Work with thought leaders and academic experts in clinical biochemistry

Companies can greatly benefit from collaborating with experts in Clinical Biochemistry. These researchers bring a deep understanding of the biochemical processes in living organisms and can provide valuable insights and solutions to various challenges. They can contribute to the development of new diagnostic tools, therapies, and treatments for diseases. Additionally, their expertise can help optimize production processes, improve quality control, and ensure regulatory compliance in industries such as pharmaceuticals, biotechnology, and healthcare. By partnering with Clinical Biochemistry researchers, companies can enhance their research and development efforts, drive innovation, and gain a competitive edge in the market.

Researchers on NotedSource with backgrounds in clinical biochemistry include Dr. Everson A Nunes, Ph.D., Garrett A. Perchetti, Research Scientist - Virology, Aimee Eggler, Maurice O'Sullivan, Giuliana Noratto, VIJAYASSHEKAR MANUKONDA, Yuri Bukhtiyarov, Giuseppe Maria de Peppo, Javier O. Morales, and Dr. Barry A. Spiering, Ph.D..

Dr. Everson A Nunes, Ph.D.

Hamilton, Ontario, Canada
Post-Doctoral Fellow at McMaster University | former Associate Professor - Physiological Sciences
Most Relevant Research Interests
Clinical Biochemistry
Other Research Interests (39)
skeletal muscle
nutrition
physical activity
obesity
cancer
And 34 more
About
Dr. Everson A Nunes is a highly accomplished researcher and educator in the field of physiological sciences. He received his Ph.D. in Cellular and Molecular Biology with a focus on Physiological Sciences from Universidade Federal do Paraná in 2009, after completing a BSc in Human Nutrition and an MSc in Physiological Sciences. He also holds a specialization in Exercise Physiology and a BSc in Biological Sciences from Universidade Federal do Paraná. Dr. Nunes has a strong background in research, having completed two post-doctoral fellowships at McMaster University and Universidade Federal do Paraná. He has also held positions as an associate professor and assistant professor at Universidade Federal de Santa Catarina. He has published numerous articles in peer-reviewed journals, and his research focuses on the effects of exercise and nutrition on physiological processes in the human body. In addition to his research, Dr. Nunes is also a dedicated educator. He has taught at various universities in Brazil, including Universidade Federal de Santa Catarina, Universidade Gama Filho, Faculdades Integradas Espírita, Pontificia Universidade Católica do Paraná, and Faculdade do Litoral Sul. He is known for his dynamic teaching style and his ability to engage students in complex physiological concepts. Dr. Nunes is a member of several professional organizations, including the American Society for Nutrition, the Canadian Society of Exercise Physiology, the Canadian Nutrition Society and the Brazilian Society of Physiology. He is also a regular speaker at national and international conferences, sharing his expertise and research findings with colleagues and students. Overall, Dr. Nunes is a highly qualified and experienced professional in physiological sciences, metabolism, cancer and nutrition. His dedication to research and education makes him a valuable asset to any institution.
Most Relevant Publications (10+)

97 total publications

Low fish oil intake improves insulin sensitivity, lipid profile and muscle metabolism on insulin resistant MSG-obese rats

Lipids in Health and Disease / Jan 01, 2011

Yamazaki, R. K., Brito, G. A., Coelho, I., Pequitto, D. C., Yamaguchi, A. A., Borghetti, G., Schiessel, D., Kryczyk, M., Machado, J., Rocha, R. E., Aikawa, J., Iagher, F., Naliwaiko, K., Tanhoffer, R. A., Nunes, E. A., & Fernandes, L. (2011). Low fish oil intake improves insulin sensitivity, lipid profile and muscle metabolism on insulin resistant MSG-obese rats. Lipids in Health and Disease, 10(1), 66. https://doi.org/10.1186/1476-511x-10-66

Antitumor and anti-cachectic effects of shark liver oil and fish oil: comparison between independent or associative chronic supplementation in Walker 256 tumor-bearing rats

Lipids in Health and Disease / Oct 16, 2013

Iagher, F., de Brito Belo, S. R., Souza, W. M., Nunes, J. R., Naliwaiko, K., Sassaki, G. L., Bonatto, S. J. R., de Oliveira, H. H. P., Brito, G. A. P., de Lima, C., Kryczyk, M., de Souza, C. F., Steffani, J. A., Nunes, E. A., & Fernandes, L. C. (2013). Antitumor and anti-cachectic effects of shark liver oil and fish oil: comparison between independent or associative chronic supplementation in Walker 256 tumor-bearing rats. Lipids in Health and Disease, 12(1). https://doi.org/10.1186/1476-511x-12-146

Nitrate consumption preserves HFD-induced skeletal muscle mitochondrial ADP sensitivity and lysine acetylation: A potential role for SIRT1

Redox Biology / Jun 01, 2022

Brunetta, H. S., Petrick, H. L., Momken, I., Handy, R. M., Pignanelli, C., Nunes, E. A., Piquereau, J., Mericskay, M., & Holloway, G. P. (2022). Nitrate consumption preserves HFD-induced skeletal muscle mitochondrial ADP sensitivity and lysine acetylation: A potential role for SIRT1. Redox Biology, 52, 102307. https://doi.org/10.1016/j.redox.2022.102307

Impact of combined long-term fructose and prednisolone intake on glucose and lipid homeostasis in rats: benefits of intake interruption or fish oil administration

The Journal of Nutritional Biochemistry / Apr 01, 2021

Santos, C. dos, da Silva, J. S., Brunetta, H. S., Chagas, T. R., Zoccal, D. B., Nunes, E. A., & Rafacho, A. (2021). Impact of combined long-term fructose and prednisolone intake on glucose and lipid homeostasis in rats: benefits of intake interruption or fish oil administration. The Journal of Nutritional Biochemistry, 90, 108572. https://doi.org/10.1016/j.jnutbio.2020.108572

Does l-leucine supplementation cause any effect on glucose homeostasis in rodent models of glucose intolerance? A systematic review

Amino Acids / Sep 27, 2018

Brunetta, H. S., de Camargo, C. Q., & Nunes, E. A. (2018). Does l-leucine supplementation cause any effect on glucose homeostasis in rodent models of glucose intolerance? A systematic review. Amino Acids, 50(12), 1663–1678. https://doi.org/10.1007/s00726-018-2658-8

Implications of Palmitoleic Acid (Palmitoleate) On Glucose Homeostasis, Insulin Resistance and Diabetes

Current Drug Targets / Mar 30, 2017

Nunes, E., & Rafacho, A. (2017). Implications of Palmitoleic Acid (Palmitoleate) On Glucose Homeostasis, Insulin Resistance and Diabetes. Current Drug Targets, 18(6), 619–628. https://doi.org/10.2174/1389450117666151209120345

Relationship between Acute Phase Proteins and Serum Fatty Acid Composition in Morbidly Obese Patients

Disease Markers / Jan 01, 2013

Fernandes, R., Beserra, B. T. S., Cunha, R. S. G., Hillesheim, E., Camargo, C. de Q., Pequito, D. C. T., de Castro, I. C., Fernandes, L. C., Nunes, E. A., & Trindade, E. B. S. de M. (2013). Relationship between Acute Phase Proteins and Serum Fatty Acid Composition in Morbidly Obese Patients. Disease Markers, 35, 105–112. https://doi.org/10.1155/2013/913715

Lymphocytes transfer [14C]‐labeled fatty acids to skeletal muscle in culture; modulation by exercise

Cell Biochemistry and Function / May 26, 2010

Brito, G. A. P., Nunes, E. A., Nogata, C., Yamazaky, R. K., Naliwaiko, K., Curi, R., & Fernandes, L. C. (2010). Lymphocytes transfer [14C]‐labeled fatty acids to skeletal muscle in culture; modulation by exercise. Cell Biochemistry and Function, 28(4), 278–282. Portico. https://doi.org/10.1002/cbf.1652

Decreased tumor growth in Walker 256 tumor-bearing rats chronically supplemented with fish oil involves COX-2 and PGE2 reduction associated with apoptosis and increased peroxidation

Prostaglandins, Leukotrienes and Essential Fatty Acids / Feb 01, 2007

Mund, R. C., Pizato, N., Bonatto, S., Nunes, E. A., Vicenzi, T., Tanhoffer, R., de Oliveira, H. H. P., Curi, R., Calder, P. C., & Fernandes, L. C. (2007). Decreased tumor growth in Walker 256 tumor-bearing rats chronically supplemented with fish oil involves COX-2 and PGE2 reduction associated with apoptosis and increased peroxidation. Prostaglandins, Leukotrienes and Essential Fatty Acids, 76(2), 113–120. https://doi.org/10.1016/j.plefa.2006.11.008

The effects of peroxovanadate and peroxovanadyl on glucose metabolism in vivo and identification of signal transduction proteins involved in the mechanism of action in isolated soleus muscle

Molecular and Cellular Biochemistry / May 01, 2005

Yamazaki, R. K., Hirabara, S. M., Tchaikovski, O., Lopes, M. C. P., Nogata, C., Aikawa, J., Nunes, E. A., Tanhoffer, R. A., Lissa, M. D., & Fernandes, L. C. (2005). The effects of peroxovanadate and peroxovanadyl on glucose metabolism in vivo and identification of signal transduction proteins involved in the mechanism of action in isolated soleus muscle. Molecular and Cellular Biochemistry, 273(1–2), 145–150. https://doi.org/10.1007/s11010-005-8265-5

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Garrett A. Perchetti, Research Scientist - Virology

New York
Research Scientist and MD Candidate in virology with publications on infectious diseases, laboratory medicine, viral genetics, and clinical medicine
Most Relevant Research Interests
Clinical Biochemistry
Other Research Interests (14)
Virology
Microbiology
Infectious Diseases
SARS-CoV-2
COVID-19
And 9 more
About
Garrett A. Perchetti is a highly accomplished research scientist in the field of virology. He received a Bachelor of Science in Microbiology and a Bachelor of Arts in Art History from the University of Washington. His interest in both science and the arts led him to pursue a career in virology, where he could combine his passion for understanding the natural world with his creative thinking skills. After completing his undergraduate studies, Garrett continued his education by earning a Medical Degree from Ross University School of Medicine in 2025. During his time in medical school, he developed a keen interest in virology and infectious diseases, which ultimately led him to specialize in this field. Garrett's educational background is complemented by his extensive experience as a research scientist. He has worked at the University of Washington School of Medicine, where he has conducted groundbreaking research on various types of viruses. His work has been published in numerous scientific journals, and he has presented his findings at international conferences. Garrett's contributions to the field of virology have been widely recognized, and he has received several awards and accolades for his work. He is known for his meticulous attention to detail, innovative thinking, and ability to collaborate effectively with other researchers. In his free time, Garrett enjoys painting, hiking, and traveling. He is also passionate about raising awareness about the importance of vaccinations and promoting public health initiatives. With his exceptional education and extensive experience, Garrett A. Perchetti is a valuable asset to the field of virology and will continue to make significant contributions in the future.
Most Relevant Publications (1+)

28 total publications

Metagenomic Analysis Reveals Clinical SARS-CoV-2 Infection and Bacterial or Viral Superinfection and Colonization

Clinical Chemistry / Jun 12, 2020

Peddu, V., Shean, R. C., Xie, H., Shrestha, L., Perchetti, G. A., Minot, S. S., Roychoudhury, P., Huang, M.-L., Nalla, A., Reddy, S. B., Phung, Q., Reinhardt, A., Jerome, K. R., & Greninger, A. L. (2020). Metagenomic Analysis Reveals Clinical SARS-CoV-2 Infection and Bacterial or Viral Superinfection and Colonization. Clinical Chemistry, 66(7), 966–972. https://doi.org/10.1093/clinchem/hvaa106

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Aimee Eggler

Villanova, Pennsylvania, United States of America
Professor of Chemistry and Biochemistry at Villanova University
Most Relevant Research Interests
Clinical Biochemistry
Other Research Interests (18)
Biochemistry
Physiology (medical)
Toxicology
Organic Chemistry
Drug Discovery
And 13 more
About
Dr. Eggler has 20 years of experience in the field of redox biology, with a focus on the Nrf2 transcription factor, a master regulator of antioxidant, detoxification and anti-inflammatory genes. She is also an award-winning educator and the recipient of the Villanova University Junior Faculty Excellence in Teaching award. Her interests in education include innovation in teaching metabolism from a logic-based perspective.
Most Relevant Publications (1+)

25 total publications

Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding

Bioorganic & Medicinal Chemistry Letters / Nov 01, 2013

Turlington, M., Chun, A., Tomar, S., Eggler, A., Grum-Tokars, V., Jacobs, J., Daniels, J. S., Dawson, E., Saldanha, A., Chase, P., Baez-Santos, Y. M., Lindsley, C. W., Hodder, P., Mesecar, A. D., & Stauffer, S. R. (2013). Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding. Bioorganic & Medicinal Chemistry Letters, 23(22), 6172–6177. https://doi.org/10.1016/j.bmcl.2013.08.112

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Maurice O'Sullivan

Cork
University College Cork, School of Food and Nutritional Sciences
Most Relevant Research Interests
Clinical Biochemistry
Other Research Interests (33)
sensory
meat
dairy
consumer
Food Science
And 28 more
About
Dr. Maurice O’ Sullivan is a sensory scientist and senior lecturer in food science working in the School of Food and Nutritional Sciences, UCC. In the past Maurice has worked in the food industry as a sensory scientist and flavour chemist for Diageo Baileys and Guinness. He has worked as a food technologist and process/product development scientist for the processed foods sector in the 1990’s as well as more recently a product development consultant to the dairy, meat and beverage industries. He has a Ph.D. in Sensory and Consumer science from the Department of Food Science, University of Copenhagen, Denmark as well as MSc. and BSc. Degrees in Food Science and Technology from University College Cork (UCC). Currently Maurice works in the School of Food and Nutritional Sciences, University College Cork as a senior lecturer and sensory and product reformulation project coordinator on large scale multi-million euro research projects. For many years he has also managed the “Sensory Unit” at UCC working on sensory and flavour based projects involving a diverse selection of products. This sensory science based service (at UCC) includes testing the difference, affective and descriptive analysis of foods and beverages as well as assessing shelf-life and comparing sensory results to microbiological and analytical (instrumental, physic-chemical) data using multivariate data analysis (MVA). Sensory testing is critical for new product development/optimisation, ingredient substitution and devising appropriate packaging and comparing foods or beverages to competitor’s products. Again, the key to unlocking the hidden secrets of this multimodal data is with MVA (Multivariate Data Analysis). To date Maurice has secured significant research funding of €5,300,000 Gross, €3,843,329.30 to UCC. He has worked in the area of targeted ingredient (salt, fat, sugar) reduction in foods since 1997. The focus of this research has been reduction of negative ingredients linked to civilisation diseases (Diabetes, Obesity, Heart Disease, Anaemia) while maintaining sensory properties, but also improving nutritional quality of developed products. To date this research has produced numerous publications with many more in development. Other research areas include Cross Cultural Sensory Perception of Irish Dairy Products in Asia, Europe and North America as well as Foods for the Elderly, Packaging and Meat optimisation. Maurice has published more than 200 sensory or consumer research based articles (papers, book chapters, proceedings etc.).
Most Relevant Publications (1+)

85 total publications

Correlating Volatile Lipid Oxidation Compounds with Consumer Sensory Data in Dairy Based Powders during Storage

Antioxidants / Apr 20, 2020

Clarke, H. J., O’Sullivan, M. G., Kerry, J. P., & Kilcawley, K. N. (2020). Correlating Volatile Lipid Oxidation Compounds with Consumer Sensory Data in Dairy Based Powders during Storage. Antioxidants, 9(4), 338. https://doi.org/10.3390/antiox9040338

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Giuliana Noratto

Food Scientist PhD and Registered Dietician - Texas A&M University
Most Relevant Research Interests
Clinical Biochemistry
Other Research Interests (28)
Food Science
Nutrition
Human Health
Analytical Chemistry
Nutrition and Dietetics
And 23 more
About
Dr. Giuliana Noratto is a senior associate research scientist at Texas A&M AgriLife. She received her Ph.D. in food science and technology from Texas A&M University System, and her M.Sc. in food science and technology from Universidad Nacional Agraria La Molina. She also holds a B.S. in food science and technology from Universidad Nacional Agraria La Molina. Dr. Noratto’s research interests include food safety and quality, sensory science, and food processing.
Most Relevant Publications (3+)

91 total publications

Antitumor potential of dark sweet cherry sweet (Prunus avium) phenolics in suppressing xenograft tumor growth of MDA-MB-453 breast cancer cells

The Journal of Nutritional Biochemistry / Oct 01, 2020

Noratto, G., Layosa, M. A., Lage, N. N., Atienza, L., Ivanov, I., Mertens-Talcott, S. U., & Chew, B. P. (2020). Antitumor potential of dark sweet cherry sweet (Prunus avium) phenolics in suppressing xenograft tumor growth of MDA-MB-453 breast cancer cells. The Journal of Nutritional Biochemistry, 84, 108437. https://doi.org/10.1016/j.jnutbio.2020.108437

Consumption of polyphenol-rich peach and plum juice prevents risk factors for obesity-related metabolic disorders and cardiovascular disease in Zucker rats

The Journal of Nutritional Biochemistry / Jun 01, 2015

Noratto, G., Martino, H. S. D., Simbo, S., Byrne, D., & Mertens-Talcott, S. U. (2015). Consumption of polyphenol-rich peach and plum juice prevents risk factors for obesity-related metabolic disorders and cardiovascular disease in Zucker rats. The Journal of Nutritional Biochemistry, 26(6), 633–641. https://doi.org/10.1016/j.jnutbio.2014.12.014

Polyphenolics from peach (Prunus persica var. Rich Lady) inhibit tumor growth and metastasis of MDA-MB-435 breast cancer cells in vivo

The Journal of Nutritional Biochemistry / Jul 01, 2014

Noratto, G., Porter, W., Byrne, D., & Cisneros-Zevallos, L. (2014). Polyphenolics from peach (Prunus persica var. Rich Lady) inhibit tumor growth and metastasis of MDA-MB-435 breast cancer cells in vivo. The Journal of Nutritional Biochemistry, 25(7), 796–800. https://doi.org/10.1016/j.jnutbio.2014.03.001

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VIJAYASSHEKAR MANUKONDA

Biotechnologist with core competence in biochemistry/cell-biology/molecular biology
Most Relevant Research Interests
Clinical Biochemistry
Other Research Interests (15)
Alzheimer
Type I and Type II Diabetes
Cancer
Neurobiology
Structural Biology
And 10 more
About
At UNC, I worked on type 1 diabetes, particularly the regulatory role of AIM2, a DNA sensor inflammasome molecule associated with autoimmune disorders. NOD mice deficient in AIM2 do not develop diabetes, indicating a potential beyond host defense. My research involves mapping AIM2's functional binding partners using various methods. During my time at FIU, I worked on characterizing glycan structures in ovarian cancer and developing a peptide and glycan array for identifying potential biomarkers. At BIIR in Dallas, I researched nuclear hormonal transcription factors implicated in autoimmune disorders and cancers, utilizing various methods. Additionally, my work at UTMB in Galveston involved studying cell adhesion molecules linked to neurological disorders, using biochemical and biophysical techniques. My academic background includes extensive knowledge of molecular and biochemical techniques gained at Jawaharlal Nehru Technological University in Hyderabad, India.
Most Relevant Publications (1+)

15 total publications

Design and synthesis of 2-substituted benzoxazoles as novel PTP1B inhibitors

Bioorganic & Medicinal Chemistry Letters / May 01, 2013

Chandrasekharappa, A. P., Badiger, S. E., Dubey, P. K., Panigrahi, S. K., & Manukonda, S. R. V. V. V. (2013). Design and synthesis of 2-substituted benzoxazoles as novel PTP1B inhibitors. Bioorganic & Medicinal Chemistry Letters, 23(9), 2579–2584. https://doi.org/10.1016/j.bmcl.2013.02.109

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Yuri Bukhtiyarov

Expert in small molecule drug discovery and preclinical/early clinical development of drug candidates with a track record of accomplishments and publications in peer-reviewed scientific journals
Most Relevant Research Interests
Clinical Biochemistry
Other Research Interests (22)
Drug Discovery
Cell Biology
Biochemistry
Molecular Biology
Molecular Medicine
And 17 more
About
Extensive industrial research experience focused on Drug Discovery, In Vitro Diagnostics, Biochemistry, Molecular and Cell Biology. • A record of accomplishments including five research projects taken from their inception to IND filing and advancing seven compounds into clinic. • Experience with validation of novel drug targets and evaluation of small molecule drug candidates in functional assays and animal models. Deep knowledge of assay development, including cell-based and enzyme/receptor assays. • Broad expertise in Biological Sciences - enzymology, molecular biology, bioanalytical protocols, protein expression and purification, protein chemistry, immunochemistry, cell biology and cell signal transduction. • Experience with outsourcing of DMPK, in vitro Pharmacology, DDI and efficacy studies, working with CRO and Academic groups on Target Validation and Preclinical Drug Development. • Expertise with database management, deposition of structured results and analysis of large data arrays including data mining and statistical analysis.
Most Relevant Publications (9+)

39 total publications

Spirocyclic ureas: Orally bioavailable 11β-HSD1 inhibitors identified by computer-aided drug design

Bioorganic & Medicinal Chemistry Letters / Feb 01, 2010

Tice, C. M., Zhao, W., Xu, Z., Cacatian, S. T., Simpson, R. D., Ye, Y.-J., Singh, S. B., McKeever, B. M., Lindblom, P., Guo, J., Krosky, P. M., Kruk, B. A., Berbaum, J., Harrison, R. K., Johnson, J. J., Bukhtiyarov, Y., Panemangalore, R., Scott, B. B., Zhao, Y., … Claremon, D. A. (2010). Spirocyclic ureas: Orally bioavailable 11β-HSD1 inhibitors identified by computer-aided drug design. Bioorganic & Medicinal Chemistry Letters, 20(3), 881–886. https://doi.org/10.1016/j.bmcl.2009.12.082

Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists

Bioorganic & Medicinal Chemistry / Mar 01, 2016

Lotesta, S. D., Marcus, A. P., Zheng, Y., Leftheris, K., Noto, P. B., Meng, S., Kandpal, G., Chen, G., Zhou, J., McKeever, B., Bukhtiyarov, Y., Zhao, Y., Lala, D. S., Singh, S. B., & McGeehan, G. M. (2016). Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists. Bioorganic & Medicinal Chemistry, 24(6), 1384–1391. https://doi.org/10.1016/j.bmc.2016.02.014

Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor

Bioorganic & Medicinal Chemistry / Jul 01, 2017

Zhuang, L., Tice, C. M., Xu, Z., Zhao, W., Cacatian, S., Ye, Y.-J., Singh, S. B., Lindblom, P., McKeever, B. M., Krosky, P. M., Zhao, Y., Lala, D., Kruk, B. A., Meng, S., Howard, L., Johnson, J. A., Bukhtiyarov, Y., Panemangalore, R., Guo, J., … Claremon, D. A. (2017). Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor. Bioorganic & Medicinal Chemistry, 25(14), 3649–3657. https://doi.org/10.1016/j.bmc.2017.04.033

Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core

Bioorganic & Medicinal Chemistry Letters / Oct 01, 2016

Tice, C. M., Noto, P. B., Fan, K. Y., Zhao, W., Lotesta, S. D., Dong, C., Marcus, A. P., Zheng, Y.-J., Chen, G., Wu, Z., Van Orden, R., Zhou, J., Bukhtiyarov, Y., Zhao, Y., Lipinski, K., Howard, L., Guo, J., Kandpal, G., Meng, S., … Claremon, D. A. (2016). Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core. Bioorganic & Medicinal Chemistry Letters, 26(20), 5044–5050. https://doi.org/10.1016/j.bmcl.2016.08.089

Prolonged stability by cyclization: Macrocyclic phosphino dipeptide isostere inhibitors of β-secretase (BACE1)

Bioorganic & Medicinal Chemistry Letters / Aug 01, 2009

Huber, T., Manzenrieder, F., Kuttruff, C. A., Dorner-Ciossek, C., & Kessler, H. (2009). Prolonged stability by cyclization: Macrocyclic phosphino dipeptide isostere inhibitors of β-secretase (BACE1). Bioorganic & Medicinal Chemistry Letters, 19(15), 4427–4431. https://doi.org/10.1016/j.bmcl.2009.05.053

Biphenyl/diphenyl ether renin inhibitors: Filling the S1 pocket of renin via the S3 pocket

Bioorganic & Medicinal Chemistry Letters / Aug 01, 2011

Yuan, J., Simpson, R. D., Zhao, W., Tice, C. M., Xu, Z., Cacatian, S., Jia, L., Flaherty, P. T., Guo, J., Ishchenko, A., Wu, Z., McKeever, B. M., Scott, B. B., Bukhtiyarov, Y., Berbaum, J., Panemangalore, R., Bentley, R., Doe, C. P., Harrison, R. K., … Claremon, D. A. (2011). Biphenyl/diphenyl ether renin inhibitors: Filling the S1 pocket of renin via the S3 pocket. Bioorganic & Medicinal Chemistry Letters, 21(16), 4836–4843. https://doi.org/10.1016/j.bmcl.2011.06.043

Discovery and optimization of adamantyl carbamate inhibitors of 11β-HSD1

Bioorganic & Medicinal Chemistry Letters / Nov 01, 2010

Tice, C. M., Zhao, W., Krosky, P. M., Kruk, B. A., Berbaum, J., Johnson, J. A., Bukhtiyarov, Y., Panemangalore, R., Scott, B. B., Zhao, Y., Bruno, J. G., Howard, L., Togias, J., Ye, Y.-J., Singh, S. B., McKeever, B. M., Lindblom, P. R., Guo, J., Guo, R., … Claremon, D. A. (2010). Discovery and optimization of adamantyl carbamate inhibitors of 11β-HSD1. Bioorganic & Medicinal Chemistry Letters, 20(22), 6725–6729. https://doi.org/10.1016/j.bmcl.2010.08.142

Optimization of orally bioavailable alkyl amine renin inhibitors

Bioorganic & Medicinal Chemistry Letters / Jan 01, 2010

Xu, Z., Cacatian, S., Yuan, J., Simpson, R. D., Jia, L., Zhao, W., Tice, C. M., Flaherty, P. T., Guo, J., Ishchenko, A., Singh, S. B., Wu, Z., McKeever, B. M., Scott, B. B., Bukhtiyarov, Y., Berbaum, J., Mason, J., Panemangalore, R., Cappiello, M. G., … Claremon, D. A. (2010). Optimization of orally bioavailable alkyl amine renin inhibitors. Bioorganic & Medicinal Chemistry Letters, 20(2), 694–699. https://doi.org/10.1016/j.bmcl.2009.11.066

Design and optimization of renin inhibitors: Orally bioavailable alkyl amines

Bioorganic & Medicinal Chemistry Letters / Jul 01, 2009

Tice, C. M., Xu, Z., Yuan, J., Simpson, R. D., Cacatian, S. T., Flaherty, P. T., Zhao, W., Guo, J., Ishchenko, A., Singh, S. B., Wu, Z., Scott, B. B., Bukhtiyarov, Y., Berbaum, J., Mason, J., Panemangalore, R., Cappiello, M. G., Müller, D., Harrison, R. K., … Claremon, D. A. (2009). Design and optimization of renin inhibitors: Orally bioavailable alkyl amines. Bioorganic & Medicinal Chemistry Letters, 19(13), 3541–3545. https://doi.org/10.1016/j.bmcl.2009.04.140

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Giuseppe Maria de Peppo

Brooklyn, New York, United States of America
Research Director
Most Relevant Research Interests
Clinical Biochemistry
Other Research Interests (21)
Cell Biology
Endocrinology
Otorhinolaryngology
Biochemistry
Biomedical Engineering
And 16 more
About
I am Director of Internal Research at Mirimus Inc, Research Assistant Professor of Cell Biology at SUNY, and Visiting Scholar at NYU Tandon School of Engineering. The major goal of my research team is to develop next generation sensing devices for the detection and monitoring of different human health hazards. Previous research directions include the engineering of tissue grafts and tissue replacement products, the manufacturing and testing of implants and biomaterials, the design and validation of bioreactor systems, organ-on-a-chip, and stem cell-based therapy. During over 15 years of research, I have had the opportunity to teach and mentor numerous undergraduate and graduate students and supervise several PhD and postdoctoral fellows.
Most Relevant Publications (2+)

33 total publications

Slow release of growth factors and thrombospondin-1 in Choukroun's platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies

Growth Factors / Jan 01, 2009

Dohan Ehrenfest, D. M., de Peppo, G. M., Doglioli, P., & Sammartino, G. (2009). Slow release of growth factors and thrombospondin-1 in Choukroun’s platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies. Growth Factors, 27(1), 63–69. https://doi.org/10.1080/08977190802636713

Make no bones about it: cells could soon be reprogrammed to grow replacement bones?

Expert Opinion on Biological Therapy / Sep 23, 2013

de Peppo, G. M., & Marolt, D. (2013). Make no bones about it: cells could soon be reprogrammed to grow replacement bones? Expert Opinion on Biological Therapy, 14(1), 1–5. https://doi.org/10.1517/14712598.2013.840581

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Javier O. Morales

Professor of drug delivery and pharmaceutical product development at University of Chile
Most Relevant Research Interests
Clinical Biochemistry
Other Research Interests (30)
Pharmaceutics
Biotechnology
Pharmaceutical Science
Drug Discovery
Agronomy and Crop Science
And 25 more
About
Javier O. Morales is a highly accomplished and experienced pharmaceutical professional with a strong academic background and extensive practical experience. He obtained his Bachelor of Science degree in Pharmacy in 2006 and the Pharmaceutical Chemist degree in 2008 from the University of Chile. He then went on to obtain his Ph.D. in Pharmaceutics from The University of Texas at Austin in 2012. Dr. Morales has since worked as an Assistant Professor and later as an Associate Professor at the University of Chile. He has also served as the Director of the Center of New Drugs for Hypertension (CENDHY), where he led a team of researchers in developing new and innovative pharmaceutical treatments for hypertension. Dr. Morales has a strong passion for research and has published numerous articles in international journals and has patented his developed technologies. His expertise in pharmaceuticals, nano and microstructured drug delivery systems, implants, and peptide drug discovery has made him a sought-after speaker at conferences and symposiums around the world. In addition to his academic and research achievements, Dr. Morales is also a dedicated mentor and has supervised and mentored several students in their research projects. He is known for his commitment to excellence and his ability to motivate and inspire others. Overall, Dr. Morales is a highly respected and accomplished pharmaceutical professional with a strong track record of success in academia. His contributions to the field of pharmaceutical sciences have made a significant impact, and he continues to be a leader in the industry.
Most Relevant Publications (1+)

63 total publications

Characterization, phase-solubility, and molecular modeling of inclusion complex of 5-nitroindazole derivative with cyclodextrins

Bioorganic & Medicinal Chemistry / May 01, 2008

Jullian, C., Morales-Montecinos, J., Zapata-Torres, G., Aguilera, B., Rodriguez, J., Arán, V., & Olea-Azar, C. (2008). Characterization, phase-solubility, and molecular modeling of inclusion complex of 5-nitroindazole derivative with cyclodextrins. Bioorganic & Medicinal Chemistry, 16(9), 5078–5084. https://doi.org/10.1016/j.bmc.2008.03.026

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Dr. Barry A. Spiering, Ph.D.

Over 20 years of experience in exercise & sports science, including directly serving athletes, astronauts, and soldiers
Most Relevant Research Interests
Clinical Biochemistry
Other Research Interests (27)
Exercise Physiology
Physical Therapy, Sports Therapy and Rehabilitation
Orthopedics and Sports Medicine
Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine
And 22 more
About
With a Ph.D. and over 20 years of experience in health & human performance research, my research has directly benefited athletes, astronauts, and soldiers. I've also had the unique distinction of working in industry (Nike, the NFL, and New Balance), government (NASA, the U.S. Army, and the U.S. Olympic Training Center), and academia (as a faculty member at California State University, Fullerton). Along the way, I've gained skills in product innovation, research program management, and communicating complex ideas to diverse audiences.
Most Relevant Publications (2+)

98 total publications

Elevated endogenous testosterone concentrations potentiate muscle androgen receptor responses to resistance exercise

The Journal of Steroid Biochemistry and Molecular Biology / Apr 01, 2009

Spiering, B. A., Kraemer, W. J., Vingren, J. L., Ratamess, N. A., Anderson, J. M., Armstrong, L. E., Nindl, B. C., Volek, J. S., Häkkinen, K., & Maresh, C. M. (2009). Elevated endogenous testosterone concentrations potentiate muscle androgen receptor responses to resistance exercise. The Journal of Steroid Biochemistry and Molecular Biology, 114(3–5), 195–199. https://doi.org/10.1016/j.jsbmb.2009.02.005

Recovery of Endocrine and Inflammatory Mediators Following an Extended Energy Deficit

The Journal of Clinical Endocrinology & Metabolism / Mar 01, 2014

Henning, P. C., Scofield, D. E., Spiering, B. A., Staab, J. S., Matheny, R. W., Smith, M. A., Bhasin, S., & Nindl, B. C. (2014). Recovery of Endocrine and Inflammatory Mediators Following an Extended Energy Deficit. The Journal of Clinical Endocrinology & Metabolism, 99(3), 956–964. https://doi.org/10.1210/jc.2013-3046

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Example clinical biochemistry projects

How can companies collaborate more effectively with researchers, experts, and thought leaders to make progress on clinical biochemistry?

Development of Novel Biomarkers

A Clinical Biochemistry expert can collaborate with a company to identify and validate novel biomarkers for early disease detection. This can lead to the development of diagnostic tests that are more accurate, sensitive, and specific, enabling early intervention and improved patient outcomes.

Drug Discovery and Development

Collaborating with a Clinical Biochemistry researcher can accelerate the drug discovery and development process. Their expertise in understanding the biochemical mechanisms of diseases can help identify potential drug targets and design effective therapeutic interventions.

Optimization of Production Processes

Clinical Biochemistry researchers can optimize production processes in industries such as pharmaceuticals and biotechnology. By studying the biochemical reactions involved in manufacturing, they can improve efficiency, reduce costs, and ensure the production of high-quality products.

Quality Control and Assurance

Companies can benefit from the expertise of Clinical Biochemistry researchers in implementing robust quality control and assurance measures. They can develop and validate analytical methods, perform rigorous testing, and ensure compliance with regulatory standards, thereby enhancing product safety and reliability.

Personalized Medicine

Collaboration with Clinical Biochemistry experts can enable the development of personalized medicine approaches. By analyzing an individual's biochemical profile, researchers can tailor treatments and therapies to specific patient characteristics, leading to improved efficacy and reduced side effects.