneous Catalysis.
Most Relevant Research Interests
Molecular Medicine
Other Research Interests (15)
Renewable Energy, Sustainability and the Environment
Materials Chemistry
Organic Chemistry
General Chemistry
Solid Waste Management
And 10 more
About
Hello, I am Sakshi Kabra Malpani, with 10+ years of experience as a green, organic chemist and lecturer. My overarching research interests revolve around solid waste management, utilization of industrial and natural wastes in the development of heterogeneous catalysts, and their further utilization in different industrially viable organic transformations, extraction of various useful metal oxides like silica, alumina from such wastes. I favor interdisciplinary approaches to solve the aforesaid issues and have incorporated synthetic green chemistry as well as material science and conventional organic chemistry approaches in my research. Post Ph.D., I continued my research work at my workplaces in the form of different student projects at college and postgraduate levels. I also describe my interest and activities in science communication. Three of my designed catalysts have been patented on my name, my research work got published in peer-reviewed journals and books, also I presented my results at different international and national conferences. My father was a College Lecturer, so, from the early stages of my life, I want to become a teacher, saying teaching is in my DNA. Stepping to freelance consulting job, I would like to use my novel training as both an organic and environmental chemist, to investigate environmental processes on a range of temporal and spatial scales. I understand being a scientist or researcher does not mean just being successful in research. At the same time, one should be excellent in his/her interactions with the community and the students, in his/her role to lead the academic society, and in responsibilities to transform the community and society. To this end, I have been engaged in several volunteer activities, such as a volunteer in National Service Scheme and Teach For India movement, guiding and encouraging students to apply for further studies, research fellowships, competitive exams.

Regan Hamel

Cambridge
Senior bioinformatics scientist, specializing in single cell omics in the context of cellular reprogramming and neuroinflammation
Most Relevant Research Interests
Molecular Medicine
Other Research Interests (17)
single cell biology
transcriptomics
Cellular and Molecular Neuroscience
Cell Biology
Developmental Biology
And 12 more
About
Regan Hamel has an MPhil and PhD in Clinical Neurosciences from University of Cambridge. She also has a Bachelor of Science in Neurosciences from McGill University. Her PhD with Stefano Pluchino and John Marioni focused on single cell transcriptomics in the context of neuroinflammation. Since 2021 she has worked as a Bioinformatics scientist at Mogrify Ltd, applying a multitude of computational biology techniques (including single cell omics, bulk RNAseq, and predictive modelling) in the context of cell reprogramming
Most Relevant Publications (1+)

12 total publications

Combination of In Situ Lcn2 pRNA-RNAi Nanotherapeutics and iNSC Transplantation Ameliorates Experimental SCI in Mice

Molecular Therapy / Dec 01, 2020

Braga, A., Bandiera, S., Verheyen, J., Hamel, R., Rutigliani, C., Edenhofer, F., Smith, J. A., & Pluchino, S. (2020). Combination of In Situ Lcn2 pRNA-RNAi Nanotherapeutics and iNSC Transplantation Ameliorates Experimental SCI in Mice. Molecular Therapy, 28(12), 2677–2690. https://doi.org/10.1016/j.ymthe.2020.08.001

Aimee Eggler

Villanova, Pennsylvania, United States of America
Professor of Chemistry and Biochemistry at Villanova University
Most Relevant Research Interests
Molecular Medicine
Other Research Interests (26)
Biochemistry
Biochemistry education
Cell culture
Oxidative stress
Natural products
And 21 more
About
Dr. Eggler has 20 years of experience in the field of redox biology, with a focus on the Nrf2 transcription factor, a master regulator of antioxidant, detoxification and anti-inflammatory genes. She is also an award-winning educator and the recipient of the Villanova University Junior Faculty Excellence in Teaching award. Her interests in education include innovation in teaching metabolism from a logic-based perspective.
Most Relevant Publications (3+)

25 total publications

Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding

Bioorganic & Medicinal Chemistry Letters / Nov 01, 2013

Turlington, M., Chun, A., Tomar, S., Eggler, A., Grum-Tokars, V., Jacobs, J., Daniels, J. S., Dawson, E., Saldanha, A., Chase, P., Baez-Santos, Y. M., Lindsley, C. W., Hodder, P., Mesecar, A. D., & Stauffer, S. R. (2013). Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding. Bioorganic & Medicinal Chemistry Letters, 23(22), 6172–6177. https://doi.org/10.1016/j.bmcl.2013.08.112

Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease

Journal of Medicinal Chemistry / Jan 03, 2013

Jacobs, J., Grum-Tokars, V., Zhou, Y., Turlington, M., Saldanha, S. A., Chase, P., Eggler, A., Dawson, E. S., Baez-Santos, Y. M., Tomar, S., Mielech, A. M., Baker, S. C., Lindsley, C. W., Hodder, P., Mesecar, A., & Stauffer, S. R. (2013). Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease. Journal of Medicinal Chemistry, 56(2), 534–546. https://doi.org/10.1021/jm301580n

Insecticidal Activity of Cyanohydrin and Monoterpenoid Compounds

Molecules / Apr 03, 2000

Peterson, C., Tsao, R., Eggler, A., & Coats, J. (2000). Insecticidal Activity of Cyanohydrin and Monoterpenoid Compounds. Molecules, 5(12), 648–654. https://doi.org/10.3390/50400648

Keisha Walters

I am the Conoco-Dupont Professor of Chemical, Biological and Materials Engineering at the University of Oklahoma (OU), and I have experience in industry (R&D, Milliken Chemical).
Most Relevant Research Interests
Molecular Medicine
Other Research Interests (46)
chemical engineering
polymers
nanotechnology
material science
General Materials Science
And 41 more
About
Chemical engineering expertise focused on polymer-based material synthesis, modification, and application and experimental and computational transport (momentum, heat, and mass) modeling. Specialties: material synthesis and characterization: bulk and surface initiated polymerization, stimuli responsive polymers, renewable polymers (bioplastics), lung simulation, transport modeling, nano- and micro-particles, and surface modification FTIR, XPS/ESCA, TGA, DSC, GPC, CA, AFM, T/SEM, LS
Most Relevant Publications (1+)

49 total publications

Bioluminescent magnetic nanoparticles as potential imaging agents for mammalian spermatozoa

Journal of Nanobiotechnology / Mar 17, 2016

Vasquez, E. S., Feugang, J. M., Willard, S. T., Ryan, P. L., & Walters, K. B. (2016). Bioluminescent magnetic nanoparticles as potential imaging agents for mammalian spermatozoa. Journal of Nanobiotechnology, 14(1). https://doi.org/10.1186/s12951-016-0168-y

Jeffrey Townsend

New Haven, CT
Professor of Biostatistics and Ecology & Evolutionary Biology
Most Relevant Research Interests
Molecular Medicine
Other Research Interests (78)
Statistics
cancer genetics
disease modeling
antibiotic resistance
Evolutionary Genomics
And 73 more
About
Jeffrey Townsend is a Professor of Organismic and Evolutionary Biology at Yale University. He received his Ph.D. from Harvard University in 2002 and his Sc.B. from Brown University in 1994. He has been a teacher at St. Ann's School and an Assistant Professor at the University of Connecticut. He is currently the Elihu Professor of Biostatistics at Yale University.
Most Relevant Publications (6+)

207 total publications

The Prognostic Value of an RT-PCR Test for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Is Contingent on Timing across Disease Time Course in addition to Assay Sensitivity

The Journal of Molecular Diagnostics / Jan 01, 2022

Townsend, J. P., & Wells, C. R. (2022). The Prognostic Value of an RT-PCR Test for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Is Contingent on Timing across Disease Time Course in addition to Assay Sensitivity. The Journal of Molecular Diagnostics, 24(1), 101–103. https://doi.org/10.1016/j.jmoldx.2021.10.002

Cost-effectiveness of next-generation vaccines: The case of pertussis

Vaccine / Jun 01, 2016

Fitzpatrick, M. C., Wenzel, N. S., Scarpino, S. V., Althouse, B. M., Atkins, K. E., Galvani, A. P., & Townsend, J. P. (2016). Cost-effectiveness of next-generation vaccines: The case of pertussis. Vaccine, 34(29), 3405–3411. https://doi.org/10.1016/j.vaccine.2016.04.010

Optimizing age of cytomegalovirus screening and vaccination to avert congenital disease in the US

Vaccine / Jan 01, 2016

Alfaro-Murillo, J. A., Townsend, J. P., & Galvani, A. P. (2016). Optimizing age of cytomegalovirus screening and vaccination to avert congenital disease in the US. Vaccine, 34(2), 225–229. https://doi.org/10.1016/j.vaccine.2015.11.039

Optimal targeting of seasonal influenza vaccination toward younger ages is robust to parameter uncertainty

Vaccine / Jun 01, 2013

Ndeffo Mbah, M. L., Medlock, J., Meyers, L. A., Galvani, A. P., & Townsend, J. P. (2013). Optimal targeting of seasonal influenza vaccination toward younger ages is robust to parameter uncertainty. Vaccine, 31(30), 3079–3089. https://doi.org/10.1016/j.vaccine.2013.04.052

Monitoring and modeling horizontal gene transfer

Nature Biotechnology / Aug 31, 2004

Nielsen, K. M., & Townsend, J. P. (2004). Monitoring and modeling horizontal gene transfer. Nature Biotechnology, 22(9), 1110–1114. https://doi.org/10.1038/nbt1006

Monitoring horizontal gene transfer

Nature Biotechnology / Nov 01, 2004

Davison, J. (2004). Monitoring horizontal gene transfer. Nature Biotechnology, 22(11), 1349–1349. https://doi.org/10.1038/nbt1104-1349a

Giuliana Noratto

Food Scientist PhD and Registered Dietician - Texas A&M University
Most Relevant Research Interests
Molecular Medicine
Molecular Medicine
Other Research Interests (48)
Food Science
human nutrition
disease prevention and treatment
Nutrition
Human Health
And 43 more
About
Dr. Giuliana Noratto is a senior associate research scientist at Texas A&M AgriLife. She received her Ph.D. in food science and technology from Texas A&M University System, and her M.Sc. in food science and technology from Universidad Nacional Agraria La Molina. She also holds a B.S. in food science and technology from Universidad Nacional Agraria La Molina. Dr. Noratto’s research interests include food safety and quality, sensory science, and food processing.
Most Relevant Publications (2+)

91 total publications

Dark Sweet Cherry (Prunus avium) Anthocyanins Suppressed ERK1/2-Akt/mTOR Cell Signaling and Oxidative Stress: Implications for TNBC Growth and Invasion

Molecules / Oct 25, 2022

Silveira Rabelo, A. C., Mertens-Talcott, S. U., Chew, B. P., & Noratto, G. (2022). Dark Sweet Cherry (Prunus avium) Anthocyanins Suppressed ERK1/2-Akt/mTOR Cell Signaling and Oxidative Stress: Implications for TNBC Growth and Invasion. Molecules, 27(21), 7245. https://doi.org/10.3390/molecules27217245

Calotropis Procera Induced Caspase-Dependent Apoptosis and Impaired Akt/mTOR Signaling in 4T1 Breast Cancer Cells

Anti-Cancer Agents in Medicinal Chemistry / Nov 01, 2022

Rabelo, A. C. S., Miglino, M. A., Arbizu, S., Carreira, A. C. O., Filho, A. J. C., Carneiro, F. J. C., Layosa, M. A. A., & Noratto, G. (2022). Calotropis Procera Induced Caspase-Dependent Apoptosis and Impaired Akt/mTOR Signaling in 4T1 Breast Cancer Cells. Anti-Cancer Agents in Medicinal Chemistry, 22(18), 3136–3147. https://doi.org/10.2174/1871520622666220608122154

Nora S Vyas, Ph.D.

Associate Professor of Mental Health, with interest in civic engagement and partnerships
Most Relevant Research Interests
Molecular Medicine
Other Research Interests (30)
Psychosis
neuroimaging
neuropsychology
mindfulness
neurodevelopmental disorders
And 25 more
About
Dr Nora S Vyas is an Associate Professor in Psychology at the Department of Psychology, Kingston University. She joined Kingston University in 2012, and previously held a Senior Lecturer position at Middlesex University. Dr Vyas completed her PhD in psychiatry at the Institute of Psychiatry, Psychology and Neuroscience (IoPPN), University of London in 2008. Following her PhD, she worked at the Child Psychiatry Branch, National Institutes of Health (Washington DC, USA) as a Lindemann Trust Fellow (English-Speaking Union), preceded by a Fulbright Distinguished Fellowship in 2010. Dr Vyas teaches at undergraduate and postgraduate level in child/adolescent and adult mental health, health psychology, and clinical/cognitive neuroscience. Her research focuses on using clinical, cognitive, and imaging techniques to study individuals with serious mental health problems such as bipolar disorder and schizophrenia. She applies these skills in other fields such as oncology and mindfulness. Her research specialism is early-onset psychosis, and she has published her work widely.
Most Relevant Publications (1+)

30 total publications

Recent Developments in Neurochemical Imaging in Schizophrenia: An Update

Current Medicinal Chemistry / Jan 01, 2013

S. Vyas, N., H. Patel, N., Herscovitch, P., K. Puri, B., & Lanzenberger, R. (2013). Recent Developments in Neurochemical Imaging in Schizophrenia: An Update. Current Medicinal Chemistry, 20(3), 351–356. https://doi.org/10.2174/092986713804870765

Craig Hawker

Professor at University of California, Santa Barbara
Most Relevant Research Interests
Molecular Medicine
Other Research Interests (30)
Materials
Polymers
General Chemistry
Colloid and Surface Chemistry
Biochemistry
And 25 more
About
Dr. Hawker is a Professor at the University of California, Santa Barbara and has a Ph.D. in Specialty Materials from the University of California, Santa Barbara. He has been working in the field of materials science for over 20 years and has published over 100 papers in leading scientific journals.
Most Relevant Publications (1+)

100 total publications

A new convergent approach to monodisperse dendritic macromolecules

J. Chem. Soc., Chem. Commun. / Jan 01, 1990

Hawker, C., & Fréchet, J. M. J. (1990). A new convergent approach to monodisperse dendritic macromolecules. J. Chem. Soc., Chem. Commun., 15, 1010–1013. https://doi.org/10.1039/c39900001010

Jennifer Aaker

General Atlantic Professor, Stanford University
Most Relevant Research Interests
Molecular Medicine
Other Research Interests (38)
The psychology of time
money
and happiness
Marketing
Economics and Econometrics
And 33 more
About
Jennifer Aaker is a marketing professor at Stanford Graduate School of Business and the author of several books on the topic, including The Dragonfly Effect: Quick, Effective, and Powerful Ways to Use Social Media to Drive Social Change. She has also conducted research on the psychology of happiness and self-regulation.
Most Relevant Publications (1+)

79 total publications

SPECIAL SYMPOSIUM LECTURE: SIR HANS L. KORNBERG

Advances in Enzyme Regulation / Jan 01, 2002

SPECIAL SYMPOSIUM LECTURE: SIR HANS L. KORNBERG. (2002). Advances in Enzyme Regulation, 42, EX17. https://doi.org/10.1016/s0065-2571(01)00055-3

Ping Luo

Postdoctoral Researcher at Princess Margaret Cancer Centre with experience in deep learning
Most Relevant Research Interests
Molecular Medicine
Other Research Interests (26)
single-cell genomics
deep learning
complex network analysis
Genetics (clinical)
Genetics
And 21 more
About
8 years of science and engineering experience integrating multi-omics data to identify biomarkers for cancer studies. Seeking to apply data analytics expertise to develop new diagnosis and treatment strategies.
Most Relevant Publications (2+)

23 total publications

deepDriver: Predicting Cancer Driver Genes Based on Somatic Mutations Using Deep Convolutional Neural Networks

Frontiers in Genetics / Jan 29, 2019

Luo, P., Ding, Y., Lei, X., & Wu, F.-X. (2019). deepDriver: Predicting Cancer Driver Genes Based on Somatic Mutations Using Deep Convolutional Neural Networks. Frontiers in Genetics, 10. https://doi.org/10.3389/fgene.2019.00013

Identifying Disease-Gene Associations With Graph-Regularized Manifold Learning

Frontiers in Genetics / Apr 02, 2019

Luo, P., Xiao, Q., Wei, P.-J., Liao, B., & Wu, F.-X. (2019). Identifying Disease-Gene Associations With Graph-Regularized Manifold Learning. Frontiers in Genetics, 10. https://doi.org/10.3389/fgene.2019.00270

Marina Baretti

Baltimore, Maryland, United States of America
I am a clinical translational researcher in gastrointestinal (GI) oncology, collaborating closely with laboratory-based researchers to move laboratory findings into patients and to answer important clinical questions.
Most Relevant Research Interests
Molecular Medicine
Other Research Interests (19)
Oncology
Pharmacology (medical)
Pharmacology
Hematology
Gastroenterology
And 14 more
About
Throughout my training, I have been focused toward my ultimate goal of becoming a clinical translational researcher in gastrointestinal (GI) oncology, collaborating closely with laboratory-based researchers to move laboratory findings into patients and to answer important clinical questions. My clinical research is centered on the development of novel agents in GI cancers, with particular interest in combinatorial approaches of epigenetic therapies and immunotherapies combinations. I ran the first phase II study of combination epigenetic therapy and immunotherapy in advanced pancreatic adenocarcinoma and cholangiocarcinoma, working with a collaborative team that incorporates leading experts in cancer immunology, epigenetics and drug development. I was awarded the 2018 ASCO Conquer Cancer Foundation Young Investigator Award for this project.  Together with Dr. Yarchoan, we are running a clinical trial of a novel neoantigen-specific vaccine in combination with immune checkpoint inhibitors for advanced fibrolamellar carcinoma (FLC) (NCT04248569). My laboratory focus has been on developing and validating a preclinical mouse model of FLC to investigate mechanisms underlying FLC pathogenesis, and will become a critical tool for investigating novel therapeutic strategies in FLC.
Most Relevant Publications (1+)

57 total publications

Emergence of KRAS-mutation in liver metastases after an anti-EGFR treatment in patient with colorectal cancer: Are we aware of the therapeutic impact of intratumor heterogeneity?

Cancer Biology & Therapy / Apr 13, 2018

Baretti, M., Personeni, N., Destro, A., Santoro, A., & Rimassa, L. (2018). Emergence of KRAS-mutation in liver metastases after an anti-EGFR treatment in patient with colorectal cancer: Are we aware of the therapeutic impact of intratumor heterogeneity? Cancer Biology & Therapy, 19(8), 659–663. https://doi.org/10.1080/15384047.2018.1450117

Samiul Amin

Professor of Practice at University of Miami Professor of Practice and Director ECAP at University of Miami with expertise in Formulation Design, Rheology, Biosurfactants, Biopolymers and Materials Science.
Most Relevant Research Interests
Molecular Medicine
Other Research Interests (59)
Complex Fluids
Rheology
Microrheology
Protein Aggregation
Colloid and Surface Chemistry
And 54 more
About
With over 22 years of industry and academic experience in SoftMatter, colloids, and complex fluids, I am a Professor of Practice and Director of the Engineering Corporate Affiliate Program (ECAP) at the University of Miami. My mission is to bridge the gap between engineering education/research and industry needs, and to foster a culture of creativity, innovation, and entrepreneurship among students and faculty. I am also co-founder of FastFormulator a Formulation Design Lab developing novel sustainable formulations for a wide range of industries utilizing an integrated approach of High THroughput FOrmulation Automation/Advanced CHaracterization/AI-ML and based on deep colloid science/complex fluids insights. <br> As a leading researcher and consultant in formulation design and performance optimization of consumer, cosmetic, biopharmaceutical, and homecare products, I collaborate with multiple global companies and organizations to develop novel and sustainable solutions based on high throughput formulation, AI/ML, advanced characterization and novel sustainable materials. I also teach courses in polymers, surfactants, emulsions, rheology, tribology, and innovation management, and chair international conferences in my field of expertise. I am passionate about advancing the science and engineering of complex fluids and cosmetics, and sharing my knowledge and insights with the next generation of engineers and innovators.
Most Relevant Publications (2+)

68 total publications

Combined Dynamic Light Scattering and Raman Spectroscopy Approach for Characterizing the Aggregation of Therapeutic Proteins

Molecules / Dec 12, 2014

Lewis, E., Qi, W., Kidder, L., Amin, S., Kenyon, S., & Blake, S. (2014). Combined Dynamic Light Scattering and Raman Spectroscopy Approach for Characterizing the Aggregation of Therapeutic Proteins. Molecules, 19(12), 20888–20905. https://doi.org/10.3390/molecules191220888

Investigating the Influence of Polysorbate 20/80 and Polaxomer P188 on the Surface & Interfacial Properties of Bovine Serum Albumin and Lysozyme

Pharmaceutical Research / May 20, 2019

Begum, F., & Amin, S. (2019). Investigating the Influence of Polysorbate 20/80 and Polaxomer P188 on the Surface &amp; Interfacial Properties of Bovine Serum Albumin and Lysozyme. Pharmaceutical Research, 36(7). https://doi.org/10.1007/s11095-019-2631-6

Katelyn Katelyn Masiuk

Co-Founder and CSO at Immunovec
Most Relevant Research Interests
Molecular Medicine
Molecular Medicine
Molecular Medicine
Molecular Medicine
Other Research Interests (23)
Cell Biology
Genetics
Genetics
Molecular Biology
Drug Discovery
And 18 more
About
Katelyn Masiuk is the co-founder and Chief Scientific Officer of ImmunoVec. She is also a medical student in the MSTP program at UCLA. Her research interests include immunology and virology.
Most Relevant Publications (6+)

13 total publications

Editing the Sickle Cell Disease Mutation in Human Hematopoietic Stem Cells: Comparison of Endonucleases and Homologous Donor Templates

Molecular Therapy / Aug 01, 2019

Romero, Z., Lomova, A., Said, S., Miggelbrink, A., Kuo, C. Y., Campo-Fernandez, B., Hoban, M. D., Masiuk, K. E., Clark, D. N., Long, J., Sanchez, J. M., Velez, M., Miyahira, E., Zhang, R., Brown, D., Wang, X., Kurmangaliyev, Y. Z., Hollis, R. P., & Kohn, D. B. (2019). Editing the Sickle Cell Disease Mutation in Human Hematopoietic Stem Cells: Comparison of Endonucleases and Homologous Donor Templates. Molecular Therapy, 27(8), 1389–1406. https://doi.org/10.1016/j.ymthe.2019.05.014

Lentiviral Gene Therapy in HSCs Restores Lineage-Specific Foxp3 Expression and Suppresses Autoimmunity in a Mouse Model of IPEX Syndrome

Cell Stem Cell / Feb 01, 2019

Masiuk, K. E., Laborada, J., Roncarolo, M. G., Hollis, R. P., & Kohn, D. B. (2019). Lentiviral Gene Therapy in HSCs Restores Lineage-Specific Foxp3 Expression and Suppresses Autoimmunity in a Mouse Model of IPEX Syndrome. Cell Stem Cell, 24(2), 309-317.e7. https://doi.org/10.1016/j.stem.2018.12.003

PGE2 and Poloxamer Synperonic F108 Enhance Transduction of Human HSPCs with a β-Globin Lentiviral Vector

Molecular Therapy - Methods &amp; Clinical Development / Jun 01, 2019

Masiuk, K. E., Zhang, R., Osborne, K., Hollis, R. P., Campo-Fernandez, B., & Kohn, D. B. (2019). PGE2 and Poloxamer Synperonic F108 Enhance Transduction of Human HSPCs with a β-Globin Lentiviral Vector. Molecular Therapy - Methods &amp; Clinical Development, 13, 390–398. https://doi.org/10.1016/j.omtm.2019.03.005

Improving Gene Therapy Efficiency through the Enrichment of Human Hematopoietic Stem Cells

Molecular Therapy / Sep 01, 2017

Masiuk, K. E., Brown, D., Laborada, J., Hollis, R. P., Urbinati, F., & Kohn, D. B. (2017). Improving Gene Therapy Efficiency through the Enrichment of Human Hematopoietic Stem Cells. Molecular Therapy, 25(9), 2163–2175. https://doi.org/10.1016/j.ymthe.2017.05.023

Enrichment of Human Hematopoietic Stem/Progenitor Cells Facilitates Transduction for Stem Cell Gene Therapy

Stem Cells / Apr 23, 2015

Baldwin, K., Urbinati, F., Romero, Z., Campo-Fernandez, B., Kaufman, M. L., Cooper, A. R., Masiuk, K., Hollis, R. P., & Kohn, D. B. (2015). Enrichment of Human Hematopoietic Stem/Progenitor Cells Facilitates Transduction for Stem Cell Gene Therapy. Stem Cells, 33(5), 1532–1542. https://doi.org/10.1002/stem.1957

Gene Therapy for Sickle Cell Disease:A Lentiviral Vector Comparison Study

Human Gene Therapy / Oct 01, 2018

Urbinati, F., Campo Fernandez, B., Masiuk, K. E., Poletti, V., Hollis, R. P., Koziol, C., Kaufman, M. L., Brown, D., Mavilio, F., & Kohn, D. B. (2018). Gene Therapy for Sickle Cell Disease:A Lentiviral Vector Comparison Study. Human Gene Therapy, 29(10), 1153–1166. https://doi.org/10.1089/hum.2018.061

Kayvan Najarian

Professor of Comp Med and Bioinf, Emergency Med, and Electrical and Comp Engineering
Most Relevant Research Interests
Molecular Medicine
Other Research Interests (40)
biomedical inforamtics
bioinformatics
singal processing
image processing
machine learning
And 35 more
Most Relevant Publications (1+)

108 total publications

Deep learning in pharmacogenomics: from gene regulation to patient stratification

Pharmacogenomics / May 01, 2018

Kalinin, A. A., Higgins, G. A., Reamaroon, N., Soroushmehr, S., Allyn-Feuer, A., Dinov, I. D., Najarian, K., & Athey, B. D. (2018). Deep learning in pharmacogenomics: from gene regulation to patient stratification. Pharmacogenomics, 19(7), 629–650. https://doi.org/10.2217/pgs-2018-0008

Maham Zain

PhD Student at University of Toronto
Most Relevant Research Interests
Molecular Medicine
Other Research Interests (17)
Neuroscience
Pain
Touch
Anesthesiology and Pain Medicine
Neurology (clinical)
And 12 more
About
Maham Zain is a 5th year PhD candidate in Dr. Robert Bonin’s laboratory at the Leslie Dan Faculty of Pharmacy. Maham completed her undergraduate degree with high distinction from the University of Toronto in 2018 and began graduate studies with Dr. Bonin in 2019.  Her thesis is focused on disentangling the neural circuits that underly pain and pleasurable touch and the systems that allow for cross talk between the two.
Most Relevant Publications (1+)

7 total publications

Differential modulation of thermal preference after sensitization by optogenetic or pharmacological activation of heat-sensitive nociceptors

Molecular Pain / Jan 01, 2021

Li, J., Zain, M., & Bonin, R. P. (2021). Differential modulation of thermal preference after sensitization by optogenetic or pharmacological activation of heat-sensitive nociceptors. Molecular Pain, 17, 174480692110009. https://doi.org/10.1177/17448069211000910

Dr. Kevin Pawlak, Ph.D.

Xavier University School of Medicine
Most Relevant Research Interests
Molecular Medicine
Other Research Interests (14)
endocrinology
steroid
medical education
Cell Biology
Molecular Biology
And 9 more
Most Relevant Publications (5+)

12 total publications

The role of progesterone metabolites in breast cancer: Potential for new diagnostics and therapeutics

The Journal of Steroid Biochemistry and Molecular Biology / Feb 01, 2005

Wiebe, J. P., Lewis, M. J., Cialacu, V., Pawlak, K. J., & Zhang, G. (2005). The role of progesterone metabolites in breast cancer: Potential for new diagnostics and therapeutics. The Journal of Steroid Biochemistry and Molecular Biology, 93(2–5), 201–208. https://doi.org/10.1016/j.jsbmb.2004.12.003

Regulation of estrogen receptor (ER) levels in MCF-7 cells by progesterone metabolites

The Journal of Steroid Biochemistry and Molecular Biology / Nov 01, 2007

Pawlak, K. J., & Wiebe, J. P. (2007). Regulation of estrogen receptor (ER) levels in MCF-7 cells by progesterone metabolites. The Journal of Steroid Biochemistry and Molecular Biology, 107(3–5), 172–179. https://doi.org/10.1016/j.jsbmb.2007.05.030

Membrane 5α-pregnane-3,20-dione (5αP) receptors in MCF-7 and MCF-10A breast cancer cells are up-regulated by estradiol and 5αP and down-regulated by the progesterone metabolites, 3α-dihydroprogesterone and 20α-dihydroprogesterone, with associated changes in cell proliferation and detachment

The Journal of Steroid Biochemistry and Molecular Biology / Nov 01, 2005

Pawlak, K. J., Zhang, G., & Wiebe, J. P. (2005). Membrane 5α-pregnane-3,20-dione (5αP) receptors in MCF-7 and MCF-10A breast cancer cells are up-regulated by estradiol and 5αP and down-regulated by the progesterone metabolites, 3α-dihydroprogesterone and 20α-dihydroprogesterone, with associated changes in cell proliferation and detachment. The Journal of Steroid Biochemistry and Molecular Biology, 97(3), 278–288. https://doi.org/10.1016/j.jsbmb.2005.05.014

Mechanism of action of the breast cancer-promoter hormone, 5α-dihydroprogesterone (5αP), involves plasma membrane-associated receptors and MAPK activation

The Journal of Steroid Biochemistry and Molecular Biology / Jan 01, 2016

Wiebe, J. P., Pawlak, K. J., & Kwok, A. (2016). Mechanism of action of the breast cancer-promoter hormone, 5α-dihydroprogesterone (5αP), involves plasma membrane-associated receptors and MAPK activation. The Journal of Steroid Biochemistry and Molecular Biology, 155, 166–176. https://doi.org/10.1016/j.jsbmb.2015.10.021

Decreased CytochromecOxidase IV Expression Reduces Steroidogenesis

Journal of Pharmacology and Experimental Therapeutics / May 10, 2011

Pawlak, K. J., Prasad, M., McKenzie, K. A., Wiebe, J. P., Gairola, C. G., Whittal, R. M., & Bose, H. S. (2011). Decreased CytochromecOxidase IV Expression Reduces Steroidogenesis. Journal of Pharmacology and Experimental Therapeutics, 338(2), 598–604. https://doi.org/10.1124/jpet.111.182634

Olivier Saulnier

The Hospital for Sick Children
Most Relevant Research Interests
Molecular Medicine
Other Research Interests (17)
Bioinformatics - single-cell omics
Neurology (clinical)
General Biochemistry, Genetics and Molecular Biology
Cancer Research
Oncology
And 12 more
Most Relevant Publications (1+)

25 total publications

The LIN28B–let‐7–PBK pathway is essential for group 3 medulloblastoma tumor growth and survival

Molecular Oncology / Aug 07, 2023

Shahab, S. W., Roggeveen, C. M., Sun, J., Kunhiraman, H., McSwain, L. F., Juraschka, K., Kumar, S. A., Saulnier, O., Taylor, M. D., Schniederjan, M., Schnepp, R. W., MacDonald, T. J., & Kenney, A. M. (2023). The <scp>LIN28B</scp>–let‐7–<scp>PBK</scp> pathway is essential for group 3 medulloblastoma tumor growth and survival. Molecular Oncology. Portico. https://doi.org/10.1002/1878-0261.13477

Andrew Mikhail

Department of Kinesiology, McMaster University
Most Relevant Research Interests
Molecular Medicine
Other Research Interests (20)
skeletal muscle
neuromuscular diseases
Food Science
Nutrition and Dietetics
Physiology
And 15 more
Most Relevant Publications (1+)

14 total publications

AMPK is mitochondrial medicine for neuromuscular disorders

Trends in Molecular Medicine / Jul 01, 2023

Mikhail, A. I., Ng, S. Y., Mattina, S. R., & Ljubicic, V. (2023). AMPK is mitochondrial medicine for neuromuscular disorders. Trends in Molecular Medicine, 29(7), 512–529. https://doi.org/10.1016/j.molmed.2023.03.008

Gianfranco Santovito

Associate Professor of Physiology at the University of Padova
Most Relevant Research Interests
Molecular Medicine
Other Research Interests (75)
Fisiologia degli organismi acquatici
Microbiology
Genetics
General Medicine
Molecular Biology
And 70 more

Ernesto Lowy

Senior Bioinformatician specialised in Cancer Genomics
Most Relevant Research Interests
Molecular Medicine
Other Research Interests (28)
Data analysis
Data science
Bioinformatics
Genomics
Multidisciplinary
And 23 more
Most Relevant Publications (2+)

67 total publications

Phylogeography of crossbills, bullfinches, grosbeaks, and rosefinches

Cellular and Molecular Life Sciences / Jul 01, 2001

Arnaiz-Villena, A., Guillén, J., Ruiz-del-Valle, V., Lowy, E., Zamora, J., Varela, P., Stefani, D., & Allende, L. M. (2001). Phylogeography of crossbills, bullfinches, grosbeaks, and rosefinches. Cellular and Molecular Life Sciences, 58(8), 1159–1166. https://doi.org/10.1007/pl00000930

Both morphological and molecular characters support speciation of South American siskins by sexual selection

Cellular and Molecular Life Sciences / Dec 01, 2001

van den Elzen, R., Guillén, J., Ruiz-del-Valle, V., Allende, L. M., Lowy, E., Zamora, J., & Arnaiz-Villena, A. (2001). Both morphological and molecular characters support speciation of South American siskins by sexual selection. Cellular and Molecular Life Sciences, 58(14), 2117–2128. https://doi.org/10.1007/pl00000841

Niko Popitsch

Senior Bioinformatician, University of Vienna
Most Relevant Research Interests
Other Research Interests (15)
Bioinformatics
Genetics (clinical)
General Physics and Astronomy
General Biochemistry, Genetics and Molecular Biology
General Chemistry
And 10 more

John Joe

Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
Most Relevant Research Interests
Molecular Medicine
Other Research Interests (73)
microbiology
systems biology
genetics
quantum biology
Genetics
And 68 more
Most Relevant Publications (2+)

95 total publications

13C-Flux Spectral Analysis of Host-Pathogen Metabolism Reveals a Mixed Diet for Intracellular Mycobacterium tuberculosis

Chemistry &amp; Biology / Aug 01, 2013

Beste, D. J. V., Nöh, K., Niedenführ, S., Mendum, T. A., Hawkins, N. D., Ward, J. L., Beale, M. H., Wiechert, W., & McFadden, J. (2013). 13C-Flux Spectral Analysis of Host-Pathogen Metabolism Reveals a Mixed Diet for Intracellular Mycobacterium tuberculosis. Chemistry &amp; Biology, 20(8), 1012–1021. https://doi.org/10.1016/j.chembiol.2013.06.012

Expression of the B-cell and T-cell epitopes of the rabies virus nucleoprotein in Mycobacterium bovis BCG and induction of an humoral response in mice

Vaccine / Dec 01, 2001

da Cruz, F. W., McBride, A. J. A., Conceição, F. R., Dale, J. W., McFadden, J., & Dellagostin, O. A. (2001). Expression of the B-cell and T-cell epitopes of the rabies virus nucleoprotein in Mycobacterium bovis BCG and induction of an humoral response in mice. Vaccine, 20(5–6), 731–736. https://doi.org/10.1016/s0264-410x(01)00414-5

Example molecular medicine projects

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